Mutagenetix > Incidental Mutation

Incidental Mutation 'R0100:Fat4'

17221

Institutional Source

Beutler Lab

Gene Symbol

Fat4

Ensembl Gene

ENSMUSG00000046743

Gene Name

FAT atypical cadherin 4

Synonyms

6030410K14Rik

MMRRC Submission

038386-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0100 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

38941089-39066134 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 39034397 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Threonine at position 2683 (N2683T)

Ref Sequence

ENSEMBL: ENSMUSP00000061836 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061260]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000061260
AA Change: N2683T

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000061836
Gene: ENSMUSG00000046743
AA Change: N2683T

Domain	Start	End	E-Value	Type
low complexity region	2	21	N/A	INTRINSIC
CA	60	133	4.09e-7	SMART
CA	157	248	4.51e-18	SMART
CA	272	351	7.66e-30	SMART
CA	380	473	2.55e-17	SMART
CA	497	580	8.27e-26	SMART
CA	605	687	6.46e-28	SMART
CA	711	791	1e-24	SMART
CA	815	891	3.78e-20	SMART
CA	915	994	8.6e-24	SMART
CA	1018	1098	7.09e-25	SMART
CA	1122	1208	6.78e-22	SMART
CA	1232	1313	2.63e-28	SMART
CA	1337	1418	7.25e-31	SMART
CA	1442	1527	4.58e-19	SMART
CA	1550	1629	4.52e-9	SMART
CA	1651	1738	1.3e-9	SMART
CA	1762	1839	2.01e-24	SMART
CA	1863	1942	3.11e-21	SMART
CA	1966	2049	5.85e-26	SMART
CA	2072	2152	1.88e-29	SMART
CA	2176	2257	3.06e-29	SMART
CA	2282	2362	2.61e-23	SMART
CA	2386	2466	2.99e-32	SMART
CA	2490	2568	9.92e-6	SMART
CA	2588	2669	6.58e-20	SMART
CA	2692	2773	7.25e-31	SMART
CA	2796	2872	1.69e-22	SMART
CA	2896	2983	3.16e-22	SMART
CA	3007	3089	1.01e-15	SMART
CA	3113	3194	1.25e-25	SMART
CA	3218	3298	7e-15	SMART
CA	3322	3405	3.96e-14	SMART
CA	3428	3510	3.41e-27	SMART
CA	3532	3614	5.64e-19	SMART
EGF	3807	3862	1.78e-2	SMART
EGF_CA	3864	3900	2.36e-16	SMART
EGF_CA	3902	3938	7.99e-14	SMART
EGF	3943	3976	1.24e-1	SMART
LamG	3996	4144	4.08e-19	SMART
EGF	4167	4200	5.88e-3	SMART
LamG	4244	4375	1.76e-23	SMART
EGF	4430	4464	1.41e-5	SMART
low complexity region	4514	4526	N/A	INTRINSIC
low complexity region	4533	4550	N/A	INTRINSIC
low complexity region	4840	4849	N/A	INTRINSIC

