Mutagenetix > Incidental Mutation

Incidental Mutation 'R1637:Cyp2c37'

173275

Institutional Source

Beutler Lab

Gene Symbol

Cyp2c37

Ensembl Gene

ENSMUSG00000042248

Gene Name

cytochrome P450, family 2. subfamily c, polypeptide 37

Synonyms

MMRRC Submission

039673-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.107) question?

Stock #

R1637 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

39980868-40000687 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 39990426 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 375 (K375*)

Ref Sequence

ENSEMBL: ENSMUSP00000045362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049178]

AlphaFold

P56654

Predicted Effect

probably null
Transcript: ENSMUST00000049178
AA Change: K375*

SMART Domains

Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: K375*

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:p450	30	487	5e-160	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.4%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	T	A	5: 109,886,858 (GRCm39)	H50L	probably benign	Het
A2m	C	A	6: 121,631,571 (GRCm39)	L623M	probably benign	Het
Agpat5	A	G	8: 18,931,827 (GRCm39)	R316G	probably benign	Het
Ankrd39	G	A	1: 36,578,573 (GRCm39)	Q151*	probably null	Het
Arl13b	T	C	16: 62,651,147 (GRCm39)	D30G	probably damaging	Het
Atpaf1	A	G	4: 115,645,499 (GRCm39)	S123G	probably benign	Het
Bicra	A	G	7: 15,706,614 (GRCm39)	S1276P	probably benign	Het
Car1	T	C	3: 14,842,846 (GRCm39)	I60V	possibly damaging	Het
Cnbd2	A	G	2: 156,215,644 (GRCm39)	I411V	probably damaging	Het
Cysrt1	T	C	2: 25,129,297 (GRCm39)	I72V	probably benign	Het
Dock9	T	A	14: 121,889,187 (GRCm39)	D312V	possibly damaging	Het
Ecd	T	C	14: 20,396,760 (GRCm39)	I42V	probably damaging	Het
Ercc5	A	G	1: 44,206,694 (GRCm39)	T536A	probably benign	Het
Gjd2	A	T	2: 113,841,789 (GRCm39)	Y229*	probably null	Het
Gramd1b	A	T	9: 40,215,834 (GRCm39)		probably null	Het
Hcrtr2	T	C	9: 76,140,281 (GRCm39)	T336A	probably benign	Het
Hjurp	G	A	1: 88,193,843 (GRCm39)	S279F	probably benign	Het
Ift140	C	T	17: 25,244,608 (GRCm39)	L152F	probably benign	Het
Izumo1r	A	G	9: 14,813,105 (GRCm39)	C56R	probably damaging	Het
Kif7	T	C	7: 79,352,585 (GRCm39)	E850G	probably damaging	Het
Larp4b	C	G	13: 9,201,133 (GRCm39)	T335S	probably benign	Het
Lmo7	A	T	14: 102,118,268 (GRCm39)	R42S	probably damaging	Het
Lrrk2	T	G	15: 91,618,261 (GRCm39)	L920R	probably benign	Het
Mapk8	G	A	14: 33,132,919 (GRCm39)	R6C	probably benign	Het
Mpped1	C	T	15: 83,676,191 (GRCm39)		probably benign	Het
Myoc	A	G	1: 162,466,936 (GRCm39)	Y35C	probably damaging	Het
Ndufb8	C	T	19: 44,543,474 (GRCm39)	M66I	probably benign	Het
Nkpd1	T	C	7: 19,257,904 (GRCm39)	I411T	probably benign	Het
Nrxn3	A	G	12: 89,321,238 (GRCm39)	N382S	possibly damaging	Het
Or2t47	A	T	11: 58,442,246 (GRCm39)	V273E	possibly damaging	Het
Or4c114	A	T	2: 88,905,396 (GRCm39)	L13Q	probably damaging	Het
Pear1	T	C	3: 87,664,060 (GRCm39)	E303G	probably damaging	Het
Plekhg4	T	A	8: 106,108,413 (GRCm39)	M1047K	probably benign	Het
Pofut1	T	G	2: 153,107,709 (GRCm39)	F268C	probably damaging	Het
Psrc1	G	T	3: 108,292,609 (GRCm39)	S134I	probably damaging	Het
Slc6a2	A	T	8: 93,708,618 (GRCm39)	I245F	probably benign	Het
Slc9a1	T	C	4: 133,149,534 (GRCm39)	S787P	probably benign	Het
Sorcs3	T	A	19: 48,736,798 (GRCm39)		probably null	Het
Syne2	C	A	12: 76,042,776 (GRCm39)	H3916N	probably damaging	Het
Taar6	A	G	10: 23,861,079 (GRCm39)	S156P	probably benign	Het
Tnn	A	G	1: 159,975,170 (GRCm39)	F86L	probably damaging	Het
Tspear	T	A	10: 77,706,253 (GRCm39)	L341H	possibly damaging	Het
Ttll8	A	G	15: 88,798,647 (GRCm39)	V696A	probably benign	Het
Utrn	C	A	10: 12,312,108 (GRCm39)	D616Y	probably damaging	Het
Vmn2r18	A	T	5: 151,508,222 (GRCm39)	C301S	probably damaging	Het
Xdh	T	C	17: 74,207,573 (GRCm39)	Y928C	probably benign	Het
Zfand1	G	A	3: 10,411,042 (GRCm39)	A104V	probably benign	Het

Other mutations in Cyp2c37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Cyp2c37	APN	19	39,990,441 (GRCm39)	missense	probably benign	0.00
IGL01307:Cyp2c37	APN	19	39,981,023 (GRCm39)	missense	probably benign	0.00
IGL01959:Cyp2c37	APN	19	39,984,277 (GRCm39)	nonsense	probably null
IGL02580:Cyp2c37	APN	19	39,982,942 (GRCm39)	missense	probably damaging	1.00
IGL02611:Cyp2c37	APN	19	39,982,309 (GRCm39)	missense	probably benign	0.00
R0124:Cyp2c37	UTSW	19	39,982,546 (GRCm39)	missense	probably damaging	1.00
R0391:Cyp2c37	UTSW	19	39,982,950 (GRCm39)	missense	probably damaging	1.00
R0420:Cyp2c37	UTSW	19	39,984,238 (GRCm39)	missense	probably benign	0.00
R0782:Cyp2c37	UTSW	19	39,982,269 (GRCm39)	missense	probably benign	0.00
R1413:Cyp2c37	UTSW	19	39,982,542 (GRCm39)	missense	probably benign	0.21
R1688:Cyp2c37	UTSW	19	39,982,887 (GRCm39)	splice site	probably null
R2258:Cyp2c37	UTSW	19	39,984,303 (GRCm39)	missense	possibly damaging	0.49
R4353:Cyp2c37	UTSW	19	39,988,989 (GRCm39)	missense	possibly damaging	0.66
R4640:Cyp2c37	UTSW	19	40,000,276 (GRCm39)	missense	possibly damaging	0.67
R4965:Cyp2c37	UTSW	19	40,000,206 (GRCm39)	missense	possibly damaging	0.79
R5053:Cyp2c37	UTSW	19	39,990,331 (GRCm39)	missense	probably benign	0.00
R5645:Cyp2c37	UTSW	19	39,982,596 (GRCm39)	missense	probably benign	0.04
R5847:Cyp2c37	UTSW	19	40,000,176 (GRCm39)	missense	probably damaging	0.98
R6487:Cyp2c37	UTSW	19	39,983,025 (GRCm39)	missense	probably benign
R6631:Cyp2c37	UTSW	19	39,998,287 (GRCm39)	missense	probably damaging	1.00
R7062:Cyp2c37	UTSW	19	39,983,990 (GRCm39)	splice site	probably null
R7937:Cyp2c37	UTSW	19	39,982,202 (GRCm39)	missense	probably damaging	1.00
R9640:Cyp2c37	UTSW	19	40,000,180 (GRCm39)	missense	probably benign	0.01
R9779:Cyp2c37	UTSW	19	39,998,323 (GRCm39)	missense	probably benign	0.09
R9784:Cyp2c37	UTSW	19	39,988,943 (GRCm39)	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- AGGCACCTTCATTAGGCCCTAGATAG -3'
(R):5'- ATGACCCTGCTTCCTGTAGAGCTG -3'

Sequencing Primer
(F):5'- AAAAAACATGTCACTTCTCTCCTTTC -3'
(R):5'- TGCTATCCCATCCATGAATCAG -3'

Posted On

2014-04-24