Incidental Mutation 'R1572:Kntc1'
| ID |
170833 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kntc1
|
| Ensembl Gene |
ENSMUSG00000029414 |
| Gene Name |
kinetochore associated 1 |
| Synonyms |
jgl |
| MMRRC Submission |
039611-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.948)
|
| Stock # |
R1572 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123887779-123959656 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 123910176 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 525
(T525A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031366
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031366]
|
| AlphaFold |
Q8C3Y4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031366
AA Change: T525A
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000031366
Gene: ENSMUSG00000029414
AA Change: T525A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
345 |
357 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
764 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1044 |
N/A |
INTRINSIC |
|
Pfam:Rod_C
|
1579 |
2128 |
3.2e-256 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197665
|
| Meta Mutation Damage Score |
0.4587 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.5%
- 10x: 92.9%
- 20x: 80.7%
|
| Validation Efficiency |
97% (130/134) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice have a kinked tail. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310030G06Rik |
G |
A |
9: 50,651,973 (GRCm39) |
T85M |
probably damaging |
Het |
| Actn1 |
A |
G |
12: 80,219,731 (GRCm39) |
|
probably benign |
Het |
| Afap1l1 |
A |
T |
18: 61,870,570 (GRCm39) |
S603T |
probably damaging |
Het |
| Ahcy |
T |
C |
2: 154,910,851 (GRCm39) |
Y39C |
probably benign |
Het |
| Ankmy2 |
T |
C |
12: 36,236,941 (GRCm39) |
|
probably null |
Het |
| Anxa13 |
A |
T |
15: 58,220,655 (GRCm39) |
|
noncoding transcript |
Het |
| Aoc1 |
T |
C |
6: 48,882,720 (GRCm39) |
S221P |
possibly damaging |
Het |
| Arhgef10 |
C |
A |
8: 15,041,211 (GRCm39) |
A770D |
possibly damaging |
Het |
| Arhgef19 |
A |
G |
4: 140,982,065 (GRCm39) |
D707G |
probably benign |
Het |
| Arhgef3 |
G |
A |
14: 27,123,692 (GRCm39) |
R444H |
probably damaging |
Het |
| Asphd1 |
T |
C |
7: 126,548,271 (GRCm39) |
I11V |
probably benign |
Het |
| Atp2b1 |
A |
G |
10: 98,830,537 (GRCm39) |
M333V |
probably benign |
Het |
| BC051665 |
T |
C |
13: 60,932,841 (GRCm39) |
Y40C |
probably damaging |
Het |
| Ccdc87 |
T |
A |
19: 4,890,341 (GRCm39) |
S278T |
probably benign |
Het |
| Ccn3 |
T |
A |
15: 54,612,648 (GRCm39) |
M219K |
possibly damaging |
Het |
| Cdcp3 |
T |
A |
7: 130,846,560 (GRCm39) |
Y777* |
probably null |
Het |
| Chaf1b |
G |
A |
16: 93,698,118 (GRCm39) |
G463D |
possibly damaging |
Het |
| Chrna4 |
T |
C |
2: 180,671,100 (GRCm39) |
T219A |
possibly damaging |
Het |
| Clcnkb |
T |
G |
4: 141,134,406 (GRCm39) |
T584P |
possibly damaging |
Het |
| Clptm1l |
T |
C |
13: 73,755,866 (GRCm39) |
S161P |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,230,777 (GRCm39) |
E1437G |
possibly damaging |
Het |
| Col13a1 |
A |
T |
10: 61,702,205 (GRCm39) |
|
probably null |
Het |
| Col3a1 |
T |
C |
1: 45,385,128 (GRCm39) |
S82P |
possibly damaging |
Het |
| Cpeb3 |
A |
T |
19: 37,116,482 (GRCm39) |
M383K |
probably benign |
Het |
| Cr2 |
T |
A |
1: 194,845,622 (GRCm39) |
H111L |
probably damaging |
Het |
| Cttnbp2 |
T |
C |
6: 18,375,974 (GRCm39) |
S1522G |
possibly damaging |
Het |
| Cul3 |
T |
C |
1: 80,260,506 (GRCm39) |
D281G |
possibly damaging |
Het |
| Cyp2c70 |
T |
G |
19: 40,172,426 (GRCm39) |
K72T |
probably benign |
Het |
| Cyp39a1 |
A |
T |
17: 43,991,020 (GRCm39) |
I110F |
probably damaging |
Het |
| Cyp46a1 |
T |
A |
12: 108,318,198 (GRCm39) |
M203K |
probably null |
Het |
| Cyp8b1 |
A |
T |
9: 121,744,024 (GRCm39) |
V436D |
possibly damaging |
Het |
| Ddx17 |
T |
C |
15: 79,422,766 (GRCm39) |
D324G |
probably damaging |
Het |
| Dop1b |
A |
G |
16: 93,567,041 (GRCm39) |
N1274S |
probably damaging |
Het |
| Dscaml1 |
G |
A |
9: 45,632,631 (GRCm39) |
V1166I |
probably benign |
Het |
| Dsp |
T |
C |
13: 38,379,714 (GRCm39) |
V1554A |
probably damaging |
Het |
| Efr3a |
T |
A |
15: 65,726,641 (GRCm39) |
|
probably null |
Het |
| Egfem1 |
A |
T |
3: 29,702,420 (GRCm39) |
N223I |
probably benign |
Het |
| Egr2 |
T |
C |
10: 67,375,805 (GRCm39) |
S147P |
probably damaging |
Het |
| Elmo3 |
A |
G |
8: 106,034,933 (GRCm39) |
T408A |
probably benign |
Het |
| Flnb |
A |
G |
14: 7,883,908 (GRCm38) |
D378G |
probably damaging |
Het |
| Foxj2 |
T |
A |
6: 122,810,220 (GRCm39) |
M193K |
probably benign |
Het |
| Gm6327 |
A |
G |
16: 12,578,020 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7694 |
T |
C |
1: 170,130,335 (GRCm39) |
H21R |
probably benign |
Het |
| Gpr107 |
A |
G |
2: 31,057,037 (GRCm39) |
D43G |
probably damaging |
Het |
| Grid2 |
T |
A |
6: 64,406,678 (GRCm39) |
Y679* |
probably null |
Het |
| Grin2c |
G |
A |
11: 115,146,900 (GRCm39) |
P432S |
possibly damaging |
Het |
| H2-M10.1 |
A |
G |
17: 36,636,625 (GRCm39) |
F60L |
possibly damaging |
Het |
| Hectd4 |
A |
G |
5: 121,439,941 (GRCm39) |
D1147G |
possibly damaging |
Het |
| Idua |
G |
T |
5: 108,828,455 (GRCm39) |
A223S |
probably benign |
Het |
| Ifi206 |
T |
C |
1: 173,314,419 (GRCm39) |
Q7R |
probably benign |
Het |
| Itgad |
T |
A |
7: 127,802,406 (GRCm39) |
V986E |
probably damaging |
Het |
| Itsn2 |
G |
A |
12: 4,700,044 (GRCm39) |
R670H |
probably benign |
Het |
| Kdm4a |
T |
C |
4: 117,996,146 (GRCm39) |
E961G |
possibly damaging |
Het |
| Klra5 |
T |
A |
6: 129,883,585 (GRCm39) |
I91L |
probably damaging |
Het |
| Lct |
A |
G |
1: 128,221,932 (GRCm39) |
F1536L |
probably benign |
Het |
| Lmod1 |
T |
A |
1: 135,291,671 (GRCm39) |
D175E |
probably benign |
Het |
| Lonrf1 |
A |
C |
8: 36,701,126 (GRCm39) |
D361E |
probably benign |
Het |
| Lrrc19 |
T |
C |
4: 94,526,666 (GRCm39) |
Y297C |
probably damaging |
Het |
| Mast4 |
T |
C |
13: 102,873,431 (GRCm39) |
E1787G |
possibly damaging |
Het |
| Mpp2 |
G |
A |
11: 101,951,374 (GRCm39) |
A452V |
probably benign |
Het |
| Msh2 |
T |
C |
17: 88,026,080 (GRCm39) |
V686A |
possibly damaging |
Het |
| Mthfd1 |
C |
T |
12: 76,317,193 (GRCm39) |
Q15* |
probably null |
Het |
| Mtnr1b |
A |
T |
9: 15,774,438 (GRCm39) |
I207N |
probably damaging |
Het |
| Nid2 |
A |
G |
14: 19,855,480 (GRCm39) |
T1207A |
probably benign |
Het |
| Nin |
A |
T |
12: 70,085,524 (GRCm39) |
V1569D |
probably damaging |
Het |
| Nrcam |
T |
A |
12: 44,584,147 (GRCm39) |
|
probably benign |
Het |
| Nsd1 |
T |
A |
13: 55,394,782 (GRCm39) |
H897Q |
probably damaging |
Het |
| Or10g9 |
A |
G |
9: 39,912,490 (GRCm39) |
F11S |
probably benign |
Het |
| Or12d2 |
A |
T |
17: 37,624,371 (GRCm39) |
N301K |
probably benign |
Het |
| Or2w2 |
T |
A |
13: 21,758,480 (GRCm39) |
I49F |
possibly damaging |
Het |
| Or7d10 |
G |
T |
9: 19,832,208 (GRCm39) |
K234N |
probably benign |
Het |
| Paip1 |
T |
C |
13: 119,588,320 (GRCm39) |
|
probably benign |
Het |
| Pcnx3 |
G |
A |
19: 5,735,375 (GRCm39) |
R484* |
probably null |
Het |
| Pdxk |
A |
G |
10: 78,283,814 (GRCm39) |
Y127H |
probably damaging |
Het |
| Phf20 |
T |
A |
2: 156,129,754 (GRCm39) |
V442E |
probably benign |
Het |
| Phlpp1 |
G |
A |
1: 106,320,519 (GRCm39) |
D1505N |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,417,664 (GRCm39) |
T2496A |
probably benign |
Het |
| Pkhd1l1 |
A |
G |
15: 44,406,869 (GRCm39) |
T2369A |
probably benign |
Het |
| Plod2 |
T |
A |
9: 92,485,120 (GRCm39) |
|
probably benign |
Het |
| Pnpla7 |
T |
A |
2: 24,905,263 (GRCm39) |
M617K |
possibly damaging |
Het |
| Ppp1r16a |
C |
T |
15: 76,577,869 (GRCm39) |
Q328* |
probably null |
Het |
| Prkch |
T |
A |
12: 73,696,131 (GRCm39) |
|
probably null |
Het |
| Prr12 |
G |
A |
7: 44,678,224 (GRCm39) |
H1974Y |
unknown |
Het |
| Prr16 |
A |
G |
18: 51,436,042 (GRCm39) |
I174V |
probably benign |
Het |
| Prss45 |
A |
T |
9: 110,667,497 (GRCm39) |
T39S |
probably benign |
Het |
| Pum1 |
T |
A |
4: 130,445,515 (GRCm39) |
D161E |
probably damaging |
Het |
| Rad51ap2 |
A |
G |
12: 11,507,113 (GRCm39) |
D345G |
probably damaging |
Het |
| Ralgapb |
A |
G |
2: 158,288,119 (GRCm39) |
|
probably benign |
Het |
| Rasgrp3 |
A |
G |
17: 75,807,729 (GRCm39) |
H262R |
possibly damaging |
Het |
| Rnf213 |
T |
A |
11: 119,327,437 (GRCm39) |
I1809N |
probably damaging |
Het |
| Ryr1 |
A |
G |
7: 28,761,616 (GRCm39) |
L3177P |
probably damaging |
Het |
| Scyl2 |
C |
A |
10: 89,486,818 (GRCm39) |
R230L |
probably damaging |
Het |
| Sfxn2 |
T |
C |
19: 46,570,915 (GRCm39) |
|
probably benign |
Het |
| Slc18b1 |
T |
C |
10: 23,674,639 (GRCm39) |
|
probably benign |
Het |
| Spata31d1d |
T |
C |
13: 59,876,005 (GRCm39) |
H510R |
probably benign |
Het |
| Stab1 |
A |
T |
14: 30,872,780 (GRCm39) |
N1109K |
probably damaging |
Het |
| Styxl2 |
C |
T |
1: 165,927,024 (GRCm39) |
V863M |
possibly damaging |
Het |
| Sult3a2 |
A |
G |
10: 33,657,973 (GRCm39) |
S47P |
probably damaging |
Het |
| Tenm3 |
T |
C |
8: 48,682,028 (GRCm39) |
N2518S |
possibly damaging |
Het |
| Tex21 |
G |
T |
12: 76,253,665 (GRCm39) |
P416Q |
probably benign |
Het |
| Tex38 |
T |
C |
4: 115,637,503 (GRCm39) |
N100S |
probably benign |
Het |
| Thsd4 |
A |
C |
9: 60,301,836 (GRCm39) |
|
probably benign |
Het |
| Ticrr |
T |
C |
7: 79,331,572 (GRCm39) |
V723A |
probably damaging |
Het |
| Tmprss15 |
A |
G |
16: 78,887,717 (GRCm39) |
V30A |
probably benign |
Het |
| Uba3 |
A |
G |
6: 97,162,298 (GRCm39) |
|
probably benign |
Het |
| Ubr1 |
T |
C |
2: 120,765,800 (GRCm39) |
|
probably benign |
Het |
| Uchl4 |
A |
T |
9: 64,143,013 (GRCm39) |
I165L |
probably benign |
Het |
| Vmn2r112 |
A |
T |
17: 22,822,125 (GRCm39) |
T268S |
possibly damaging |
Het |
| Wfdc3 |
T |
C |
2: 164,586,114 (GRCm39) |
|
probably benign |
Het |
| Zfp282 |
T |
A |
6: 47,869,801 (GRCm39) |
L282Q |
probably damaging |
Het |
| Zfp422 |
A |
T |
6: 116,603,745 (GRCm39) |
C85S |
probably damaging |
Het |
| Zfp790 |
A |
T |
7: 29,527,564 (GRCm39) |
Q83L |
probably benign |
Het |
|
| Other mutations in Kntc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00087:Kntc1
|
APN |
5 |
123,928,222 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL00514:Kntc1
|
APN |
5 |
123,929,590 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01103:Kntc1
|
APN |
5 |
123,902,283 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01106:Kntc1
|
APN |
5 |
123,900,666 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01357:Kntc1
|
APN |
5 |
123,895,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01367:Kntc1
