Incidental Mutation 'R1579:Olfr1153'
ID171262
Institutional Source Beutler Lab
Gene Symbol Olfr1153
Ensembl Gene ENSMUSG00000048197
Gene Nameolfactory receptor 1153
SynonymsGA_x6K02T2Q125-49395950-49396882, MOR177-7
MMRRC Submission 039616-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.090) question?
Stock #R1579 (G1)
Quality Score225
Status Not validated
Chromosome2
Chromosomal Location87894962-87898310 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 87896942 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 248 (A248T)
Ref Sequence ENSEMBL: ENSMUSP00000150945 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052300] [ENSMUST00000215017] [ENSMUST00000215862] [ENSMUST00000217436]
Predicted Effect probably benign
Transcript: ENSMUST00000052300
AA Change: A256T

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000057839
Gene: ENSMUSG00000048197
AA Change: A256T

DomainStartEndE-ValueType
Pfam:7tm_4 38 315 4.9e-45 PFAM
Pfam:7tm_1 48 297 5.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215017
Predicted Effect probably benign
Transcript: ENSMUST00000215862
Predicted Effect probably benign
Transcript: ENSMUST00000217436
AA Change: A248T

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700037C18Rik T C 16: 3,906,175 R162G probably benign Het
Adamtsl4 T A 3: 95,685,497 probably benign Het
Adgrv1 A T 13: 81,563,779 L306H probably damaging Het
Aknad1 T A 3: 108,752,136 Y155* probably null Het
Aldh6a1 C T 12: 84,441,848 R88H possibly damaging Het
Apc2 G C 10: 80,311,345 K715N probably damaging Het
Arhgap45 G A 10: 80,028,977 V798M probably damaging Het
BC037034 T C 5: 138,261,866 I338V probably benign Het
Calcrl T C 2: 84,333,537 T437A probably benign Het
Cdan1 A G 2: 120,730,739 F183L probably damaging Het
Chmp7 C T 14: 69,719,450 M336I probably benign Het
Cntnap4 A G 8: 112,881,830 E1294G possibly damaging Het
Crybg3 C A 16: 59,530,198 G2607V probably damaging Het
Dhx29 G T 13: 112,935,598 probably null Het
Dmrtb1 T A 4: 107,684,125 H13L probably damaging Het
Echdc2 A G 4: 108,173,809 M162V probably benign Het
Entpd8 A G 2: 25,084,974 D439G possibly damaging Het
Fastkd2 C G 1: 63,745,887 H477Q probably null Het
Fbrs A G 7: 127,485,357 E517G probably damaging Het
Gchfr A G 2: 119,172,021 T71A possibly damaging Het
Hecw1 A T 13: 14,377,907 C35S probably damaging Het
Izumo1r C T 9: 14,901,802 R58H probably benign Het
Kif13a T C 13: 46,752,856 E537G possibly damaging Het
Kif13b G A 14: 64,782,341 probably null Het
Kremen1 CGGG CGGGGGG 11: 5,201,791 probably benign Het
Lnpk A T 2: 74,547,996 D140E probably damaging Het
Ltbp1 A G 17: 75,252,367 M284V probably benign Het
Me3 A T 7: 89,845,842 T323S possibly damaging Het
Mtus1 A G 8: 41,082,858 V607A probably damaging Het
Myh14 A T 7: 44,655,694 probably null Het
Myo1h T A 5: 114,347,435 C545* probably null Het
Nbn T A 4: 15,964,289 D121E probably damaging Het
Nox4 A G 7: 87,370,023 Y408C probably damaging Het
Nup214 C T 2: 32,034,466 S1669F probably damaging Het
Olfr1491 A G 19: 13,705,202 D125G probably damaging Het
Olfr653 T A 7: 104,580,061 Y138* probably null Het
Osbpl5 T C 7: 143,709,202 T150A possibly damaging Het
Pgap3 C A 11: 98,390,053 M265I probably benign Het
Pirb A T 7: 3,717,638 L287Q probably benign Het
Pkd2l2 A T 18: 34,427,393 N351I possibly damaging Het
Prkdc T A 16: 15,675,328 Y700N probably benign Het
Pzp A G 6: 128,523,968 probably null Het
Rfwd3 C T 8: 111,288,242 R326Q probably damaging Het
Rptor A T 11: 119,896,001 Q1264L probably benign Het
Scnn1a T C 6: 125,322,140 F61S probably damaging Het
Tenm2 C A 11: 36,106,783 W825C probably damaging Het
Tex264 A T 9: 106,681,917 I70N possibly damaging Het
Tns2 G T 15: 102,111,210 D504Y probably damaging Het
Trpc2 T A 7: 102,084,240 F132Y probably damaging Het
Trpm4 A G 7: 45,308,597 F816S probably damaging Het
Uqcc1 G A 2: 155,921,721 Q5* probably null Het
Usp36 G T 11: 118,284,945 T130N probably damaging Het
Vav1 A G 17: 57,297,252 M165V probably benign Het
Vmn1r64 A T 7: 5,883,804 F247I probably damaging Het
Vmn2r26 G C 6: 124,039,747 R390P probably benign Het
Vmn2r57 G T 7: 41,400,124 H734N probably benign Het
Wfdc16 G T 2: 164,635,923 H69N possibly damaging Het
Zfp316 C T 5: 143,253,562 E901K probably damaging Het
Zfp334 T C 2: 165,381,799 E108G probably damaging Het
Zfp407 T C 18: 84,209,638 S1949G probably benign Het
Zfp408 A G 2: 91,646,128 L227P probably benign Het
Zfp560 T C 9: 20,347,991 H525R possibly damaging Het
Zfp609 G A 9: 65,704,472 A403V possibly damaging Het
Other mutations in Olfr1153
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01075:Olfr1153 APN 2 87896921 missense probably benign 0.00
IGL02024:Olfr1153 APN 2 87896899 missense possibly damaging 0.81
IGL02219:Olfr1153 APN 2 87896973 missense possibly damaging 0.93
IGL02693:Olfr1153 APN 2 87896533 missense probably damaging 1.00
R0121:Olfr1153 UTSW 2 87897090 missense possibly damaging 0.93
R0315:Olfr1153 UTSW 2 87897066 missense probably damaging 1.00
R0446:Olfr1153 UTSW 2 87896855 missense possibly damaging 0.51
R0472:Olfr1153 UTSW 2 87896493 missense possibly damaging 0.47
R0720:Olfr1153 UTSW 2 87896669 missense probably benign 0.31
R1968:Olfr1153 UTSW 2 87897039 missense probably damaging 1.00
R3909:Olfr1153 UTSW 2 87896949 unclassified probably null
R4936:Olfr1153 UTSW 2 87896813 missense probably benign 0.06
R5520:Olfr1153 UTSW 2 87896409 unclassified probably null
R5585:Olfr1153 UTSW 2 87896675 missense possibly damaging 0.54
R6176:Olfr1153 UTSW 2 87896936 missense probably benign 0.18
R6272:Olfr1153 UTSW 2 87896657 missense probably benign 0.00
R6451:Olfr1153 UTSW 2 87896591 missense probably damaging 1.00
Z1088:Olfr1153 UTSW 2 87896633 missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GGTTGGAATGGTAGATGCTTTGACACA -3'
(R):5'- CTTTTCTTGGGTGCATAGTTGCAAACA -3'

Sequencing Primer
(F):5'- GGTAGATGCTTTGACACATACAACG -3'
(R):5'- GCAGCGACTAAAGTATGCATTAC -3'
Posted On2014-04-13