Incidental Mutation 'R0069:Lzts3'
ID |
17247 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Lzts3
|
Ensembl Gene |
ENSMUSG00000037703 |
Gene Name |
leucine zipper, putative tumor suppressor family member 3 |
Synonyms |
Prosapip1 |
MMRRC Submission |
038360-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.206)
|
Stock # |
R0069 (G1)
|
Quality Score |
|
Status
|
Validated
|
Chromosome |
2 |
Chromosomal Location |
130474759-130484723 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 130478460 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Serine
at position 213
(T213S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000086990
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045761]
[ENSMUST00000089561]
[ENSMUST00000110260]
|
AlphaFold |
A2AHG0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000045761
AA Change: T213S
PolyPhen 2
Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
|
SMART Domains |
Protein: ENSMUSP00000037109 Gene: ENSMUSG00000037703 AA Change: T213S
Domain | Start | End | E-Value | Type |
low complexity region
|
86 |
107 |
N/A |
INTRINSIC |
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
low complexity region
|
240 |
250 |
N/A |
INTRINSIC |
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
low complexity region
|
285 |
297 |
N/A |
INTRINSIC |
low complexity region
|
301 |
333 |
N/A |
INTRINSIC |
low complexity region
|
337 |
346 |
N/A |
INTRINSIC |
low complexity region
|
349 |
361 |
N/A |
INTRINSIC |
low complexity region
|
402 |
436 |
N/A |
INTRINSIC |
Pfam:Fez1
|
465 |
665 |
1.4e-62 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000089561
AA Change: T213S
PolyPhen 2
Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
|
SMART Domains |
Protein: ENSMUSP00000086990 Gene: ENSMUSG00000037703 AA Change: T213S
Domain | Start | End | E-Value | Type |
low complexity region
|
86 |
107 |
N/A |
INTRINSIC |
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
low complexity region
|
240 |
250 |
N/A |
INTRINSIC |
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
low complexity region
|
285 |
297 |
N/A |
INTRINSIC |
low complexity region
|
301 |
333 |
N/A |
INTRINSIC |
low complexity region
|
337 |
346 |
N/A |
INTRINSIC |
low complexity region
|
349 |
361 |
N/A |
INTRINSIC |
low complexity region
|
402 |
436 |
N/A |
INTRINSIC |
Pfam:Fez1
|
465 |
666 |
2.1e-74 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000110260
AA Change: T99S
PolyPhen 2
Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
|
SMART Domains |
Protein: ENSMUSP00000105889 Gene: ENSMUSG00000037703 AA Change: T99S
Domain | Start | End | E-Value | Type |
low complexity region
|
126 |
136 |
N/A |
INTRINSIC |
low complexity region
|
139 |
151 |
N/A |
INTRINSIC |
low complexity region
|
171 |
183 |
N/A |
INTRINSIC |
low complexity region
|
187 |
219 |
N/A |
INTRINSIC |
low complexity region
|
223 |
232 |
N/A |
INTRINSIC |
low complexity region
|
235 |
247 |
N/A |
INTRINSIC |
low complexity region
|
288 |
322 |
N/A |
INTRINSIC |
Pfam:Fez1
|
351 |
552 |
1.5e-74 |
PFAM |
|
Meta Mutation Damage Score |
0.0582 |
Coding Region Coverage |
- 1x: 86.4%
- 3x: 80.4%
- 10x: 57.4%
- 20x: 26.1%
|
Validation Efficiency |
94% (60/64) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 25 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A2ml1 |
A |
T |
6: 128,538,525 (GRCm39) |
C632S |
probably damaging |
Het |
Ccnb1ip1 |
G |
A |
14: 81,519,382 (GRCm38) |
Q322* |
probably null |
Het |
Cd101 |
A |
G |
