Incidental Mutation 'R1634:Or4k45'
ID 172959
Institutional Source Beutler Lab
Gene Symbol Or4k45
Ensembl Gene ENSMUSG00000108919
Gene Name olfactory receptor family 4 subfamily K member 45
Synonyms MOR248-10, GA_x6K02T2Q125-72616944-72616006, Olfr1295
MMRRC Submission 039671-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # R1634 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111394849-111395787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 111395691 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 33 (M33V)
Ref Sequence ENSEMBL: ENSMUSP00000151314 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207283] [ENSMUST00000207786] [ENSMUST00000217772]
AlphaFold Q8VF48
Predicted Effect probably benign
Transcript: ENSMUST00000099613
AA Change: M33V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097208
Gene: ENSMUSG00000074959
AA Change: M33V

DomainStartEndE-ValueType
Pfam:7tm_4 31 304 3.8e-49 PFAM
Pfam:7tm_1 41 287 6.2e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207283
AA Change: M33V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000207786
AA Change: M33V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209152
AA Change: M33V
Predicted Effect probably benign
Transcript: ENSMUST00000217772
AA Change: M33V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.7%
  • 20x: 90.4%
Validation Efficiency 97% (67/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam2 A T 14: 66,295,180 (GRCm39) F222I probably damaging Het
Adam34 A T 8: 44,105,127 (GRCm39) C173S possibly damaging Het
Ahi1 T C 10: 20,841,592 (GRCm39) V293A probably damaging Het
AI182371 A T 2: 34,976,497 (GRCm39) Y223N probably damaging Het
Asmt C A X: 169,109,564 (GRCm39) F181L probably damaging Het
Axin1 T A 17: 26,406,965 (GRCm39) H519Q probably damaging Het
Cdc5l A T 17: 45,715,632 (GRCm39) V660E probably damaging Het
Cep152 C T 2: 125,425,809 (GRCm39) R852H probably benign Het
Cpne4 T C 9: 104,866,778 (GRCm39) V230A possibly damaging Het
Cttnbp2 A T 6: 18,408,656 (GRCm39) N988K probably benign Het
D430041D05Rik A G 2: 104,051,556 (GRCm39) I767T probably damaging Het
Dgki A G 6: 36,892,425 (GRCm39) M851T probably benign Het
Dnah8 T C 17: 30,932,072 (GRCm39) probably null Het
Dscaml1 A G 9: 45,584,047 (GRCm39) E504G probably damaging Het
Dzank1 G A 2: 144,323,589 (GRCm39) A618V probably benign Het
Entrep3 A C 3: 89,095,401 (GRCm39) Y511S probably damaging Het
Fat2 T A 11: 55,158,510 (GRCm39) S3403C probably damaging Het
Fat2 C T 11: 55,175,545 (GRCm39) V1723I probably benign Het
Flt1 A T 5: 147,613,240 (GRCm39) F334I probably damaging Het
Galnt12 G T 4: 47,108,585 (GRCm39) probably null Het
Gzmc T C 14: 56,469,737 (GRCm39) I188V possibly damaging Het
Herc1 T C 9: 66,380,820 (GRCm39) S3566P possibly damaging Het
Hoxb4 C A 11: 96,211,099 (GRCm39) probably benign Het
Idh3b C T 2: 130,123,665 (GRCm39) V141I probably benign Het
Kif24 A G 4: 41,393,529 (GRCm39) S1249P probably benign Het
Leo1 T C 9: 75,373,542 (GRCm39) Y656H possibly damaging Het
Map3k20 G A 2: 72,240,521 (GRCm39) W339* probably null Het
Map3k5 T C 10: 20,012,657 (GRCm39) V1259A possibly damaging Het
Masp2 A G 4: 148,698,812 (GRCm39) D631G probably damaging Het
Mink1 T C 11: 70,499,706 (GRCm39) S713P probably benign Het
Mpp7 A T 18: 7,350,984 (GRCm39) V571E possibly damaging Het
Nell1 A G 7: 50,498,306 (GRCm39) D574G possibly damaging Het
