Incidental Mutation 'R1617:Or8k25'
ID 174330
Institutional Source Beutler Lab
Gene Symbol Or8k25
Ensembl Gene ENSMUSG00000075185
Gene Name olfactory receptor family 8 subfamily K member 25
Synonyms MOR188-1, MOR188-9, Olfr1515, Olfr1061, MOR188-1, MOR188-7, GA_x6K02T2Q125-47883395-47882454
MMRRC Submission 039654-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R1617 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86243453-86244394 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 86244035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 120 (Y120*)
Ref Sequence ENSEMBL: ENSMUSP00000097474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099889]
AlphaFold Q7TR72
Predicted Effect probably null
Transcript: ENSMUST00000099889
AA Change: Y120*
SMART Domains Protein: ENSMUSP00000097474
Gene: ENSMUSG00000075185
AA Change: Y120*

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-51 PFAM
Pfam:7tm_1 41 291 2.2e-17 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 91.0%
Validation Efficiency 98% (83/85)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T A 13: 119,603,473 (GRCm39) I91K probably damaging Het
AAdacl4fm3 T G 4: 144,441,961 (GRCm39) T97P probably damaging Het
Adamts16 T A 13: 70,946,154 (GRCm39) M254L probably benign Het
Adgre5 T C 8: 84,456,806 (GRCm39) I192V possibly damaging Het
Akr1c21 G A 13: 4,626,351 (GRCm39) probably null Het
Amz2 A G 11: 109,324,850 (GRCm39) T245A probably benign Het
Aqp7 A C 4: 41,036,109 (GRCm39) M43R probably null Het
Arid3c G A 4: 41,725,103 (GRCm39) P315S probably damaging Het
Birc2 A T 9: 7,826,952 (GRCm39) Y345N possibly damaging Het
Blnk T C 19: 40,950,807 (GRCm39) T115A probably benign Het
Col5a1 T C 2: 27,842,393 (GRCm39) S423P unknown Het
Corin A T 5: 72,661,295 (GRCm39) F66Y possibly damaging Het
Cpd A T 11: 76,737,495 (GRCm39) W100R probably damaging Het
Cpsf1 A T 15: 76,486,570 (GRCm39) Y296* probably null Het
Cyp2d34 T C 15: 82,505,046 (GRCm39) T5A probably benign Het
Dhrs7c G T 11: 67,705,903 (GRCm39) V219L possibly damaging Het
Dnah3 T C 7: 119,689,169 (GRCm39) M82V probably benign Het
Dnah9 A G 11: 65,786,747 (GRCm39) S3629P probably damaging Het
Fbrs T C 7: 127,086,883 (GRCm39) L33P probably damaging Het
Fhip1b A G 7: 105,034,269 (GRCm39) L454P probably damaging Het
Galnt11 T A 5: 25,463,891 (GRCm39) S388T probably damaging Het
Glmp A G 3: 88,235,426 (GRCm39) probably benign Het
Gm9894 A G 13: 67,920,845 (GRCm39) noncoding transcript Het
Grik3 A G 4: 125,584,985 (GRCm39) M618V probably benign Het
Hmcn1 T C 1: 150,620,778 (GRCm39) D1144G probably damaging Het
Hnrnpa2b1 T C 6: 51,443,378 (GRCm39) K161R possibly damaging Het
Kmt2c T C 5: 25,580,925 (GRCm39) I523V probably benign Het
Lmln C T 16: 32,937,500 (GRCm39) P622S probably damaging Het
Lmtk2 A G 5: 144,110,680 (GRCm39) T467A probably damaging Het
Map1s T A 8: 71,366,095 (GRCm39) N333K probably damaging Het
Mgat4d C A 8: 84,092,340 (GRCm39) A242D probably damaging Het
Muc5b T A 7: 141,417,261 (GRCm39) Y3402* probably null Het
Myo3b G T 2: 70,111,562 (GRCm39) A922S probably benign Het
Nphs1 T C 7: 30,181,956 (GRCm39) V1183A probably benign Het
Nup160 T A 2: 90,509,843 (GRCm39) C31S probably benign Het
Or4c58 T C 2: 89,674,598 (GRCm39) T240A probably benign Het
Pcdhb5 T G 18: 37,454,455 (GRCm39) Y278* probably null Het
Pkhd1 T A 1: 20,268,274 (GRCm39) E3368V possibly damaging Het
Pla2g6 A G 15: 79,173,341 (GRCm39) M676T probably benign Het
Plcb1 A T 2: 135,179,361 (GRCm39) N590Y probably damaging Het
Prr12 G A 7: 44,699,018 (GRCm39) probably benign Het
Psat1 A G 19: 15,901,666 (GRCm39) probably null Het
Ptpn9 T G 9: 56,934,692 (GRCm39) I152S possibly damaging Het
Ric8b T A 10: 84,783,475 (GRCm39) F111Y probably damaging Het
Slc44a3 G A 3: 121,254,914 (GRCm39) A568V probably benign Het
Smarcd3 T G 5: 24,800,192 (GRCm39) R213S probably damaging Het
Snx13 T C 12: 35,136,895 (GRCm39) Y119H probably damaging Het
Socs2 C A 10: 95,248,943 (GRCm39) E57* probably null Het
Spred1 C T 2: 117,005,828 (GRCm39) P197S probably benign Het
Srek1 G T 13: 103,880,112 (GRCm39) P482Q unknown Het
Tapbp A G 17: 34,139,405 (GRCm39) T134A probably benign Het
Tarbp1 T C 8: 127,171,007 (GRCm39) I998V possibly damaging Het
Tbcel G T 9: 42,372,589 (GRCm39) probably benign Het
Tec A G 5: 72,939,448 (GRCm39) F189S probably damaging Het
Tmprss11g A T 5: 86,647,422 (GRCm39) Y39N probably damaging Het
Tmtc1 A G 6: 148,256,902 (GRCm39) probably benign Het
Trpa1 A G 1: 14,943,899 (GRCm39) I1070T probably damaging Het
Trpm2 T A 10: 77,771,709 (GRCm39) probably null Het
Ttc21b G T 2: 66,056,379 (GRCm39) T669K probably benign Het
Ttll4 G A 1: 74,718,560 (GRCm39) R137H probably benign Het
Ubqln3 G T 7: 103,792,067 (GRCm39) L8I possibly damaging Het
Ung C A 5: 114,269,415 (GRCm39) N42K probably benign Het
Upp1 T C 11: 9,084,865 (GRCm39) S195P probably damaging Het
Urb1 T C 16: 90,557,340 (GRCm39) E1762G possibly damaging Het
Utp11 T C 4: 124,579,904 (GRCm39) K35E probably damaging Het
Vav3 A T 3: 109,418,294 (GRCm39) K305I probably damaging Het
Vmn1r197 A G 13: 22,512,498 (GRCm39) I140V possibly damaging Het
Vmn2r-ps158 A G 7: 42,673,503 (GRCm39) E187G probably benign Het
Zfc3h1 A G 10: 115,226,827 (GRCm39) T295A probably benign Het
Zfp268 A T 4: 145,350,877 (GRCm39) probably benign Het
Zfp46 T C 4: 136,017,823 (GRCm39) L219P probably damaging Het
Zfp493 G A 13: 67,931,999 (GRCm39) V33M probably damaging Het
Zfp92 T C X: 72,463,466 (GRCm39) probably benign Het
Other mutations in Or8k25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01714:Or8k25 APN 2 86,244,144 (GRCm39) missense probably benign 0.35
IGL01721:Or8k25 APN 2 86,243,677 (GRCm39) missense probably damaging 1.00
IGL02696:Or8k25 APN 2 86,243,959 (GRCm39) missense probably benign 0.03
BB007:Or8k25 UTSW 2 86,243,560 (GRCm39) missense probably damaging 1.00
BB017:Or8k25 UTSW 2 86,243,560 (GRCm39) missense probably damaging 1.00
R0366:Or8k25 UTSW 2 86,244,369 (GRCm39) missense possibly damaging 0.71
R0607:Or8k25 UTSW 2 86,243,514 (GRCm39) missense probably damaging 1.00
R1013:Or8k25 UTSW 2 86,244,319 (GRCm39) missense possibly damaging 0.61
R1017:Or8k25 UTSW 2 86,243,855 (GRCm39) missense probably damaging 1.00
R1690:Or8k25 UTSW 2 86,244,298 (GRCm39) missense probably benign 0.03
R4126:Or8k25 UTSW 2 86,243,568 (GRCm39) missense probably damaging 0.99
R5053:Or8k25 UTSW 2 86,243,682 (GRCm39) missense probably damaging 1.00
R5443:Or8k25 UTSW 2 86,243,937 (GRCm39) missense possibly damaging 0.54
R6195:Or8k25 UTSW 2 86,243,551 (GRCm39) missense probably damaging 0.98
R6233:Or8k25 UTSW 2 86,243,551 (GRCm39) missense probably damaging 0.98
R6468:Or8k25 UTSW 2 86,244,381 (GRCm39) missense probably damaging 0.99
R7188:Or8k25 UTSW 2 86,243,695 (GRCm39) nonsense probably null
R7300:Or8k25 UTSW 2 86,244,330 (GRCm39) missense probably null 0.27
R7374:Or8k25 UTSW 2 86,244,196 (GRCm39) missense probably benign 0.39
R7392:Or8k25 UTSW 2 86,243,496 (GRCm39) missense probably benign
R7494:Or8k25 UTSW 2 86,243,592 (GRCm39) missense probably benign 0.24
R7930:Or8k25 UTSW 2 86,243,560 (GRCm39) missense probably damaging 1.00
R8491:Or8k25 UTSW 2 86,244,099 (GRCm39) missense probably benign 0.00
R8680:Or8k25 UTSW 2 86,243,935 (GRCm39) missense probably benign 0.16
R8848:Or8k25 UTSW 2 86,243,821 (GRCm39) missense probably benign 0.05
R9175:Or8k25 UTSW 2 86,244,099 (GRCm39) missense probably benign 0.00
X0023:Or8k25 UTSW 2 86,244,303 (GRCm39) missense probably benign 0.29
Z1176:Or8k25 UTSW 2 86,243,872 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- CGTAGAGAAAGCCTTCCATTTGCCC -3'
(R):5'- AGACACCTCGCTACTACTGACCTTG -3'

Sequencing Primer
(F):5'- GCCCTCAGCAGAGTTAATCCTTAG -3'
(R):5'- ACTGACCTTGGTTATTCAACAGC -3'
Posted On 2014-04-24