Mutagenetix > Incidental Mutation

Incidental Mutation 'R1627:Vmn2r80'

172565

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r80

Ensembl Gene

ENSMUSG00000091888

Gene Name

vomeronasal 2, receptor 80

Synonyms

EG624765

MMRRC Submission

039664-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R1627 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

78984650-79030767 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 79030249 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 692 (R692G)

Ref Sequence

ENSEMBL: ENSMUSP00000132299 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165834]

AlphaFold

E9Q1L0

Predicted Effect

probably damaging
Transcript: ENSMUST00000165834
AA Change: R692G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000132299
Gene: ENSMUSG00000091888
AA Change: R692G

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	79	474	1.5e-36	PFAM
Pfam:NCD3G	517	570	7.9e-22	PFAM
Pfam:7tm_3	603	838	6.2e-49	PFAM

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.3%
20x: 89.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	A	G	5: 105,083,880 (GRCm39)	M630T	probably benign	Het
Anpep	T	C	7: 79,491,759 (GRCm39)	I81V	probably benign	Het
Bub1	A	G	2: 127,650,933 (GRCm39)	S627P	probably benign	Het
C1s1	T	A	6: 124,514,439 (GRCm39)	N139I	probably damaging	Het
Car6	A	T	4: 150,277,035 (GRCm39)	V152D	probably damaging	Het
Cdh19	C	A	1: 110,847,375 (GRCm39)	M411I	probably benign	Het
Cep95	A	G	11: 106,700,531 (GRCm39)	E322G	probably damaging	Het
Chek1	C	A	9: 36,625,737 (GRCm39)	V303L	probably benign	Het
Dctn1	T	A	6: 83,172,064 (GRCm39)	I818N	probably damaging	Het
Dscaml1	T	C	9: 45,664,445 (GRCm39)	S2107P	probably damaging	Het
Dusp14	A	G	11: 83,939,597 (GRCm39)	I148T	probably damaging	Het
Eps15	A	G	4: 109,227,754 (GRCm39)	D645G	probably damaging	Het
Etl4	A	G	2: 20,806,390 (GRCm39)	N1153S	possibly damaging	Het
Fer1l6	A	G	15: 58,513,728 (GRCm39)	D1541G	probably benign	Het
Gm14496	A	G	2: 181,640,571 (GRCm39)	S513G	probably damaging	Het
H2-D1	G	T	17: 35,482,471 (GRCm39)	A64S	possibly damaging	Het
Hsd17b2	T	A	8: 118,428,909 (GRCm39)	F59I	possibly damaging	Het
Itgb7	T	G	15: 102,131,911 (GRCm39)	Q224P	probably damaging	Het
Jak1	A	G	4: 101,048,821 (GRCm39)		probably null	Het
Kdm1b	G	A	13: 47,217,707 (GRCm39)		probably null	Het
Lrp8	A	G	4: 107,711,613 (GRCm39)	I466V	probably damaging	Het
Mga	A	G	2: 119,795,043 (GRCm39)	D2909G	probably damaging	Het
Nol8	T	C	13: 49,814,980 (GRCm39)	S345P	probably benign	Het
Nup210l	T	C	3: 90,051,476 (GRCm39)	M540T	probably benign	Het
Obscn	C	T	11: 59,003,464 (GRCm39)	R1370H	probably benign	Het
Or2ad1	A	G	13: 21,327,125 (GRCm39)	F34S	probably damaging	Het
Pbx3	A	G	2: 34,065,965 (GRCm39)	V375A	probably benign	Het
Ppp1r9a	T	C	6: 4,906,168 (GRCm39)	V241A	possibly damaging	Het
Psmd6	C	T	14: 14,112,539 (GRCm38)	V354M	probably damaging	Het
Rab2a	T	C	4: 8,578,481 (GRCm39)	F94L	probably damaging	Het
Rev1	T	C	1: 38,094,571 (GRCm39)	D949G	probably damaging	Het
Ric8a	A	G	7: 140,438,091 (GRCm39)	D110G	probably damaging	Het
Rlf	A	T	4: 121,007,197 (GRCm39)	D594E	probably benign	Het
Septin1	C	A	7: 126,817,230 (GRCm39)		probably null	Het
Slco5a1	G	C	1: 13,060,607 (GRCm39)	P38R	probably damaging	Het
Snx33	C	A	9: 56,833,241 (GRCm39)	R276L	probably damaging	Het
Taf11	A	T	17: 28,124,253 (GRCm39)	D101E	probably benign	Het
Ttn	A	G	2: 76,764,564 (GRCm39)	S3168P	probably damaging	Het
Uggt2	T	C	14: 119,295,075 (GRCm39)	E41G	possibly damaging	Het
Zfp763	A	T	17: 33,240,758 (GRCm39)	W24R	probably damaging	Het

Other mutations in Vmn2r80

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01084:Vmn2r80	APN	10	79,030,433 (GRCm39)	missense	probably damaging	1.00
IGL01325:Vmn2r80	APN	10	79,030,081 (GRCm39)	missense	possibly damaging	0.62
IGL01611:Vmn2r80	APN	10	79,007,488 (GRCm39)	missense	probably damaging	1.00
IGL01799:Vmn2r80	APN	10	79,007,385 (GRCm39)	missense	possibly damaging	0.95
IGL01877:Vmn2r80	APN	10	79,007,334 (GRCm39)	splice site	probably null
IGL02673:Vmn2r80	APN	10	79,005,318 (GRCm39)	missense	probably benign	0.02
IGL02756:Vmn2r80	APN	10	79,030,145 (GRCm39)	missense	probably damaging	1.00
IGL02820:Vmn2r80	APN	10	79,007,439 (GRCm39)	missense	probably benign	0.04
IGL03382:Vmn2r80	APN	10	79,005,362 (GRCm39)	missense	probably damaging	1.00
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0071:Vmn2r80	UTSW	10	79,007,566 (GRCm39)	missense	possibly damaging	0.83
R0129:Vmn2r80	UTSW	10	79,005,330 (GRCm39)	missense	probably damaging	1.00
R0325:Vmn2r80	UTSW	10	78,984,773 (GRCm39)	missense	possibly damaging	0.89
R0567:Vmn2r80	UTSW	10	79,030,665 (GRCm39)	missense	possibly damaging	0.89
R1510:Vmn2r80	UTSW	10	79,005,553 (GRCm39)	missense	possibly damaging	0.69
R1519:Vmn2r80	UTSW	10	79,030,053 (GRCm39)	missense	probably damaging	1.00
R1520:Vmn2r80	UTSW	10	79,030,594 (GRCm39)	missense	probably damaging	1.00
R1709:Vmn2r80	UTSW	10	79,030,223 (GRCm39)	missense	probably benign	0.04
R2116:Vmn2r80	UTSW	10	79,030,558 (GRCm39)	missense	probably benign	0.09
R2237:Vmn2r80	UTSW	10	79,004,104 (GRCm39)	missense	probably damaging	1.00
R2308:Vmn2r80	UTSW	10	79,007,455 (GRCm39)	missense	probably damaging	1.00
R2893:Vmn2r80	UTSW	10	78,984,699 (GRCm39)	missense	possibly damaging	0.63
R3408:Vmn2r80	UTSW	10	79,004,227 (GRCm39)	missense	possibly damaging	0.95
R4502:Vmn2r80	UTSW	10	78,984,764 (GRCm39)	missense	probably benign	0.00
R4685:Vmn2r80	UTSW	10	79,030,162 (GRCm39)	missense	possibly damaging	0.95
R4851:Vmn2r80	UTSW	10	79,030,156 (GRCm39)	missense	possibly damaging	0.68
R4947:Vmn2r80	UTSW	10	79,030,532 (GRCm39)	missense	probably damaging	1.00
R5112:Vmn2r80	UTSW	10	79,030,292 (GRCm39)	missense	possibly damaging	0.61
R5217:Vmn2r80	UTSW	10	79,004,980 (GRCm39)	missense	possibly damaging	0.62
R5226:Vmn2r80	UTSW	10	79,029,874 (GRCm39)	missense	probably benign	0.36
R5512:Vmn2r80	UTSW	10	79,004,066 (GRCm39)	missense	probably benign	0.00
R5618:Vmn2r80	UTSW	10	78,984,755 (GRCm39)	missense	probably benign
R5959:Vmn2r80	UTSW	10	79,005,313 (GRCm39)	missense	probably benign	0.00
