Incidental Mutation 'R1622:Lrrc4b'
ID 174703
Institutional Source Beutler Lab
Gene Symbol Lrrc4b
Ensembl Gene ENSMUSG00000047085
Gene Name leucine rich repeat containing 4B
Synonyms NGL-3, Lrig4, Ngl3
MMRRC Submission 039659-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R1622 (G1)
Quality Score 190
Status Validated
Chromosome 7
Chromosomal Location 44091911-44112775 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) GAGAAG to GAG at 44111654 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000121766 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035929] [ENSMUST00000058667] [ENSMUST00000127790] [ENSMUST00000135624] [ENSMUST00000146128] [ENSMUST00000156957] [ENSMUST00000152902] [ENSMUST00000156093]
AlphaFold P0C192
Predicted Effect probably benign
Transcript: ENSMUST00000035929
SMART Domains Protein: ENSMUSP00000039202
Gene: ENSMUSG00000038704

DomainStartEndE-ValueType
Pfam:NAD_binding_3 17 128 3.8e-24 PFAM
Pfam:DUF108 174 265 2.9e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000058667
SMART Domains Protein: ENSMUSP00000053123
Gene: ENSMUSG00000047085

DomainStartEndE-ValueType
signal peptide 1 38 N/A INTRINSIC
LRRNT 58 92 5.6e-8 SMART
LRR 91 110 1.62e2 SMART
LRR 111 134 1.16e-1 SMART
LRR_TYP 135 158 8.22e-2 SMART
LRR_TYP 159 182 5.99e-4 SMART
LRR 208 229 1.62e2 SMART
LRR_TYP 230 253 3.63e-3 SMART
LRR 254 277 9.75e0 SMART
LRR_TYP 278 301 5.29e-5 SMART
LRRCT 313 364 1.92e-3 SMART
IGc2 378 445 1.45e-9 SMART
low complexity region 462 482 N/A INTRINSIC
low complexity region 528 547 N/A INTRINSIC
transmembrane domain 573 595 N/A INTRINSIC
low complexity region 596 607 N/A INTRINSIC
low complexity region 624 644 N/A INTRINSIC
low complexity region 673 686 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127790
SMART Domains Protein: ENSMUSP00000123389
Gene: ENSMUSG00000047085

DomainStartEndE-ValueType
signal peptide 1 38 N/A INTRINSIC
LRRNT 58 92 5.6e-8 SMART
LRR 91 110 1.62e2 SMART
LRR 111 134 1.16e-1 SMART
LRR_TYP 135 158 8.22e-2 SMART
LRR_TYP 159 182 5.99e-4 SMART
Blast:LRR 183 207 2e-6 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133801
Predicted Effect probably benign
Transcript: ENSMUST00000135624
Predicted Effect probably benign
Transcript: ENSMUST00000146128
SMART Domains Protein: ENSMUSP00000119474
Gene: ENSMUSG00000038704

DomainStartEndE-ValueType
Pfam:NAD_binding_3 5 110 1e-19 PFAM
Pfam:DUF108 153 252 7.5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000156957
SMART Domains Protein: ENSMUSP00000121766
Gene: ENSMUSG00000038704

DomainStartEndE-ValueType
Pfam:DUF108 52 151 2.6e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000152902
Predicted Effect probably benign
Transcript: ENSMUST00000156093
SMART Domains Protein: ENSMUSP00000119374
Gene: ENSMUSG00000047085

