Incidental Mutation 'R1539:Dock3'
| ID |
171567 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock3
|
| Ensembl Gene |
ENSMUSG00000039716 |
| Gene Name |
dedicator of cyto-kinesis 3 |
| Synonyms |
Moca, PBP |
| MMRRC Submission |
039578-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.549)
|
| Stock # |
R1539 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 106874112 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Valine
at position 453
(A453V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044532
AA Change: A453V
PolyPhen 2
Score 0.227 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000047652
Gene: ENSMUSG00000039716
AA Change: A453V
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
3.85e-9 |
SMART |
|
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
|
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
|
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
|
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
|
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
|
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
|
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 97.9%
- 10x: 94.9%
- 20x: 88.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrv1 |
T |
A |
13: 81,652,097 (GRCm39) |
|
probably null |
Het |
| Adh7 |
A |
C |
3: 137,929,716 (GRCm39) |
T131P |
possibly damaging |
Het |
| Agxt |
G |
A |
1: 93,065,701 (GRCm39) |
G190D |
probably damaging |
Het |
| AI182371 |
A |
G |
2: 34,978,815 (GRCm39) |
I193T |
probably damaging |
Het |
| Akna |
T |
A |
4: 63,297,547 (GRCm39) |
T836S |
probably benign |
Het |
| Alox12 |
T |
C |
11: 70,144,069 (GRCm39) |
|
probably null |
Het |
| Anapc2 |
C |
A |
2: 25,163,075 (GRCm39) |
T104K |
probably benign |
Het |
| Ank1 |
T |
C |
8: 23,583,935 (GRCm39) |
L346P |
probably damaging |
Het |
| Ankfn1 |
A |
T |
11: 89,332,217 (GRCm39) |
I443N |
probably damaging |
Het |
| Arhgef17 |
G |
A |
7: 100,539,680 (GRCm39) |
T1066I |
probably damaging |
Het |
| Atg2a |
C |
A |
19: 6,296,801 (GRCm39) |
|
probably null |
Het |
| Bpifb5 |
T |
A |
2: 154,065,776 (GRCm39) |
H24Q |
probably benign |
Het |
| Brd9 |
A |
G |
13: 74,092,862 (GRCm39) |
E283G |
probably damaging |
Het |
| Cadm2 |
C |
A |
16: 66,581,727 (GRCm39) |
V184F |
probably damaging |
Het |
| Casr |
A |
G |
16: 36,315,499 (GRCm39) |
V857A |
probably benign |
Het |
| Ccdc18 |
A |
T |
5: 108,339,843 (GRCm39) |
Q796L |
probably damaging |
Het |
| Cep290 |
T |
C |
10: 100,332,690 (GRCm39) |
V263A |
probably benign |
Het |
| Clec10a |
A |
T |
11: 70,060,645 (GRCm39) |
N167Y |
probably damaging |
Het |
| Cog1 |
A |
G |
11: 113,543,058 (GRCm39) |
I189V |
possibly damaging |
Het |
| Commd2 |
A |
G |
3: 57,554,269 (GRCm39) |
I144T |
probably benign |
Het |
| Cse1l |
A |
G |
2: 166,768,292 (GRCm39) |
T197A |
probably benign |
Het |
| Csmd3 |
A |
T |
15: 47,683,794 (GRCm39) |
S1783R |
probably benign |
Het |
| Cxxc1 |
T |
C |
18: 74,352,278 (GRCm39) |
V334A |
possibly damaging |
Het |
| Dennd2d |
A |
G |
3: 106,394,236 (GRCm39) |
I39V |
probably benign |
Het |
| Dgkz |
G |
A |
2: 91,768,405 (GRCm39) |
P734S |
probably damaging |
Het |
| Diaph3 |
T |