R6104:Vmn2r80	UTSW	10	78,984,854 (GRCm39)	missense	probably benign	0.00
R6110:Vmn2r80	UTSW	10	79,017,837 (GRCm39)	missense	probably damaging	1.00
R6270:Vmn2r80	UTSW	10	79,030,159 (GRCm39)	missense	probably benign	0.00
R6508:Vmn2r80	UTSW	10	79,030,290 (GRCm39)	missense	probably benign	0.03
R6843:Vmn2r80	UTSW	10	79,005,502 (GRCm39)	missense	probably benign	0.08
R6894:Vmn2r80	UTSW	10	79,005,438 (GRCm39)	missense	probably benign	0.06
R7048:Vmn2r80	UTSW	10	79,030,153 (GRCm39)	missense	probably damaging	1.00
R7149:Vmn2r80	UTSW	10	79,030,654 (GRCm39)	missense	probably benign	0.00
R7262:Vmn2r80	UTSW	10	79,005,579 (GRCm39)	missense	probably damaging	0.98
R7559:Vmn2r80	UTSW	10	79,030,459 (GRCm39)	missense	probably benign	0.00
R7622:Vmn2r80	UTSW	10	79,030,097 (GRCm39)	missense	probably damaging	1.00
R8003:Vmn2r80	UTSW	10	78,984,711 (GRCm39)	missense	probably benign	0.16
R8207:Vmn2r80	UTSW	10	79,030,150 (GRCm39)	nonsense	probably null
R8330:Vmn2r80	UTSW	10	79,007,550 (GRCm39)	missense	probably damaging	1.00
R8337:Vmn2r80	UTSW	10	78,984,707 (GRCm39)	missense	probably benign	0.00
R8354:Vmn2r80	UTSW	10	78,984,710 (GRCm39)	missense	probably benign
R8688:Vmn2r80	UTSW	10	79,004,069 (GRCm39)	missense	probably damaging	1.00
R8903:Vmn2r80	UTSW	10	79,017,928 (GRCm39)	missense	probably damaging	1.00
R9088:Vmn2r80	UTSW	10	79,005,378 (GRCm39)	missense	probably benign	0.05
R9125:Vmn2r80	UTSW	10	78,984,760 (GRCm39)	missense	probably benign	0.12
R9147:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9148:Vmn2r80	UTSW	10	79,030,687 (GRCm39)	missense	probably damaging	0.98
R9187:Vmn2r80	UTSW	10	79,030,438 (GRCm39)	missense	probably benign	0.20
R9218:Vmn2r80	UTSW	10	79,030,270 (GRCm39)	missense	possibly damaging	0.61
R9553:Vmn2r80	UTSW	10	78,984,743 (GRCm39)	missense	probably benign
R9612:Vmn2r80	UTSW	10	79,030,712 (GRCm39)	missense	probably damaging	1.00
R9677:Vmn2r80	UTSW	10	78,984,672 (GRCm39)	missense	probably benign	0.15
R9769:Vmn2r80	UTSW	10	79,005,443 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,441 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r80	UTSW	10	79,030,232 (GRCm39)	missense	possibly damaging	0.65
Z1176:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run
Z1176:Vmn2r80	UTSW	10	79,030,605 (GRCm39)	missense	probably damaging	1.00
Z1177:Vmn2r80	UTSW	10	79,005,311 (GRCm39)	missense	not run

Predicted Primers

PCR Primer
(F):5'- GGGTATTTGTAGACCACAGAGGCAC -3'
(R):5'- GAGGTAACTCCCAAAGGCCATGAC -3'

Sequencing Primer
(F):5'- ATAGATCCCTCAGTTACATACTGC -3'
(R):5'- TGACTCCCAGGTAAGCCAGAG -3'

Posted On

2014-04-24