DomainStartEndE-ValueType
signal peptide 1 38 N/A INTRINSIC
LRRNT 58 92 5.6e-8 SMART
LRR 91 110 1.62e2 SMART
LRR 111 134 1.16e-1 SMART
LRR_TYP 135 158 8.22e-2 SMART
LRR_TYP 159 182 5.99e-4 SMART
Blast:LRR 183 207 2e-6 BLAST
LRR 208 230 3.65e1 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldoart2 A G 12: 55,612,696 (GRCm39) E207G probably benign Het
Arhgap19 T A 19: 41,790,412 (GRCm39) S19C probably benign Het
Arhgef18 T A 8: 3,491,272 (GRCm39) D374E possibly damaging Het
Atf2 A G 2: 73,684,133 (GRCm39) probably null Het
Cadm1 A G 9: 47,725,139 (GRCm39) N300S probably benign Het
Ccdc159 A T 9: 21,840,666 (GRCm39) I78F possibly damaging Het
Cdh4 T C 2: 179,530,885 (GRCm39) I589T possibly damaging Het
Clstn1 T C 4: 149,713,864 (GRCm39) I182T probably damaging Het
Cnga3 T A 1: 37,283,909 (GRCm39) probably benign Het
Cntln T A 4: 84,981,418 (GRCm39) S865R probably damaging Het
Col5a3 C T 9: 20,683,516 (GRCm39) G1552E unknown Het
Col6a4 A C 9: 105,874,334 (GRCm39) S2218A probably benign Het
Ephb1 T C 9: 101,878,910 (GRCm39) T527A probably benign Het
Fkbp15 T A 4: 62,241,439 (GRCm39) I569F possibly damaging Het
Gabra4 A G 5: 71,729,329 (GRCm39) S484P possibly damaging Het
Glce T C 9: 61,977,843 (GRCm39) I14V possibly damaging Het
Gm4884 A T 7: 40,692,265 (GRCm39) Q78L probably damaging Het
Gpn1 A G 5: 31,660,748 (GRCm39) T180A possibly damaging Het
Gpr6 A T 10: 40,947,288 (GRCm39) I98N probably damaging Het
Hcrtr2 T C 9: 76,230,722 (GRCm39) N22S probably benign Het
Hfm1 C T 5: 107,041,389 (GRCm39) V665I possibly damaging Het
Il4ra T A 7: 125,169,225 (GRCm39) I159N possibly damaging Het
Irf8 G C 8: 121,466,561 (GRCm39) C2S possibly damaging Het
Itih2 A T 2: 10,106,890 (GRCm39) N701K probably benign Het
Mmp10 T A 9: 7,504,996 (GRCm39) Y263* probably null Het
Morc3 T A 16: 93,671,694 (GRCm39) M835K probably benign Het
Msh3 A G 13: 92,481,462 (GRCm39) probably null Het
Ncbp1 A G 4: 46,171,963 (GRCm39) H777R possibly damaging Het
Nfatc1 A G 18: 80,710,182 (GRCm39) M514T probably damaging Het
Nlrp3 T A 11: 59,439,302 (GRCm39) I293N probably damaging Het
Pank2 A T 2: 131,115,889 (GRCm39) E102D probably damaging Het
Pbrm1 A G 14: 30,754,505 (GRCm39) D175G probably benign Het
Pcdh9 T C 14: 94,123,311 (GRCm39) D953G probably benign Het
Pibf1 G A 14: 99,423,917 (GRCm39) V497I probably benign Het
Pkd1 G A 17: 24,800,614 (GRCm39) M3085I probably benign Het
Prss58 A T 6: 40,874,248 (GRCm39) C143S possibly damaging Het
Rassf8 A G 6: 145,765,829 (GRCm39) probably benign Het
Sp140l2 A G 1: 85,231,907 (GRCm39) probably benign Het
Spag7 T A 11: 70,555,688 (GRCm39) D73V probably damaging Het
Sult3a1 A T 10: 33,746,246 (GRCm39) M189L probably benign Het
Syt4 T C 18: 31,577,069 (GRCm39) D95G probably damaging Het
Tbc1d8 A C 1: 39,419,317 (GRCm39) S766A probably benign Het
Tmco5 A T 2: 116,710,796 (GRCm39) M39L probably benign Het
Trcg1 A G 9: 57,155,955 (GRCm39) N797S possibly damaging Het
Trim34a A T 7: 103,910,545 (GRCm39) probably null Het
Ubr5 T C 15: 38,009,357 (GRCm39) probably benign Het
Urb2 A G 8: 124,756,363 (GRCm39) N690S probably benign Het
Zfp445 A G 9: 122,681,614 (GRCm39) Y776H possibly damaging Het
Zfp52 G A 17: 21,781,833 (GRCm39) M560I probably benign Het
Zfp608 A G 18: 55,121,366 (GRCm39) S74P probably benign Het
Zfp629 A G 7: 127,211,012 (GRCm39) C266R probably damaging Het
Zscan2 A G 7: 80,525,134 (GRCm39) K285R probably benign Het
Other mutations in Lrrc4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0165:Lrrc4b UTSW 7 44,111,739 (GRCm39) missense probably damaging 0.99
R1398:Lrrc4b UTSW 7 44,111,876 (GRCm39) missense probably benign 0.44
R1421:Lrrc4b UTSW 7 44,110,475 (GRCm39) missense probably benign 0.00
R1681:Lrrc4b UTSW 7 44,110,601 (GRCm39) missense probably damaging 0.99
R1778:Lrrc4b UTSW 7 44,111,823 (GRCm39) missense probably benign
R1967:Lrrc4b UTSW 7 44,111,654 (GRCm39) unclassified probably benign
R1989:Lrrc4b UTSW 7 44,111,654 (GRCm39) unclassified probably benign
R2427:Lrrc4b UTSW 7 44,111,976 (GRCm39) missense probably damaging 1.00
R3820:Lrrc4b UTSW 7 44,111,982 (GRCm39) missense probably damaging 1.00
R3822:Lrrc4b UTSW 7 44,111,982 (GRCm39) missense probably damaging 1.00
R4774:Lrrc4b UTSW 7 44,111,796 (GRCm39) splice site probably null
R5249:Lrrc4b UTSW 7 44,111,988 (GRCm39) missense possibly damaging 0.93
R5268:Lrrc4b UTSW 7 44,110,787 (GRCm39) missense probably damaging 1.00
R6029:Lrrc4b UTSW 7 44,111,754 (GRCm39) missense probably benign 0.00
R6984:Lrrc4b UTSW 7 44,110,722 (GRCm39) missense possibly damaging 0.62
R7003:Lrrc4b UTSW 7 44,094,580 (GRCm39) missense probably damaging 1.00
R7392:Lrrc4b UTSW 7 44,111,439 (GRCm39) missense probably damaging 1.00
R7544:Lrrc4b UTSW 7 44,111,975 (GRCm39) missense probably damaging 1.00
R7582:Lrrc4b UTSW 7 44,111,234 (GRCm39) missense probably benign 0.00
R7596:Lrrc4b UTSW 7 44,111,310 (GRCm39) missense probably damaging 1.00
R7830:Lrrc4b UTSW 7 44,111,231 (GRCm39) missense possibly damaging 0.76
R7836:Lrrc4b UTSW 7 44,094,316 (GRCm39) start gained probably benign
R8116:Lrrc4b UTSW 7 44,110,533 (GRCm39) missense probably damaging 1.00
R8147:Lrrc4b UTSW 7 44,111,829 (GRCm39) missense probably damaging 1.00
R8376:Lrrc4b UTSW 7 44,112,018 (GRCm39) missense probably benign 0.00
R9226:Lrrc4b UTSW 7 44,112,099 (GRCm39) missense possibly damaging 0.85
R9674:Lrrc4b UTSW 7 44,111,852 (GRCm39) missense probably damaging 1.00
Z1176:Lrrc4b UTSW 7 44,110,736 (GRCm39) frame shift probably null
Z1176:Lrrc4b UTSW 7 44,094,547 (GRCm39) missense probably damaging 1.00
Z1177:Lrrc4b UTSW 7 44,111,335 (GRCm39) missense probably damaging 1.00
Z1177:Lrrc4b UTSW 7 44,094,404 (GRCm39) missense unknown
Z1177:Lrrc4b UTSW 7 44,094,403 (GRCm39) missense unknown
Z1177:Lrrc4b UTSW 7 44,112,041 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACTTCACCAATGTCACCGTGCAG -3'
(R):5'- TAAGCGCATTCTCCGTCACGTC -3'

Sequencing Primer
(F):5'- GCATGGTGACAAACTCGGC -3'
(R):5'- ACGTCCGTGATGGGCAC -3'
Posted On 2014-04-24