C |
14: 86,893,916 (GRCm39) |
D31G |
probably damaging |
Het |
| Dlec1 |
T |
C |
9: 118,956,518 (GRCm39) |
S731P |
probably benign |
Het |
| Dmac2l |
G |
A |
12: 69,787,845 (GRCm39) |
D94N |
probably benign |
Het |
| Dnah11 |
T |
C |
12: 117,894,991 (GRCm39) |
R3619G |
probably benign |
Het |
| Doc2b |
A |
G |
11: 75,662,783 (GRCm39) |
L405P |
probably damaging |
Het |
| Ece2 |
T |
A |
16: 20,461,263 (GRCm39) |
I474N |
probably damaging |
Het |
| Etv4 |
A |
T |
11: 101,662,513 (GRCm39) |
|
probably null |
Het |
| Fam171b |
A |
T |
2: 83,710,442 (GRCm39) |
M705L |
probably benign |
Het |
| Frem2 |
T |
C |
3: 53,561,631 (GRCm39) |
K959E |
probably benign |
Het |
| Fyn |
T |
C |
10: 39,408,066 (GRCm39) |
M251T |
possibly damaging |
Het |
| Galnt13 |
G |
A |
2: 54,747,869 (GRCm39) |
G250E |
probably damaging |
Het |
| Ggh |
T |
C |
4: 20,054,204 (GRCm39) |
|
probably null |
Het |
| Glcci1 |
A |
G |
6: 8,591,620 (GRCm39) |
E222G |
probably damaging |
Het |
| Gm1968 |
G |
A |
16: 29,777,659 (GRCm39) |
|
noncoding transcript |
Het |
| Gm3604 |
T |
A |
13: 62,519,414 (GRCm39) |
I52F |
possibly damaging |
Het |
| Gm43302 |
T |
C |
5: 105,422,635 (GRCm39) |
I466V |
probably benign |
Het |
| Gm9789 |
T |
C |
16: 88,955,034 (GRCm39) |
S48P |
unknown |
Het |
| Gpat3 |
A |
T |
5: 101,031,254 (GRCm39) |
Y136F |
probably benign |
Het |
| Gpr171 |
T |
C |
3: 59,005,142 (GRCm39) |
D211G |
possibly damaging |
Het |
| Grep1 |
T |
A |
17: 23,936,118 (GRCm39) |
|
probably benign |
Het |
| Hs3st1 |
T |
C |
5: 39,771,791 (GRCm39) |
K284R |
probably benign |
Het |
| Htr2a |
C |
T |
14: 74,882,608 (GRCm39) |
A198V |
possibly damaging |
Het |
| Ice1 |
C |
A |
13: 70,754,023 (GRCm39) |
D688Y |
probably damaging |
Het |
| Jade1 |
T |
C |
3: 41,559,431 (GRCm39) |
M504T |
probably benign |
Het |
| Lrp1 |
T |
C |
10: 127,420,250 (GRCm39) |
|
probably null |
Het |
| Lsr |
A |
T |
7: 30,671,517 (GRCm39) |
I72N |
possibly damaging |
Het |
| Magel2 |
G |
A |
7: 62,028,557 (GRCm39) |
R487H |
possibly damaging |
Het |
| Mertk |
A |
G |
2: 128,624,446 (GRCm39) |
D619G |
probably benign |
Het |
| Myo1b |
A |
T |
1: 51,838,722 (GRCm39) |
V245E |
probably damaging |
Het |
| Myrip |
T |
A |
9: 120,253,689 (GRCm39) |
L254Q |
probably benign |
Het |
| Nav3 |
A |
G |
10: 109,603,031 (GRCm39) |
S1173P |
probably damaging |
Het |
| Ncoa7 |
T |
C |
10: 30,647,725 (GRCm39) |
Y17C |
probably damaging |
Het |
| Ncor2 |
T |
C |
5: 125,187,003 (GRCm39) |
E7G |
probably benign |
Het |
| Ninl |
A |
G |
2: 150,817,867 (GRCm39) |
V99A |
probably damaging |
Het |
| Noct |
G |
T |
3: 51,155,333 (GRCm39) |
E34* |
probably null |
Het |
| Notch1 |
A |
T |
2: 26,362,125 (GRCm39) |
Y1043* |
probably null |
Het |
| Or10v1 |
T |
C |
19: 11,873,855 (GRCm39) |
S157P |
possibly damaging |
Het |
| Or13a21 |
T |
A |
7: 139,999,326 (GRCm39) |
Y120F |
probably benign |
Het |
| Or2d3 |
A |
G |
7: 106,490,483 (GRCm39) |
Y278H |
probably damaging |
Het |
| Or6c88 |
G |
A |
10: 129,406,640 (GRCm39) |
G39R |
probably damaging |
Het |
| Pde7b |
C |
A |
10: 20,355,432 (GRCm39) |
R104L |
possibly damaging |
Het |
| Pkn1 |
C |
A |
8: 84,396,966 (GRCm39) |
R890L |