Obscn T C 11: 58,967,722 (GRCm39) Y392C probably damaging Het
Odad2 A G 18: 7,286,688 (GRCm39) L181P probably damaging Het
Olfml2a A T 2: 38,850,231 (GRCm39) Y649F probably benign Het
Or1f19 A G 16: 3,411,073 (GRCm39) D271G probably benign Het
Prkcg A G 7: 3,371,986 (GRCm39) D484G probably damaging Het
Rab27a T C 9: 72,982,851 (GRCm39) probably null Het
Rapgef6 TG TGG 11: 54,437,223 (GRCm39) probably null Het
Rgl1 C T 1: 152,400,523 (GRCm39) R624H probably damaging Het
Ric8b G A 10: 84,806,612 (GRCm39) G159D probably damaging Het
Sbno2 C A 10: 79,896,468 (GRCm39) A880S possibly damaging Het
Scn9a A G 2: 66,318,361 (GRCm39) S1477P probably damaging Het
Sec22a T C 16: 35,139,243 (GRCm39) probably benign Het
Snx14 T C 9: 88,267,792 (GRCm39) I714M probably benign Het
Snx14 T C 9: 88,289,543 (GRCm39) probably benign Het
Sphk2 T A 7: 45,360,964 (GRCm39) T347S probably benign Het
Spns1 C T 7: 125,970,343 (GRCm39) probably benign Het
Susd2 A G 10: 75,473,389 (GRCm39) V675A probably benign Het
Sytl2 A T 7: 90,044,390 (GRCm39) D566V probably damaging Het
Tcf25 T A 8: 124,123,830 (GRCm39) I464N possibly damaging Het
Tex261 A T 6: 83,752,004 (GRCm39) I49N possibly damaging Het
Tjp1 A G 7: 64,952,700 (GRCm39) F1545L possibly damaging Het
Tmem176b A G 6: 48,811,500 (GRCm39) S216P probably damaging Het
Topaz1 C T 9: 122,609,740 (GRCm39) probably benign Het
Tra2a C T 6: 49,227,891 (GRCm39) probably benign Het
Ttn A G 2: 76,553,126 (GRCm39) F22794S possibly damaging Het
Uox G A 3: 146,318,138 (GRCm39) W93* probably null Het
Zan A T 5: 137,411,052 (GRCm39) probably benign Het
Zfp106 G A 2: 120,364,158 (GRCm39) R750* probably null Het
Zfp638 A T 6: 83,956,894 (GRCm39) probably null Het
Other mutations in Or4k45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02110:Or4k45 APN 2 111,395,252 (GRCm39) missense probably damaging 1.00
IGL02426:Or4k45 APN 2 111,394,883 (GRCm39) missense probably benign
IGL02638:Or4k45 APN 2 111,395,249 (GRCm39) missense probably damaging 1.00
IGL02743:Or4k45 APN 2 111,394,888 (GRCm39) missense possibly damaging 0.95
IGL03161:Or4k45 APN 2 111,395,676 (GRCm39) missense possibly damaging 0.78
G1patch:Or4k45 UTSW 2 111,395,252 (GRCm39) missense probably damaging 1.00
PIT4377001:Or4k45 UTSW 2 111,395,556 (GRCm39) missense probably damaging 0.98
R0448:Or4k45 UTSW 2 111,395,559 (GRCm39) missense probably benign 0.42
R2065:Or4k45 UTSW 2 111,395,057 (GRCm39) missense probably damaging 0.99
R5308:Or4k45 UTSW 2 111,394,899 (GRCm39) missense probably damaging 0.99
R5534:Or4k45 UTSW 2 111,395,349 (GRCm39) missense probably benign 0.00
R5990:Or4k45 UTSW 2 111,395,019 (GRCm39) missense probably damaging 0.99
R6725:Or4k45 UTSW 2 111,395,252 (GRCm39) missense probably damaging 1.00
R7492:Or4k45 UTSW 2 111,395,166 (GRCm39) missense probably benign 0.00
R8116:Or4k45 UTSW 2 111,395,783 (GRCm39) missense probably benign 0.01
R8400:Or4k45 UTSW 2 111,395,747 (GRCm39) missense probably damaging 1.00
R8493:Or4k45 UTSW 2 111,395,324 (GRCm39) missense probably damaging 1.00
R9636:Or4k45 UTSW 2 111,395,786 (GRCm39) start codon destroyed probably null 1.00
R9736:Or4k45 UTSW 2 111,395,626 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- GCATCCTGCAAAGGAAATGGTCTTG -3'
(R):5'- TGGGGAAACAATGTCACTCATGTTTGG -3'

Sequencing Primer
(F):5'- CAAAGGAAATGGTCTTGTTTTCCC -3'
(R):5'- TTCTACAAAGGAAGTACCTTATCCC -3'
Posted On 2014-04-24