Meta Mutation Damage Score

0.3295

Coding Region Coverage

1x: 90.3%
3x: 88.1%
10x: 82.7%
20x: 75.2%

Validation Efficiency

89% (68/76)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
PHENOTYPE: Homozygous inactivation of this gene leads to neonatal lethality, reduced birth body size, curly tails, kyphosis, small lungs, renal cysts, and defects in sternum and vertebrae morphology, neural tube width, cochlear elongation, stereocilia orientation, kidney development, and intestinal elongation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agrn	A	G	4: 156,259,415 (GRCm39)	C814R	probably damaging	Het
Aoc1	T	C	6: 48,885,538 (GRCm39)	I681T	possibly damaging	Het
Atp13a4	T	C	16: 29,240,542 (GRCm39)	H793R	probably damaging	Het
Atp6v0a4	T	C	6: 38,053,750 (GRCm39)	I351V	probably benign	Het
Bbof1	T	A	12: 84,457,829 (GRCm39)	D31E	probably benign	Het
Cpxm2	T	A	7: 131,656,600 (GRCm39)	H554L	possibly damaging	Het
Ddx55	C	T	5: 124,694,845 (GRCm39)	T91I	probably damaging	Het
Dhx57	T	C	17: 80,582,585 (GRCm39)	D340G	possibly damaging	Het
Dnah1	C	T	14: 30,984,109 (GRCm39)		probably null	Het
Dpp9	C	T	17: 56,512,854 (GRCm39)	G118D	possibly damaging	Het
Etl4	T	C	2: 20,344,716 (GRCm39)	S4P	probably benign	Het
Gabrb2	A	G	11: 42,378,141 (GRCm39)	D119G	probably damaging	Het
Garre1	A	G	7: 33,953,436 (GRCm39)	I442T	possibly damaging	Het
Greb1	T	A	12: 16,730,225 (GRCm39)	Q1734L	probably benign	Het
Gtf2ird2	T	C	5: 134,245,857 (GRCm39)	L705P	probably damaging	Het
H13	T	A	2: 152,531,783 (GRCm39)		probably null	Het
Hgs	T	G	11: 120,373,678 (GRCm39)	Y708D	possibly damaging	Het
Hip1	T	C	5: 135,465,307 (GRCm39)	D367G	probably benign	Het
Ift140	C	T	17: 25,309,928 (GRCm39)	Q1112*	probably null	Het
Il17b	A	G	18: 61,823,342 (GRCm39)	M59V	probably benign	Het
Lpin3	T	C	2: 160,747,260 (GRCm39)	Y829H	probably damaging	Het
Lrrk2	A	T	15: 91,629,999 (GRCm39)	N1230I	probably damaging	Het
Mindy2	C	A	9: 70,514,731 (GRCm39)		probably benign	Het
Nup210	T	G	6: 91,046,175 (GRCm39)	E586A	probably benign	Het
Or1j17	A	T	2: 36,578,923 (GRCm39)	N303I	probably benign	Het
Or2bd2	C	T	7: 6,443,399 (GRCm39)	R167C	probably damaging	Het
Or5be3	T	C	2: 86,863,939 (GRCm39)	T209A	probably benign	Het
Osgepl1	A	G	1: 53,362,372 (GRCm39)	I405V	probably damaging	Het
Pdcd11	T	C	19: 47,091,105 (GRCm39)	S360P	probably benign	Het
Plekha6	T	C	1: 133,197,915 (GRCm39)	S271P	probably damaging	Het
Plekhs1	A	G	19: 56,466,934 (GRCm39)	E255G	probably damaging	Het
Pram1	T	A	17: 33,860,373 (GRCm39)	N313K	possibly damaging	Het
Rapgef5	C	T	12: 117,685,034 (GRCm39)	S261L	probably benign	Het
Spint5	T	A	2: 164,558,920 (GRCm39)	C49S	probably damaging	Het
Tex22	T	A	12: 113,052,392 (GRCm39)	I150N	probably benign	Het
Thoc6	A	T	17: 23,888,824 (GRCm39)	W195R	probably damaging	Het
Tmem106a	T	C	11: 101,477,084 (GRCm39)	S98P	probably benign	Het
Tnfrsf18	A	G	4: 156,112,823 (GRCm39)	T170A	probably benign	Het
Tor1aip1	A	T	1: 155,882,821 (GRCm39)	D342E	probably damaging	Het
Trav7-6	T	C	14: 53,954,529 (GRCm39)	S20P	probably damaging	Het
Trpc6	C	T	9: 8,653,035 (GRCm39)	P614S	probably damaging	Het
Washc5	A	G	15: 59,215,947 (GRCm39)	F811L	possibly damaging	Het