possibly damaging |
Het |
| Podn |
A |
T |
4: 107,878,764 (GRCm39) |
Y368N |
probably damaging |
Het |
| Polr1b |
G |
A |
2: 128,960,019 (GRCm39) |
|
probably null |
Het |
| Ppp1r3c |
A |
T |
19: 36,711,361 (GRCm39) |
F136L |
probably benign |
Het |
| Ppp2ca |
T |
A |
11: 52,011,800 (GRCm39) |
F260Y |
probably damaging |
Het |
| Prss39 |
A |
G |
1: 34,537,616 (GRCm39) |
S27G |
possibly damaging |
Het |
| Ptch1 |
A |
G |
13: 63,689,101 (GRCm39) |
V340A |
probably benign |
Het |
| Ranbp17 |
T |
C |
11: 33,247,394 (GRCm39) |
I246V |
probably damaging |
Het |
| Rilpl1 |
T |
A |
5: 124,653,618 (GRCm39) |
D181V |
probably damaging |
Het |
| Sdk1 |
T |
A |
5: 142,080,354 (GRCm39) |
V1282D |
probably damaging |
Het |
| Sh3rf2 |
T |
C |
18: 42,282,887 (GRCm39) |
S514P |
probably damaging |
Het |
| Slc35f2 |
A |
T |
9: 53,716,992 (GRCm39) |
I252F |
possibly damaging |
Het |
| Slc7a1 |
A |
G |
5: 148,272,403 (GRCm39) |
Y425H |
possibly damaging |
Het |
| Spaca4 |
G |
T |
7: 45,374,984 (GRCm39) |
|
probably benign |
Het |
| Spata31d1b |
T |
C |
13: 59,863,733 (GRCm39) |
S294P |
possibly damaging |
Het |
| Ssh1 |
T |
G |
5: 114,090,064 (GRCm39) |
T342P |
probably damaging |
Het |
| Stk10 |
T |
A |
11: 32,483,440 (GRCm39) |
S13T |
possibly damaging |
Het |
| Tbx1 |
G |
T |
16: 18,402,843 (GRCm39) |
D214E |
probably benign |
Het |
| Tdp1 |
A |
G |
12: 99,878,571 (GRCm39) |
E453G |
probably damaging |
Het |
| Tlr1 |
T |
C |
5: 65,084,319 (GRCm39) |
Y86C |
probably damaging |
Het |
| Tmem241 |
A |
T |
18: 12,176,297 (GRCm39) |
C124S |
possibly damaging |
Het |
| Trp63 |
A |
G |
16: 25,703,599 (GRCm39) |
M516V |
probably benign |
Het |
| Ttc28 |
T |
C |
5: 111,248,677 (GRCm39) |
V210A |
possibly damaging |
Het |
| Tut1 |
C |
T |
19: 8,942,850 (GRCm39) |
R646W |
probably benign |
Het |
| Ubald1 |
C |
T |
16: 4,694,261 (GRCm39) |
E49K |
possibly damaging |
Het |
| Usp28 |
T |
C |
9: 48,949,096 (GRCm39) |
Y897H |
probably benign |
Het |
| Vmn2r27 |
A |
C |
6: 124,168,730 (GRCm39) |
F800C |
probably damaging |
Het |
| Vmn2r83 |
T |
A |
10: 79,327,759 (GRCm39) |
M789K |
probably damaging |
Het |
| Vwa8 |
A |
G |
14: 79,300,002 (GRCm39) |
D945G |
probably benign |
Het |
| Wdhd1 |
T |
A |
14: 47,482,507 (GRCm39) |
K947N |
possibly damaging |
Het |
| Wdr12 |
A |
T |
1: 60,123,007 (GRCm39) |
|
probably null |
Het |
| Xrra1 |
A |
T |
7: 99,520,564 (GRCm39) |
E57V |
probably damaging |
Het |
|
| Other mutations in Dock3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4664:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Dock3
|
UTSW |
9 |
106,829,557 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4898:Dock3
|
UTSW |
9 |
106,807,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Dock3
|
UTSW |
9 |
106,868,354 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7426:Dock3
|
UTSW |
9 |
106,772,782 (GRCm39) |
missense |
probably benign |
|
|
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTGTTCTAAACCCGGCACCAAG -3'
(R):5'- ACTAACCTGAGTACTGCCGCACTG -3'
Sequencing Primer
(F):5'- TCTAAAGCGTGGTTACAGGC -3'
(R):5'- CTAGCCTGATGTTCCATGCAG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation