Incidental Mutation 'R1629:Vmn1r59'
ID 172673
Institutional Source Beutler Lab
Gene Symbol Vmn1r59
Ensembl Gene ENSMUSG00000074401
Gene Name vomeronasal 1 receptor 59
Synonyms V1rd10
MMRRC Submission 039666-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R1629 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 5456826-5457758 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 5457466 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 98 (C98Y)
Ref Sequence ENSEMBL: ENSMUSP00000073768 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074132]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000074132
AA Change: C98Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073768
Gene: ENSMUSG00000074401
AA Change: C98Y

DomainStartEndE-ValueType
Pfam:TAS2R 1 289 2e-14 PFAM
Pfam:7tm_1 20 279 1.9e-6 PFAM
Pfam:V1R 31 287 3e-16 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 A C 18: 59,087,691 (GRCm39) I574L probably damaging Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
BC005624 T C 2: 30,864,020 (GRCm39) E191G probably damaging Het
Cbx2 A G 11: 118,919,806 (GRCm39) D457G probably damaging Het
Ccdc110 A G 8: 46,395,164 (GRCm39) K352E probably benign Het
Cdk14 A T 5: 5,153,807 (GRCm39) H183Q probably benign Het
Cfap58 A G 19: 47,929,778 (GRCm39) T80A probably benign Het
Cftr C T 6: 18,226,105 (GRCm39) T351I probably damaging Het
Col27a1 A G 4: 63,248,100 (GRCm39) probably benign Het
Cp T A 3: 20,020,614 (GRCm39) probably null Het
Cpne8 A T 15: 90,456,175 (GRCm39) V196E probably benign Het
Dmxl1 T G 18: 49,992,353 (GRCm39) probably null Het
Dnm2 T A 9: 21,415,754 (GRCm39) L642Q probably damaging Het
Dock2 G T 11: 34,212,480 (GRCm39) probably null Het
Dock9 A G 14: 121,780,986 (GRCm39) F2091L possibly damaging Het
Eaf2 A G 16: 36,645,063 (GRCm39) V53A probably damaging Het
Fbl G T 7: 27,874,212 (GRCm39) probably benign Het
Fbn2 T C 18: 58,159,610 (GRCm39) D2373G probably damaging Het
Gbp2b A G 3: 142,316,735 (GRCm39) Y462C possibly damaging Het
Il1rl2 T A 1: 40,396,020 (GRCm39) F348I probably benign Het
Khdc1a T A 1: 21,421,121 (GRCm39) I102N possibly damaging Het
Klhl11 T C 11: 100,355,012 (GRCm39) T270A probably benign Het
Lama1 T C 17: 68,112,423 (GRCm39) S2288P probably benign Het
Lrfn4 T C 19: 4,663,523 (GRCm39) E337G possibly damaging Het
Macf1 C A 4: 123,402,208 (GRCm39) E549* probably null Het
Mmp3 G T 9: 7,447,641 (GRCm39) V209F probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Myh9 G A 15: 77,648,601 (GRCm39) R1725W probably damaging Het
Nbea A T 3: 55,910,312 (GRCm39) D1294E possibly damaging Het
Nrcam G A 12: 44,610,769 (GRCm39) A496T probably benign Het
Nufip2 A G 11: 77,583,834 (GRCm39) T583A probably benign Het
Or5m3b A G 2: 85,871,766 (GRCm39) T36A probably damaging Het
Ppig C A 2: 69,566,217 (GRCm39) T128K probably damaging Het
Ppp2r2a A T 14: 67,257,208 (GRCm39) C341S possibly damaging Het
Ptpre A T 7: 135,271,528 (GRCm39) D374V probably damaging Het
Ranbp3l A C 15: 9,065,068 (GRCm39) Q485P probably damaging Het
Rapgef6 TG TGG 11: 54,437,223 (GRCm39) probably null Het
Slc1a7 A G 4: 107,865,340 (GRCm39) Y276C probably damaging Het
Smarcad1 A G 6: 65,044,091 (GRCm39) D221G probably benign Het