Other mutations in Fat4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00235:Fat4	APN	3	39,036,398 (GRCm39)	missense	probably damaging	1.00
IGL00509:Fat4	APN	3	38,943,188 (GRCm39)	missense	probably damaging	1.00
IGL00698:Fat4	APN	3	39,035,294 (GRCm39)	missense	probably benign	0.17
IGL00934:Fat4	APN	3	38,944,822 (GRCm39)	missense	probably damaging	1.00
IGL01063:Fat4	APN	3	38,944,728 (GRCm39)	missense	possibly damaging	0.80
IGL01123:Fat4	APN	3	39,011,418 (GRCm39)	missense	probably benign	0.00
IGL01313:Fat4	APN	3	39,061,350 (GRCm39)	missense	possibly damaging	0.53
IGL01328:Fat4	APN	3	39,034,807 (GRCm39)	missense	probably damaging	1.00
IGL01328:Fat4	APN	3	38,944,140 (GRCm39)	missense	probably damaging	1.00
IGL01374:Fat4	APN	3	38,941,647 (GRCm39)	missense	probably damaging	1.00
IGL01412:Fat4	APN	3	38,945,330 (GRCm39)	missense	probably benign	0.09
IGL01472:Fat4	APN	3	38,942,219 (GRCm39)	missense	probably damaging	1.00
IGL01514:Fat4	APN	3	39,003,683 (GRCm39)	missense	possibly damaging	0.89
IGL01548:Fat4	APN	3	39,063,406 (GRCm39)	missense	probably damaging	1.00
IGL01548:Fat4	APN	3	38,941,907 (GRCm39)	missense	probably damaging	0.99
IGL01576:Fat4	APN	3	38,943,096 (GRCm39)	missense	probably damaging	1.00
IGL01591:Fat4	APN	3	39,064,524 (GRCm39)	nonsense	probably null
IGL01626:Fat4	APN	3	39,005,181 (GRCm39)	missense	probably damaging	1.00
IGL01746:Fat4	APN	3	39,045,880 (GRCm39)	nonsense	probably null
IGL01800:Fat4	APN	3	39,035,878 (GRCm39)	missense	probably damaging	0.99
IGL01815:Fat4	APN	3	38,942,922 (GRCm39)	missense	probably damaging	1.00
IGL01863:Fat4	APN	3	39,024,768 (GRCm39)	splice site	probably benign
IGL01917:Fat4	APN	3	38,943,879 (GRCm39)	missense	possibly damaging	0.89
IGL01936:Fat4	APN	3	39,033,923 (GRCm39)	missense	probably benign	0.10
IGL02060:Fat4	APN	3	39,064,420 (GRCm39)	missense	probably damaging	1.00
IGL02103:Fat4	APN	3	38,943,348 (GRCm39)	missense	probably damaging	0.97
IGL02119:Fat4	APN	3	39,037,088 (GRCm39)	missense	probably benign	0.10
IGL02124:Fat4	APN	3	38,942,553 (GRCm39)	missense	probably damaging	1.00
IGL02164:Fat4	APN	3	39,050,354 (GRCm39)	critical splice donor site	probably null
IGL02182:Fat4	APN	3	38,944,695 (GRCm39)	missense	probably damaging	1.00
IGL02207:Fat4	APN	3	39,005,412 (GRCm39)	missense	probably benign	0.16
IGL02210:Fat4	APN	3	38,946,002 (GRCm39)	missense	probably benign	0.01
IGL02257:Fat4	APN	3	39,055,288 (GRCm39)	missense	probably benign	0.09
IGL02271:Fat4	APN	3	39,034,068 (GRCm39)	missense	probably benign	0.18
IGL02305:Fat4	APN	3	39,064,137 (GRCm39)	missense	probably damaging	1.00
IGL02314:Fat4	APN	3	38,941,779 (GRCm39)	missense	probably damaging	1.00
IGL02455:Fat4	APN	3	39,005,280 (GRCm39)	missense	possibly damaging	0.48
IGL02468:Fat4	APN	3	39,037,195 (GRCm39)	missense	probably benign
IGL02478:Fat4	APN	3	38,942,364 (GRCm39)	missense	probably damaging	1.00
IGL02480:Fat4	APN	3	39,064,579 (GRCm39)	missense	probably damaging	1.00
IGL02487:Fat4	APN	3	38,941,394 (GRCm39)	missense	probably damaging	1.00
IGL02632:Fat4	APN	3	39,056,913 (GRCm39)	missense	probably benign	0.04
IGL02665:Fat4	APN	3	39,056,985 (GRCm39)	missense	probably benign	0.08
IGL02674:Fat4	APN	3	39,037,486 (GRCm39)	missense	probably benign	0.35
IGL02692:Fat4	APN	3	39,005,235 (GRCm39)	missense	probably damaging	1.00
IGL02710:Fat4	APN	3	38,944,744 (GRCm39)	missense	probably damaging	1.00
IGL02803:Fat4	APN	3	38,943,444 (GRCm39)	missense	probably damaging	1.00
IGL02834:Fat4	APN	3	39,010,893 (GRCm39)	missense	probably damaging	1.00
IGL02891:Fat4	APN	3	39,005,422 (GRCm39)	missense	probably damaging	1.00
IGL02982:Fat4	APN	3	38,944,992 (GRCm39)	missense	probably damaging	1.00
IGL02993:Fat4	APN	3	39,011,304 (GRCm39)	missense	probably damaging	1.00
IGL02996:Fat4	APN	3	39,012,674 (GRCm39)	missense	probably damaging	1.00
IGL03029:Fat4	APN	3	39,036,740 (GRCm39)	missense	possibly damaging	0.46
IGL03124:Fat4	APN	3	39,035,701 (GRCm39)	missense	possibly damaging	0.61
IGL03144:Fat4	APN	3	39,011,008 (GRCm39)	missense	possibly damaging	0.68
IGL03149:Fat4	APN	3	39,045,834 (GRCm39)	missense	probably damaging	1.00
IGL03169:Fat4	APN	3	39,011,547 (GRCm39)	missense	probably benign	0.02
IGL03190:Fat4	APN	3	39,035,390 (GRCm39)	missense	probably damaging	1.00
IGL03272:Fat4	APN	3	39,063,852 (GRCm39)	missense	probably benign
IGL03371:Fat4	APN	3	39,037,336 (GRCm39)	missense	possibly damaging	0.65
IGL03372:Fat4	APN	3	38,943,283 (GRCm39)	missense	possibly damaging	0.88
IGL03388:Fat4	APN	3	39,011,376 (GRCm39)	missense	probably damaging	1.00
IGL03394:Fat4	APN	3	38,946,168 (GRCm39)	missense	probably damaging	0.99
IGL03394:Fat4	APN	3	39,063,513 (GRCm39)	missense	probably damaging	1.00
IGL03405:Fat4	APN	3	39,012,599 (GRCm39)	missense	probably benign	0.02
IGL03410:Fat4	APN	3	38,945,325 (GRCm39)	missense	probably damaging	1.00
Asahi	UTSW	3	39,035,968 (GRCm39)	missense	probably damaging	1.00
Expulsion	UTSW	3	38,943,798 (GRCm39)	missense	probably benign	0.00
heineken	UTSW	3	39,034,529 (GRCm39)	missense	probably damaging	1.00
schlitz	UTSW	3	39,034,808 (GRCm39)	missense	probably damaging	1.00
PIT4696001:Fat4	UTSW	3	39,036,506 (GRCm39)	missense	probably damaging	0.98
PIT4696001:Fat4	UTSW	3	38,943,153 (GRCm39)	missense	probably benign	0.04
R0015:Fat4	UTSW	3	39,036,652 (GRCm39)	missense	probably damaging	1.00
R0015:Fat4	UTSW	3	39,036,652 (GRCm39)	missense	probably damaging	1.00
R0078:Fat4	UTSW	3	38,943,080 (GRCm39)	missense	probably benign	0.35
R0100:Fat4	UTSW	3	39,034,397 (GRCm39)	missense	probably damaging	1.00
R0201:Fat4	UTSW	3	38,945,745 (GRCm39)	missense	probably damaging	0.99
R0280:Fat4	UTSW	3	38,944,965 (GRCm39)	missense	probably benign
R0357:Fat4	UTSW	3	38,945,376 (GRCm39)	missense	probably damaging	1.00
R0409:Fat4	UTSW	3	39,031,562 (GRCm39)	missense	probably damaging	1.00
R0498:Fat4	UTSW	3	39,034,786 (GRCm39)	missense	probably benign	0.00
R0502:Fat4	UTSW	3	39,057,073 (GRCm39)	missense	probably damaging	0.98
R0506:Fat4	UTSW	3	38,942,463 (GRCm39)	missense	probably benign	0.00
R0532:Fat4	UTSW	3	39,035,870 (GRCm39)	missense	probably benign	0.02
R0616:Fat4	UTSW	3	38,997,019 (GRCm39)	missense	probably damaging	1.00
R0630:Fat4	UTSW	3	39,054,321 (GRCm39)	missense	probably damaging	1.00
R0678:Fat4	UTSW	3	38,943,843 (GRCm39)	missense	probably damaging	1.00
R0685:Fat4	UTSW	3	39,055,327 (GRCm39)	missense	probably benign
R0729:Fat4	UTSW	3	39,054,444 (GRCm39)	splice site	probably benign
R0748:Fat4	UTSW	3	38,941,977 (GRCm39)	missense	possibly damaging	0.67
R0811:Fat4	UTSW	3	39,011,623 (GRCm39)	missense	probably damaging	1.00
R0812:Fat4	UTSW	3	39,011,623 (GRCm39)	missense	probably damaging	1.00
R0830:Fat4	UTSW	3	39,053,258 (GRCm39)	missense	probably benign	0.26
R0841:Fat4	UTSW	3	39,050,147 (GRCm39)	missense	probably damaging	0.99
R0884:Fat4	UTSW	3	39,037,007 (GRCm39)	missense	possibly damaging	0.89
R1056:Fat4	UTSW	3	38,945,541 (GRCm39)	missense	probably damaging	1.00
R1066:Fat4	UTSW	3	39,011,376 (GRCm39)	missense	probably damaging	1.00
R1078:Fat4	UTSW	3	39,037,235 (GRCm39)	missense	probably benign	0.10
R1084:Fat4	UTSW	3	39,033,974 (GRCm39)	missense	possibly damaging	0.88
R1118:Fat4	UTSW	3	39,037,091 (GRCm39)	missense	possibly damaging	0.88
R1213:Fat4	UTSW	3	38,944,520 (GRCm39)	missense	probably benign	0.01
R1418:Fat4	UTSW	3	38,944,962 (GRCm39)	missense	probably damaging	1.00
R1475:Fat4	UTSW	3	38,942,472 (GRCm39)	missense	probably damaging	1.00
R1487:Fat4	UTSW	3	39,050,066 (GRCm39)	missense	possibly damaging	0.77
R1511:Fat4	UTSW	3	39,037,225 (GRCm39)	missense	probably damaging	0.97
R1534:Fat4	UTSW	3	38,944,238 (GRCm39)	missense	probably damaging	1.00
R1558:Fat4	UTSW	3	38,943,135 (GRCm39)	missense	probably damaging	1.00
