Incidental Mutation 'R1562:Olfr898'
ID170685
Institutional Source Beutler Lab
Gene Symbol Olfr898
Ensembl Gene ENSMUSG00000094588
Gene Nameolfactory receptor 898
SynonymsGA_x6K02T2PVTD-32037624-32038565, MOR170-3
MMRRC Submission 039601-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.236) question?
Stock #R1562 (G1)
Quality Score225
Status Not validated
Chromosome9
Chromosomal Location38348411-38352919 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 38349362 bp
ZygosityHeterozygous
Amino Acid Change Serine to Stop codon at position 87 (S87*)
Ref Sequence ENSEMBL: ENSMUSP00000149554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076504] [ENSMUST00000216304] [ENSMUST00000217063]
Predicted Effect probably null
Transcript: ENSMUST00000076504
AA Change: S93*
SMART Domains Protein: ENSMUSP00000075824
Gene: ENSMUSG00000094588
AA Change: S93*

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 2.2e-47 PFAM
Pfam:7tm_1 47 313 1.7e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216304
AA Change: S87*
Predicted Effect probably null
Transcript: ENSMUST00000217063
AA Change: S87*
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 91.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016K19Rik A T 11: 76,003,198 I134F probably damaging Het
Abca2 A G 2: 25,446,319 I2201V probably benign Het
Adam22 T C 5: 8,095,007 N817S probably damaging Het
Alox12 C A 11: 70,250,165 R348L probably damaging Het
Asb17 A T 3: 153,853,506 T285S probably benign Het
Casp4 T C 9: 5,324,733 S182P possibly damaging Het
Cenpe T C 3: 135,238,394 M985T possibly damaging Het
Clcn1 C T 6: 42,300,235 P420L probably benign Het
Coro2a T C 4: 46,548,917 I126V probably benign Het
Cubn T C 2: 13,427,967 Y1181C probably damaging Het
Cyp2d22 A T 15: 82,373,978 L147Q probably damaging Het
D430042O09Rik C A 7: 125,842,848 S643Y probably damaging Het
Dna2 C T 10: 62,949,187 R28W probably benign Het
Ecm1 G A 3: 95,735,963 R342C probably damaging Het
Fat2 T C 11: 55,309,974 N758S probably damaging Het
Fbxo43 T C 15: 36,163,016 D15G probably damaging Het
Flt3 T C 5: 147,344,513 E803G probably damaging Het
Folr1 T G 7: 101,858,594 D213A probably damaging Het
Fus T C 7: 127,979,922 V359A probably damaging Het
Gabrb3 C T 7: 57,765,514 R111* probably null Het
Gm17324 T C 9: 78,448,682 probably benign Het
Hormad2 A T 11: 4,408,848 probably null Het
Ifi27l2b T A 12: 103,456,521 probably null Het
Isg20 G T 7: 78,920,143 C176F probably benign Het
Krt15 C A 11: 100,133,181 V346L probably benign Het
Med13l A G 5: 118,738,519 K920R probably damaging Het
Mlh3 A T 12: 85,266,920 F831I probably benign Het
Mtmr9 A G 14: 63,534,337 S267P probably benign Het
Mybpc1 C T 10: 88,553,331 A406T probably damaging Het
Myh1 T C 11: 67,211,370 M829T probably benign Het
Myo10 A G 15: 25,780,411 Q209R possibly damaging Het
Nceh1 T A 3: 27,239,552 V153D probably damaging Het
Olfr1195 T A 2: 88,683,079 I218F probably benign Het
Olfr348 A G 2: 36,786,684 D53G probably damaging Het
Olfr694 C T 7: 106,688,980 M250I probably benign Het
Oog3 A T 4: 144,162,599 I3N probably damaging Het
Pcnt G A 10: 76,367,330 T2646M probably benign Het
Phf10 A T 17: 14,946,250 C453S probably damaging Het
Plcb4 T A 2: 135,970,447 probably null Het
Plekhh1 A G 12: 79,076,708 H1185R probably benign Het
Prmt3 G T 7: 49,826,854 V404L probably benign Het
Ptprb T A 10: 116,339,467 D1122E probably benign Het
Rars A G 11: 35,821,094 probably null Het
Rasa2 G T 9: 96,545,750 N687K possibly damaging Het
Rbm11 A G 16: 75,596,535 T40A probably damaging Het
Rem2 T C 14: 54,476,318 V16A probably benign Het
Rlf A T 4: 121,150,391 M574K possibly damaging Het
Rpap3 A T 15: 97,694,217 V186D possibly damaging Het
Sertad3 G A 7: 27,476,623 E161K probably damaging Het
Sh3gl2 T C 4: 85,385,893 S278P probably benign Het
Strn3 T C 12: 51,633,618 T400A probably benign Het
Sycp2 A T 2: 178,382,385 I402N probably damaging Het
Synj1 C T 16: 90,987,402 V283I probably benign Het
Tas2r108 A G 6: 40,494,066 probably null Het
Ttpal A G 2: 163,615,403 N265S probably benign Het
Unc80 G A 1: 66,637,957 G2015D probably damaging Het
Upf1 C T 8: 70,343,367 W138* probably null Het
Vmn1r25 T G 6: 57,978,801 M168L probably benign Het
Vmn2r18 A T 5: 151,586,836 F24Y probably benign Het
Vmn2r4 G T 3: 64,389,444 T640N probably damaging Het
Wdr75 T A 1: 45,803,870 probably null Het
Zdbf2 T G 1: 63,303,588 S375R possibly damaging Het
Zfp648 A G 1: 154,204,392 Q99R probably benign Het
Zfp964 C T 8: 69,663,004 P85S probably benign Het
Other mutations in Olfr898
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01394:Olfr898 APN 9 38349805 missense possibly damaging 0.95
IGL02477:Olfr898 APN 9 38349125 missense probably benign 0.16
IGL02858:Olfr898 APN 9 38349173 missense probably benign 0.04
PIT4362001:Olfr898 UTSW 9 38349198 missense probably benign 0.34
R0060:Olfr898 UTSW 9 38349512 missense probably benign 0.23
R0518:Olfr898 UTSW 9 38349203 missense probably damaging 0.99
R0521:Olfr898 UTSW 9 38349203 missense probably damaging 0.99
R0622:Olfr898 UTSW 9 38349371 missense possibly damaging 0.74
R0898:Olfr898 UTSW 9 38349442 missense probably damaging 0.97
R3903:Olfr898 UTSW 9 38349658 nonsense probably null
R4375:Olfr898 UTSW 9 38349169 missense probably benign
R4459:Olfr898 UTSW 9 38349992 missense probably damaging 1.00
R4762:Olfr898 UTSW 9 38349281 missense probably damaging 1.00
R4943:Olfr898 UTSW 9 38349628 missense probably damaging 1.00
R5033:Olfr898 UTSW 9 38349628 missense probably damaging 1.00
R5442:Olfr898 UTSW 9 38349862 missense probably benign 0.06
R5863:Olfr898 UTSW 9 38349787 missense probably benign 0.09
R5988:Olfr898 UTSW 9 38349749 missense probably benign 0.30
R7077:Olfr898 UTSW 9 38349970 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCAACGAGAGTTCCAGTTGCCC -3'
(R):5'- ATGGCTTGACATAAGCAAGGAGACC -3'

Sequencing Primer
(F):5'- GTTCCAGTTGCCCCTGTTTG -3'
(R):5'- CCTGATCATAAACCCTGTGTGAG -3'
Posted On2014-04-13