Incidental Mutation 'R1637:Mpped1'
ID 173267
Institutional Source Beutler Lab
Gene Symbol Mpped1
Ensembl Gene ENSMUSG00000041708
Gene Name metallophosphoesterase domain containing 1
Synonyms
MMRRC Submission 039673-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # R1637 (G1)
Quality Score 186
Status Not validated
Chromosome 15
Chromosomal Location 83663668-83742695 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) C to T at 83676191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000131333 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046168] [ENSMUST00000109469] [ENSMUST00000109470] [ENSMUST00000123387] [ENSMUST00000163723] [ENSMUST00000172115] [ENSMUST00000172398]
AlphaFold Q91ZG2
Predicted Effect probably benign
Transcript: ENSMUST00000046168
SMART Domains Protein: ENSMUSP00000041981
Gene: ENSMUSG00000041708

DomainStartEndE-ValueType
Pfam:Metallophos 90 288 1e-13 PFAM
Pfam:Metallophos_2 91 314 8.3e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109469
Predicted Effect probably benign
Transcript: ENSMUST00000109470
SMART Domains Protein: ENSMUSP00000105096
Gene: ENSMUSG00000041708

DomainStartEndE-ValueType
Pfam:Metallophos 90 288 1.9e-13 PFAM
Pfam:Metallophos_2 91 318 4.9e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123387
SMART Domains Protein: ENSMUSP00000123230
Gene: ENSMUSG00000041708

DomainStartEndE-ValueType
PDB:3RL3|A 33 137 2e-54 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000150489
SMART Domains Protein: ENSMUSP00000128786
Gene: ENSMUSG00000041708

DomainStartEndE-ValueType
Pfam:Metallophos 87 217 6.7e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000163723
SMART Domains Protein: ENSMUSP00000126242
Gene: ENSMUSG00000041708

DomainStartEndE-ValueType
Pfam:Metallophos 5 130 3e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172115
SMART Domains Protein: ENSMUSP00000132518
Gene: ENSMUSG00000041708

DomainStartEndE-ValueType
PDB:3RL3|A 33 136 1e-52 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000172398
SMART Domains Protein: ENSMUSP00000131333
Gene: ENSMUSG00000041708

DomainStartEndE-ValueType
PDB:3RL3|A 33 140 2e-47 PDB
SCOP:d4kbpa2 84 133 9e-3 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik T A 5: 109,886,858 (GRCm39) H50L probably benign Het
A2m C A 6: 121,631,571 (GRCm39) L623M probably benign Het
Agpat5 A G 8: 18,931,827 (GRCm39) R316G probably benign Het
Ankrd39 G A 1: 36,578,573 (GRCm39) Q151* probably null Het
Arl13b T C 16: 62,651,147 (GRCm39) D30G probably damaging Het
Atpaf1 A G 4: 115,645,499 (GRCm39) S123G probably benign Het
Bicra A G 7: 15,706,614 (GRCm39) S1276P probably benign Het
Car1 T C 3: 14,842,846 (GRCm39) I60V possibly damaging Het
Cnbd2 A G 2: 156,215,644 (GRCm39) I411V probably damaging Het
Cyp2c37 A T 19: 39,990,426 (GRCm39) K375* probably null Het
Cysrt1 T C 2: 25,129,297 (GRCm39) I72V probably benign Het
Dock9 T A 14: 121,889,187 (GRCm39) D312V possibly damaging Het
Ecd T C 14: 20,396,760 (GRCm39) I42V probably damaging Het
Ercc5 A G 1: 44,206,694 (GRCm39) T536A probably benign Het
Gjd2 A T 2: 113,841,789 (GRCm39) Y229* probably null Het
Gramd1b A T 9: 40,215,834 (GRCm39) probably null Het
Hcrtr2 T C 9: 76,140,281 (GRCm39) T336A probably benign Het
Hjurp G A 1: 88,193,843 (GRCm39) S279F probably benign Het
Ift140 C T 17: 25,244,608 (GRCm39) L152F probably benign Het
Izumo1r A G 9: 14,813,105 (GRCm39) C56R probably damaging Het
Kif7 T C 7: 79,352,585 (GRCm39) E850G probably damaging Het
Larp4b C G 13: 9,201,133 (GRCm39) T335S probably benign Het
Lmo7 A T 14: 102,118,268 (GRCm39) R42S probably damaging Het
Lrrk2 T G 15: 91,618,261 (GRCm39) L920R probably benign Het
Mapk8 G A 14: 33,132,919 (GRCm39) R6C probably benign Het
Myoc A G 1: 162,466,936 (GRCm39) Y35C probably damaging Het
Ndufb8 C T 19: 44,543,474 (GRCm39) M66I probably benign Het
Nkpd1 T C 7: 19,257,904 (GRCm39) I411T probably benign Het
Nrxn3 A G 12: 89,321,238 (GRCm39) N382S possibly damaging Het
Or2t47 A T 11: 58,442,246 (GRCm39) V273E possibly damaging Het
Or4c114 A T 2: 88,905,396 (GRCm39) L13Q probably damaging Het
Pear1 T C 3: 87,664,060 (GRCm39) E303G probably damaging Het
Plekhg4 T A 8: 106,108,413 (GRCm39) M1047K probably benign Het
Pofut1 T G 2: 153,107,709 (GRCm39) F268C probably damaging Het
Psrc1 G T 3: 108,292,609 (GRCm39) S134I probably damaging Het
Slc6a2 A T 8: 93,708,618 (GRCm39) I245F probably benign Het
Slc9a1 T C 4: 133,149,534 (GRCm39) S787P probably benign Het
Sorcs3 T A 19: 48,736,798 (GRCm39) probably null Het
Syne2 C A 12: 76,042,776 (GRCm39) H3916N probably damaging Het
Taar6 A G 10: 23,861,079 (GRCm39) S156P probably benign Het
Tnn A G 1: 159,975,170 (GRCm39) F86L probably damaging Het
Tspear T A 10: 77,706,253 (GRCm39) L341H possibly damaging Het
Ttll8 A G 15: 88,798,647 (GRCm39) V696A probably benign Het
Utrn C A 10: 12,312,108 (GRCm39) D616Y probably damaging Het
Vmn2r18 A T 5: 151,508,222 (GRCm39) C301S probably damaging Het
Xdh T C 17: 74,207,573 (GRCm39) Y928C probably benign Het
Zfand1 G A 3: 10,411,042 (GRCm39) A104V probably benign Het
Other mutations in Mpped1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01330:Mpped1 APN 15 83,684,320 (GRCm39) missense probably damaging 1.00
IGL01402:Mpped1 APN 15 83,676,414 (GRCm39) missense possibly damaging 0.94
IGL02004:Mpped1 APN 15 83,684,357 (GRCm39) missense probably damaging 1.00
R0336:Mpped1 UTSW 15 83,720,483 (GRCm39) missense probably damaging 1.00
R1582:Mpped1 UTSW 15 83,676,191 (GRCm39) unclassified probably benign
R1635:Mpped1 UTSW 15 83,676,191 (GRCm39) unclassified probably benign
R1636:Mpped1 UTSW 15 83,676,191 (GRCm39) unclassified probably benign
R1778:Mpped1 UTSW 15 83,676,191 (GRCm39) unclassified probably benign
R3787:Mpped1 UTSW 15 83,680,784 (GRCm39) intron probably benign
R4114:Mpped1 UTSW 15 83,680,910 (GRCm39) intron probably benign
R4116:Mpped1 UTSW 15 83,680,910 (GRCm39) intron probably benign
R4977:Mpped1 UTSW 15 83,680,907 (GRCm39) intron probably benign
R4982:Mpped1 UTSW 15 83,720,528 (GRCm39) missense probably damaging 1.00
R6352:Mpped1 UTSW 15 83,720,564 (GRCm39) missense probably damaging 1.00
R6765:Mpped1 UTSW 15 83,720,584 (GRCm39) missense probably damaging 1.00
R7499:Mpped1 UTSW 15 83,684,251 (GRCm39) missense probably damaging 1.00
R8056:Mpped1 UTSW 15 83,720,663 (GRCm39) missense possibly damaging 0.63
R8395:Mpped1 UTSW 15 83,684,257 (GRCm39) missense probably damaging 1.00
R8956:Mpped1 UTSW 15 83,740,469 (GRCm39) missense probably damaging 1.00
R8959:Mpped1 UTSW 15 83,676,342 (GRCm39) missense probably damaging 0.99
R9229:Mpped1 UTSW 15 83,738,673 (GRCm39) missense possibly damaging 0.79
R9747:Mpped1 UTSW 15 83,684,305 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGTTGGACCATGCACGCATC -3'
(R):5'- TTGGAGCTGTATTCGTCCACCTCG -3'

Sequencing Primer
(F):5'- TTCATCAAACTGCTGAGATGGAAAG -3'
(R):5'- GTCCACCTCGATGATGAGTC -3'
Posted On 2014-04-24