Mutagenetix > Incidental Mutation

Incidental Mutation 'R1637:Taar6'

173255

Institutional Source

Beutler Lab

Gene Symbol

Taar6

Ensembl Gene

ENSMUSG00000045111

Gene Name

trace amine-associated receptor 6

Synonyms

LOC215855

MMRRC Submission

039673-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

R1637 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23860507-23861544 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23861079 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 156 (S156P)

Ref Sequence

ENSEMBL: ENSMUSP00000097603 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057080]

AlphaFold

Q5QD13

Predicted Effect

probably benign
Transcript: ENSMUST00000057080
AA Change: S156P

PolyPhen 2 Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000097603
Gene: ENSMUSG00000045111
AA Change: S156P

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	43	326	5.5e-13	PFAM
Pfam:7tm_1	49	311	5.9e-58	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.4%
20x: 92.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	T	A	5: 109,886,858 (GRCm39)	H50L	probably benign	Het
A2m	C	A	6: 121,631,571 (GRCm39)	L623M	probably benign	Het
Agpat5	A	G	8: 18,931,827 (GRCm39)	R316G	probably benign	Het
Ankrd39	G	A	1: 36,578,573 (GRCm39)	Q151*	probably null	Het
Arl13b	T	C	16: 62,651,147 (GRCm39)	D30G	probably damaging	Het
Atpaf1	A	G	4: 115,645,499 (GRCm39)	S123G	probably benign	Het
Bicra	A	G	7: 15,706,614 (GRCm39)	S1276P	probably benign	Het
Car1	T	C	3: 14,842,846 (GRCm39)	I60V	possibly damaging	Het
Cnbd2	A	G	2: 156,215,644 (GRCm39)	I411V	probably damaging	Het
Cyp2c37	A	T	19: 39,990,426 (GRCm39)	K375*	probably null	Het
Cysrt1	T	C	2: 25,129,297 (GRCm39)	I72V	probably benign	Het
Dock9	T	A	14: 121,889,187 (GRCm39)	D312V	possibly damaging	Het
Ecd	T	C	14: 20,396,760 (GRCm39)	I42V	probably damaging	Het
Ercc5	A	G	1: 44,206,694 (GRCm39)	T536A	probably benign	Het
Gjd2	A	T	2: 113,841,789 (GRCm39)	Y229*	probably null	Het
Gramd1b	A	T	9: 40,215,834 (GRCm39)		probably null	Het
Hcrtr2	T	C	9: 76,140,281 (GRCm39)	T336A	probably benign	Het
Hjurp	G	A	1: 88,193,843 (GRCm39)	S279F	probably benign	Het
Ift140	C	T	17: 25,244,608 (GRCm39)	L152F	probably benign	Het
Izumo1r	A	G	9: 14,813,105 (GRCm39)	C56R	probably damaging	Het
Kif7	T	C	7: 79,352,585 (GRCm39)	E850G	probably damaging	Het
Larp4b	C	G	13: 9,201,133 (GRCm39)	T335S	probably benign	Het
Lmo7	A	T	14: 102,118,268 (GRCm39)	R42S	probably damaging	Het
Lrrk2	T	G	15: 91,618,261 (GRCm39)	L920R	probably benign	Het
Mapk8	G	A	14: 33,132,919 (GRCm39)	R6C	probably benign	Het
Mpped1	C	T	15: 83,676,191 (GRCm39)		probably benign	Het
Myoc	A	G	1: 162,466,936 (GRCm39)	Y35C	probably damaging	Het
Ndufb8	C	T	19: 44,543,474 (GRCm39)	M66I	probably benign	Het
Nkpd1	T	C	7: 19,257,904 (GRCm39)	I411T	probably benign	Het
Nrxn3	A	G	12: 89,321,238 (GRCm39)	N382S	possibly damaging	Het
Or2t47	A	T	11: 58,442,246 (GRCm39)	V273E	possibly damaging	Het
Or4c114	A	T	2: 88,905,396 (GRCm39)	L13Q	probably damaging	Het
Pear1	T	C	3: 87,664,060 (GRCm39)	E303G	probably damaging	Het
Plekhg4	T	A	8: 106,108,413 (GRCm39)	M1047K	probably benign	Het
Pofut1	T	G	2: 153,107,709 (GRCm39)	F268C	probably damaging	Het
Psrc1	G	T	3: 108,292,609 (GRCm39)	S134I	probably damaging	Het
Slc6a2	A	T	8: 93,708,618 (GRCm39)	I245F	probably benign	Het
Slc9a1	T	C	4: 133,149,534 (GRCm39)	S787P	probably benign	Het
Sorcs3	T	A	19: 48,736,798 (GRCm39)		probably null	Het
Syne2	C	A	12: 76,042,776 (GRCm39)	H3916N	probably damaging	Het
Tnn	A	G	1: 159,975,170 (GRCm39)	F86L	probably damaging	Het
Tspear	T	A	10: 77,706,253 (GRCm39)	L341H	possibly damaging	Het
Ttll8	A	G	15: 88,798,647 (GRCm39)	V696A	probably benign	Het
Utrn	C	A	10: 12,312,108 (GRCm39)	D616Y	probably damaging	Het
Vmn2r18	A	T	5: 151,508,222 (GRCm39)	C301S	probably damaging	Het
Xdh	T	C	17: 74,207,573 (GRCm39)	Y928C	probably benign	Het
Zfand1	G	A	3: 10,411,042 (GRCm39)	A104V	probably benign	Het

Other mutations in Taar6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00648:Taar6	APN	10	23,861,406 (GRCm39)	missense	probably benign	0.15
IGL00918:Taar6	APN	10	23,861,480 (GRCm39)	missense	probably damaging	1.00
IGL01060:Taar6	APN	10	23,860,970 (GRCm39)	missense	probably benign
IGL02608:Taar6	APN	10	23,861,081 (GRCm39)	missense	probably benign	0.01
R0042:Taar6	UTSW	10	23,861,021 (GRCm39)	missense	probably benign	0.36
R0042:Taar6	UTSW	10	23,861,021 (GRCm39)	missense	probably benign	0.36
R0360:Taar6	UTSW	10	23,861,046 (GRCm39)	missense	probably benign	0.01
R0364:Taar6	UTSW	10	23,861,046 (GRCm39)	missense	probably benign	0.01
R0746:Taar6	UTSW	10	23,861,258 (GRCm39)	missense	probably benign	0.43
R4893:Taar6	UTSW	10	23,861,298 (GRCm39)	missense	probably benign
R4944:Taar6	UTSW	10	23,860,613 (GRCm39)	missense	probably damaging	1.00
R4951:Taar6	UTSW	10	23,861,106 (GRCm39)	missense	probably benign	0.09
R5173:Taar6	UTSW	10	23,861,250 (GRCm39)	missense	probably damaging	1.00
R5181:Taar6	UTSW	10	23,860,683 (GRCm39)	missense	possibly damaging	0.76
R5919:Taar6	UTSW	10	23,861,168 (GRCm39)	missense	probably damaging	1.00
R5988:Taar6	UTSW	10	23,861,154 (GRCm39)	missense	probably damaging	0.98
R6327:Taar6	UTSW	10	23,861,177 (GRCm39)	missense	probably damaging	1.00
R6493:Taar6	UTSW	10	23,861,021 (GRCm39)	missense	probably benign	0.36
R7595:Taar6	UTSW	10	23,860,968 (GRCm39)	missense	probably benign
R7802:Taar6	UTSW	10	23,861,151 (GRCm39)	missense	probably benign	0.02
R8053:Taar6	UTSW	10	23,861,144 (GRCm39)	missense	possibly damaging	0.59
R8506:Taar6	UTSW	10	23,861,529 (GRCm39)	missense	probably benign	0.01
R9169:Taar6	UTSW	10	23,861,273 (GRCm39)	missense	probably damaging	0.99
R9272:Taar6	UTSW	10	23,860,903 (GRCm39)	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GAATGCTACCACGGTAATCCCCAG -3'
(R):5'- TTCAGCATGGTCAGGTCCATCGAG -3'

Sequencing Primer
(F):5'- AGCCTGTTGTCTAGCTACCAG -3'
(R):5'- TCAGGTCCATCGAGAGCTG -3'

Posted On

2014-04-24