R1586:Fat4	UTSW	3	38,943,009 (GRCm39)	missense	probably damaging	1.00
R1592:Fat4	UTSW	3	39,061,326 (GRCm39)	missense	probably damaging	0.99
R1655:Fat4	UTSW	3	39,011,467 (GRCm39)	missense	probably damaging	0.97
R1662:Fat4	UTSW	3	39,034,928 (GRCm39)	missense	probably damaging	1.00
R1710:Fat4	UTSW	3	39,005,304 (GRCm39)	missense	probably damaging	1.00
R1731:Fat4	UTSW	3	38,945,459 (GRCm39)	missense	probably damaging	1.00
R1761:Fat4	UTSW	3	38,941,638 (GRCm39)	missense	possibly damaging	0.61
R1770:Fat4	UTSW	3	39,064,417 (GRCm39)	missense	probably damaging	1.00
R1828:Fat4	UTSW	3	39,037,607 (GRCm39)	missense	probably damaging	1.00
R1835:Fat4	UTSW	3	39,037,720 (GRCm39)	missense	probably benign	0.00
R1846:Fat4	UTSW	3	39,036,532 (GRCm39)	missense	probably benign	0.00
R1861:Fat4	UTSW	3	39,064,633 (GRCm39)	missense	probably benign	0.09
R1871:Fat4	UTSW	3	39,035,221 (GRCm39)	missense	possibly damaging	0.63
R1981:Fat4	UTSW	3	39,045,813 (GRCm39)	missense	probably damaging	1.00
R1988:Fat4	UTSW	3	39,050,239 (GRCm39)	missense	probably damaging	1.00
R1988:Fat4	UTSW	3	38,941,264 (GRCm39)	missense	probably benign
R2056:Fat4	UTSW	3	38,945,319 (GRCm39)	missense	possibly damaging	0.88
R2058:Fat4	UTSW	3	38,945,319 (GRCm39)	missense	possibly damaging	0.88
R2059:Fat4	UTSW	3	38,945,319 (GRCm39)	missense	possibly damaging	0.88
R2070:Fat4	UTSW	3	39,064,804 (GRCm39)	missense	probably benign	0.00
R2078:Fat4	UTSW	3	38,943,822 (GRCm39)	missense	probably damaging	1.00
R2114:Fat4	UTSW	3	39,035,633 (GRCm39)	missense	probably benign	0.01
R2135:Fat4	UTSW	3	39,034,882 (GRCm39)	missense	probably damaging	0.98
R2152:Fat4	UTSW	3	39,037,544 (GRCm39)	missense	probably damaging	1.00
R2153:Fat4	UTSW	3	39,037,544 (GRCm39)	missense	probably damaging	1.00
R2154:Fat4	UTSW	3	38,941,688 (GRCm39)	missense	probably damaging	1.00
R2196:Fat4	UTSW	3	39,035,566 (GRCm39)	missense	probably benign	0.23
R2211:Fat4	UTSW	3	38,945,676 (GRCm39)	missense	possibly damaging	0.77
R2219:Fat4	UTSW	3	39,064,364 (GRCm39)	missense	probably damaging	1.00
R2247:Fat4	UTSW	3	38,946,198 (GRCm39)	missense	probably damaging	1.00
R2263:Fat4	UTSW	3	38,943,138 (GRCm39)	missense	possibly damaging	0.93
R2264:Fat4	UTSW	3	38,944,571 (GRCm39)	missense	probably benign	0.25
R2274:Fat4	UTSW	3	39,050,048 (GRCm39)	missense	possibly damaging	0.47
R2337:Fat4	UTSW	3	39,034,160 (GRCm39)	missense	probably damaging	1.00
R2343:Fat4	UTSW	3	39,011,254 (GRCm39)	missense	probably damaging	0.97
R2365:Fat4	UTSW	3	39,034,568 (GRCm39)	missense	probably benign
R2412:Fat4	UTSW	3	39,011,221 (GRCm39)	missense	probably benign	0.05
R2883:Fat4	UTSW	3	39,034,953 (GRCm39)	missense	probably damaging	1.00
R2942:Fat4	UTSW	3	39,036,485 (GRCm39)	missense	probably damaging	1.00
R2989:Fat4	UTSW	3	39,061,302 (GRCm39)	missense	probably benign
R3103:Fat4	UTSW	3	38,946,089 (GRCm39)	missense	probably benign	0.03
R3158:Fat4	UTSW	3	38,944,940 (GRCm39)	missense	possibly damaging	0.87
R3800:Fat4	UTSW	3	39,035,423 (GRCm39)	missense	possibly damaging	0.48
R3808:Fat4	UTSW	3	39,036,587 (GRCm39)	missense	possibly damaging	0.52
R3848:Fat4	UTSW	3	39,061,410 (GRCm39)	missense	probably benign	0.10
R3850:Fat4	UTSW	3	39,061,410 (GRCm39)	missense	probably benign	0.10
R3957:Fat4	UTSW	3	39,036,495 (GRCm39)	missense	probably benign
R4065:Fat4	UTSW	3	39,063,346 (GRCm39)	missense	probably benign	0.13
R4078:Fat4	UTSW	3	39,034,169 (GRCm39)	missense	probably damaging	1.00
R4096:Fat4	UTSW	3	38,942,024 (GRCm39)	missense	possibly damaging	0.46
R4161:Fat4	UTSW	3	38,996,958 (GRCm39)	missense	possibly damaging	0.95
R4273:Fat4	UTSW	3	38,945,776 (GRCm39)	missense	probably damaging	1.00
R4285:Fat4	UTSW	3	38,943,320 (GRCm39)	missense	probably benign	0.00
R4288:Fat4	UTSW	3	38,945,912 (GRCm39)	missense	probably damaging	1.00
R4407:Fat4	UTSW	3	39,012,689 (GRCm39)	missense	probably benign	0.05
R4528:Fat4	UTSW	3	38,945,443 (GRCm39)	missense	probably benign	0.01
R4547:Fat4	UTSW	3	39,005,432 (GRCm39)	missense	probably damaging	1.00
R4681:Fat4	UTSW	3	38,941,491 (GRCm39)	missense	probably damaging	1.00
R4826:Fat4	UTSW	3	39,037,106 (GRCm39)	missense	probably damaging	1.00
R4855:Fat4	UTSW	3	38,942,466 (GRCm39)	missense	probably benign
R4871:Fat4	UTSW	3	38,945,754 (GRCm39)	missense	probably damaging	1.00
R4897:Fat4	UTSW	3	39,034,781 (GRCm39)	missense	probably damaging	1.00
R4928:Fat4	UTSW	3	39,064,614 (GRCm39)	missense	probably damaging	1.00
R4932:Fat4	UTSW	3	39,061,352 (GRCm39)	missense	probably benign	0.00
R4941:Fat4	UTSW	3	39,011,601 (GRCm39)	missense	probably damaging	1.00
R4943:Fat4	UTSW	3	39,034,322 (GRCm39)	missense	probably benign	0.19
R4959:Fat4	UTSW	3	39,037,195 (GRCm39)	missense	probably benign	0.00
R4973:Fat4	UTSW	3	39,037,195 (GRCm39)	missense	probably benign	0.00
R5098:Fat4	UTSW	3	38,942,438 (GRCm39)	missense	probably benign	0.34
R5163:Fat4	UTSW	3	39,034,946 (GRCm39)	missense	probably damaging	1.00
R5213:Fat4	UTSW	3	39,034,340 (GRCm39)	missense	possibly damaging	0.56
R5328:Fat4	UTSW	3	39,011,017 (GRCm39)	missense	probably damaging	1.00
R5337:Fat4	UTSW	3	39,064,527 (GRCm39)	missense	probably benign	0.44
R5337:Fat4	UTSW	3	38,945,776 (GRCm39)	missense	probably damaging	1.00
R5363:Fat4	UTSW	3	38,942,154 (GRCm39)	missense	probably damaging	1.00
R5380:Fat4	UTSW	3	38,943,013 (GRCm39)	missense	probably damaging	1.00
R5384:Fat4	UTSW	3	39,050,095 (GRCm39)	missense	possibly damaging	0.87
R5422:Fat4	UTSW	3	38,941,394 (GRCm39)	missense	possibly damaging	0.92
R5436:Fat4	UTSW	3	38,945,495 (GRCm39)	missense	probably benign	0.00
R5443:Fat4	UTSW	3	39,064,519 (GRCm39)	missense	probably damaging	1.00
R5501:Fat4	UTSW	3	38,941,364 (GRCm39)	missense	probably benign	0.09
R5571:Fat4	UTSW	3	39,064,423 (GRCm39)	missense	probably damaging	1.00
R5625:Fat4	UTSW	3	38,943,083 (GRCm39)	missense	possibly damaging	0.78
R5652:Fat4	UTSW	3	39,057,117 (GRCm39)	missense	probably damaging	0.99
R5725:Fat4	UTSW	3	38,943,774 (GRCm39)	missense	probably damaging	1.00
R5735:Fat4	UTSW	3	39,003,725 (GRCm39)	missense	probably damaging	1.00
R5739:Fat4	UTSW	3	39,037,283 (GRCm39)	missense	probably benign	0.01
R5766:Fat4	UTSW	3	38,943,617 (GRCm39)	missense	probably damaging	1.00
R5780:Fat4	UTSW	3	39,035,104 (GRCm39)	missense	probably damaging	0.96
R5811:Fat4	UTSW	3	38,945,936 (GRCm39)	missense	probably damaging	1.00
R5829:Fat4	UTSW	3	39,061,454 (GRCm39)	missense	probably damaging	1.00
R5879:Fat4	UTSW	3	38,941,485 (GRCm39)	missense	probably benign
R5933:Fat4	UTSW	3	39,005,524 (GRCm39)	critical splice donor site	probably null
R5938:Fat4	UTSW	3	39,005,388 (GRCm39)	missense	probably damaging	1.00
R5940:Fat4	UTSW	3	38,943,798 (GRCm39)	missense	probably benign	0.00
R5945:Fat4	UTSW	3	39,037,355 (GRCm39)	missense	probably benign	0.19
R5963:Fat4	UTSW	3	39,064,696 (GRCm39)	missense	probably damaging	1.00
R6077:Fat4	UTSW	3	39,056,951 (GRCm39)	missense	probably damaging	1.00
R6158:Fat4	UTSW	3	39,037,411 (GRCm39)	missense	possibly damaging	0.95
R6246:Fat4	UTSW	3	38,945,870 (GRCm39)	missense	probably damaging	1.00
R6253:Fat4	UTSW	3	39,005,505 (GRCm39)	missense	probably damaging	0.99
R6259:Fat4	UTSW	3	39,061,395 (GRCm39)	missense	probably benign	0.18
R6295:Fat4	UTSW	3	39,061,229 (GRCm39)	splice site	probably null
R6387:Fat4	UTSW	3	39,037,934 (GRCm39)	missense	probably damaging	1.00
R6390:Fat4	UTSW	3	39,034,529 (GRCm39)	missense	probably damaging	1.00
R6456:Fat4	UTSW	3	39,038,128 (GRCm39)	missense	possibly damaging	0.90
R6493:Fat4	UTSW	3	38,945,036 (GRCm39)	missense	probably damaging	1.00
R6500:Fat4	UTSW	3	39,035,418 (GRCm39)	nonsense	probably null
R6503:Fat4	UTSW	3	39,036,406 (GRCm39)	missense	probably benign	0.00
R6519:Fat4	UTSW	3	39,057,020 (GRCm39)	missense	probably benign
R6566:Fat4	UTSW	3	39,011,275 (GRCm39)	missense	possibly damaging	0.78
R6576:Fat4	UTSW	3	39,033,839 (GRCm39)	missense	probably benign
R6590:Fat4	UTSW	3	39,037,688 (GRCm39)	missense	probably damaging	1.00
R6658:Fat4	UTSW	3	38,997,077 (GRCm39)	missense	probably benign	0.01
R6662:Fat4	UTSW	3	39,010,970 (GRCm39)	missense	possibly damaging	0.95
R6690:Fat4	UTSW	3	39,037,688 (GRCm39)	missense	probably damaging	1.00
R6807:Fat4	UTSW	3	39,036,589 (GRCm39)	missense	probably benign	0.18
R6823:Fat4	UTSW	3	39,038,088 (GRCm39)	missense	probably benign	0.05
R6824:Fat4	UTSW	3	39,011,674 (GRCm39)	missense	probably benign	0.00
R6830:Fat4	UTSW	3	39,035,966 (GRCm39)	missense	probably benign	0.00
R6925:Fat4	UTSW	3	39,050,353 (GRCm39)	critical splice donor site	probably null
R6948:Fat4	UTSW	3	39,063,595 (GRCm39)	missense	probably damaging	1.00
R6970:Fat4	UTSW	3	39,050,120 (GRCm39)	missense	probably damaging	1.00
R6970:Fat4	UTSW	3	39,035,924 (GRCm39)	missense	probably damaging	1.00
R7017:Fat4	UTSW	3	38,945,692 (GRCm39)	missense	probably benign
R7030:Fat4	UTSW	3	39,036,107 (GRCm39)	missense	probably damaging	1.00
R7044:Fat4	UTSW	3	39,064,960 (GRCm39)	missense	probably benign	0.02
R7044:Fat4	UTSW	3	39,064,959 (GRCm39)	missense	probably benign
R7045:Fat4	UTSW	3	38,942,750 (GRCm39)	missense	probably benign	0.01
R7094:Fat4	UTSW	3	38,944,023 (GRCm39)	missense	probably damaging	1.00
R7111:Fat4	UTSW	3	39,064,682 (GRCm39)	missense	probably damaging	1.00
R7130:Fat4	UTSW	3	39,034,936 (GRCm39)	missense	probably damaging	0.99
R7168:Fat4	UTSW	3	39,034,808 (GRCm39)	missense	probably damaging	1.00
R7192:Fat4	UTSW	3	39,034,613 (GRCm39)	missense	probably benign	0.04
R7194:Fat4	UTSW	3	39,038,044 (GRCm39)	missense	probably damaging	1.00
R7194:Fat4	UTSW	3	38,943,033 (GRCm39)	missense	probably damaging	1.00
R7199:Fat4	UTSW	3	39,031,511 (GRCm39)	missense	probably damaging	0.98
R7213:Fat4	UTSW	3	39,053,236 (GRCm39)	missense	possibly damaging	0.63
R7216:Fat4	UTSW	3	38,945,192 (GRCm39)	missense	probably damaging	1.00
R7225:Fat4	UTSW	3	39,034,325 (GRCm39)	missense	possibly damaging	0.50
R7238:Fat4	UTSW	3	38,944,562 (GRCm39)	missense	probably benign	0.31
R7239:Fat4	UTSW	3	39,037,989 (GRCm39)	missense	possibly damaging	0.85
R7283:Fat4	UTSW	3	38,943,842 (GRCm39)	missense	probably damaging	1.00
R7296:Fat4	UTSW	3	38,943,294 (GRCm39)	nonsense	probably null
R7372:Fat4	UTSW	3	38,944,358 (GRCm39)	missense	probably damaging	1.00
R7400:Fat4	UTSW	3	38,942,073 (GRCm39)	missense	probably damaging	1.00
R7419:Fat4	UTSW	3	39,054,385 (GRCm39)	missense	probably damaging	1.00
R7430:Fat4	UTSW	3	39,063,793 (GRCm39)	missense	probably damaging	1.00
R7430:Fat4	UTSW	3	38,941,599 (GRCm39)	missense	probably damaging	0.97
R7431:Fat4	UTSW	3	39,063,306 (GRCm39)	missense	possibly damaging	0.80
R7486:Fat4	UTSW	3	39,011,576 (GRCm39)	nonsense	probably null
R7501:Fat4	UTSW	3	39,012,597 (GRCm39)	nonsense	probably null
R7533:Fat4	UTSW	3	39,061,406 (GRCm39)	missense	probably benign	0.43
R7542:Fat4	UTSW	3	39,035,770 (GRCm39)	missense	possibly damaging	0.64
R7542:Fat4	UTSW	3	39,035,504 (GRCm39)	missense	possibly damaging	0.56
R7548:Fat4	UTSW	3	39,035,263 (GRCm39)	missense	probably benign	0.13
R7567:Fat4	UTSW	3	38,943,485 (GRCm39)	missense	probably damaging	1.00
R7644:Fat4	UTSW	3	39,064,390 (GRCm39)	missense	possibly damaging	0.64
R7660:Fat4	UTSW	3	39,035,309 (GRCm39)	missense	probably benign
R7665:Fat4	UTSW	3	38,943,327 (GRCm39)	missense	probably benign	0.00
R7676:Fat4	UTSW	3	38,945,846 (GRCm39)	missense	probably damaging	0.98
R7832:Fat4	UTSW	3	39,055,353 (GRCm39)	missense	probably benign	0.00
R7848:Fat4	UTSW	3	38,942,000 (GRCm39)	missense	probably benign
R7883:Fat4	UTSW	3	39,035,968 (GRCm39)	missense	probably damaging	1.00
R7892:Fat4	UTSW	3	39,003,588 (GRCm39)	critical splice acceptor site	probably null
R7904:Fat4	UTSW	3	38,941,690 (GRCm39)	missense	probably damaging	1.00
R7952:Fat4	UTSW	3	38,945,870 (GRCm39)	missense	probably damaging	0.98
R8015:Fat4	UTSW	3	39,036,065 (GRCm39)	missense	possibly damaging	0.79
R8040:Fat4	UTSW	3	39,035,815 (GRCm39)	missense	probably damaging	1.00
R8142:Fat4	UTSW	3	38,945,352 (GRCm39)	missense	probably damaging	1.00
R8151:Fat4	UTSW	3	38,946,203 (GRCm39)	missense	probably damaging	0.99
R8163:Fat4	UTSW	3	39,033,881 (GRCm39)	missense	possibly damaging	0.88
R8317:Fat4	UTSW	3	39,012,659 (GRCm39)	missense	possibly damaging	0.80
R8413:Fat4	UTSW	3	39,063,128 (GRCm39)	critical splice acceptor site	probably null
R8447:Fat4	UTSW	3	39,033,824 (GRCm39)	missense	possibly damaging	0.88
R8458:Fat4	UTSW	3	39,035,702 (GRCm39)	missense	probably benign	0.25
R8509:Fat4	UTSW	3	39,036,052 (GRCm39)	missense	probably benign
R8543:Fat4	UTSW	3	39,031,643 (GRCm39)	missense	probably damaging	1.00
R8679:Fat4	UTSW	3	39,064,842 (GRCm39)	missense	probably damaging	1.00
R8726:Fat4	UTSW	3	39,064,647 (GRCm39)	missense	probably damaging	1.00
R8743:Fat4	UTSW	3	38,942,592 (GRCm39)	missense	probably benign	0.16
R8751:Fat4	UTSW	3	38,946,002 (GRCm39)	missense	probably benign	0.01
R8779:Fat4	UTSW	3	39,033,898 (GRCm39)	missense	probably damaging	1.00
R8797:Fat4	UTSW	3	39,053,278 (GRCm39)	missense	probably benign	0.01
R8860:Fat4	UTSW	3	38,946,269 (GRCm39)	missense	probably benign	0.26
R8955:Fat4	UTSW	3	39,037,778 (GRCm39)	missense	probably benign	0.01
R9053:Fat4	UTSW	3	38,941,324 (GRCm39)	nonsense	probably null
R9071:Fat4	UTSW	3	39,037,598 (GRCm39)	missense	probably benign	0.29
R9088:Fat4	UTSW	3	39,061,448 (GRCm39)	missense	probably benign	0.02
R9100:Fat4	UTSW	3	39,064,803 (GRCm39)	missense
R9180:Fat4	UTSW	3	38,942,556 (GRCm39)	missense	possibly damaging	0.78
R9184:Fat4	UTSW	3	39,036,592 (GRCm39)	missense	probably damaging	0.99
R9201:Fat4	UTSW	3	38,945,079 (GRCm39)	missense	probably damaging	1.00
R9206:Fat4	UTSW	3	39,063,390 (GRCm39)	missense	probably damaging	0.99
R9268:Fat4	UTSW	3	38,942,396 (GRCm39)	missense	probably damaging	1.00
R9278:Fat4	UTSW	3	38,945,171 (GRCm39)	missense	probably benign	0.44
R9287:Fat4	UTSW	3	38,945,781 (GRCm39)	missense	probably damaging	0.98
R9355:Fat4	UTSW	3	39,036,047 (GRCm39)	missense	probably damaging	1.00
R9437:Fat4	UTSW	3	38,945,417 (GRCm39)	missense	probably benign	0.00
R9455:Fat4	UTSW	3	38,945,412 (GRCm39)	missense
R9456:Fat4	UTSW	3	38,942,571 (GRCm39)	missense	possibly damaging	0.50
R9476:Fat4	UTSW	3	39,037,886 (GRCm39)	missense	probably benign	0.04
R9510:Fat4	UTSW	3	39,037,886 (GRCm39)	missense	probably benign	0.04
R9511:Fat4	UTSW	3	39,034,802 (GRCm39)	missense	probably damaging	0.98
R9540:Fat4	UTSW	3	39,063,346 (GRCm39)	missense	probably benign
R9568:Fat4	UTSW	3	38,946,156 (GRCm39)	missense	probably damaging	1.00
R9646:Fat4	UTSW	3	39,035,813 (GRCm39)	missense	probably damaging	1.00
R9683:Fat4	UTSW	3	38,943,332 (GRCm39)	missense	possibly damaging	0.52
R9711:Fat4	UTSW	3	39,055,374 (GRCm39)	missense	probably benign	0.00
X0017:Fat4	UTSW	3	39,063,255 (GRCm39)	missense	probably benign	0.00
X0019:Fat4	UTSW	3	39,035,189 (GRCm39)	missense	probably damaging	1.00
X0020:Fat4	UTSW	3	39,054,300 (GRCm39)	missense	probably damaging	1.00
X0024:Fat4	UTSW	3	38,997,051 (GRCm39)	missense	probably benign	0.43
X0064:Fat4	UTSW	3	39,024,901 (GRCm39)	missense	probably damaging	1.00
Z1088:Fat4	UTSW	3	39,012,641 (GRCm39)	missense	probably benign	0.00
Z1088:Fat4	UTSW	3	38,941,199 (GRCm39)	missense	possibly damaging	0.88
Z1176:Fat4	UTSW	3	39,037,964 (GRCm39)	missense	probably damaging	1.00
Z1176:Fat4	UTSW	3	39,037,508 (GRCm39)	missense	probably benign	0.00
Z1177:Fat4	UTSW	3	38,944,496 (GRCm39)	missense	probably damaging	1.00
Z1177:Fat4	UTSW	3	38,942,733 (GRCm39)	missense	probably damaging	1.00
Z1177:Fat4	UTSW	3	39,035,987 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-01-20