Incidental Mutation 'R1617:Map1s'
ID 174364
Institutional Source Beutler Lab
Gene Symbol Map1s
Ensembl Gene ENSMUSG00000019261
Gene Name microtubule-associated protein 1S
Synonyms VCY2IP1, Mtap1s, Map8, 6430517J16Rik, Bpy2ip1
MMRRC Submission 039654-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1617 (G1)
Quality Score 169
Status Validated
Chromosome 8
Chromosomal Location 71358618-71370173 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 71366095 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 333 (N333K)
Ref Sequence ENSEMBL: ENSMUSP00000019405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019405] [ENSMUST00000211910] [ENSMUST00000212227] [ENSMUST00000212511] [ENSMUST00000213001]
AlphaFold Q8C052
Predicted Effect probably damaging
Transcript: ENSMUST00000019405
AA Change: N333K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000019405
Gene: ENSMUSG00000019261
AA Change: N333K

DomainStartEndE-ValueType
low complexity region 1 32 N/A INTRINSIC
low complexity region 125 137 N/A INTRINSIC
low complexity region 155 165 N/A INTRINSIC
low complexity region 208 225 N/A INTRINSIC
SCOP:d1e5da2 237 300 2e-3 SMART
Blast:Lactamase_B 244 475 1e-85 BLAST
low complexity region 536 550 N/A INTRINSIC
low complexity region 597 621 N/A INTRINSIC
low complexity region 679 691 N/A INTRINSIC
low complexity region 698 714 N/A INTRINSIC
low complexity region 715 734 N/A INTRINSIC
low complexity region 735 751 N/A INTRINSIC
low complexity region 774 801 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211880
Predicted Effect probably benign
Transcript: ENSMUST00000211910
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212143
Predicted Effect probably damaging
Transcript: ENSMUST00000212227
AA Change: N333K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000212511
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212697
Predicted Effect probably benign
Transcript: ENSMUST00000213001
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213083
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212544
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 95.8%
  • 20x: 91.0%
Validation Efficiency 98% (83/85)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit defective biogenesis and degradation of autophagosomes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4833420G17Rik T A 13: 119,603,473 (GRCm39) I91K probably damaging Het
AAdacl4fm3 T G 4: 144,441,961 (GRCm39) T97P probably damaging Het
Adamts16 T A 13: 70,946,154 (GRCm39) M254L probably benign Het
Adgre5 T C 8: 84,456,806 (GRCm39) I192V possibly damaging Het
Akr1c21 G A 13: 4,626,351 (GRCm39) probably null Het
Amz2 A G 11: 109,324,850 (GRCm39) T245A probably benign Het
Aqp7 A C 4: 41,036,109 (GRCm39) M43R probably null Het
Arid3c G A 4: 41,725,103 (GRCm39) P315S probably damaging Het
Birc2 A T 9: 7,826,952 (GRCm39) Y345N possibly damaging Het
Blnk T C 19: 40,950,807 (GRCm39) T115A probably benign Het
Col5a1 T C 2: 27,842,393 (GRCm39) S423P unknown Het
Corin A T 5: 72,661,295 (GRCm39) F66Y possibly damaging Het
Cpd A T 11: 76,737,495 (GRCm39) W100R probably damaging Het
Cpsf1 A T 15: 76,486,570 (GRCm39) Y296* probably null Het
Cyp2d34 T C 15: 82,505,046 (GRCm39) T5A probably benign Het
Dhrs7c G T 11: 67,705,903 (GRCm39) V219L possibly damaging Het
Dnah3 T C 7: 119,689,169 (GRCm39) M82V probably benign Het
Dnah9 A G 11: 65,786,747 (GRCm39) S3629P probably damaging Het
Fbrs T C 7: 127,086,883 (GRCm39) L33P probably damaging Het
Fhip1b A G 7: 105,034,269 (GRCm39) L454P probably damaging Het
Galnt11 T A 5: 25,463,891 (GRCm39) S388T probably damaging Het
Glmp A G 3: 88,235,426 (GRCm39) probably benign Het
Gm9894 A G 13: 67,920,845 (GRCm39) noncoding transcript Het
Grik3 A G 4: 125,584,985 (GRCm39) M618V probably benign Het
Hmcn1 T C 1: 150,620,778 (GRCm39) D1144G probably damaging Het
Hnrnpa2b1 T C 6: 51,443,378 (GRCm39) K161R possibly damaging Het
Kmt2c T C 5: 25,580,925 (GRCm39) I523V probably benign Het
Lmln C T 16: 32,937,500 (GRCm39) P622S probably damaging Het
Lmtk2 A G 5: 144,110,680 (GRCm39) T467A probably damaging Het
Mgat4d C A 8: 84,092,340 (GRCm39) A242D probably damaging Het
Muc5b T A 7: 141,417,261 (GRCm39) Y3402* probably null Het
Myo3b G T 2: 70,111,562 (GRCm39) A922S probably benign Het
Nphs1 T C 7: 30,181,956 (GRCm39) V1183A probably benign Het
Nup160 T A 2: 90,509,843 (GRCm39) C31S probably benign Het
Or4c58 T C 2: 89,674,598 (GRCm39) T240A probably benign Het
Or8k25 A T 2: 86,244,035 (GRCm39) Y120* probably null Het
Pcdhb5 T G 18: 37,454,455 (GRCm39) Y278* probably null Het
Pkhd1 T A 1: 20,268,274 (GRCm39) E3368V possibly damaging Het
Pla2g6 A G 15: 79,173,341 (GRCm39) M676T probably benign Het
Plcb1 A T 2: 135,179,361 (GRCm39) N590Y probably damaging Het
Prr12 G A 7: 44,699,018 (GRCm39) probably benign Het
Psat1 A G 19: 15,901,666 (GRCm39) probably null Het
Ptpn9 T G 9: 56,934,692 (GRCm39) I152S possibly damaging Het
Ric8b T A 10: 84,783,475 (GRCm39) F111Y probably damaging Het
Slc44a3 G A 3: 121,254,914 (GRCm39) A568V probably benign Het
Smarcd3 T G 5: 24,800,192 (GRCm39) R213S probably damaging Het
Snx13 T C 12: 35,136,895 (GRCm39) Y119H probably damaging Het
Socs2 C A 10: 95,248,943 (GRCm39) E57* probably null Het
Spred1 C T 2: 117,005,828 (GRCm39) P197S probably benign Het
Srek1 G T 13: 103,880,112 (GRCm39) P482Q unknown Het
Tapbp A G 17: 34,139,405 (GRCm39) T134A probably benign Het
Tarbp1 T C 8: 127,171,007 (GRCm39) I998V possibly damaging Het
Tbcel G T 9: 42,372,589 (GRCm39) probably benign Het
Tec A G 5: 72,939,448 (GRCm39) F189S probably damaging Het
Tmprss11g A T 5: 86,647,422 (GRCm39) Y39N probably damaging Het
Tmtc1 A G 6: 148,256,902 (GRCm39) probably benign Het
Trpa1 A G 1: 14,943,899 (GRCm39) I1070T probably damaging Het
Trpm2 T A 10: 77,771,709 (GRCm39) probably null Het
Ttc21b G T 2: 66,056,379 (GRCm39) T669K probably benign Het
Ttll4 G A 1: 74,718,560 (GRCm39) R137H probably benign Het
Ubqln3 G T 7: 103,792,067 (GRCm39) L8I possibly damaging Het
Ung C A 5: 114,269,415 (GRCm39) N42K probably benign Het
Upp1 T C 11: 9,084,865 (GRCm39) S195P probably damaging Het
Urb1 T C 16: 90,557,340 (GRCm39) E1762G possibly damaging Het
Utp11 T C 4: 124,579,904 (GRCm39) K35E probably damaging Het
Vav3 A T 3: 109,418,294 (GRCm39) K305I probably damaging Het
Vmn1r197 A G 13: 22,512,498 (GRCm39) I140V possibly damaging Het
Vmn2r-ps158 A G 7: 42,673,503 (GRCm39) E187G probably benign Het
Zfc3h1 A G 10: 115,226,827 (GRCm39) T295A probably benign Het
Zfp268 A T 4: 145,350,877 (GRCm39) probably benign Het
Zfp46 T C 4: 136,017,823 (GRCm39) L219P probably damaging Het
Zfp493 G A 13: 67,931,999 (GRCm39) V33M probably damaging Het
Zfp92 T C X: 72,463,466 (GRCm39) probably benign Het
Other mutations in Map1s
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00905:Map1s APN 8 71,358,673 (GRCm39) unclassified probably benign
IGL01012:Map1s APN 8 71,366,554 (GRCm39) missense probably benign 0.00
IGL01729:Map1s APN 8 71,365,712 (GRCm39) missense probably damaging 1.00
IGL03158:Map1s APN 8 71,367,378 (GRCm39) missense probably damaging 0.97
E0374:Map1s UTSW 8 71,358,661 (GRCm39) unclassified probably benign
R0026:Map1s UTSW 8 71,367,282 (GRCm39) missense probably damaging 1.00
R0172:Map1s UTSW 8 71,367,612 (GRCm39) missense probably benign 0.00
R0571:Map1s UTSW 8 71,365,551 (GRCm39) missense probably damaging 1.00
R0666:Map1s UTSW 8 71,366,696 (GRCm39) missense possibly damaging 0.88
R0904:Map1s UTSW 8 71,366,832 (GRCm39) missense probably damaging 0.96
R1834:Map1s UTSW 8 71,369,055 (GRCm39) missense probably damaging 0.97
R2134:Map1s UTSW 8 71,366,526 (GRCm39) missense probably benign 0.00
R2143:Map1s UTSW 8 71,363,608 (GRCm39) missense probably damaging 1.00
R3413:Map1s UTSW 8 71,365,163 (GRCm39) missense probably damaging 0.99
R3870:Map1s UTSW 8 71,369,745 (GRCm39) missense possibly damaging 0.82
R5555:Map1s UTSW 8 71,369,751 (GRCm39) missense probably damaging 0.97
R5784:Map1s UTSW 8 71,367,002 (GRCm39) missense probably damaging 1.00
R6630:Map1s UTSW 8 71,366,442 (GRCm39) missense probably damaging 1.00
R7379:Map1s UTSW 8 71,366,219 (GRCm39) missense possibly damaging 0.87
R7569:Map1s UTSW 8 71,366,142 (GRCm39) missense probably benign 0.05
R8415:Map1s UTSW 8 71,365,910 (GRCm39) missense probably damaging 1.00
R8440:Map1s UTSW 8 71,365,163 (GRCm39) missense probably damaging 0.99
R8784:Map1s UTSW 8 71,358,909 (GRCm39) missense unknown
R8974:Map1s UTSW 8 71,366,994 (GRCm39) missense probably damaging 1.00
R9161:Map1s UTSW 8 71,366,250 (GRCm39) missense probably damaging 1.00
R9555:Map1s UTSW 8 71,367,236 (GRCm39) missense probably benign 0.27
R9566:Map1s UTSW 8 71,365,580 (GRCm39) missense probably benign 0.03
R9701:Map1s UTSW 8 71,369,712 (GRCm39) missense possibly damaging 0.92
R9730:Map1s UTSW 8 71,369,178 (GRCm39) missense possibly damaging 0.90
Z1088:Map1s UTSW 8 71,369,093 (GRCm39) missense possibly damaging 0.66
Z1177:Map1s UTSW 8 71,367,161 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGGCCCTGTTGCTATGTGTTCC -3'
(R):5'- CCCAGCTTCTCGAAAAGGACAGTG -3'

Sequencing Primer
(F):5'- GTCAACGGCTTTACAGTGC -3'
(R):5'- CAGTGGGGCAAGAGGGC -3'
Posted On 2014-04-24