Incidental Mutation 'R1635:Drc7'
ID173077
Institutional Source Beutler Lab
Gene Symbol Drc7
Ensembl Gene ENSMUSG00000031786
Gene Namedynein regulatory complex subunit 7
SynonymsSRG-L, LOC330830, Ccdc135
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #R1635 (G1)
Quality Score194
Status Not validated
Chromosome8
Chromosomal Location95055103-95078141 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to A at 95074332 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000053972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058479]
Predicted Effect probably null
Transcript: ENSMUST00000058479
SMART Domains Protein: ENSMUSP00000053972
Gene: ENSMUSG00000031786

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 229 246 N/A INTRINSIC
coiled coil region 258 295 N/A INTRINSIC
low complexity region 388 411 N/A INTRINSIC
low complexity region 544 555 N/A INTRINSIC
low complexity region 695 710 N/A INTRINSIC
low complexity region 798 809 N/A INTRINSIC
low complexity region 848 864 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212980
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 91.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 95 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 A T 2: 25,444,856 I1947F probably benign Het
Adgrd1 G T 5: 129,128,907 V182F probably damaging Het
Agmat A G 4: 141,747,069 D87G probably damaging Het
AI182371 T C 2: 35,088,737 probably null Het
Anapc1 G T 2: 128,628,532 H1559Q probably damaging Het
Ankar T C 1: 72,650,138 Y1278C probably damaging Het
Arhgef2 A T 3: 88,639,321 probably null Het
Arsi G A 18: 60,916,651 G202E probably benign Het
Banp A T 8: 122,001,011 I130F probably damaging Het
C130050O18Rik G T 5: 139,414,493 R100S probably benign Het
Carmil3 A G 14: 55,496,282 T374A possibly damaging Het
Cc2d2a T A 5: 43,722,470 W1076R probably damaging Het
Cdc34 T G 10: 79,688,054 S235A probably benign Het
Cdh8 G T 8: 99,031,024 H647Q probably damaging Het
Cdk1 A T 10: 69,338,547 L282Q probably damaging Het
Ceacam3 A G 7: 17,159,977 D471G probably damaging Het
Cltc A T 11: 86,757,279 I4N probably benign Het
Cntfr T A 4: 41,658,816 E305V probably damaging Het
Cwh43 T A 5: 73,434,310 I496N probably damaging Het
Cyp2f2 A G 7: 27,129,724 N218S probably benign Het
D16Ertd472e A G 16: 78,546,504 probably null Het
Dab2 A G 15: 6,429,870 Q400R possibly damaging Het
Dapl1 A T 2: 59,496,562 I51F probably benign Het
Etl4 A G 2: 20,806,408 T1101A probably damaging Het
Fam83c C A 2: 155,830,051 R488M possibly damaging Het
Fam96b A T 8: 104,640,988 I108N possibly damaging Het
Fbxo42 A G 4: 141,200,529 T707A probably damaging Het
Fcmr A T 1: 130,876,185 probably null Het
Fer1l6 G C 15: 58,647,081 K1687N probably damaging Het
Fgd4 G A 16: 16,475,029 R275* probably null Het
Fxr2 G A 11: 69,641,313 C87Y possibly damaging Het
Gja4 A T 4: 127,312,679 I97N probably damaging Het
Gm136 A G 4: 34,750,919 probably null Het
Gm14496 A G 2: 182,001,044 D836G possibly damaging Het
Gm8882 A G 6: 132,363,006 probably null Het
Grm3 T A 5: 9,511,520 T777S probably damaging Het
Guca2b A G 4: 119,657,715 Y50H probably damaging Het
Herc2 C T 7: 56,136,667 P1587S probably benign Het
Hmcn1 C T 1: 150,669,558 S2766N probably benign Het
Idi2 T A 13: 8,959,419 I224K probably damaging Het
Kmt2a A T 9: 44,824,369 probably benign Het
Lonp2 A T 8: 86,713,450 M693L possibly damaging Het
Megf8 G T 7: 25,346,747 M1525I possibly damaging Het
Mgme1 T C 2: 144,279,098 V276A possibly damaging Het
Mief2 G T 11: 60,731,408 W268L probably damaging Het
Mpped1 C T 15: 83,791,990 probably benign Het
Mreg T C 1: 72,192,197 N34S probably benign Het
Myf6 T C 10: 107,494,673 Y11C probably damaging Het
Myh9 C A 15: 77,771,167 Q1196H probably benign Het
Myh9 A T 15: 77,775,899 D56E probably benign Het
Myo5c A T 9: 75,277,075 R949S probably benign Het
Ncapg2 TAA TA 12: 116,434,685 probably null Het
Nfx1 T A 4: 40,977,004 V226E probably benign Het
Nlrp10 T A 7: 108,924,530 K581M possibly damaging Het
Nmd3 T G 3: 69,739,984 I273S probably benign Het
Olfr1264 A T 2: 90,021,970 I32N possibly damaging Het
P4hb T C 11: 120,571,616 E88G probably damaging Het
Pcnx3 A T 19: 5,665,745 H1444Q probably benign Het
Pdia4 A T 6: 47,799,199 F421L possibly damaging Het
Picalm T A 7: 90,191,251 S538T probably damaging Het
Ppp2r2b T A 18: 43,059,210 I11F probably benign Het
Ptk7 C T 17: 46,573,534 E757K possibly damaging Het
Rbm22 T G 18: 60,561,268 C24W probably damaging Het
Rev3l A G 10: 39,806,662 D288G probably damaging Het
Rgs18 T A 1: 144,754,053 H156L probably benign Het
Rnf213 A G 11: 119,442,579 I2871M probably damaging Het
Rrm2b A T 15: 37,945,084 M137K probably damaging Het
Rrp12 A T 19: 41,868,785 D1183E probably benign Het
Sacs G A 14: 61,203,828 V1108M probably damaging Het
Scube2 A T 7: 109,843,214 D270E possibly damaging Het
Serpina3a T A 12: 104,116,478 F170Y probably damaging Het
Serpinb3b T C 1: 107,154,673 E287G probably benign Het
Slamf8 C T 1: 172,584,619 V130M probably damaging Het
Slc5a3 T C 16: 92,077,396 S114P possibly damaging Het
Sos1 T A 17: 80,422,679 probably null Het
Sox10 A T 15: 79,156,460 D293E probably damaging Het
Sphk1 A G 11: 116,535,770 D177G probably damaging Het
Sphkap T G 1: 83,278,400 M543L probably benign Het
Syt13 A T 2: 92,953,415 K343N probably damaging Het
Tatdn3 A G 1: 191,060,176 M34T probably benign Het
Timd4 T G 11: 46,842,162 V305G possibly damaging Het
Tnnc2 T C 2: 164,777,592 I111V probably benign Het
Togaram2 C T 17: 71,697,851 P301L probably benign Het
Trpc3 T C 3: 36,640,627 N726S probably damaging Het
Tspear T A 10: 77,870,419 L341H possibly damaging Het
Ugt1a5 T A 1: 88,166,083 probably benign Het
Ulk3 A T 9: 57,593,160 probably null Het
Unc5d T A 8: 28,760,749 I297L probably benign Het
Usp20 A G 2: 31,018,818 I804V probably benign Het
Usp22 G T 11: 61,161,318 C278* probably null Het
Usp53 A T 3: 122,934,223 N903K probably benign Het
V1rd19 T C 7: 24,003,387 F93L probably benign Het
Zdbf2 T A 1: 63,304,334 V624E possibly damaging Het
Zfyve16 A T 13: 92,509,020 S1073T probably damaging Het
Zkscan8 T C 13: 21,526,595 H115R possibly damaging Het
Other mutations in Drc7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Drc7 APN 8 95056001 splice site probably benign
IGL00922:Drc7 APN 8 95077978 missense probably benign 0.00
IGL01610:Drc7 APN 8 95077802 missense probably damaging 1.00
IGL01642:Drc7 APN 8 95059139 missense probably benign 0.34
IGL01793:Drc7 APN 8 95071277 missense probably benign 0.25
IGL01936:Drc7 APN 8 95074132 missense possibly damaging 0.89
IGL01953:Drc7 APN 8 95059125 missense probably damaging 1.00
IGL01998:Drc7 APN 8 95059193 missense probably damaging 1.00
IGL02237:Drc7 APN 8 95072879 missense probably damaging 1.00
IGL02259:Drc7 APN 8 95056105 missense probably benign
IGL02285:Drc7 APN 8 95071233 splice site probably benign
IGL02940:Drc7 APN 8 95074297 missense probably damaging 0.99
IGL03032:Drc7 APN 8 95076247 splice site probably benign
IGL03181:Drc7 APN 8 95068127 missense probably benign 0.00
R0018:Drc7 UTSW 8 95074234 missense probably damaging 0.99
R0018:Drc7 UTSW 8 95074234 missense probably damaging 0.99
R0281:Drc7 UTSW 8 95071253 missense possibly damaging 0.61
R0304:Drc7 UTSW 8 95059128 missense probably damaging 1.00
R0362:Drc7 UTSW 8 95072855 missense probably benign 0.00
R1127:Drc7 UTSW 8 95072788 missense probably damaging 0.98
R1921:Drc7 UTSW 8 95056016 missense unknown
R1931:Drc7 UTSW 8 95071253 missense possibly damaging 0.61
R2256:Drc7 UTSW 8 95075009 missense probably benign 0.16
R3851:Drc7 UTSW 8 95061836 nonsense probably null
R4797:Drc7 UTSW 8 95074297 missense probably damaging 0.96
R4827:Drc7 UTSW 8 95071639 missense probably damaging 0.98
R4966:Drc7 UTSW 8 95071596 missense probably benign 0.45
R5194:Drc7 UTSW 8 95061717 missense probably benign 0.00
R5721:Drc7 UTSW 8 95074333 critical splice donor site probably null
R5911:Drc7 UTSW 8 95074126 missense probably damaging 1.00
R5993:Drc7 UTSW 8 95074192 missense probably benign
R6056:Drc7 UTSW 8 95075051 missense probably damaging 1.00
R6534:Drc7 UTSW 8 95071282 missense probably damaging 1.00
R6576:Drc7 UTSW 8 95075258 missense probably damaging 0.98
R6861:Drc7 UTSW 8 95062397 critical splice donor site probably null
R7104:Drc7 UTSW 8 95059083 missense probably damaging 0.99
R7157:Drc7 UTSW 8 95074150 missense probably damaging 0.99
R7205:Drc7 UTSW 8 95077921 missense probably damaging 1.00
R7283:Drc7 UTSW 8 95071579 missense probably damaging 0.99
Y5404:Drc7 UTSW 8 95068150 small deletion probably benign
Predicted Primers PCR Primer
(F):5'- TGATAGTGGAAGAGCGCATCCAGC -3'
(R):5'- GAATATTAGTCGTGTGCCCAACCCC -3'

Sequencing Primer
(F):5'- ATCCAGCTTCGCTACCATTG -3'
(R):5'- GGGCATTCCAGTTACATCTGATAG -3'
Posted On2014-04-24