|
APN |
5 |
123,896,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01538:Kntc1
|
APN |
5 |
123,919,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01546:Kntc1
|
APN |
5 |
123,903,068 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01595:Kntc1
|
APN |
5 |
123,941,758 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01725:Kntc1
|
APN |
5 |
123,902,253 (GRCm39) |
missense |
probably benign |
|
|
IGL01916:Kntc1
|
APN |
5 |
123,939,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01936:Kntc1
|
APN |
5 |
123,949,439 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01942:Kntc1
|
APN |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01973:Kntc1
|
APN |
5 |
123,904,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01982:Kntc1
|
APN |
5 |
123,947,159 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02145:Kntc1
|
APN |
5 |
123,900,661 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02510:Kntc1
|
APN |
5 |
123,957,125 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02611:Kntc1
|
APN |
5 |
123,950,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Kntc1
|
APN |
5 |
123,893,727 (GRCm39) |
splice site |
probably benign |
|
|
IGL02737:Kntc1
|
APN |
5 |
123,957,183 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL02793:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02809:Kntc1
|
APN |
5 |
123,914,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02860:Kntc1
|
APN |
5 |
123,907,936 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02875:Kntc1
|
APN |
5 |
123,916,340 (GRCm39) |
splice site |
probably null |
|
|
IGL02931:Kntc1
|
APN |
5 |
123,937,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03169:Kntc1
|
APN |
5 |
123,913,884 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03267:Kntc1
|
APN |
5 |
123,896,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0006:Kntc1
|
UTSW |
5 |
123,927,201 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0017:Kntc1
|
UTSW |
5 |
123,919,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0125:Kntc1
|
UTSW |
5 |
123,903,120 (GRCm39) |
splice site |
probably benign |
|
|
R0324:Kntc1
|
UTSW |
5 |
123,916,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0580:Kntc1
|
UTSW |
5 |
123,941,732 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0608:Kntc1
|
UTSW |
5 |
123,924,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0725:Kntc1
|
UTSW |
5 |
123,907,767 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0733:Kntc1
|
UTSW |
5 |
123,928,979 (GRCm39) |
missense |
probably null |
|
|
R0781:Kntc1
|
UTSW |
5 |
123,937,965 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Kntc1
|
UTSW |
5 |
123,934,167 (GRCm39) |
missense |
probably benign |
|
|
R1250:Kntc1
|
UTSW |
5 |
123,922,262 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1253:Kntc1
|
UTSW |
5 |
123,948,925 (GRCm39) |
frame shift |
probably null |
|
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1467:Kntc1
|
UTSW |
5 |
123,925,047 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1481:Kntc1
|
UTSW |
5 |
123,916,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1624:Kntc1
|
UTSW |
5 |
123,896,540 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1749:Kntc1
|
UTSW |
5 |
123,927,162 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1993:Kntc1
|
UTSW |
5 |
123,948,874 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1993:Kntc1
|
UTSW |
5 |
123,897,162 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2071:Kntc1
|
