Incidental Mutation 'R1542:Plxnb2'
| ID |
171863 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnb2
|
| Ensembl Gene |
ENSMUSG00000036606 |
| Gene Name |
plexin B2 |
| Synonyms |
1110007H23Rik, Debt |
| MMRRC Submission |
039581-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.943)
|
| Stock # |
R1542 (G1)
|
| Quality Score |
163 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
89039752-89064960 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 89050124 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 491
(C491Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104955
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060808]
[ENSMUST00000060808]
[ENSMUST00000109331]
[ENSMUST00000109331]
|
| AlphaFold |
B2RXS4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000060808
AA Change: C491Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000051731
Gene: ENSMUSG00000036606
AA Change: C491Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1275 |
1809 |
1.6e-225 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000060808
AA Change: C491Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000051731
Gene: ENSMUSG00000036606
AA Change: C491Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1275 |
1809 |
1.6e-225 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109331
AA Change: C491Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000104955
Gene: ENSMUSG00000036606
AA Change: C491Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1274 |
1809 |
4.4e-251 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109331
AA Change: C491Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000104955
Gene: ENSMUSG00000036606
AA Change: C491Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1274 |
1809 |
4.4e-251 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131062
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139372
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197760
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.5%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700006A11Rik |
A |
G |
3: 124,208,055 (GRCm39) |
M208T |
possibly damaging |
Het |
| Acsbg2 |
T |
A |
17: 57,156,791 (GRCm39) |
I416F |
probably damaging |
Het |
| Adam6b |
G |
A |
12: 113,454,559 (GRCm39) |
D459N |
possibly damaging |
Het |
| Adprh |
A |
T |
16: 38,266,286 (GRCm39) |
D285E |
probably damaging |
Het |
| Aggf1 |
A |
T |
13: 95,507,450 (GRCm39) |
C112S |
probably benign |
Het |
| Als2cl |
T |
C |
9: 110,723,102 (GRCm39) |
V602A |
probably benign |
Het |
| Angptl2 |
G |
T |
2: 33,118,897 (GRCm39) |
V224F |
probably benign |
Het |
| Ap3b2 |
A |
T |
7: 81,127,825 (GRCm39) |
|
probably null |
Het |
| Aqp2 |
A |
C |
15: 99,481,723 (GRCm39) |
I206L |
probably benign |
Het |
| Asap2 |
A |
G |
12: 21,315,998 (GRCm39) |
D930G |
probably damaging |
Het |
| Cacna1e |
T |
A |
1: 154,353,525 (GRCm39) |
M682L |
probably benign |
Het |
| Ccdc18 |
A |
G |
5: 108,360,054 (GRCm39) |
N1146S |
probably benign |
Het |
| Ccr4 |
G |
A |
9: 114,321,073 (GRCm39) |
H331Y |
probably benign |
Het |
| Cd33 |
A |
G |
7: 43,181,530 (GRCm39) |
L210P |
probably damaging |
Het |
| Cep85l |
T |
C |
10: 53,177,680 (GRCm39) |
E351G |
probably damaging |
Het |
| Cntn6 |
C |
A |
6: 104,825,061 (GRCm39) |
T867K |
probably damaging |
Het |
| Cpeb2 |
C |
T |
5: 43,443,218 (GRCm39) |
R970C |
probably damaging |
Het |
| Cul7 |
T |
A |
17: 46,974,116 (GRCm39) |
L1467H |
probably damaging |
Het |
| Dscaml1 |
T |
A |
9: 45,660,738 (GRCm39) |
I1693K |
possibly damaging |
Het |
| Ebf4 |
A |
T |
2: 130,207,418 (GRCm39) |
M621L |
probably benign |
Het |
| Elp4 |
G |
T |
2: 105,624,954 (GRCm39) |
T313N |
probably benign |
Het |
| Epas1 |
T |
A |
17: 87,131,918 (GRCm39) |
I373N |
possibly damaging |
Het |
| Etnk1 |
A |
T |
6: 143,126,367 (GRCm39) |
M71L |
probably benign |
Het |
| Fry |
C |
T |
5: 150,328,431 (GRCm39) |
T1257I |
probably benign |
Het |
| Gm21834 |
A |
G |
17: 58,048,946 (GRCm39) |
F90S |
possibly damaging |
Het |
| Gm8674 |
T |
A |
13: 50,054,039 (GRCm39) |
|
noncoding transcript |
Het |
| Gna11 |
T |
C |
10: 81,369,162 (GRCm39) |
T134A |
probably benign |
Het |
| Golga5 |
C |
T |
12: 102,440,979 (GRCm39) |
S238F |
probably damaging |
Het |
| Grin2a |
T |
A |
16: 9,397,067 (GRCm39) |
N1007Y |
probably damaging |
Het |
| H3c6 |
A |
G |
13: 23,746,338 (GRCm39) |
F68L |
probably damaging |
Het |
| Ifnar2 |
G |
A |
16: 91,196,153 (GRCm39) |
V253M |
possibly damaging |
Het |
| Insl5 |
A |
T |
4: 102,875,382 (GRCm39) |
S123T |
probably damaging |
Het |
| Itgb2 |
T |
C |
10: 77,395,320 (GRCm39) |
S474P |
probably benign |
Het |
| Kcnb2 |
A |
G |
1: 15,781,012 (GRCm39) |
H628R |
probably benign |
Het |
| L3mbtl2 |
G |
A |
15: 81,566,352 (GRCm39) |
D392N |
probably null |
Het |
| Lrp1b |
G |
T |
2: 41,013,724 (GRCm39) |
T1813K |
probably damaging |
Het |
| Map3k4 |
A |
G |
17: 12,454,793 (GRCm39) |
L1399P |
probably damaging |
Het |
| Mbtps1 |
A |
C |
8: 120,272,986 (GRCm39) |
|
probably null |
Het |
| Mettl25 |
A |
T |
10: 105,661,981 (GRCm39) |
S330T |
probably benign |
Het |
| Mical2 |
T |
C |
7: 111,908,675 (GRCm39) |
L211P |
probably damaging |
Het |
| Mmrn1 |
T |
A |
6: 60,922,102 (GRCm39) |
S186R |
probably damaging |
Het |
| Mob3b |
C |
A |
4: 35,084,046 (GRCm39) |
V48L |
possibly damaging |
Het |
| Napsa |
A |
T |
7: 44,231,113 (GRCm39) |
H114L |
probably damaging |
Het |
| Nsmce4a |
A |
T |
7: 130,147,623 (GRCm39) |
|
probably null |
Het |
| Nup62 |
A |
G |
7: 44,479,353 (GRCm39) |
K456R |
possibly damaging |
Het |
| Nwd2 |
T |
A |
5: 63,964,318 (GRCm39) |
W1301R |
probably damaging |
Het |
| Oprm1 |
G |
T |
10: 6,738,960 (GRCm39) |
W29L |
probably damaging |
Het |
| Or10al2 |
A |
T |
17: 37,983,142 (GRCm39) |
E76V |
probably damaging |
Het |
| Or1l4b |
T |
A |
2: 37,036,978 (GRCm39) |
S251R |
probably damaging |
Het |
| Or2c1 |
T |
A |
16: 3,657,696 (GRCm39) |
N286K |
probably damaging |
Het |
| Or5w17 |
A |
G |
2: 87,583,662 (GRCm39) |
V225A |
probably damaging |
Het |
| Pals2 |
A |
G |
6: 50,175,306 (GRCm39) |
Y539C |
probably damaging |
Het |
| Pcnt |
T |
G |
10: 76,225,221 (GRCm39) |
N1761T |
probably benign |
Het |
| Pcnt |
C |
T |
10: 76,237,220 (GRCm39) |
M1355I |
probably benign |
Het |
| Pde11a |
A |
T |
2: 75,877,199 (GRCm39) |
S757T |
probably benign |
Het |
| Pde6a |
T |
A |
18: 61,390,116 (GRCm39) |
I490N |
possibly damaging |
Het |
| Pgap1 |
A |
G |
1: 54,531,249 (GRCm39) |
V742A |
probably benign |
Het |
| Pik3c2b |
T |
C |
1: 133,017,772 (GRCm39) |
L915P |
probably damaging |
Het |
| Pkd1l1 |
A |
G |
11: 8,824,179 (GRCm39) |
C1129R |
possibly damaging |
Het |
| Pkhd1l1 |
A |
T |
15: 44,391,587 (GRCm39) |
H1551L |
probably benign |
Het |
| Ppt1 |
C |
A |
4: 122,751,402 (GRCm39) |
H300N |
probably benign |
Het |
| Prpf3 |
T |
A |
3: 95,743,782 (GRCm39) |
Q457L |
probably benign |
Het |
| Ranbp17 |
C |
T |
11: 33,214,672 (GRCm39) |
V914I |
probably benign |
Het |
| Rasal2 |
T |
C |
1: 157,003,421 (GRCm39) |
I413V |
possibly damaging |
Het |
| Rb1cc1 |
G |
A |
1: 6,314,473 (GRCm39) |
V382I |
possibly damaging |
Het |
| Rere |
T |
A |
4: 150,700,399 (GRCm39) |
F1125I |
probably damaging |
Het |
| Rprd2 |
A |
T |
3: 95,672,988 (GRCm39) |
V805E |
possibly damaging |
Het |
| Septin10 |
T |
G |
10: 59,002,428 (GRCm39) |
E162A |
probably damaging |
Het |
| Septin12 |
G |
T |
16: 4,810,159 (GRCm39) |
D125E |
probably benign |
Het |
| Serpina6 |
A |
G |
12: 103,620,732 (GRCm39) |
Y6H |
probably benign |
Het |
| Serpinb3c |
T |
C |
1: 107,200,517 (GRCm39) |
M209V |
probably damaging |
Het |
| Slc2a7 |
A |
T |
4: 150,252,928 (GRCm39) |
T523S |
probably damaging |
Het |
| Smdt1 |
T |
C |
15: 82,230,376 (GRCm39) |
V31A |
possibly damaging |
Het |
| Snrnp48 |
T |
C |
13: 38,404,680 (GRCm39) |
I245T |
probably damaging |
Het |
| Spink2 |
G |
A |
5: 77,354,812 (GRCm39) |
T33I |
probably damaging |
Het |
| Sptan1 |
A |
G |
2: 29,917,139 (GRCm39) |
T2204A |
probably damaging |
Het |
| Synj2 |
A |
G |
17: 6,075,292 (GRCm39) |
D306G |
probably benign |
Het |
| Tas2r109 |
A |
G |
6: 132,957,873 (GRCm39) |
I19T |
possibly damaging |
Het |
| Tbk1 |
C |
T |
10: 121,395,840 (GRCm39) |
V418M |
probably benign |
Het |
| Tcerg1 |
A |
G |
18: 42,686,495 (GRCm39) |
E684G |
probably damaging |
Het |
| Tenm2 |
T |
C |
11: 36,191,047 (GRCm39) |
N308S |
probably damaging |
Het |
| Tfb2m |
A |
T |
1: 179,365,426 (GRCm39) |
|
probably null |
Het |
| Tmc1 |
T |
A |
19: 20,793,486 (GRCm39) |
L558F |
probably damaging |
Het |
| Tmprss5 |
T |
A |
9: 49,020,434 (GRCm39) |
I80N |
possibly damaging |
Het |
| Trappc2l |
G |
A |
8: 123,342,146 (GRCm39) |
V131M |
probably damaging |
Het |
| Trpm7 |
A |
C |
2: 126,664,519 (GRCm39) |
Y953* |
probably null |
Het |
| Ttn |
T |
C |
2: 76,583,859 (GRCm39) |
R22383G |
probably damaging |
Het |
| Ugt1a6b |
G |
A |
1: 88,034,983 (GRCm39) |
G107D |
probably benign |
Het |
| Vmn1r197 |
A |
T |
13: 22,512,520 (GRCm39) |
Y147F |
probably benign |
Het |
| Zfp507 |
A |
T |
7: 35,494,226 (GRCm39) |
N272K |
possibly damaging |
Het |
| Zfp526 |
G |
A |
7: 24,925,687 (GRCm39) |
E649K |
probably benign |
Het |
| Zswim6 |
G |
A |
13: 107,863,769 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Plxnb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00546:Plxnb2
|
APN |
15 |
89,046,569 (GRCm39) |
splice site |
probably benign |
|
|
IGL01574:Plxnb2
|
APN |
15 |
89,046,886 (GRCm39) |
splice site |
probably null |
|
|
IGL01695:Plxnb2
|
APN |
15 |
89,041,417 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL01763:Plxnb2
|
APN |
15 |
89,046,184 (GRCm39) |
splice site |
probably null |
|
|
IGL01921:Plxnb2
|
APN |
15 |
89,048,474 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02129:Plxnb2
|
APN |
15 |
89,044,613 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02153:Plxnb2
|
APN |
15 |
89,050,016 (GRCm39) |
nonsense |
probably null |
|
|
IGL02637:Plxnb2
|
APN |
15 |
89,048,260 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02892:Plxnb2
|
APN |
15 |
89,045,425 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03108:Plxnb2
