Incidental Mutation 'R1582:Or6z3'
ID 171467
Institutional Source Beutler Lab
Gene Symbol Or6z3
Ensembl Gene ENSMUSG00000048620
Gene Name olfactory receptor family 6 subfamily Z member 3
Synonyms MOR103-7, Olfr1336, GA_x6K02T2QGBW-3190370-3191314
MMRRC Submission 039619-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R1582 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 6463225-6464454 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 6463813 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 102 (M102V)
Ref Sequence ENSEMBL: ENSMUSP00000150162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056120] [ENSMUST00000214301]
AlphaFold Q8VGH5
Predicted Effect probably benign
Transcript: ENSMUST00000056120
AA Change: M102V

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000056956
Gene: ENSMUSG00000048620
AA Change: M102V

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 3.2e-52 PFAM
Pfam:7tm_1 45 294 2.2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214301
AA Change: M102V

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.4%
  • 20x: 89.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 C G 2: 31,690,371 (GRCm39) A630G probably damaging Het
Actr3 A G 1: 125,333,662 (GRCm39) Y202H probably benign Het
Adamts19 A G 18: 59,103,013 (GRCm39) N685D probably damaging Het
Atl3 A G 19: 7,494,264 (GRCm39) T138A probably damaging Het
Bpifa2 T C 2: 153,855,638 (GRCm39) S188P probably damaging Het
Bsn T C 9: 107,982,291 (GRCm39) T3821A unknown Het
Dcun1d2 A G 8: 13,330,926 (GRCm39) L68P probably damaging Het
Ddhd1 A T 14: 45,842,566 (GRCm39) L630I probably damaging Het
Ddx25 T C 9: 35,457,272 (GRCm39) T348A probably damaging Het
Dtnb C T 12: 3,823,554 (GRCm39) T580M possibly damaging Het
Dysf A G 6: 84,074,749 (GRCm39) S561G probably damaging Het
Ehbp1l1 A G 19: 5,771,995 (GRCm39) I101T possibly damaging Het
Erich3 T C 3: 154,469,960 (GRCm39) probably benign Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fam135a T C 1: 24,068,398 (GRCm39) T611A probably damaging Het
Gpbp1 T C 13: 111,573,066 (GRCm39) probably null Het
H2-Oa A T 17: 34,313,695 (GRCm39) T218S probably damaging Het
Kctd19 G A 8: 106,122,092 (GRCm39) L152F probably damaging Het
Kdm5b T A 1: 134,552,591 (GRCm39) M1189K probably damaging Het
Kif13a A G 13: 46,947,398 (GRCm39) V862A probably benign Het
Lct T C 1: 128,228,299 (GRCm39) T1065A probably damaging Het
Mark3 G A 12: 111,621,744 (GRCm39) A697T probably benign Het
Mosmo A G 7: 120,329,728 (GRCm39) I116M possibly damaging Het
Mpped1 C T 15: 83,676,191 (GRCm39) probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Muc15 A T 2: 110,567,817 (GRCm39) M321L probably benign Het
Naa25 T A 5: 121,572,892 (GRCm39) N670K probably benign Het
Or1e1c T A 11: 73,266,090 (GRCm39) C172S probably damaging Het
Or5e1 G T 7: 108,354,317 (GRCm39) V85L probably benign Het
Ppara T C 15: 85,682,429 (GRCm39) I375T possibly damaging Het
Prss27 A G 17: 24,263,877 (GRCm39) I188V probably benign Het
Rbms1 A T 2: 60,589,179 (GRCm39) M287K possibly damaging Het
Relt C T 7: 100,500,560 (GRCm39) probably null Het
Rsf1 CG CGACGGCGGGG 7: 97,229,115 (GRCm39) probably benign Het
Sec24a A G 11: 51,599,794 (GRCm39) V837A probably benign Het
Smarca2 G A 19: 26,729,305 (GRCm39) D19N probably damaging Het
Sorbs2 G A 8: 46,258,814 (GRCm39) G620D probably damaging Het
Spata31d1c C A 13: 65,181,038 (GRCm39) Q46K probably benign Het
Spata6 C G 4: 111,637,992 (GRCm39) S274* probably null Het
Spata6 C T 4: 111,637,994 (GRCm39) P275S probably benign Het
Tas2r108 T A 6: 40,470,566 (GRCm39) V14D probably benign Het
Thbs2 G T 17: 14,891,550 (GRCm39) P996T probably damaging Het
Tmem131l T C 3: 83,839,090 (GRCm39) Q620R probably damaging Het
Ubap2l A G 3: 89,941,978 (GRCm39) S203P probably damaging Het
Unc45b G A 11: 82,816,771 (GRCm39) G404S probably benign Het
Uri1 A G 7: 37,664,811 (GRCm39) S292P possibly damaging Het
Usp21 A T 1: 171,110,655 (GRCm39) C444S probably damaging Het
Vmn1r117 A T 7: 20,617,484 (GRCm39) V188D possibly damaging Het
Vmn1r7 T C 6: 57,002,143 (GRCm39) D39G probably damaging Het
Wdr25 T C 12: 108,863,980 (GRCm39) F42L possibly damaging Het
Other mutations in Or6z3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01889:Or6z3 APN 7 6,463,502 (GRCm39) splice site probably benign
IGL02730:Or6z3 APN 7 6,464,123 (GRCm39) missense possibly damaging 0.75
R1193:Or6z3 UTSW 7 6,463,715 (GRCm39) missense probably benign 0.14
R1616:Or6z3 UTSW 7 6,463,744 (GRCm39) missense probably damaging 1.00
R1954:Or6z3 UTSW 7 6,464,144 (GRCm39) missense probably benign 0.11
R2889:Or6z3 UTSW 7 6,463,940 (GRCm39) missense probably damaging 1.00
R4881:Or6z3 UTSW 7 6,463,753 (GRCm39) missense probably benign 0.01
R4958:Or6z3 UTSW 7 6,464,057 (GRCm39) missense probably damaging 1.00
R5849:Or6z3 UTSW 7 6,463,993 (GRCm39) missense possibly damaging 0.46
R6253:Or6z3 UTSW 7 6,463,547 (GRCm39) missense probably benign 0.09
R7289:Or6z3 UTSW 7 6,463,777 (GRCm39) missense probably benign 0.00
R8810:Or6z3 UTSW 7 6,463,763 (GRCm39) missense probably damaging 1.00
Z1177:Or6z3 UTSW 7 6,464,226 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- AGGGACGCCCTGTTTGTCATCTTC -3'
(R):5'- TTTGATCACTGAGACCAGCAGCC -3'

Sequencing Primer
(F):5'- GCTGACCCTCCTGGAGAAC -3'
(R):5'- GCCCACCTAGCCATGAAG -3'
Posted On 2014-04-13