3: 100,915,533 (GRCm39) |
V678A |
probably benign |
Het |
Creb1 |
A |
G |
1: 64,615,367 (GRCm39) |
I240V |
possibly damaging |
Het |
Dctn2 |
A |
T |
10: 127,113,354 (GRCm39) |
|
probably null |
Het |
Diablo |
A |
T |
5: 123,656,087 (GRCm39) |
S117R |
probably damaging |
Het |
Ebf2 |
A |
T |
14: 67,647,499 (GRCm39) |
R349S |
probably damaging |
Het |
Gne |
A |
C |
4: 44,060,099 (GRCm39) |
V98G |
probably damaging |
Het |
Ints3 |
A |
G |
3: 90,307,954 (GRCm39) |
|
probably benign |
Het |
Itgal |
A |
G |
7: 126,909,503 (GRCm39) |
T56A |
probably benign |
Het |
Myo1d |
A |
G |
11: 80,528,779 (GRCm39) |
I681T |
probably damaging |
Het |
Pde8a |
T |
C |
7: 80,968,871 (GRCm39) |
|
probably benign |
Het |
Pole2 |
A |
T |
12: 69,256,661 (GRCm39) |
V288E |
probably damaging |
Het |
Poteg |
T |
C |
8: 27,937,849 (GRCm39) |
S2P |
probably benign |
Het |
Ppp2r5c |
A |
T |
12: 110,534,204 (GRCm39) |
M356L |
probably benign |
Het |
Rad54l2 |
C |
A |
9: 106,587,564 (GRCm39) |
V734L |
possibly damaging |
Het |
Ryr1 |
A |
C |
7: 28,809,930 (GRCm39) |
|
probably benign |
Het |
Slfn10-ps |
A |
G |
11: 82,926,368 (GRCm39) |
|
noncoding transcript |
Het |
Sult1e1 |
A |
T |
5: 87,727,756 (GRCm39) |
H175Q |
probably damaging |
Het |
Trgv7 |
A |
G |
13: 19,362,592 (GRCm39) |
R94G |
probably benign |
Het |
Ube2e3 |
C |
A |
2: 78,750,293 (GRCm39) |
|
probably benign |
Het |
Vps13d |
A |
G |
4: 144,789,133 (GRCm39) |
I746T |
probably benign |
Het |
Xpnpep3 |
T |
C |
15: 81,314,999 (GRCm39) |
V233A |
probably benign |
Het |
Zfp329 |
A |
T |
7: 12,544,859 (GRCm39) |
S222T |
probably damaging |
Het |
Zswim6 |
T |
C |
13: 107,875,098 (GRCm39) |
|
noncoding transcript |
Het |
|
Other mutations in Lzts3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01072:Lzts3
|
APN |
2 |
130,477,365 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01541:Lzts3
|
APN |
2 |
130,478,126 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01649:Lzts3
|
APN |
2 |
130,477,351 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02746:Lzts3
|
APN |
2 |
130,478,261 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02927:Lzts3
|
APN |
2 |
130,479,877 (GRCm39) |
utr 5 prime |
probably benign |
|
R0069:Lzts3
|
UTSW |
2 |
130,478,460 (GRCm39) |
missense |
probably benign |
0.16 |
R0173:Lzts3
|
UTSW |
2 |
130,476,688 (GRCm39) |
makesense |
probably null |
|
R1381:Lzts3
|
UTSW |
2 |
130,477,219 (GRCm39) |
missense |
probably damaging |
0.99 |
R4127:Lzts3
|
UTSW |
2 |
130,477,285 (GRCm39) |
missense |
probably damaging |
0.99 |
R4301:Lzts3
|
UTSW |
2 |
130,478,358 (GRCm39) |
missense |
probably damaging |
0.99 |
R4588:Lzts3
|
UTSW |
2 |
130,476,686 (GRCm39) |
makesense |
probably null |
|
R5289:Lzts3
|
UTSW |
2 |
130,478,021 (GRCm39) |
missense |
probably benign |
0.18 |
R5878:Lzts3
|
UTSW |
2 |
130,478,459 (GRCm39) |
missense |
probably damaging |
1.00 |
R5964:Lzts3
|
UTSW |
2 |
130,478,208 (GRCm39) |
missense |
probably damaging |
0.99 |
R6193:Lzts3
|
UTSW |
2 |
130,479,306 (GRCm39) |
missense |
probably damaging |
0.97 |
R7692:Lzts3
|
UTSW |
2 |
130,477,306 (GRCm39) |
missense |
probably benign |
0.27 |
R8195:Lzts3
|
UTSW |
2 |
130,477,105 (GRCm39) |
missense |
probably benign |
0.01 |
R8273:Lzts3
|
UTSW |
2 |
130,476,801 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9126:Lzts3
|
UTSW |
2 |
130,477,248 (GRCm39) |
missense |
possibly damaging |
0.66 |
R9129:Lzts3
|
UTSW |
2 |
130,476,865 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Posted On |
2013-01-20 |