|
APN |
15 |
89,042,234 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03115:Plxnb2
|
APN |
15 |
89,046,641 (GRCm39) |
splice site |
probably benign |
|
|
P0040:Plxnb2
|
UTSW |
15 |
89,047,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0022:Plxnb2
|
UTSW |
15 |
89,047,479 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0095:Plxnb2
|
UTSW |
15 |
89,049,534 (GRCm39) |
missense |
probably benign |
|
|
R0103:Plxnb2
|
UTSW |
15 |
89,045,972 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0544:Plxnb2
|
UTSW |
15 |
89,042,816 (GRCm39) |
splice site |
probably benign |
|
|
R0671:Plxnb2
|
UTSW |
15 |
89,042,184 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1279:Plxnb2
|
UTSW |
15 |
89,046,524 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1530:Plxnb2
|
UTSW |
15 |
89,051,395 (GRCm39) |
missense |
probably benign |
|
|
R1610:Plxnb2
|
UTSW |
15 |
89,042,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Plxnb2
|
UTSW |
15 |
89,046,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Plxnb2
|
UTSW |
15 |
89,046,187 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1996:Plxnb2
|
UTSW |
15 |
89,042,971 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1997:Plxnb2
|
UTSW |
15 |
89,042,971 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2031:Plxnb2
|
UTSW |
15 |
89,047,013 (GRCm39) |
nonsense |
probably null |
|
|
R2049:Plxnb2
|
UTSW |
15 |
89,043,205 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2072:Plxnb2
|
UTSW |
15 |
89,042,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Plxnb2
|
UTSW |
15 |
89,042,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Plxnb2
|
UTSW |
15 |
89,040,765 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2418:Plxnb2
|
UTSW |
15 |
89,045,272 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R2419:Plxnb2
|
UTSW |
15 |
89,045,272 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R3752:Plxnb2
|
UTSW |
15 |
89,041,458 (GRCm39) |
splice site |
probably benign |
|
|
R3825:Plxnb2
|
UTSW |
15 |
89,050,602 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4154:Plxnb2
|
UTSW |
15 |
89,043,845 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4197:Plxnb2
|
UTSW |
15 |
89,041,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Plxnb2
|
UTSW |
15 |
89,044,826 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4434:Plxnb2
|
UTSW |
15 |
89,047,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4678:Plxnb2
|
UTSW |
15 |
89,045,131 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4717:Plxnb2
|
UTSW |
15 |
89,041,622 (GRCm39) |
nonsense |
probably null |
|
|
R4773:Plxnb2
|
UTSW |
15 |
89,051,150 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4905:Plxnb2
|
UTSW |
15 |
89,041,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5368:Plxnb2
|
UTSW |
15 |
89,043,796 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5418:Plxnb2
|
UTSW |
15 |
89,050,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5484:Plxnb2
|
UTSW |
15 |
89,048,412 (GRCm39) |
splice site |
probably null |
|
|
R5520:Plxnb2
|
UTSW |
15 |
89,051,746 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5566:Plxnb2
|
UTSW |
15 |
89,048,223 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5568:Plxnb2
|
UTSW |
15 |
89,041,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5619:Plxnb2
|