Smn1 C A 13: 100,264,404 (GRCm39) T45N probably damaging Het
Son T C 16: 91,454,510 (GRCm39) S1086P probably damaging Het
Ssmem1 T A 6: 30,512,491 (GRCm39) Y45N possibly damaging Het
Tasor2 T C 13: 3,624,121 (GRCm39) H1943R possibly damaging Het
Tmem184c A C 8: 78,329,551 (GRCm39) F170V possibly damaging Het
Tmem184c A T 8: 78,332,791 (GRCm39) probably null Het
Vmn2r23 T A 6: 123,690,386 (GRCm39) S421T probably benign Het
Vmn2r98 T C 17: 19,287,645 (GRCm39) S493P possibly damaging Het
Other mutations in Vmn1r59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01684:Vmn1r59 APN 7 5,457,299 (GRCm39) missense probably benign 0.12
IGL02035:Vmn1r59 APN 7 5,457,208 (GRCm39) missense possibly damaging 0.87
IGL02039:Vmn1r59 APN 7 5,457,380 (GRCm39) missense probably benign 0.23
IGL02812:Vmn1r59 APN 7 5,457,176 (GRCm39) missense probably damaging 1.00
R0033:Vmn1r59 UTSW 7 5,457,433 (GRCm39) missense probably benign 0.08
R0115:Vmn1r59 UTSW 7 5,457,115 (GRCm39) missense probably benign 0.07
R1164:Vmn1r59 UTSW 7 5,457,410 (GRCm39) missense probably benign 0.00
R1845:Vmn1r59 UTSW 7 5,457,553 (GRCm39) missense probably benign 0.03
R1969:Vmn1r59 UTSW 7 5,457,038 (GRCm39) missense probably damaging 1.00
R1970:Vmn1r59 UTSW 7 5,457,038 (GRCm39) missense probably damaging 1.00
R1971:Vmn1r59 UTSW 7 5,457,038 (GRCm39) missense probably damaging 1.00
R2011:Vmn1r59 UTSW 7 5,457,283 (GRCm39) missense probably damaging 1.00
R3712:Vmn1r59 UTSW 7 5,457,637 (GRCm39) missense probably damaging 0.99
R4580:Vmn1r59 UTSW 7 5,457,136 (GRCm39) missense probably damaging 0.98
R4593:Vmn1r59 UTSW 7 5,457,686 (GRCm39) missense possibly damaging 0.46
R4697:Vmn1r59 UTSW 7 5,457,451 (GRCm39) missense probably damaging 1.00
R4856:Vmn1r59 UTSW 7 5,457,532 (GRCm39) missense possibly damaging 0.92
R4873:Vmn1r59 UTSW 7 5,457,108 (GRCm39) missense probably benign
R4875:Vmn1r59 UTSW 7 5,457,108 (GRCm39) missense probably benign
R4925:Vmn1r59 UTSW 7 5,457,115 (GRCm39) missense probably benign 0.07
R5319:Vmn1r59 UTSW 7 5,457,209 (GRCm39) missense probably damaging 0.99
R6239:Vmn1r59 UTSW 7 5,457,539 (GRCm39) missense probably damaging 1.00
R6533:Vmn1r59 UTSW 7 5,457,463 (GRCm39) missense probably benign 0.00
R6912:Vmn1r59 UTSW 7 5,457,599 (GRCm39) missense probably benign 0.01
R7023:Vmn1r59 UTSW 7 5,457,477 (GRCm39) missense probably benign 0.37
R7205:Vmn1r59 UTSW 7 5,457,725 (GRCm39) missense probably damaging 1.00
R7374:Vmn1r59 UTSW 7 5,457,160 (GRCm39) missense probably damaging 0.99
R7390:Vmn1r59 UTSW 7 5,456,986 (GRCm39) missense possibly damaging 0.59
R7776:Vmn1r59 UTSW 7 5,457,634 (GRCm39) missense probably damaging 0.97
R8306:Vmn1r59 UTSW 7 5,456,966 (GRCm39) missense probably benign 0.01
R8473:Vmn1r59 UTSW 7 5,457,064 (GRCm39) missense possibly damaging 0.84
R8499:Vmn1r59 UTSW 7 5,457,750 (GRCm39) missense probably benign 0.00
R8523:Vmn1r59 UTSW 7 5,457,053 (GRCm39) missense probably damaging 1.00
R8706:Vmn1r59 UTSW 7 5,457,715 (GRCm39) missense possibly damaging 0.83
R9104:Vmn1r59 UTSW 7 5,457,166 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTACATTGACCCCAGAGATGGAGC -3'
(R):5'- TCTTGACTGACTCCAGACTGAGGC -3'

Sequencing Primer
(F):5'- CCCCAGAGATGGAGCATATTG -3'
(R):5'- TGAGGCCCATACAGGTCATTC -3'
Posted On 2014-04-24