Incidental Mutation 'R1643:Vmn2r98'
| ID |
173715 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r98
|
| Ensembl Gene |
ENSMUSG00000096717 |
| Gene Name |
vomeronasal 2, receptor 98 |
| Synonyms |
EG224552 |
| MMRRC Submission |
039679-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.096)
|
| Stock # |
R1643 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 19301170 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 724
(D724G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
| AlphaFold |
E9PZ56 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170424
AA Change: D724G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: D724G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.2%
- 20x: 92.5%
|
| Validation Efficiency |
99% (74/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700037C18Rik |
T |
A |
16: 3,724,942 (GRCm39) |
K45* |
probably null |
Het |
| Abcc1 |
T |
A |
16: 14,231,232 (GRCm39) |
Y457N |
probably damaging |
Het |
| Actr3b |
A |
G |
5: 26,017,009 (GRCm39) |
D19G |
probably damaging |
Het |
| Adam39 |
T |
C |
8: 41,279,523 (GRCm39) |
V638A |
possibly damaging |
Het |
| Adamts1 |
G |
T |
16: 85,593,705 (GRCm39) |
|
probably benign |
Het |
| AI661453 |
A |
G |
17: 47,778,791 (GRCm39) |
|
probably benign |
Het |
| Ank3 |
G |
A |
10: 69,720,632 (GRCm39) |
S565N |
probably benign |
Het |
| Casd1 |
A |
G |
6: 4,621,243 (GRCm39) |
E267G |
probably benign |
Het |
| Casr |
T |
C |
16: 36,320,567 (GRCm39) |
K527R |
probably damaging |
Het |
| Cep128 |
A |
C |
12: 91,292,306 (GRCm39) |
S248A |
probably damaging |
Het |
| Clic4 |
A |
G |
4: 134,966,206 (GRCm39) |
V50A |
possibly damaging |
Het |
| Cylc2 |
C |
T |
4: 51,225,173 (GRCm39) |
A36V |
probably benign |
Het |
| Derl1 |
T |
A |
15: 57,741,955 (GRCm39) |
M127L |
probably benign |
Het |
| Dnah6 |
A |
G |
6: 73,021,735 (GRCm39) |
V3529A |
possibly damaging |
Het |
| Dock1 |
G |
T |
7: 134,700,508 (GRCm39) |
L1089F |
probably damaging |
Het |
| Edil3 |
T |
A |
13: 89,437,695 (GRCm39) |
|
probably null |
Het |
| Efcab3 |
A |
T |
11: 104,589,804 (GRCm39) |
T134S |
probably benign |
Het |
| Ephb1 |
A |
G |
9: 101,874,024 (GRCm39) |
V550A |
probably damaging |
Het |
| Fcho2 |
G |
A |
13: 98,921,324 (GRCm39) |
T187I |
probably benign |
Het |
| Gas6 |
T |
C |
8: 13,515,902 (GRCm39) |
|
probably null |
Het |
| Gdf7 |
T |
C |
12: 8,347,971 (GRCm39) |
Y442C |
probably damaging |
Het |
| Gm11567 |
G |
A |
11: 99,770,623 (GRCm39) |
G187E |
unknown |
Het |
| Gm8674 |
T |
C |
13: 50,055,394 (GRCm39) |
|
noncoding transcript |
Het |
| Ift80 |
T |
A |
3: 68,823,490 (GRCm39) |
I591F |
probably benign |
Het |
| Kcnn3 |
C |
T |
3: 89,427,804 (GRCm39) |
S10L |
unknown |
Het |
| Keg1 |
A |
G |
19: 12,696,406 (GRCm39) |
I197V |
probably benign |
Het |
| Klhdc9 |
A |
G |
1: 171,187,034 (GRCm39) |
|
probably null |
Het |
| Klhl11 |
A |
G |
11: 100,353,841 (GRCm39) |
V660A |
probably benign |
Het |
| Lamc1 |
T |
C |
1: 153,133,818 (GRCm39) |
|
probably benign |
Het |
| Lrrc73 |
G |
T |
17: 46,566,266 (GRCm39) |
|
probably null |
Het |
| Lrriq1 |
G |
A |
10: 103,050,685 (GRCm39) |
S689L |
probably benign |
Het |
| Magi2 |
A |
G |
5: 20,910,504 (GRCm39) |
|
probably benign |
Het |
| Meis1 |
A |
G |
11: 18,966,278 (GRCm39) |
S32P |
probably benign |
Het |
| Mia2 |
A |
G |
12: 59,226,631 (GRCm39) |
|
probably null |
Het |
| Mlph |
T |
C |
1: 90,869,456 (GRCm39) |
L486P |
probably damaging |
Het |
| Myh10 |
A |
G |
11: 68,682,836 (GRCm39) |
E1090G |
probably damaging |
Het |
| Mylk |
T |
C |
