Incidental Mutation 'R1638:Or1e29'
ID 173321
Institutional Source Beutler Lab
Gene Symbol Or1e29
Ensembl Gene ENSMUSG00000070383
Gene Name olfactory receptor family 1 subfamily E member 29
Synonyms MOR135-6, GA_x6K02T2P1NL-3932085-3931147, Olfr389
MMRRC Submission 039674-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R1638 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73667213-73671415 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73667974 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 60 (Y60H)
Ref Sequence ENSEMBL: ENSMUSP00000149734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122224] [ENSMUST00000124927] [ENSMUST00000215418]
AlphaFold Q7TRX7
Predicted Effect possibly damaging
Transcript: ENSMUST00000122224
AA Change: Y60H

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000113364
Gene: ENSMUSG00000070383
AA Change: Y60H

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.8e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 4.2e-6 PFAM
Pfam:7tm_1 41 290 2e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000124927
AA Change: Y60H

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000115639
Gene: ENSMUSG00000070383
AA Change: Y60H

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 221 6.6e-7 PFAM
Pfam:7tm_1 41 224 3.5e-29 PFAM
Pfam:7tm_4 139 224 1.4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215418
AA Change: Y60H

PolyPhen 2 Score 0.946 (Sensitivity: 0.80; Specificity: 0.95)
Meta Mutation Damage Score 0.2118 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.9%
  • 10x: 94.9%
  • 20x: 87.8%
Validation Efficiency 99% (79/80)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m C A 6: 121,631,571 (GRCm39) L623M probably benign Het
Adamts13 A G 2: 26,886,595 (GRCm39) E938G possibly damaging Het
Agfg1 A T 1: 82,871,259 (GRCm39) Q497L probably damaging Het
Ahnak A G 19: 8,986,813 (GRCm39) H2699R probably benign Het
Antxrl G T 14: 33,792,453 (GRCm39) probably null Het
Apol7c A T 15: 77,410,418 (GRCm39) V176E probably damaging Het
Arid5b T C 10: 68,113,777 (GRCm39) N87D possibly damaging Het
Atp2c1 A T 9: 105,309,897 (GRCm39) I560N probably damaging Het
Atp2c2 T C 8: 120,482,742 (GRCm39) F868S possibly damaging Het
Blnk G C 19: 40,926,122 (GRCm39) F326L probably benign Het
Bltp1 C T 3: 37,089,961 (GRCm39) R4130* probably null Het
Ckap2 C T 8: 22,665,812 (GRCm39) V412I possibly damaging Het
Clmn A G 12: 104,748,281 (GRCm39) V422A probably benign Het
Ctnnal1 A G 4: 56,813,856 (GRCm39) S638P probably benign Het
Cyp2j5 T C 4: 96,524,052 (GRCm39) S327G probably benign Het
Dhx38 G A 8: 110,280,177 (GRCm39) T871M probably damaging Het
Dmxl1 A T 18: 50,023,834 (GRCm39) K1706* probably null Het
Dnah11 A G 12: 117,979,154 (GRCm39) L2648P possibly damaging Het
Elf2 G A 3: 51,215,530 (GRCm39) T60I probably damaging Het
Fam120b T A 17: 15,622,759 (GRCm39) C246S possibly damaging Het
Fcho2 G T 13: 98,882,403 (GRCm39) T451K possibly damaging Het
Fzd9 T A 5: 135,278,602 (GRCm39) I428F probably damaging Het
Galnt13 T A 2: 54,744,667 (GRCm39) V122E probably damaging Het
Gm21738 T A 14: 19,418,908 (GRCm38) Y8F probably benign Het
Gnptab A G 10: 88,272,029 (GRCm39) I940V possibly damaging Het
Gp2 A G 7: 119,050,721 (GRCm39) probably null Het
Gpr6 A G 10: 40,946,530 (GRCm39) S351P probably benign Het
Gprin1 T C 13: 54,887,689 (GRCm39) E195G possibly damaging Het
Grm8 A T 6: 28,125,882 (GRCm39) Y81* probably null Het
Gtf3c3 A T 1: 54,444,278 (GRCm39) N703K probably damaging Het
Hhipl2 G A 1: 183,208,921 (GRCm39) V495I probably benign Het
Islr G A 9: 58,065,502 (GRCm39) probably benign Het
Lrrc36 T C 8: 106,176,273 (GRCm39) Y216H possibly damaging Het
Macroh2a1 T A 13: 56,252,722 (GRCm39) N87Y probably damaging Het
Me2 A G 18: 73,906,205 (GRCm39) I528T probably benign Het
Mecr A T 4: 131,585,127 (GRCm39) I156F possibly damaging Het
Megf6 A G 4: 154,346,967 (GRCm39) probably benign Het
Mn1 T A 5: 111,569,435 (GRCm39) L1135H probably damaging Het
Naip5 A G 13: 100,349,177 (GRCm39) S1384P probably damaging Het
Nav2 A G 7: 49,102,213 (GRCm39) N337S probably benign Het
Ndn C T 7: 61,998,256 (GRCm39) P34L probably benign Het
Neb A T 2: 52,139,293 (GRCm39) H3107Q probably benign Het
Nebl A G 2: 17,381,462 (GRCm39) V738A possibly damaging Het
Nsd2 G A 5: 34,039,464 (GRCm39) R825Q possibly damaging Het
Nsun2 A G 13: 69,775,705 (GRCm39) N383S probably damaging Het
Ntrk3 A T 7: 77,897,036 (GRCm39) M667K probably damaging Het
Or10a48 A C 7: 108,424,442 (GRCm39) C255G probably benign Het
Or11h6 G A 14: 50,880,565 (GRCm39) V276M possibly damaging Het
Or6c2 A T 10: 129,362,488 (GRCm39) M131L probably benign Het
Pex6 T C 17: 47,033,558 (GRCm39) V633A probably benign Het
Phactr1 C T 13: 43,110,147 (GRCm39) T95M probably damaging Het
Pik3r4 A G 9: 105,564,408 (GRCm39) D1334G probably damaging Het
Pkhd1l1 A C 15: 44,460,513 (GRCm39) I4241L probably benign Het
Ppwd1 T C 13: 104,356,771 (GRCm39) E248G probably damaging Het
Prepl A C 17: 85,379,509 (GRCm39) M393R probably benign Het
Ptpn6 T C 6: 124,698,148 (GRCm39) S532G probably benign Het
Rnase11 G T 14: 51,287,058 (GRCm39) H165Q possibly damaging Het
Sf1 A G 19: 6,422,090 (GRCm39) N172S possibly damaging Het
Shprh T A 10: 11,032,822 (GRCm39) D269E probably benign Het
Slc16a1 T C 3: 104,556,798 (GRCm39) I61T possibly damaging Het
Slc38a2 A C 15: 96,590,417 (GRCm39) I309S probably damaging Het
Sry C G Y: 2,663,149 (GRCm39) Q170H unknown Het
Stk3 A C 15: 35,008,454 (GRCm39) probably null Het
Tg C A 15: 66,568,015 (GRCm39) C1306* probably null Het
Tnik A G 3: 28,719,889 (GRCm39) M1254V probably damaging Het
U2surp T C 9: 95,366,280 (GRCm39) E474G possibly damaging Het
Vmn1r224 T A 17: 20,639,587 (GRCm39) F55I probably benign Het
Vmn1r32 A G 6: 66,529,939 (GRCm39) I279T possibly damaging Het
Zc2hc1a A G 3: 7,581,543 (GRCm39) D15G probably benign Het
Zfp827 C A 8: 79,802,975 (GRCm39) P516T possibly damaging Het
Zfyve9 A T 4: 108,542,104 (GRCm39) probably null Het
Other mutations in Or1e29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Or1e29 APN 11 73,667,532 (GRCm39) missense probably benign 0.44
