Incidental Mutation 'R1577:Or2ag2'
ID 171226
Institutional Source Beutler Lab
Gene Symbol Or2ag2
Ensembl Gene ENSMUSG00000109354
Gene Name olfactory receptor family 2 subfamily AG member 2
Synonyms MOR283-11, GA_x6K02T2PBJ9-9271198-9270248, Olfr706
MMRRC Submission 039615-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.289) question?
Stock # R1577 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 106485072-106486022 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 106485217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 269 (K269R)
Ref Sequence ENSEMBL: ENSMUSP00000150075 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052535] [ENSMUST00000209025] [ENSMUST00000210644] [ENSMUST00000213251] [ENSMUST00000213918] [ENSMUST00000214112]
AlphaFold Q9EPF8
Predicted Effect probably benign
Transcript: ENSMUST00000052535
AA Change: K269R

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000057180
Gene: ENSMUSG00000064223
AA Change: K269R

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 4.1e-43 PFAM
Pfam:7tm_1 41 290 9.1e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209025
AA Change: K269R

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000210644
Predicted Effect probably benign
Transcript: ENSMUST00000213251
Predicted Effect probably benign
Transcript: ENSMUST00000213918
AA Change: K269R

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000214112
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214495
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216085
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216099
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.6%
  • 20x: 87.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 T C 1: 25,133,264 (GRCm39) N404S possibly damaging Het
Cep85 T C 4: 133,879,599 (GRCm39) E383G probably damaging Het
Chst4 A T 8: 110,756,476 (GRCm39) H379Q probably benign Het
Clca3b A T 3: 144,529,280 (GRCm39) I798N probably damaging Het
Cldnd1 T G 16: 58,553,016 (GRCm39) L159R possibly damaging Het
Cntnap3 T C 13: 64,906,104 (GRCm39) E834G probably damaging Het
Col2a1 C T 15: 97,877,083 (GRCm39) R1065Q probably damaging Het
Dchs1 T C 7: 105,415,162 (GRCm39) D674G probably damaging Het
Dntt A G 19: 41,044,224 (GRCm39) Y463C probably damaging Het
Egfr A G 11: 16,819,241 (GRCm39) E257G probably benign Het
Eif4b C T 15: 101,998,336 (GRCm39) R339* probably null Het
Fat1 C T 8: 45,476,420 (GRCm39) T1822M probably benign Het
Fgd3 T C 13: 49,435,413 (GRCm39) N282D probably damaging Het
Fmo4 T C 1: 162,631,269 (GRCm39) M233V possibly damaging Het
Gabbr2 T A 4: 46,684,319 (GRCm39) M652L probably benign Het
Gal3st2c G A 1: 93,934,650 (GRCm39) V13M probably damaging Het
Gapvd1 C T 2: 34,599,240 (GRCm39) G686D probably damaging Het
Gdap1l1 T G 2: 163,280,524 (GRCm39) L20R probably damaging Het
Gm5800 A T 14: 51,952,016 (GRCm39) M82K probably benign Het
Grm6 T A 11: 50,753,972 (GRCm39) C759S probably damaging Het
Hs3st1 A T 5: 39,772,393 (GRCm39) D83E probably benign Het
Il12rb1 A G 8: 71,263,250 (GRCm39) D39G probably damaging Het
Ldhb C A 6: 142,438,324 (GRCm39) K244N possibly damaging Het
Lypd6 C T 2: 50,080,710 (GRCm39) R133* probably null Het
