Incidental Mutation 'R1616:Tlr4'
| ID |
174234 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tlr4
|
| Ensembl Gene |
ENSMUSG00000039005 |
| Gene Name |
toll-like receptor 4 |
| Synonyms |
Lps, lipopolysaccharide response, Rasl2-8 |
| MMRRC Submission |
039653-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1616 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
66745788-66765338 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 66757717 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Tyrosine
at position 170
(F170Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000045770
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048096]
[ENSMUST00000107365]
|
| AlphaFold |
Q9QUK6 |
| PDB Structure |
Crystal structure of mouse TLR4 and mouse MD-2 complex [X-RAY DIFFRACTION]
Crystal structure of mouse TLR4/MD-2/lipid IVa complex [X-RAY DIFFRACTION]
Crystal structure of mouse TLR4/MD-2/LPS complex [X-RAY DIFFRACTION]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000048096
AA Change: F170Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000045770
Gene: ENSMUSG00000039005
AA Change: F170Y
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
76 |
99 |
7.36e0 |
SMART |
|
LRR
|
100 |
123 |
1.86e0 |
SMART |
|
LRR
|
173 |
196 |
8.24e0 |
SMART |
|
LRR
|
370 |
401 |
4.33e1 |
SMART |
|
LRR
|
468 |
492 |
2.54e2 |
SMART |
|
LRR
|
493 |
516 |
1.86e2 |
SMART |
|
LRR
|
517 |
540 |
1.67e2 |
SMART |
|
LRR
|
541 |
563 |
1.92e2 |
SMART |
|
LRRCT
|
576 |
626 |
4.74e-3 |
SMART |
|
transmembrane domain
|
636 |
658 |
N/A |
INTRINSIC |
|
TIR
|
671 |
816 |
7.3e-39 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107365
|
| SMART Domains |
Protein: ENSMUSP00000102988
Gene: ENSMUSG00000039005
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:3VQ2|B
|
22 |
86 |
2e-38 |
PDB |
|
SCOP:d1m0za_
|
27 |
86 |
4e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143580
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147008
|
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.8%
- 10x: 94.3%
- 20x: 85.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene belongs to the evolutionarily-conserved Toll-like receptor family, whose members are type-1 transmembrane proteins that are involved in innate immunity. Toll-like receptors are characterized by an extracellular leucine-rich repeat domain that functions in ligand recognition and an intracellular toll/interleukin-1 receptor-like domain that is crucial for signal transduction. The receptor encoded by this gene mediates the innate immune response to bacterial lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria, through synthesis of pro-inflammatory cytokines and chemokines. In addition, this protein can recognize other pathogens from Gram-negative and Gram-positive bacteria as well as viral components. Mice deficient in this gene display a number of immune response-related phenotypes including hyporesponsiveness to bacterial lipopolysaccharide and increased levels of respiratory syncytial virus compared to controls. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide and more susceptible to infection by gram negative bacteria. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(10) : Targeted(2) Spontaneous(6) Chemically induced(2)
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933406P04Rik |
T |
C |
10: 20,187,087 (GRCm39) |
|
probably benign |
Het |
| A1cf |
A |
G |
19: 31,912,175 (GRCm39) |
E430G |
probably damaging |
Het |
| Aacs |
T |
A |
5: 125,561,590 (GRCm39) |
|
probably null |
Het |
| Acot12 |
G |
A |
13: 91,920,886 (GRCm39) |
V331I |
probably benign |
Het |
| Acp7 |
A |
G |
7: 28,310,503 (GRCm39) |
W445R |
probably damaging |
Het |
| Actl11 |
C |
A |
9: 107,809,135 (GRCm39) |
Q1153K |
probably benign |
Het |
| Actr8 |
A |
G |
14: 29,704,601 (GRCm39) |
T34A |
possibly damaging |
Het |
| Ahnak |
A |
G |
19: 8,986,351 (GRCm39) |
D2545G |
possibly damaging |
Het |
| Ap5z1 |
A |
G |
5: 142,457,991 (GRCm39) |
Y388C |
probably benign |
Het |
| Apol7a |
C |
T |
15: 77,273,806 (GRCm39) |
G219S |
probably damaging |
Het |
| Arid1b |
T |
A |
17: 5,389,569 (GRCm39) |
I1705N |
probably damaging |
Het |
| Bod1l |
T |
C |
5: 41,966,058 (GRCm39) |
Q2669R |
probably benign |
Het |
| Braf |
A |
T |
6: 39,620,067 (GRCm39) |
S504T |
probably benign |
Het |
| Cbl |
A |
T |
9: 44,064,197 (GRCm39) |
Y780N |
probably damaging |
Het |
| Cd86 |
T |
C |
16: 36,449,338 (GRCm39) |
I20V |
probably benign |
Het |
| Cep290 |
T |
G |
10: 100,404,698 (GRCm39) |
D2353E |
probably benign |
Het |
| Ckmt2 |
G |
A |
13: 92,007,328 (GRCm39) |
R289C |
probably benign |
Het |
| Col3a1 |
T |
C |
1: 45,367,648 (GRCm39) |
|
probably null |
Het |
| Cyp4f16 |
T |
A |
17: 32,761,942 (GRCm39) |
Y163* |
probably null |
Het |
| Dimt1 |
T |
C |
13: 107,089,958 (GRCm39) |
V227A |
possibly damaging |
Het |
| Dnah6 |
A |
T |
6: 73,077,095 (GRCm39) |
M2338K |
probably benign |
Het |
| Dock4 |
T |
G |
12: 40,719,044 (GRCm39) |
I274S |
probably damaging |
Het |
| Enthd1 |
T |
C |
15: 80,336,586 (GRCm39) |
D616G |
probably damaging |
Het |
| Fignl2 |
T |
C |
15: 100,951,997 (GRCm39) |
E95G |
probably damaging |
Het |
| Foxn1 |
A |
G |
11: 78,249,692 (GRCm39) |
M611T |
probably benign |
Het |
| Foxs1 |
T |
C |
2: 152,774,559 (GRCm39) |
S165G |
probably benign |
Het |
| Fzd3 |
G |
T |
14: 65,472,956 (GRCm39) |
Q271K |
probably benign |
Het |
| Hadhb |
A |
T |
5: 30,371,713 (GRCm39) |
I55F |
probably damaging |
Het |
| Hipk3 |
G |
A |
2: 104,264,090 (GRCm39) |
Q824* |
probably null |
Het |
| Hps1 |
G |
A |
19: 42,755,624 (GRCm39) |
R201W |
probably damaging |
Het |
| Kif21b |
T |
C |
1: 136,099,423 (GRCm39) |
S1477P |
probably damaging |
Het |
| Kif26a |
A |
T |
12: 112,123,680 (GRCm39) |
|
probably null |
Het |
| Krt90 |
T |
C |
15: 101,469,026 (GRCm39) |
E172G |
possibly damaging |
Het |
| Lama4 |
T |
G |
10: 38,951,446 (GRCm39) |
F1064V |
probably damaging |
Het |
| Leng9 |
A |
G |
7: 4,151,902 (GRCm39) |
V258A |
probably benign |
Het |
| Lgi2 |
A |
C |
5: 52,703,980 (GRCm39) |
V217G |
probably benign |
Het |
| Lpgat1 |
T |
C |
1: 191,495,741 (GRCm39) |
I310T |
possibly damaging |
Het |
| Ltbp3 |
A |
G |
19: 5,796,995 (GRCm39) |
Y374C |
probably damaging |
Het |
| Magi2 |
C |
A |
5: 20,814,324 (GRCm39) |
T1075K |
probably damaging |
Het |
| Man2c1 |
T |
C |
9: 57,042,793 (GRCm39) |
I221T |
probably benign |
Het |
| Mydgf |
A |
G |
17: 56,486,415 (GRCm39) |
M72T |
possibly damaging |
Het |
| Myo1b |
T |
C |
1: 51,815,474 (GRCm39) |
N624S |
probably damaging |
Het |
| Myo5c |
T |
A |
9: 75,203,299 (GRCm39) |
M1465K |
probably damaging |
Het |
| Nek4 |
A |
T |
14: 30,709,094 (GRCm39) |
D716V |
probably damaging |
Het |
| Nfxl1 |
T |
A |
5: 72,686,380 (GRCm39) |
Q607L |
probably benign |
Het |
| Nlrp9c |
A |
T |
7: 26,083,862 (GRCm39) |
D572E |
probably benign |
Het |
| Nop14 |
G |
T |
5: 34,807,757 (GRCm39) |
Q402K |
possibly damaging |
Het |
| Npy5r |
C |
G |
8: 67,134,052 (GRCm39) |
C247S |
probably damaging |
Het |
| Nrap |
T |
A |
19: 56,378,255 (GRCm39) |
I19F |
probably damaging |
Het |
| Or4c102 |
A |
G |
2: 88,422,352 (GRCm39) |
D68G |
probably damaging |
Het |
| Or51t4 |
T |
A |
7: 102,597,721 (GRCm39) |
N16K |
probably damaging |
Het |
| Or6z3 |
T |
G |
7: 6,463,744 (GRCm39) |
S79A |
probably damaging |
Het |
| Pcdh9 |
A |
T |
14: 94,124,405 (GRCm39) |
Y588* |
probably null |
Het |
| Ppp1r12a |
A |
G |
10: 108,096,728 (GRCm39) |
E183G |
probably damaging |
Het |
| Ppp2r2b |
T |
A |
18: 42,821,375 (GRCm39) |
H261L |
probably benign |
Het |
| Ptch1 |
G |
T |
13: 63,687,656 (GRCm39) |
T374K |
possibly damaging |
Het |
| Ptpn13 |
A |
T |
5: 103,713,103 (GRCm39) |
N1742I |
possibly damaging |
Het |
| Rab33a |
C |
T |
X: 47,608,521 (GRCm39) |
S15L |
probably benign |
Het |
| Ralb |
T |
C |
1: 119,405,744 (GRCm39) |
Y75C |
probably damaging |
Het |
| Rassf7 |
T |
A |
7: 140,796,645 (GRCm39) |
V2D |
probably damaging |
Het |
| Rbm10 |
A |
G |
X: 20,512,230 (GRCm39) |
N397S |
probably benign |
Het |
| Rbm15 |
T |
C |
3: 107,238,197 (GRCm39) |
T734A |
probably benign |
Het |
| Rbm8a |
G |
T |
3: 96,539,046 (GRCm39) |
|
probably benign |
Het |
| Rock2 |
T |
C |
12: 17,022,986 (GRCm39) |
I1095T |
probably benign |
Het |
| Rxfp3 |
T |
A |
15: 11,036,389 (GRCm39) |
T328S |
probably damaging |
Het |
| Sec31a |
T |
A |
5: 100,534,054 (GRCm39) |
K505N |
possibly damaging |
Het |
| Selenof |
A |
G |
3: 144,302,642 (GRCm39) |
*122W |
probably null |
Het |
| Sh3pxd2b |
T |
C |
11: 32,331,441 (GRCm39) |
M55T |
possibly damaging |
Het |
| Slc15a2 |
T |
C |
16: 36,574,843 (GRCm39) |
D522G |
probably benign |
Het |
| Slc2a1 |
T |
C |
4: 118,993,503 (GRCm39) |
F447L |
probably damaging |
Het |
| Slc45a2 |
T |
A |
15: 11,022,214 (GRCm39) |
C319S |
probably null |
Het |
| Smad4 |
T |
C |
18: 73,773,333 (GRCm39) |
D551G |
probably benign |
Het |
| Smarcc2 |
A |
G |
10: 128,318,662 (GRCm39) |
Y648C |
probably damaging |
Het |
| Snrnp40 |
C |
G |
4: 130,271,836 (GRCm39) |
|
probably null |
Het |
| Stab2 |
A |
T |
10: 86,721,582 (GRCm39) |
|
probably null |
Het |
| Tanc1 |
A |
G |
2: 59,615,731 (GRCm39) |
D246G |
probably damaging |
Het |
| Tekt3 |
T |
G |
11: 62,978,024 (GRCm39) |
|
probably null |
Het |
| Them5 |
G |
A |
3: 94,253,567 (GRCm39) |
|
probably null |
Het |
| Tmem214 |
T |
G |
5: 31,028,907 (GRCm39) |
Y165* |
probably null |
Het |
| Tmem94 |
T |
C |
11: 115,686,971 (GRCm39) |
|
probably null |
Het |
| Tom1l1 |
A |
G |
11: 90,547,177 (GRCm39) |
L301S |
possibly damaging |
Het |
| Trpm3 |
A |
G |
19: 22,960,076 (GRCm39) |
E1237G |
probably damaging |
Het |
| Ube2d1 |
C |
A |
10: 71,092,523 (GRCm39) |
C107F |
probably damaging |
Het |
| Ugt3a1 |
C |
T |
15: 9,306,330 (GRCm39) |
R160* |
probably null |
Het |
| Vcan |
G |
A |
13: 89,853,782 (GRCm39) |
P393S |
probably damaging |
Het |
| Virma |
T |
C |
4: 11,544,954 (GRCm39) |
F1638L |
probably damaging |
Het |
| Vmn1r31 |
G |
A |
6: 58,449,043 (GRCm39) |
T274I |
probably damaging |
Het |
| Xylt2 |
C |
T |
11: 94,559,035 (GRCm39) |
S445N |
probably damaging |
Het |
| Zfp457 |
A |
G |
13: 67,444,375 (GRCm39) |
F43L |
possibly damaging |
Het |
| Zfp879 |
T |
A |
11: 50,723,473 (GRCm39) |
M455L |
probably benign |
Het |
|
| Other mutations in Tlr4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01120:Tlr4
|
APN |
4 |
66,758,662 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01343:Tlr4
|
APN |
4 |
66,752,124 (GRCm39) |
splice site |
probably benign |
|
|
IGL01669:Tlr4
|
APN |
4 |
66,759,504 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL01875:Tlr4
|
APN |
4 |
66,757,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02138:Tlr4
|
APN |
4 |
66,759,202 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02244:Tlr4
|
APN |
4 |
66,752,298 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02793:Tlr4
|
APN |
4 |
66,757,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03269:Tlr4
|
APN |
4 |
66,759,033 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03288:Tlr4
|
APN |
4 |
66,757,990 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bugsy
|
UTSW |
4 |
66,757,491 (GRCm39) |
nonsense |
probably null |
|
|
Cruyff
|
UTSW |
4 |
66,758,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
don_knotts
|
UTSW |
4 |
66,759,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Guardiola
|
UTSW |
4 |
66,757,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lops
|
UTSW |
4 |
66,752,117 (GRCm39) |
splice site |
probably null |
|
|
lps3
|
UTSW |
4 |
66,759,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lps4
|
UTSW |
4 |
66,759,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
milquetoast
|
UTSW |
4 |
66,757,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
salvador
|
UTSW |
4 |
66,758,443 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0449:Tlr4
|
UTSW |
4 |
66,757,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0481:Tlr4
|
UTSW |
4 |
66,746,153 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0576:Tlr4
|
UTSW |
4 |
66,757,732 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0827:Tlr4
|
UTSW |
4 |
66,752,117 (GRCm39) |
splice site |
probably null |
|
|
R1488:Tlr4
|
UTSW |
4 |
66,757,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1490:Tlr4
|
UTSW |
4 |
66,757,611 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1522:Tlr4
|
UTSW |
4 |
66,757,933 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1681:Tlr4
|
UTSW |
4 |
66,759,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1738:Tlr4
|
UTSW |
4 |
66,759,313 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1888:Tlr4
|
UTSW |
4 |
66,759,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Tlr4
|
UTSW |
4 |
66,759,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1929:Tlr4
|
UTSW |
4 |
66,757,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1982:Tlr4
|
UTSW |
4 |
66,759,272 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1998:Tlr4
|
UTSW |
4 |
66,758,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2186:Tlr4
|
UTSW |
4 |
66,758,220 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2305:Tlr4
|
UTSW |
4 |
66,758,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3011:Tlr4
|
UTSW |
4 |
66,757,491 (GRCm39) |
nonsense |
probably null |
|
|
R3420:Tlr4
|
UTSW |
4 |
66,757,773 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3422:Tlr4
|
UTSW |
4 |
66,757,773 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3818:Tlr4
|
UTSW |
4 |
66,759,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4212:Tlr4
|
UTSW |
4 |
66,758,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4213:Tlr4
|
UTSW |
4 |
66,758,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4417:Tlr4
|
UTSW |
4 |
66,757,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Tlr4
|
UTSW |
4 |
66,757,477 (GRCm39) |
missense |
probably benign |
0.44 |
|
R4735:Tlr4
|
UTSW |
4 |
66,759,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5191:Tlr4
|
UTSW |
4 |
66,759,616 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5613:Tlr4
|
UTSW |
4 |
66,759,122 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5705:Tlr4
|
UTSW |
4 |
66,752,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Tlr4
|
UTSW |
4 |
66,758,652 (GRCm39) |
missense |
probably benign |
|
|
R6021:Tlr4
|
UTSW |
4 |
66,759,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6159:Tlr4
|
UTSW |
4 |
66,758,070 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6227:Tlr4
|
UTSW |
4 |
66,758,832 (GRCm39) |
missense |
probably benign |
|
|
R7139:Tlr4
|
UTSW |
4 |
66,758,520 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7199:Tlr4
|
UTSW |
4 |
66,759,430 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7220:Tlr4
|
UTSW |
4 |
66,758,188 (GRCm39) |
missense |
probably benign |
|
|
R7337:Tlr4
|
UTSW |
4 |
66,758,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7487:Tlr4
|
UTSW |
4 |
66,842,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7638:Tlr4
|
UTSW |
4 |
66,758,443 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7773:Tlr4
|
UTSW |
4 |
66,757,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7814:Tlr4
|
UTSW |
4 |
66,759,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7897:Tlr4
|
UTSW |
4 |
66,758,058 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8044:Tlr4
|
UTSW |
4 |
66,746,084 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8062:Tlr4
|
UTSW |
4 |
66,758,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8080:Tlr4
|
UTSW |
4 |
66,757,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8446:Tlr4
|
UTSW |
4 |
66,757,673 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8916:Tlr4
|
UTSW |
4 |
66,847,268 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9100:Tlr4
|
UTSW |
4 |
66,758,518 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9415:Tlr4
|
UTSW |
4 |
66,746,160 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9562:Tlr4
|
UTSW |
4 |
66,759,522 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9565:Tlr4
|
UTSW |
4 |
66,759,522 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9752:Tlr4
|
UTSW |
4 |
66,757,912 (GRCm39) |
missense |
probably benign |
0.02 |
|
X0064:Tlr4
|
UTSW |
4 |
66,758,377 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Tlr4
|
UTSW |
4 |
66,847,319 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGCATGGCTTACACCACCTCTC -3'
(R):5'- TCAACCGATGGACGTGTAAACCAG -3'
Sequencing Primer
(F):5'- TTGATACTGACAGGAAACCCTATCC -3'
(R):5'- CGTGTAAACCAGCCAGGTTTTG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation