Incidental Mutation 'R1575:Scara5'
ID 171125
Institutional Source Beutler Lab
Gene Symbol Scara5
Ensembl Gene ENSMUSG00000022032
Gene Name scavenger receptor class A, member 5
Synonyms 4933425F03Rik, 4932433F15Rik
MMRRC Submission 039613-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R1575 (G1)
Quality Score 149
Status Validated
Chromosome 14
Chromosomal Location 65903852-66002275 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 65968314 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 196 (Q196K)
Ref Sequence ENSEMBL: ENSMUSP00000063391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022610] [ENSMUST00000069226]
AlphaFold Q8K299
Predicted Effect probably benign
Transcript: ENSMUST00000022610
AA Change: Q196K

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000022610
Gene: ENSMUSG00000022032
AA Change: Q196K

DomainStartEndE-ValueType
transmembrane domain 60 82 N/A INTRINSIC
Pfam:Collagen 304 357 1.8e-8 PFAM
Pfam:Collagen 327 383 1.1e-8 PFAM
SR 389 489 5.5e-56 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000069226
AA Change: Q196K

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000063391
Gene: ENSMUSG00000022032
AA Change: Q196K

DomainStartEndE-ValueType
transmembrane domain 60 82 N/A INTRINSIC
Pfam:Collagen 304 360 1e-11 PFAM
Pfam:Collagen 329 386 1.9e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154373
Meta Mutation Damage Score 0.1438 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.5%
Validation Efficiency 100% (72/72)
MGI Phenotype PHENOTYPE: Homozygous deletion of this gene results in decreased male fertility and lymphocytic infiltration of the stroma of various tissues, particularly in the lungs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl2 T A 3: 148,558,398 (GRCm39) T437S probably benign Het
Akna A G 4: 63,297,570 (GRCm39) F828S probably benign Het
Alg9 G T 9: 50,686,802 (GRCm39) A40S possibly damaging Het
Alox8 T A 11: 69,076,067 (GRCm39) H628L possibly damaging Het
Aox3 T C 1: 58,191,713 (GRCm39) W422R probably benign Het
Atp13a4 T C 16: 29,228,528 (GRCm39) D984G probably benign Het
Bcam T C 7: 19,494,307 (GRCm39) E363G possibly damaging Het
Cadps2 C A 6: 23,429,217 (GRCm39) V519F probably damaging Het
Calca A G 7: 114,234,396 (GRCm39) Y18H probably damaging Het
Cd70 A G 17: 57,453,364 (GRCm39) I100T probably damaging Het
Cdk4 T A 10: 126,900,520 (GRCm39) H95Q probably damaging Het
Chchd1 T A 14: 20,753,410 (GRCm39) N11K probably damaging Het
Cma2 T A 14: 56,210,272 (GRCm39) N52K probably damaging Het
Cyp3a16 A G 5: 145,373,267 (GRCm39) V500A probably benign Het
Dicer1 A G 12: 104,688,228 (GRCm39) probably null Het
Dnajc13 A G 9: 104,034,037 (GRCm39) S2206P probably benign Het
Dtl T C 1: 191,293,658 (GRCm39) probably null Het
Fam186b T C 15: 99,184,852 (GRCm39) T24A probably benign Het
Fbxw21 A G 9: 108,990,984 (GRCm39) V25A probably benign Het
Gins1 T C 2: 150,754,758 (GRCm39) S45P probably benign Het
Gtpbp2 T A 17: 46,476,869 (GRCm39) V349D probably damaging Het
Hyal5 G T 6: 24,876,792 (GRCm39) D222Y probably damaging Het
Itgal A G 7: 126,900,060 (GRCm39) probably null Het
Klk14 A G 7: 43,343,377 (GRCm39) probably null Het
Lama1 T A 17: 68,117,404 (GRCm39) L2518Q possibly damaging Het
Lrrc2 G A 9: 110,808,555 (GRCm39) G264D probably benign Het
Ltbp4 A G 7: 27,022,245 (GRCm39) S893P probably damaging Het
Mast4 G A 13: 102,875,771 (GRCm39) P1107L probably damaging Het
Mbd1 T A 18: 74,408,490 (GRCm39) probably null Het
Naip2 A T 13: 100,291,529 (GRCm39) D1136E probably benign Het
Naip2 G A 13: 100,291,537 (GRCm39) probably benign Het
Ncan G A 8: 70,562,848 (GRCm39) T470I probably benign Het
Npy1r A T 8: 67,156,813 (GRCm39) I78F probably damaging Het
Or10q1b A T 19: 13,682,889 (GRCm39) M233L probably benign Het
Or8b52 G A 9: 38,576,573 (GRCm39) T189M probably damaging Het
Palb2 A T 7: 121,710,061 (GRCm39) probably null Het
Pax3 T C 1: 78,080,121 (GRCm39) T422A probably benign Het
Pebp1 A T 5: 117,424,229 (GRCm39) D72E possibly damaging Het
Pnliprp1 A T 19: 58,728,901 (GRCm39) T363S probably benign Het
Rbm44 G A 1: 91,084,565 (GRCm39) probably null Het
Rbm47 T A 5: 66,182,358 (GRCm39) Y425F probably benign Het
Robo3 G T 9: 37,340,957 (GRCm39) A83E probably damaging Het
Rrm1 A G 7: 102,105,721 (GRCm39) Y279C probably damaging Het
Rslcan18 A T 13: 67,256,121 (GRCm39) probably benign Het
Setd1b C T 5: 123,301,210 (GRCm39) probably benign Het
Siah1a A G 8: 87,451,869 (GRCm39) F205S probably damaging Het
Smr2 AT ATT 5: 88,256,683 (GRCm39) probably null Het
Ssu72 A G 4: 155,815,814 (GRCm39) D86G probably benign Het
St7 G T 6: 17,886,110 (GRCm39) K357N probably damaging Het
Sv2b G A 7: 74,797,425 (GRCm39) T323I probably damaging Het
Syt1 T C 10: 108,340,361 (GRCm39) N319S probably benign Het
Tanc1 T A 2: 59,621,995 (GRCm39) F371L probably damaging Het
Tcf20 C A 15: 82,739,693 (GRCm39) G586V probably benign Het
Tg T C 15: 66,601,534 (GRCm39) probably null Het
Tyk2 A T 9: 21,026,758 (GRCm39) N620K probably benign Het
Ube2j1 T A 4: 33,045,116 (GRCm39) S130T probably benign Het
Ubr2 G T 17: 47,243,418 (GRCm39) P1696H probably damaging Het
Ubr5 A T 15: 38,041,085 (GRCm39) D266E probably damaging Het
Vipr2 A G 12: 116,107,892 (GRCm39) T426A probably benign Het
Vmn2r104 A T 17: 20,262,477 (GRCm39) W218R probably damaging Het
Vmn2r83 T A 10: 79,314,956 (GRCm39) N401K probably damaging Het
Vwf A G 6: 125,632,214 (GRCm39) E82G unknown Het
Vwf T A 6: 125,640,534 (GRCm39) Y2323* probably null Het
Wdr76 T G 2: 121,359,402 (GRCm39) V329G probably damaging Het
Zan A G 5: 137,460,214 (GRCm39) C1226R unknown Het
Zbtb16 G T 9: 48,743,572 (GRCm39) Q247K probably damaging Het
Zfp541 T C 7: 15,812,640 (GRCm39) V431A possibly damaging Het
Other mutations in Scara5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00402:Scara5 APN 14 65,975,864 (GRCm39) splice site probably benign
IGL00772:Scara5 APN 14 65,908,011 (GRCm39) utr 5 prime probably benign
IGL01768:Scara5 APN 14 65,927,224 (GRCm39) nonsense probably null
IGL02081:Scara5 APN 14 65,968,104 (GRCm39) missense possibly damaging 0.96
IGL02280:Scara5 APN 14 65,968,227 (GRCm39) missense probably benign
IGL02795:Scara5 APN 14 65,968,129 (GRCm39) missense possibly damaging 0.72
IGL02887:Scara5 APN 14 66,000,278 (GRCm39) missense unknown
R0040:Scara5 UTSW 14 66,000,166 (GRCm39) splice site probably benign
R0605:Scara5 UTSW 14 65,997,097 (GRCm39) missense possibly damaging 0.85
R0735:Scara5 UTSW 14 65,968,468 (GRCm39) missense possibly damaging 0.85
R0925:Scara5 UTSW 14 66,000,167 (GRCm39) critical splice acceptor site probably benign
R1746:Scara5 UTSW 14 65,968,539 (GRCm39) missense probably benign
R1968:Scara5 UTSW 14 65,927,249 (GRCm39) missense possibly damaging 0.73
R4455:Scara5 UTSW 14 66,000,196 (GRCm39) missense probably benign 0.01
R4547:Scara5 UTSW 14 65,908,023 (GRCm39) missense possibly damaging 0.72
R4779:Scara5 UTSW 14 65,968,198 (GRCm39) missense probably benign 0.03
R5218:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5316:Scara5 UTSW 14 65,927,264 (GRCm39) missense possibly damaging 0.73
R5331:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5332:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5366:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5367:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5368:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5369:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5417:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5418:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5420:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5447:Scara5 UTSW 14 65,997,111 (GRCm39) frame shift probably null
R5473:Scara5 UTSW 14 65,977,788 (GRCm39) missense possibly damaging 0.84
R5580:Scara5 UTSW 14 65,968,528 (GRCm39) missense probably benign 0.02
R7734:Scara5 UTSW 14 65,968,600 (GRCm39) missense possibly damaging 0.85
R7995:Scara5 UTSW 14 65,997,057 (GRCm39) missense possibly damaging 0.53
R8090:Scara5 UTSW 14 65,979,586 (GRCm39) nonsense probably null
R8308:Scara5 UTSW 14 65,927,234 (GRCm39) missense probably damaging 0.97
R9036:Scara5 UTSW 14 66,000,197 (GRCm39) missense probably benign 0.24
Predicted Primers PCR Primer
(F):5'- TGCAGAACCAGACAGACTCGTTG -3'
(R):5'- TTGGCAAGGGTGATGTTCCTCAAG -3'

Sequencing Primer
(F):5'- ACAGACTCGTTGTTGGCCC -3'
(R):5'- TCCTCAAGGCGATGGAGTG -3'
Posted On 2014-04-13