IGL01766:Or1e29 APN 11 73,667,901 (GRCm39) missense probably benign 0.41
IGL01771:Or1e29 APN 11 73,667,490 (GRCm39) missense probably damaging 1.00
IGL02535:Or1e29 APN 11 73,667,442 (GRCm39) missense probably benign 0.00
IGL02639:Or1e29 APN 11 73,667,371 (GRCm39) missense probably benign 0.21
IGL03060:Or1e29 APN 11 73,667,289 (GRCm39) missense probably damaging 1.00
IGL03075:Or1e29 APN 11 73,667,298 (GRCm39) missense probably damaging 1.00
R0081:Or1e29 UTSW 11 73,667,935 (GRCm39) missense possibly damaging 0.59
R0426:Or1e29 UTSW 11 73,667,263 (GRCm39) missense probably benign 0.13
R1140:Or1e29 UTSW 11 73,667,680 (GRCm39) missense probably benign
R2001:Or1e29 UTSW 11 73,667,539 (GRCm39) missense probably benign
R2214:Or1e29 UTSW 11 73,667,655 (GRCm39) nonsense probably null
R3076:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3077:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3078:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3081:Or1e29 UTSW 11 73,668,051 (GRCm39) missense probably damaging 1.00
R3430:Or1e29 UTSW 11 73,667,365 (GRCm39) missense probably damaging 1.00
R3731:Or1e29 UTSW 11 73,667,565 (GRCm39) missense probably benign 0.08
R4090:Or1e29 UTSW 11 73,667,667 (GRCm39) missense probably damaging 1.00
R4303:Or1e29 UTSW 11 73,667,664 (GRCm39) missense possibly damaging 0.78
R4516:Or1e29 UTSW 11 73,667,866 (GRCm39) missense probably benign 0.06
R4556:Or1e29 UTSW 11 73,667,307 (GRCm39) missense possibly damaging 0.65
R4557:Or1e29 UTSW 11 73,667,307 (GRCm39) missense possibly damaging 0.65
R4775:Or1e29 UTSW 11 73,667,377 (GRCm39) missense probably damaging 1.00
R4858:Or1e29 UTSW 11 73,667,372 (GRCm39) missense probably benign 0.44
R5015:Or1e29 UTSW 11 73,668,007 (GRCm39) missense probably benign 0.07
R5087:Or1e29 UTSW 11 73,668,084 (GRCm39) missense possibly damaging 0.75
R6599:Or1e29 UTSW 11 73,667,506 (GRCm39) missense probably benign
R6701:Or1e29 UTSW 11 73,667,296 (GRCm39) missense probably damaging 1.00
R6784:Or1e29 UTSW 11 73,667,676 (GRCm39) missense probably damaging 1.00
R6916:Or1e29 UTSW 11 73,667,895 (GRCm39) missense probably benign 0.00
R7066:Or1e29 UTSW 11 73,668,018 (GRCm39) missense probably damaging 0.99
R7226:Or1e29 UTSW 11 73,667,503 (GRCm39) missense possibly damaging 0.95
R7457:Or1e29 UTSW 11 73,667,652 (GRCm39) missense probably benign 0.06
R7486:Or1e29 UTSW 11 73,667,847 (GRCm39) missense probably damaging 1.00
R7990:Or1e29 UTSW 11 73,667,497 (GRCm39) missense probably benign 0.00
R8289:Or1e29 UTSW 11 73,667,839 (GRCm39) missense probably benign
R9131:Or1e29 UTSW 11 73,668,150 (GRCm39) start codon destroyed probably null 1.00
R9160:Or1e29 UTSW 11 73,667,881 (GRCm39) missense probably benign 0.01
R9239:Or1e29 UTSW 11 73,667,346 (GRCm39) missense probably benign 0.00
R9666:Or1e29 UTSW 11 73,667,976 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGTTGTCAGCATCCACAGTAGTAGC -3'
(R):5'- CCTTGTGTGTCACAAACCACATCCC -3'

Sequencing Primer
(F):5'- CAGAACTTGGTACTCATGATGCTG -3'
(R):5'- TGGTCTATGATATACAGGCACAACC -3'
Posted On 2014-04-24