16: 34,696,005 (GRCm39) |
S247P |
probably benign |
Het |
| Naip2 |
C |
T |
13: 100,298,489 (GRCm39) |
A516T |
possibly damaging |
Het |
| Ndufc1 |
T |
C |
3: 51,315,664 (GRCm39) |
T25A |
probably benign |
Het |
| Nedd4l |
A |
G |
18: 65,331,712 (GRCm39) |
Y636C |
probably damaging |
Het |
| Nfib |
A |
T |
4: 82,416,916 (GRCm39) |
Y40N |
probably damaging |
Het |
| Niban3 |
A |
G |
8: 72,052,808 (GRCm39) |
D94G |
probably benign |
Het |
| Nisch |
T |
C |
14: 30,895,125 (GRCm39) |
D1057G |
probably damaging |
Het |
| P3h2 |
T |
C |
16: 25,791,041 (GRCm39) |
H475R |
probably benign |
Het |
| Pde6c |
C |
A |
19: 38,150,406 (GRCm39) |
T517K |
possibly damaging |
Het |
| Piezo2 |
T |
C |
18: 63,215,986 (GRCm39) |
I994V |
probably benign |
Het |
| Pik3r4 |
A |
G |
9: 105,564,351 (GRCm39) |
D1315G |
possibly damaging |
Het |
| Pip5k1c |
T |
G |
10: 81,150,828 (GRCm39) |
V46G |
probably damaging |
Het |
| Pole |
A |
G |
5: 110,465,711 (GRCm39) |
E1213G |
probably damaging |
Het |
| Prl7d1 |
T |
C |
13: 27,896,114 (GRCm39) |
S88G |
possibly damaging |
Het |
| Prodh |
T |
A |
16: 17,898,933 (GRCm39) |
N72I |
probably benign |
Het |
| Prrc2a |
G |
A |
17: 35,375,930 (GRCm39) |
R907C |
probably damaging |
Het |
| Ptger2 |
T |
A |
14: 45,226,423 (GRCm39) |
M1K |
probably null |
Het |
| Samd4b |
G |
C |
7: 28,123,041 (GRCm39) |
Q6E |
probably damaging |
Het |
| Sec24a |
C |
T |
11: 51,595,212 (GRCm39) |
R916H |
probably benign |
Het |
| Slc12a5 |
C |
A |
2: 164,835,947 (GRCm39) |
D865E |
probably benign |
Het |
| Slc17a3 |
T |
C |
13: 24,041,181 (GRCm39) |
|
probably benign |
Het |
| Ssrp1 |
T |
C |
2: 84,871,529 (GRCm39) |
V317A |
possibly damaging |
Het |
| Stim1 |
A |
G |
7: 102,035,307 (GRCm39) |
D95G |
possibly damaging |
Het |
| Taok2 |
A |
T |
7: 126,475,110 (GRCm39) |
|
probably benign |
Het |
| Tcof1 |
T |
G |
18: 60,949,300 (GRCm39) |
K1205T |
possibly damaging |
Het |
| Trim43c |
C |
T |
9: 88,729,530 (GRCm39) |
R325C |
probably damaging |
Het |
| Trub2 |
T |
G |
2: 29,667,948 (GRCm39) |
T231P |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Uty |
T |
A |
Y: 1,152,054 (GRCm39) |
D724V |
probably damaging |
Het |
| Wdfy3 |
A |
G |
5: 102,023,781 (GRCm39) |
I2442T |
possibly damaging |
Het |
| Wdfy4 |
T |
C |
14: 32,795,542 (GRCm39) |
|
probably null |
Het |
| Zfp280b |
A |
G |
10: 75,875,444 (GRCm39) |
H441R |
probably damaging |
Het |
| Zfp60 |
A |
T |
7: 27,436,400 (GRCm39) |
Q7L |
probably damaging |
Het |
| Zzef1 |
T |
C |
11: 72,717,028 (GRCm39) |
L406S |
probably damaging |
Het |
|
| Other mutations in Vmn2r98 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0122:Vmn2r98
|
UTSW |
17 |
19,286,662 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0689:Vmn2r98
|
UTSW |
17 |
19,300,782 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
|
R4570:Vmn2r98
|
UTSW |
17 |
19,286,354 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4706:Vmn2r98
|
UTSW |
17 |
19,290,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
|
R5371:Vmn2r98
|
UTSW |
17 |
19,290,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
|
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
|
R7607:Vmn2r98
|
UTSW |
17 |
19,287,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9344:Vmn2r98
|
UTSW |
17 |
19,286,777 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCAAAGCTATCACTGTGGTCCTTGC -3'
(R):5'- TGCTGTGCTGGAAGCCAAGATG -3'
Sequencing Primer
(F):5'- GCCTTTAAGATCAGTTTTCCAGG -3'
(R):5'- GAAGAACACCAGCATACTGAATG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation