Incidental Mutation 'R1573:Zfp975'
ID 170966
Institutional Source Beutler Lab
Gene Symbol Zfp975
Ensembl Gene ENSMUSG00000069727
Gene Name zinc finger protein 975
Synonyms Gm5595
MMRRC Submission 039612-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R1573 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 42309529-42342166 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 42311507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 369 (Y369N)
Ref Sequence ENSEMBL: ENSMUSP00000103626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107992]
AlphaFold Q6NVD6
Predicted Effect probably benign
Transcript: ENSMUST00000107992
AA Change: Y369N

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000103626
Gene: ENSMUSG00000069727
AA Change: Y369N

DomainStartEndE-ValueType
KRAB 4 66 1.53e-19 SMART
ZnF_C2H2 131 153 7.78e-3 SMART
ZnF_C2H2 159 181 9.73e-4 SMART
ZnF_C2H2 187 209 1.47e-3 SMART
ZnF_C2H2 215 237 3.89e-3 SMART
ZnF_C2H2 243 265 2.57e-3 SMART
ZnF_C2H2 271 293 7.26e-3 SMART
ZnF_C2H2 299 321 1.58e-3 SMART
ZnF_C2H2 327 349 7.9e-4 SMART
ZnF_C2H2 355 377 5.9e-3 SMART
ZnF_C2H2 383 405 1.58e-3 SMART
ZnF_C2H2 411 433 6.32e-3 SMART
ZnF_C2H2 439 461 8.47e-4 SMART
ZnF_C2H2 467 489 2.57e-3 SMART
ZnF_C2H2 495 517 3.16e-3 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.6%
  • 20x: 87.1%
Validation Efficiency 98% (90/92)
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam19 T C 11: 46,004,445 (GRCm39) probably benign Het
Add1 C G 5: 34,758,740 (GRCm39) A18G possibly damaging Het
Alk T C 17: 72,910,113 (GRCm39) K198E possibly damaging Het
Angptl1 T A 1: 156,684,740 (GRCm39) L303Q possibly damaging Het
Aox1 A T 1: 58,348,186 (GRCm39) I635L probably benign Het
Atp5mk T A 19: 47,074,634 (GRCm39) Q9L possibly damaging Het
Atp8a2 G T 14: 60,097,655 (GRCm39) T791K probably benign Het
Auts2 T C 5: 131,469,325 (GRCm39) K664R probably damaging Het
Birc6 T A 17: 74,967,685 (GRCm39) probably benign Het
Cacna1i C A 15: 80,277,869 (GRCm39) probably null Het
Cacna2d1 T C 5: 16,575,625 (GRCm39) F1077L probably damaging Het
Camkk1 C T 11: 72,918,307 (GRCm39) R52C probably damaging Het
Camkmt T A 17: 85,403,958 (GRCm39) V60E probably damaging Het
Car9 G T 4: 43,512,439 (GRCm39) probably null Het
Cbr2 A T 11: 120,622,791 (GRCm39) L3Q possibly damaging Het
Ccar1 A T 10: 62,586,434 (GRCm39) D920E unknown Het
Cdc20b A G 13: 113,192,478 (GRCm39) N57S probably benign Het
Cep83 G A 10: 94,624,525 (GRCm39) E601K probably damaging Het
Cldn10 A T 14: 119,111,080 (GRCm39) I176L probably benign Het
Cpeb2 T C 5: 43,441,273 (GRCm39) probably benign Het
Crb1 A G 1: 139,265,344 (GRCm39) S25P probably damaging Het
Cyp3a59 A T 5: 146,039,684 (GRCm39) Y319F probably damaging Het
Dst C T 1: 34,240,312 (GRCm39) S1561F probably damaging Het
Dxo C T 17: 35,057,270 (GRCm39) R221C probably damaging Het
Dynlt4 A T 4: 116,985,191 (GRCm39) T5S probably benign Het
Epc2 A G 2: 49,439,984 (GRCm39) T801A possibly damaging Het
Fndc3a C A 14: 72,806,384 (GRCm39) C373F probably damaging Het
Frmpd1 T C 4: 45,283,932 (GRCm39) S918P probably benign Het
Fuca2 A G 10: 13,381,587 (GRCm39) T84A possibly damaging Het
Garin4 G A 1: 190,896,682 (GRCm39) probably benign Het
Gmeb1 A T 4: 131,979,051 (GRCm39) N21K probably benign Het
Htt T C 5: 35,021,718 (GRCm39) probably benign Het
Igsf1 T C X: 48,880,863 (GRCm39) R251G possibly damaging Het
Itih4 A T 14: 30,619,504 (GRCm39) H720L probably benign Het
Kank4 A T 4: 98,663,073 (GRCm39) L705* probably null Het
Krt34 A T 11: 99,931,854 (GRCm39) S122T probably benign Het
L1td1 A G 4: 98,625,517 (GRCm39) T571A probably benign Het
Lag3 T C 6: 124,886,210 (GRCm39) T248A possibly damaging Het
Lgi1 T A 19: 38,272,629 (GRCm39) H133Q probably benign Het
Map1a A T 2: 121,134,607 (GRCm39) T1808S probably benign Het
Mcm9 T C 10: 53,424,752 (GRCm39) T613A probably damaging Het
Meaf6 A G 4: 124,983,931 (GRCm39) I111V probably benign Het
Mki67 G A 7: 135,296,845 (GRCm39) P2730S possibly damaging Het
Mlc1 A C 15: 88,842,350 (GRCm39) C337G probably damaging Het
Mrc2 T A 11: 105,227,482 (GRCm39) Y572N probably damaging Het
Mterf3 T C 13: 67,070,967 (GRCm39) N172S possibly damaging Het
Or3a1c T A 11: 74,046,196 (GRCm39) M72K probably benign Het
Or4b1 A T 2: 89,979,068 (GRCm39) probably benign Het
Or4c115 T A 2: 88,928,064 (GRCm39) D69V probably damaging Het
Or5ak4 A T 2: 85,161,687 (GRCm39) L185H probably damaging Het
Or6c6c T C 10: 129,541,487 (GRCm39) S247P probably damaging Het
Padi4 T G 4: 140,484,881 (GRCm39) T327P possibly damaging Het
Pga5 T A 19: 10,651,201 (GRCm39) I151F probably benign Het
Pkdrej G T 15: 85,702,275 (GRCm39) D1220E probably benign Het
Prokr2 T A 2: 132,215,684 (GRCm39) Q259L probably damaging Het
Ptbp2 C A 3: 119,546,754 (GRCm39) D43Y probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Ralgps2 C T 1: 156,660,500 (GRCm39) R237Q possibly damaging Het
Rap1gds1 C A 3: 138,671,624 (GRCm39) probably null Het
Saa2 T A 7: 46,401,716 (GRCm39) M1K probably null Het
Samd9l T C 6: 3,375,426 (GRCm39) I612V probably damaging Het
Scn10a C T 9: 119,442,692 (GRCm39) V1518I probably benign Het
Serpina6 T C 12: 103,618,012 (GRCm39) D267G probably damaging Het
Sh2d4b A G 14: 40,564,329 (GRCm39) probably null Het
Sh3bp2 T C 5: 34,718,034 (GRCm39) V505A probably benign Het
Smad2 A G 18: 76,395,657 (GRCm39) E32G possibly damaging Het
Smn1 T G 13: 100,263,118 (GRCm39) D32E probably damaging Het
Spata31d1c T C 13: 65,182,883 (GRCm39) S142P possibly damaging Het
Stk39 A T 2: 68,221,293 (GRCm39) I210N probably damaging Het
Tcte2 A G 17: 13,937,899 (GRCm39) probably benign Het
Tctn3 C A 19: 40,597,361 (GRCm39) E230* probably null Het
Tenm2 A T 11: 35,937,896 (GRCm39) H1592Q probably damaging Het
Tescl A G 7: 24,032,668 (GRCm39) V219A probably damaging Het
Tgm6 C T 2: 129,993,660 (GRCm39) S633L probably benign Het
Tmcc1 C T 6: 116,110,924 (GRCm39) S123N probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ulk2 G A 11: 61,670,581 (GRCm39) R992C probably damaging Het
Vwa5b1 G A 4: 138,332,184 (GRCm39) H278Y probably damaging Het
Wwp2 C T 8: 108,275,121 (GRCm39) R373W probably damaging Het
Zfp24 A T 18: 24,150,399 (GRCm39) D170E possibly damaging Het
Zfp808 T C 13: 62,319,311 (GRCm39) I180T possibly damaging Het
Zfp820 T A 17: 22,037,737 (GRCm39) Q530H probably benign Het
Other mutations in Zfp975
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02008:Zfp975 APN 7 42,312,215 (GRCm39) missense probably damaging 1.00
R0194:Zfp975 UTSW 7 42,311,916 (GRCm39) missense probably benign 0.02
R0662:Zfp975 UTSW 7 42,311,950 (GRCm39) missense probably benign 0.02
R1491:Zfp975 UTSW 7 42,312,236 (GRCm39) missense probably benign 0.19
R1738:Zfp975 UTSW 7 42,312,373 (GRCm39) missense probably benign 0.05
R1833:Zfp975 UTSW 7 42,311,263 (GRCm39) missense probably benign 0.01
R2185:Zfp975 UTSW 7 42,311,105 (GRCm39) missense possibly damaging 0.90
R4031:Zfp975 UTSW 7 42,312,377 (GRCm39) nonsense probably null
R4090:Zfp975 UTSW 7 42,312,298 (GRCm39) missense probably benign 0.10
R4356:Zfp975 UTSW 7 42,311,251 (GRCm39) missense probably damaging 1.00
R4631:Zfp975 UTSW 7 42,312,369 (GRCm39) missense probably benign 0.09
R4795:Zfp975 UTSW 7 42,314,570 (GRCm39) critical splice acceptor site probably null
R4896:Zfp975 UTSW 7 42,311,716 (GRCm39) missense probably damaging 1.00
R5266:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5267:Zfp975 UTSW 7 42,311,654 (GRCm39) missense probably damaging 1.00
R5580:Zfp975 UTSW 7 42,314,513 (GRCm39) nonsense probably null
R5874:Zfp975 UTSW 7 42,312,312 (GRCm39) missense probably benign 0.00
R5898:Zfp975 UTSW 7 42,311,963 (GRCm39) missense probably damaging 1.00
R6529:Zfp975 UTSW 7 42,311,325 (GRCm39) missense possibly damaging 0.79
R6782:Zfp975 UTSW 7 42,311,454 (GRCm39) missense probably benign 0.41
R6937:Zfp975 UTSW 7 42,314,480 (GRCm39) missense possibly damaging 0.61
R7088:Zfp975 UTSW 7 42,312,096 (GRCm39) missense probably benign 0.02
R7233:Zfp975 UTSW 7 42,311,918 (GRCm39) missense probably benign 0.38
R7253:Zfp975 UTSW 7 42,311,036 (GRCm39) makesense probably null
R7358:Zfp975 UTSW 7 42,312,215 (GRCm39) missense probably damaging 1.00
R7659:Zfp975 UTSW 7 42,311,848 (GRCm39) missense probably benign 0.00
R7999:Zfp975 UTSW 7 42,312,356 (GRCm39) missense probably benign 0.02
R8676:Zfp975 UTSW 7 42,312,264 (GRCm39) missense probably benign 0.44
R8957:Zfp975 UTSW 7 42,311,157 (GRCm39) missense probably damaging 1.00
R9274:Zfp975 UTSW 7 42,312,299 (GRCm39) missense probably benign 0.02
R9326:Zfp975 UTSW 7 42,311,837 (GRCm39) nonsense probably null
R9536:Zfp975 UTSW 7 42,312,345 (GRCm39) missense probably benign 0.11
R9569:Zfp975 UTSW 7 42,311,413 (GRCm39) missense probably benign 0.00
R9717:Zfp975 UTSW 7 42,312,332 (GRCm39) missense possibly damaging 0.50
Predicted Primers
Posted On 2014-04-13