Med13l G A 5: 118,859,457 (GRCm39) G215S probably damaging Het
Ncoa1 T C 12: 4,345,196 (GRCm39) D606G probably damaging Het
Noc2l C T 4: 156,325,079 (GRCm39) T151M probably damaging Het
Or10q3 T C 19: 11,847,741 (GRCm39) T280A probably damaging Het
Or2at4 T C 7: 99,384,563 (GRCm39) L71P probably damaging Het
Or2t26 T A 11: 49,040,016 (GRCm39) C311S probably benign Het
Or5aq1b T C 2: 86,901,741 (GRCm39) T246A probably benign Het
Ppm1l G A 3: 69,460,403 (GRCm39) G327R probably damaging Het
Rapgef5 C T 12: 117,558,911 (GRCm39) A282V probably benign Het
Rnf139 T C 15: 58,771,367 (GRCm39) V464A probably damaging Het
Rprd2 C T 3: 95,672,047 (GRCm39) E1119K probably damaging Het
Sipa1l2 G A 8: 126,219,001 (GRCm39) T112I probably benign Het
Skint6 T C 4: 113,005,720 (GRCm39) T363A possibly damaging Het
Slc22a16 G T 10: 40,479,811 (GRCm39) E607* probably null Het
Slc24a2 T C 4: 86,909,648 (GRCm39) Y690C probably damaging Het
Slc25a23 T C 17: 57,354,306 (GRCm39) S115G probably benign Het
Slc4a3 T C 1: 75,527,535 (GRCm39) L168P probably damaging Het
Spats2 T A 15: 99,076,333 (GRCm39) I137N possibly damaging Het
Stard4 A T 18: 33,338,151 (GRCm39) V133D probably damaging Het
Syn3 A G 10: 86,284,728 (GRCm39) probably null Het
Tfpi A G 2: 84,263,447 (GRCm39) I305T probably damaging Het
Tmtc1 T A 6: 148,314,318 (GRCm39) probably null Het
Tpcn1 A C 5: 120,682,485 (GRCm39) W508G probably damaging Het
Ubr5 A T 15: 38,030,974 (GRCm39) N406K possibly damaging Het
Xrcc1 T A 7: 24,265,052 (GRCm39) L118* probably null Het
Zbtb5 T C 4: 44,995,129 (GRCm39) Y85C probably damaging Het
Zfand4 C A 6: 116,306,373 (GRCm39) Y735* probably null Het
Zfp180 G T 7: 23,805,333 (GRCm39) C584F probably damaging Het
Other mutations in Or2ag2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02311:Or2ag2 APN 7 106,485,101 (GRCm39) missense probably benign 0.00
IGL03093:Or2ag2 APN 7 106,485,410 (GRCm39) missense probably benign 0.02
IGL03354:Or2ag2 APN 7 106,485,307 (GRCm39) missense probably benign 0.07
R0334:Or2ag2 UTSW 7 106,485,622 (GRCm39) missense probably benign 0.00
R4083:Or2ag2 UTSW 7 106,485,851 (GRCm39) missense probably damaging 0.97
R4399:Or2ag2 UTSW 7 106,485,660 (GRCm39) missense probably damaging 1.00
R4421:Or2ag2 UTSW 7 106,485,660 (GRCm39) missense probably damaging 1.00
R5202:Or2ag2 UTSW 7 106,485,803 (GRCm39) missense possibly damaging 0.90
R6031:Or2ag2 UTSW 7 106,485,134 (GRCm39) missense possibly damaging 0.93
R6031:Or2ag2 UTSW 7 106,485,134 (GRCm39) missense possibly damaging 0.93
R6375:Or2ag2 UTSW 7 106,485,221 (GRCm39) missense probably benign
R6475:Or2ag2 UTSW 7 106,485,604 (GRCm39) missense probably benign 0.00
R7665:Or2ag2 UTSW 7 106,485,880 (GRCm39) missense possibly damaging 0.95
R7742:Or2ag2 UTSW 7 106,485,829 (GRCm39) missense probably damaging 1.00
R7956:Or2ag2 UTSW 7 106,485,178 (GRCm39) missense possibly damaging 0.88
R8678:Or2ag2 UTSW 7 106,485,280 (GRCm39) missense probably damaging 1.00
Z1088:Or2ag2 UTSW 7 106,485,503 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GCTACTGGGGACTTCCCATTTTGTC -3'
(R):5'- AGATCCTGCCTTTGCTGAAGCTG -3'

Sequencing Primer
(F):5'- GTGAATCCCAAACTATGTCTACCTTG -3'
(R):5'- CTGTGTAGATACCTCCCAATATGAGC -3'
Posted On 2014-04-13