UTSW |
5 |
123,932,340 (GRCm39) |
splice site |
probably null |
|
|
R2237:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2239:Kntc1
|
UTSW |
5 |
123,941,733 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2366:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2367:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2382:Kntc1
|
UTSW |
5 |
123,898,411 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2389:Kntc1
|
UTSW |
5 |
123,919,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2413:Kntc1
|
UTSW |
5 |
123,902,212 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2442:Kntc1
|
UTSW |
5 |
123,948,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Kntc1
|
UTSW |
5 |
123,916,410 (GRCm39) |
nonsense |
probably null |
|
|
R2943:Kntc1
|
UTSW |
5 |
123,935,847 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3116:Kntc1
|
UTSW |
5 |
123,940,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4107:Kntc1
|
UTSW |
5 |
123,900,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4176:Kntc1
|
UTSW |
5 |
123,914,680 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4275:Kntc1
|
UTSW |
5 |
123,905,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4440:Kntc1
|
UTSW |
5 |
123,932,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4575:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4578:Kntc1
|
UTSW |
5 |
123,904,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4612:Kntc1
|
UTSW |
5 |
123,950,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Kntc1
|
UTSW |
5 |
123,949,496 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4720:Kntc1
|
UTSW |
5 |
123,903,086 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4784:Kntc1
|
UTSW |
5 |
123,954,825 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4785:Kntc1
|
UTSW |
5 |
123,954,825 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4824:Kntc1
|
UTSW |
5 |
123,928,196 (GRCm39) |
nonsense |
probably null |
|
|
R4847:Kntc1
|
UTSW |
5 |
123,940,337 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4849:Kntc1
|
UTSW |
5 |
123,897,128 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4904:Kntc1
|
UTSW |
5 |
123,916,396 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4922:Kntc1
|
UTSW |
5 |
123,940,309 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5080:Kntc1
|
UTSW |
5 |
123,900,649 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5114:Kntc1
|
UTSW |
5 |
123,919,118 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5171:Kntc1
|
UTSW |
5 |
123,937,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5220:Kntc1
|
UTSW |
5 |
123,950,160 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5226:Kntc1
|
UTSW |
5 |
123,932,235 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5278:Kntc1
|
UTSW |
5 |
123,919,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5329:Kntc1
|
UTSW |
5 |
123,902,254 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5496:Kntc1
|
UTSW |
5 |
123,922,245 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5503:Kntc1
|
UTSW |
5 |
123,957,939 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5633:Kntc1
|
UTSW |
5 |
123,957,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5638:Kntc1
|
UTSW |
5 |
123,956,538 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5697:Kntc1
|
UTSW |
5 |
123,903,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5757:Kntc1
|
UTSW |
5 |
123,945,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5773:Kntc1
|
UTSW |
5 |
123,932,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5940:Kntc1
|
UTSW |
5 |
123,924,258 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6019:Kntc1
|
UTSW |
5 |
123,900,579 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6230:Kntc1
|
UTSW |
5 |
123,927,072 (GRCm39) |
splice site |
probably null |
|
|
R6437:Kntc1
|
UTSW |
5 |
123,907,754 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6888:Kntc1
|
UTSW |
5 |
123,949,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6907:Kntc1
|
UTSW |
5 |
123,939,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7123:Kntc1
|
UTSW |
5 |
123,919,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7262:Kntc1
|
UTSW |
5 |
123,925,036 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7381:Kntc1
|
UTSW |
5 |
123,948,971 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7485:Kntc1
|
UTSW |
5 |
123,925,019 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7512:Kntc1
|
UTSW |
5 |
123,929,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7581:Kntc1
|
UTSW |
5 |
123,954,818 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7687:Kntc1
|
UTSW |
5 |
123,897,152 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7798:Kntc1
|
UTSW |
5 |
123,957,180 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7798:Kntc1
|
UTSW |
5 |
123,924,357 (GRCm39) |
missense |
probably benign |
|
|
R7871:Kntc1
|
UTSW |
5 |
123,922,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7876:Kntc1
|
UTSW |
5 |
123,913,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7947:Kntc1
|
UTSW |
5 |
123,919,951 (GRCm39) |
missense |
unknown |
|
|
R7997:Kntc1
|
UTSW |
5 |
123,916,117 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8231:Kntc1
|
UTSW |
5 |
123,920,959 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8257:Kntc1
|
UTSW |
5 |
123,896,586 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8345:Kntc1
|
UTSW |
5 |
123,924,993 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8354:Kntc1
|
UTSW |
5 |
123,916,330 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8732:Kntc1
|
UTSW |
5 |
123,928,180 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8754:Kntc1
|
UTSW |
5 |
123,897,115 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8947:Kntc1
|
UTSW |
5 |
123,925,041 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9041:Kntc1
|
UTSW |
5 |
123,927,093 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Kntc1
|
UTSW |
5 |
123,940,355 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9432:Kntc1
|
UTSW |
5 |
123,925,112 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9460:Kntc1
|
UTSW |
5 |
123,941,378 (GRCm39) |
nonsense |
probably null |
|
|
R9468:Kntc1
|
UTSW |
5 |
123,954,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9643:Kntc1
|
UTSW |
5 |
123,949,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Kntc1
|
UTSW |
5 |
123,897,119 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9721:Kntc1
|
UTSW |
5 |
123,939,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9789:Kntc1
|
UTSW |
5 |
123,898,706 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
X0027:Kntc1
|
UTSW |
5 |
123,948,992 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Kntc1
|
UTSW |
5 |
123,916,100 (GRCm39) |
nonsense |
probably null |
|
|
X0067:Kntc1
|
UTSW |
5 |
123,916,137 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGGAGAAGACTGGCCCTTGTT -3'
(R):5'- GCAACTGTGCTCCCAAATACTGACT -3'
Sequencing Primer
(F):5'- atgtggaggtcaggacaatg -3'
(R):5'- CTTGAGCCAATTCTTGCTGGAAAG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation