Incidental Mutation 'IGL00090:Or10ak9'
ID 1706
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ak9
Ensembl Gene ENSMUSG00000073769
Gene Name olfactory receptor family 10 subfamily AK member 9
Synonyms MOR259-3P, GA_x6K02T2QD9B-18670866-18669913, Olfr1331
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # IGL00090
Quality Score
Status
Chromosome 4
Chromosomal Location 118725980-118726933 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 118726484 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 168 (Y168N)
Ref Sequence ENSEMBL: ENSMUSP00000154685 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094831] [ENSMUST00000106360] [ENSMUST00000216589]
AlphaFold K7N684
Predicted Effect probably damaging
Transcript: ENSMUST00000094831
AA Change: Y169N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000092426
Gene: ENSMUSG00000073769
AA Change: Y169N

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 2.1e-53 PFAM
Pfam:7tm_1 42 291 3.9e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106360
AA Change: Y169N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000101967
Gene: ENSMUSG00000073769
AA Change: Y169N

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 1.2e-28 PFAM
Pfam:7tm_4 139 283 2.8e-45 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216589
AA Change: Y168N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,854,345 (GRCm39) T857A probably benign Het
Abcc9 A T 6: 142,578,916 (GRCm39) probably benign Het
Adam11 A G 11: 102,667,657 (GRCm39) T709A probably benign Het
Adgre1 A G 17: 57,757,055 (GRCm39) I771V probably benign Het
Adgrv1 T G 13: 81,553,527 (GRCm39) probably null Het
Adgrv1 C T 13: 81,726,220 (GRCm39) D602N probably damaging Het
Adra1d G T 2: 131,403,597 (GRCm39) D164E possibly damaging Het
Ago3 A G 4: 126,265,334 (GRCm39) L319P probably damaging Het
Aim2 A G 1: 173,283,031 (GRCm39) S38G probably benign Het
Apoh A G 11: 108,286,660 (GRCm39) D28G probably benign Het
Atm C T 9: 53,435,743 (GRCm39) R189K probably damaging Het
Bbs1 T C 19: 4,943,038 (GRCm39) T451A probably benign Het
BC034090 T C 1: 155,101,193 (GRCm39) D719G possibly damaging Het
Bcr T C 10: 74,992,903 (GRCm39) probably benign Het
Bmp2 A T 2: 133,402,947 (GRCm39) Q166L probably benign Het
Bms1 A T 6: 118,381,544 (GRCm39) S665T probably benign Het
Ccser1 A T 6: 62,357,126 (GRCm39) T855S possibly damaging Het
Cfap36 C T 11: 29,172,875 (GRCm39) V217M probably benign Het
Clca3b T C 3: 144,542,393 (GRCm39) N470D probably damaging Het
Cort A G 4: 149,209,752 (GRCm39) F100S probably damaging Het
Cyp4f14 G T 17: 33,133,540 (GRCm39) D105E probably benign Het
Dnah1 A G 14: 31,009,830 (GRCm39) S1913P probably benign Het
Fam91a1 A T 15: 58,302,584 (GRCm39) H308L probably damaging Het
Fbn1 A C 2: 125,166,867 (GRCm39) I2016M probably damaging Het
Fibcd1 T A 2: 31,723,886 (GRCm39) Q251L possibly damaging Het
Flg2 T A 3: 93,109,416 (GRCm39) Y481* probably null Het
Ly9 A T 1: 171,421,019 (GRCm39) I624N probably damaging Het
Mapt C T 11: 104,213,311 (GRCm39) S301L probably damaging Het
Meiob G A 17: 25,042,603 (GRCm39) V144I probably benign Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Myo5a T A 9: 75,068,779 (GRCm39) C660* probably null Het
Necab3 G T 2: 154,389,488 (GRCm39) probably benign Het
Nr2c2ap A G 8: 70,585,279 (GRCm39) Y93C probably damaging Het
Nxpe5 A G 5: 138,247,096 (GRCm39) D356G probably benign Het
Or2w25 A T 11: 59,504,147 (GRCm39) Y119F possibly damaging Het
Plce1 A G 19: 38,734,232 (GRCm39) Q1544R probably damaging Het
Plppr4 T A 3: 117,115,869 (GRCm39) T605S probably benign Het
Poglut1 C A 16: 38,363,278 (GRCm39) W167L possibly damaging Het
Pou2f1 G T 1: 165,729,867 (GRCm39) R162S probably damaging Het
Ptprf A G 4: 118,080,417 (GRCm39) probably benign Het
Reln C A 5: 22,244,563 (GRCm39) G805V possibly damaging Het
Rexo2 A G 9: 48,385,747 (GRCm39) S126P probably damaging Het
Robo4 A G 9: 37,322,400 (GRCm39) S844G probably damaging Het
Scn7a A G 2: 66,513,671 (GRCm39) probably benign Het
Sdc1 A G 12: 8,840,459 (GRCm39) T75A possibly damaging Het
Slc38a4 C T 15: 96,917,690 (GRCm39) E12K probably benign Het
Spata31h1 T G 10: 82,119,586 (GRCm39) M4475L probably benign Het
Tbck T C 3: 132,448,854 (GRCm39) probably null Het
Tex2 A T 11: 106,459,361 (GRCm39) V23E probably damaging Het
Zfp770 A G 2: 114,026,413 (GRCm39) V552A probably benign Het
Zfyve26 T C 12: 79,296,234 (GRCm39) probably benign Het
Other mutations in Or10ak9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01314:Or10ak9 APN 4 118,726,328 (GRCm39) missense probably benign 0.26
IGL02025:Or10ak9 APN 4 118,726,362 (GRCm39) missense probably damaging 1.00
IGL02458:Or10ak9 APN 4 118,726,497 (GRCm39) missense possibly damaging 0.83
IGL02793:Or10ak9 APN 4 118,726,794 (GRCm39) missense probably damaging 1.00
IGL02827:Or10ak9 APN 4 118,726,157 (GRCm39) missense probably damaging 0.99
IGL02863:Or10ak9 APN 4 118,726,083 (GRCm39) missense possibly damaging 0.52
IGL03125:Or10ak9 APN 4 118,726,118 (GRCm39) missense possibly damaging 0.95
R0078:Or10ak9 UTSW 4 118,726,424 (GRCm39) missense probably benign
R0152:Or10ak9 UTSW 4 118,726,083 (GRCm39) missense possibly damaging 0.89
R0299:Or10ak9 UTSW 4 118,726,613 (GRCm39) missense probably benign 0.00
R3881:Or10ak9 UTSW 4 118,726,550 (GRCm39) missense probably benign 0.00
R3928:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R3929:Or10ak9 UTSW 4 118,726,179 (GRCm39) missense probably damaging 1.00
R5288:Or10ak9 UTSW 4 118,726,772 (GRCm39) missense probably damaging 1.00
R5552:Or10ak9 UTSW 4 118,726,665 (GRCm39) missense probably damaging 1.00
R5672:Or10ak9 UTSW 4 118,726,379 (GRCm39) missense possibly damaging 0.83
R5773:Or10ak9 UTSW 4 118,726,718 (GRCm39) missense probably damaging 0.97
R6117:Or10ak9 UTSW 4 118,726,341 (GRCm39) missense probably benign 0.39
R6910:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6911:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R6912:Or10ak9 UTSW 4 118,726,335 (GRCm39) missense probably damaging 1.00
R7164:Or10ak9 UTSW 4 118,726,922 (GRCm39) missense probably benign 0.30
R7446:Or10ak9 UTSW 4 118,726,019 (GRCm39) missense possibly damaging 0.83
R9747:Or10ak9 UTSW 4 118,726,217 (GRCm39) missense probably damaging 1.00
T0975:Or10ak9 UTSW 4 118,726,500 (GRCm39) missense probably benign 0.02
Posted On 2011-07-12