UTSW |
15 |
89,047,012 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5685:Plxnb2
|
UTSW |
15 |
89,051,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5688:Plxnb2
|
UTSW |
15 |
89,042,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5809:Plxnb2
|
UTSW |
15 |
89,051,774 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5813:Plxnb2
|
UTSW |
15 |
89,044,962 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5866:Plxnb2
|
UTSW |
15 |
89,051,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6016:Plxnb2
|
UTSW |
15 |
89,045,225 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6117:Plxnb2
|
UTSW |
15 |
89,042,203 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6187:Plxnb2
|
UTSW |
15 |
89,051,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6260:Plxnb2
|
UTSW |
15 |
89,049,494 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6263:Plxnb2
|
UTSW |
15 |
89,046,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6269:Plxnb2
|
UTSW |
15 |
89,044,916 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6351:Plxnb2
|
UTSW |
15 |
89,041,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6522:Plxnb2
|
UTSW |
15 |
89,048,629 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6856:Plxnb2
|
UTSW |
15 |
89,048,523 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6930:Plxnb2
|
UTSW |
15 |
89,044,592 (GRCm39) |
missense |
probably benign |
|
|
R7354:Plxnb2
|
UTSW |
15 |
89,049,928 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7513:Plxnb2
|
UTSW |
15 |
89,042,525 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7522:Plxnb2
|
UTSW |
15 |
89,045,977 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7730:Plxnb2
|
UTSW |
15 |
89,046,533 (GRCm39) |
missense |
probably benign |
|
|
R7766:Plxnb2
|
UTSW |
15 |
89,045,474 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7781:Plxnb2
|
UTSW |
15 |
89,041,225 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8126:Plxnb2
|
UTSW |
15 |
89,047,506 (GRCm39) |
missense |
probably benign |
|
|
R8131:Plxnb2
|
UTSW |
15 |
89,042,916 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Plxnb2
|
UTSW |
15 |
89,042,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8736:Plxnb2
|
UTSW |
15 |
89,046,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8772:Plxnb2
|
UTSW |
15 |
89,046,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9022:Plxnb2
|
UTSW |
15 |
89,048,471 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9044:Plxnb2
|
UTSW |
15 |
89,044,566 (GRCm39) |
splice site |
probably benign |
|
|
R9253:Plxnb2
|
UTSW |
15 |
89,052,015 (GRCm39) |
missense |
probably benign |
|
|
R9398:Plxnb2
|
UTSW |
15 |
89,045,122 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9562:Plxnb2
|
UTSW |
15 |
89,050,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9568:Plxnb2
|
UTSW |
15 |
89,045,160 (GRCm39) |
nonsense |
probably null |
|
|
R9613:Plxnb2
|
UTSW |
15 |
89,048,496 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0027:Plxnb2
|
UTSW |
15 |
89,044,916 (GRCm39) |
missense |
probably benign |
0.18 |
|
Z1177:Plxnb2
|
UTSW |
15 |
89,043,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATAGTAGTACCTCCAGCCCTGCTC -3'
(R):5'- GCCACTTGTCCCTGAACAGTCTAAC -3'
Sequencing Primer
(F):5'- GCTGTGTTAAGGAGAATTCCACC -3'
(R):5'- CTGAACAGTCTAACACCAGGGATG -3'
|
| Posted On |
2014-04-13 |
Incidental Mutation