Incidental Mutation 'R1631:Gal3st2b'
ID 172772
Institutional Source Beutler Lab
Gene Symbol Gal3st2b
Ensembl Gene ENSMUSG00000093805
Gene Name galactose-3-O-sulfotransferase 2B
Synonyms Gm9994
MMRRC Submission 039668-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R1631 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 93846159-93870367 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93868505 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 243 (D243E)
Ref Sequence ENSEMBL: ENSMUSP00000136012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177958] [ENSMUST00000178757]
AlphaFold Q6XQH0
Predicted Effect probably damaging
Transcript: ENSMUST00000177958
AA Change: D245E

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000136311
Gene: ENSMUSG00000093805
AA Change: D245E

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 1 382 6.5e-151 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000178757
AA Change: D243E

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000136012
Gene: ENSMUSG00000093805
AA Change: D243E

DomainStartEndE-ValueType
Pfam:Gal-3-0_sulfotr 13 380 1.1e-151 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 93.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts10 T A 17: 33,756,316 (GRCm39) S320T probably benign Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Als2 T C 1: 59,257,226 (GRCm39) E12G probably benign Het
Arhgef10 A T 8: 14,997,157 (GRCm39) D321V probably damaging Het
Atp8a1 T G 5: 67,906,395 (GRCm39) probably null Het
Avil A G 10: 126,846,494 (GRCm39) probably null Het
C2cd3 G A 7: 100,021,704 (GRCm39) probably null Het
Cdhr18 C T 14: 13,829,796 (GRCm38) E649K probably damaging Het
Col18a1 G A 10: 76,895,131 (GRCm39) P1177S probably damaging Het
Copb2 T A 9: 98,462,213 (GRCm39) F428L probably benign Het
Cpa1 A G 6: 30,640,923 (GRCm39) E138G probably damaging Het
Ctsm T C 13: 61,686,249 (GRCm39) I12V possibly damaging Het
Dctn1 A G 6: 83,174,578 (GRCm39) Q967R possibly damaging Het
Dok2 T C 14: 71,014,393 (GRCm39) Y194H probably damaging Het
Ezh2 C T 6: 47,554,592 (GRCm39) M1I probably null Het
Fkbp8 T A 8: 70,984,282 (GRCm39) L210Q probably damaging Het
Fpr1 T A 17: 18,097,263 (GRCm39) Q242L probably benign Het
Gm5422 A G 10: 31,125,802 (GRCm39) noncoding transcript Het
Gucy1a2 A G 9: 3,533,052 (GRCm39) N84D probably damaging Het
Hsd3b5 A C 3: 98,529,393 (GRCm39) V79G probably damaging Het
Htr6 A T 4: 138,788,804 (GRCm39) V417E probably benign Het
Ifnar2 G A 16: 91,188,755 (GRCm39) V79I probably benign Het
Ighv10-1 T C 12: 114,443,102 (GRCm39) probably benign Het
Itpr2 A G 6: 146,081,788 (GRCm39) F182L probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lama3 A G 18: 12,540,551 (GRCm39) Y285C probably damaging Het
Lamc2 C A 1: 153,034,680 (GRCm39) V108L possibly damaging Het
Lrrc14b A G 13: 74,509,373 (GRCm39) probably null Het
Magi3 T C 3: 103,958,493 (GRCm39) T531A probably benign Het
Mapre2 A G 18: 23,966,011 (GRCm39) Y32C probably damaging Het
Med1 C T 11: 98,046,452 (GRCm39) probably benign Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Nt5el C A 13: 105,218,749 (GRCm39) Q28K probably benign Het
Or10a3b A C 7: 108,445,064 (GRCm39) L51R probably damaging Het
Or51h1 A G 7: 102,308,408 (GRCm39) I127V probably damaging Het
Or5h23 G A 16: 58,906,408 (GRCm39) T146I probably benign Het
Or7a35 A T 10: 78,853,239 (GRCm39) I28L probably benign Het
Pde1b A G 15: 103,430,099 (GRCm39) T143A probably damaging Het
Pkhd1 T C 1: 20,593,121 (GRCm39) D1664G probably benign Het
Plod3 C T 5: 137,017,847 (GRCm39) R208W probably damaging Het
Pstk G A 7: 130,986,271 (GRCm39) A277T possibly damaging Het
Qrich1 T C 9: 108,411,684 (GRCm39) V403A probably damaging Het
Rad21 C A 15: 51,833,436 (GRCm39) V348F probably damaging Het
Sacs T A 14: 61,448,181 (GRCm39) L3409* probably null Het
Setd4 T A 16: 93,390,136 (GRCm39) K98* probably null Het
Skint5 A G 4: 113,341,123 (GRCm39) V1385A probably benign Het
Stam C A 2: 14,151,059 (GRCm39) S472* probably null Het
Stx2 A G 5: 129,069,289 (GRCm39) F141L probably damaging Het
Tia1 A G 6: 86,397,330 (GRCm39) D101G probably damaging Het
Ttc21a T A 9: 119,783,228 (GRCm39) probably null Het
Usp34 T A 11: 23,410,651 (GRCm39) N2700K probably damaging Het
Other mutations in Gal3st2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0593:Gal3st2b UTSW 1 93,868,549 (GRCm39) missense probably benign 0.05
R1753:Gal3st2b UTSW 1 93,868,338 (GRCm39) missense probably damaging 1.00
R2354:Gal3st2b UTSW 1 93,867,508 (GRCm39) missense probably damaging 0.99
R3926:Gal3st2b UTSW 1 93,868,512 (GRCm39) missense probably benign 0.06
R4347:Gal3st2b UTSW 1 93,867,530 (GRCm39) missense probably damaging 1.00
R6132:Gal3st2b UTSW 1 93,867,688 (GRCm39) missense possibly damaging 0.57
R7069:Gal3st2b UTSW 1 93,868,341 (GRCm39) missense possibly damaging 0.95
R7116:Gal3st2b UTSW 1 93,868,498 (GRCm39) missense possibly damaging 0.58
R7662:Gal3st2b UTSW 1 93,868,614 (GRCm39) missense probably damaging 1.00
R7775:Gal3st2b UTSW 1 93,868,506 (GRCm39) missense probably damaging 1.00
R8669:Gal3st2b UTSW 1 93,868,764 (GRCm39) missense possibly damaging 0.90
R8924:Gal3st2b UTSW 1 93,868,653 (GRCm39) missense probably benign 0.18
R8937:Gal3st2b UTSW 1 93,868,570 (GRCm39) missense probably benign 0.15
R9635:Gal3st2b UTSW 1 93,868,777 (GRCm39) missense probably benign 0.12
R9645:Gal3st2b UTSW 1 93,866,328 (GRCm39) missense probably damaging 0.97
R9713:Gal3st2b UTSW 1 93,866,409 (GRCm39) missense probably benign
Z1176:Gal3st2b UTSW 1 93,866,407 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TTTGGTTTTGACAACAACGCCCC -3'
(R):5'- AGCCCAGAATATTGGCCTTCCCAC -3'

Sequencing Primer
(F):5'- GCCCCAGCAGACATGGAC -3'
(R):5'- TAAGGACGCAGATTCTGGTCATC -3'
Posted On 2014-04-24