Incidental Mutation 'R1623:Vmn2r60'
| ID |
174788 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r60
|
| Ensembl Gene |
ENSMUSG00000090619 |
| Gene Name |
vomeronasal 2, receptor 60 |
| Synonyms |
Casr-rs3, EG637898, Gprc2a-rs3 |
| MMRRC Submission |
039660-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R1623 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41765895-41845200 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 41785279 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 164
(K164*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128493
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166447]
|
| AlphaFold |
A0A3B2WBC8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000166447
AA Change: K164*
|
| SMART Domains |
Protein: ENSMUSP00000128493
Gene: ENSMUSG00000090619
AA Change: K164*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
471 |
1.2e-44 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
1.4e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.0%
- 10x: 94.9%
- 20x: 87.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acbd5 |
A |
T |
2: 22,984,356 (GRCm39) |
D294V |
probably damaging |
Het |
| Actn2 |
A |
T |
13: 12,355,320 (GRCm39) |
I21N |
probably benign |
Het |
| Adamts2 |
C |
A |
11: 50,558,942 (GRCm39) |
P219H |
possibly damaging |
Het |
| Atg16l2 |
A |
G |
7: 100,939,113 (GRCm39) |
F584L |
probably benign |
Het |
| Ccdc81 |
C |
T |
7: 89,535,390 (GRCm39) |
R282Q |
probably benign |
Het |
| Ccn4 |
G |
T |
15: 66,763,448 (GRCm39) |
V12L |
possibly damaging |
Het |
| Cd200r3 |
G |
A |
16: 44,771,811 (GRCm39) |
C25Y |
possibly damaging |
Het |
| Cdkl4 |
C |
T |
17: 80,863,731 (GRCm39) |
|
probably null |
Het |
| Chrne |
T |
C |
11: 70,509,254 (GRCm39) |
E109G |
possibly damaging |
Het |
| Clmp |
A |
G |
9: 40,693,856 (GRCm39) |
T358A |
probably benign |
Het |
| Cmtr1 |
G |
T |
17: 29,906,021 (GRCm39) |
|
probably null |
Het |
| Col25a1 |
A |
G |
3: 130,343,699 (GRCm39) |
E389G |
probably damaging |
Het |
| Ctc1 |
C |
T |
11: 68,911,968 (GRCm39) |
T49M |
probably damaging |
Het |
| Cyth3 |
T |
A |
5: 143,687,127 (GRCm39) |
M120K |
probably damaging |
Het |
| D430041D05Rik |
T |
A |
2: 103,983,308 (GRCm39) |
E1996V |
probably damaging |
Het |
| Dnah9 |
T |
C |
11: 65,928,463 (GRCm39) |
M2069V |
probably damaging |
Het |
| Dsg1c |
T |
C |
18: 20,408,234 (GRCm39) |
Y428H |
probably damaging |
Het |
| Exosc8 |
T |
A |
3: 54,641,752 (GRCm39) |
T7S |
probably damaging |
Het |
| F5 |
A |
G |
1: 164,023,191 (GRCm39) |
Y1583C |
probably damaging |
Het |
| Fam178b |
A |
G |
1: 36,683,405 (GRCm39) |
I105T |
probably damaging |
Het |
| Fam181a |
T |
A |
12: 103,282,591 (GRCm39) |
Y165* |
probably null |
Het |
| Fbn2 |
G |
T |
18: 58,181,620 (GRCm39) |
N1880K |
possibly damaging |
Het |
| Gbgt1 |
A |
T |
2: 28,394,988 (GRCm39) |
M209L |
probably benign |
Het |
| Gkn2 |
C |
A |
6: 87,355,152 (GRCm39) |
Y120* |
probably null |
Het |
| Gm14295 |
T |
A |
2: 176,499,157 (GRCm39) |
D1E |
probably damaging |
Het |
| Gpr141 |
A |
T |
13: 19,936,082 (GRCm39) |
|
probably null |
Het |
| Gramd2b |
C |
A |
18: 56,565,423 (GRCm39) |
P26Q |
probably benign |
Het |
| Greb1 |
A |
G |
12: 16,724,771 (GRCm39) |
I1801T |
probably damaging |
Het |
| Gstm3 |
T |
A |
3: 107,875,151 (GRCm39) |
I64F |
possibly damaging |
Het |
| Gtse1 |
A |
G |
15: 85,751,779 (GRCm39) |
Y324C |
probably benign |
Het |
| Hal |
C |
G |
10: 93,352,159 (GRCm39) |
T650R |
probably benign |
Het |
| Hdac7 |
G |
A |
15: 97,706,285 (GRCm39) |
Q293* |
probably null |
Het |
| Hdlbp |
A |
T |
1: 93,351,591 (GRCm39) |
N437K |
probably damaging |
Het |
| Hif1an |
A |
G |
19: 44,557,862 (GRCm39) |
D248G |
probably damaging |
Het |
| Hivep3 |
T |
C |
4: 119,952,901 (GRCm39) |
S406P |
possibly damaging |
Het |
| Hmcn2 |
A |
T |
2: 31,348,051 (GRCm39) |
D4899V |
possibly damaging |
Het |
| Ikzf3 |
C |
T |
11: 98,381,157 (GRCm39) |
|
probably null |
Het |
| Inka2 |
G |
A |
3: 105,624,136 (GRCm39) |
G151D |
probably damaging |
Het |
| Itgb4 |
C |
A |
11: 115,882,142 (GRCm39) |
Y819* |
probably null |
Het |
| Itpripl1 |
T |
C |
2: 126,983,555 (GRCm39) |
D189G |
possibly damaging |
Het |
| Kmt2e |
A |
G |
5: 23,687,500 (GRCm39) |
Y450C |
probably damaging |
Het |
| Mc4r |
A |
G |
18: 66,993,068 (GRCm39) |
L15P |
probably benign |
Het |
| Mical1 |
T |
G |
10: 41,357,389 (GRCm39) |
|
probably null |
Het |
| Mical3 |
C |
T |
6: 121,001,768 (GRCm39) |
V575M |
probably damaging |
Het |
| Mki67 |
A |
T |
7: 135,310,547 (GRCm39) |
|
probably null |
Het |
| Mocs2 |
G |
A |
13: 114,961,158 (GRCm39) |
E52K |
probably benign |
Het |
| Myo7b |
T |
C |
18: 32,133,104 (GRCm39) |
N415S |
probably damaging |
Het |
| Notch1 |
G |
A |
2: 26,368,624 (GRCm39) |
T555I |
possibly damaging |
Het |
| Notch3 |
T |
C |
17: 32,358,165 (GRCm39) |
D1686G |
probably benign |
Het |
| Oit3 |
A |
G |
10: 59,264,061 (GRCm39) |
F358L |
probably damaging |
Het |
| Or10x1 |
A |
C |
1: 174,196,515 (GRCm39) |
I11L |
probably benign |
Het |
| Or6k4 |
A |
T |
1: 173,964,883 (GRCm39) |
D191V |
probably damaging |
Het |
| Orai1 |
T |
A |
5: 123,167,265 (GRCm39) |
I146N |
probably damaging |
Het |
| Pck1 |
A |
G |
2: 172,996,511 (GRCm39) |
I142V |
probably benign |
Het |
| Pdap1 |
C |
T |
5: 145,069,739 (GRCm39) |
V89M |
possibly damaging |
Het |
| Phf11a |
T |
C |
14: 59,525,000 (GRCm39) |
D68G |
possibly damaging |
Het |
| Pilrb2 |
T |
C |
5: 137,869,510 (GRCm39) |
N30S |
probably damaging |
Het |
| Pkd1 |
G |
A |
17: 24,797,243 (GRCm39) |
V2551I |
probably damaging |
Het |
| Pnpla7 |
T |
C |
2: 24,942,611 (GRCm39) |
V132A |
probably damaging |
Het |
| Prr35 |
G |
A |
17: 26,166,508 (GRCm39) |
P343L |
probably benign |
Het |
| Rad18 |
C |
T |
6: 112,605,480 (GRCm39) |
S398N |
probably damaging |
Het |
| Rdh16f1 |
C |
A |
10: 127,626,722 (GRCm39) |
N258K |
probably benign |
Het |
| Riox2 |
A |
G |
16: 59,303,405 (GRCm39) |
H240R |
probably damaging |
Het |
| Ruvbl1 |
C |
T |
6: 88,462,752 (GRCm39) |
A292V |
probably damaging |
Het |
| Ryr1 |
C |
T |
7: 28,794,915 (GRCm39) |
G1151S |
probably damaging |
Het |
| Serpinb9b |
T |
C |
13: 33,213,548 (GRCm39) |
I35T |
possibly damaging |
Het |
| Slc1a1 |
T |
A |
19: 28,882,122 (GRCm39) |
M328K |
probably benign |
Het |
| Slc7a13 |
A |
T |
4: 19,824,031 (GRCm39) |
T267S |
possibly damaging |
Het |
| Speer3 |
G |
T |
5: 13,846,335 (GRCm39) |
M218I |
probably benign |
Het |
| Sptan1 |
A |
G |
2: 29,876,432 (GRCm39) |
I271V |
probably damaging |
Het |
| Swap70 |
A |
G |
7: 109,863,255 (GRCm39) |
T195A |
probably benign |
Het |
| Tgs1 |
T |
A |
4: 3,585,964 (GRCm39) |
N280K |
probably benign |
Het |
| Tonsl |
A |
G |
15: 76,522,709 (GRCm39) |
C181R |
probably damaging |
Het |
| Trdn |
A |
G |
10: 33,134,098 (GRCm39) |
K333R |
possibly damaging |
Het |
| Trpc4 |
T |
A |
3: 54,206,600 (GRCm39) |
M600K |
probably damaging |
Het |
| Ubr3 |
C |
T |
2: 69,808,067 (GRCm39) |
Q1183* |
probably null |
Het |
| Ubxn4 |
T |
A |
1: 128,200,588 (GRCm39) |
L360I |
possibly damaging |
Het |
| Ugt2b1 |
T |
A |
5: 87,074,267 (GRCm39) |
T31S |
probably benign |
Het |
| Uspl1 |
T |
C |
5: 149,152,009 (GRCm39) |
S1056P |
probably damaging |
Het |
| Vwce |
T |
A |
19: 10,624,108 (GRCm39) |
L333* |
probably null |
Het |
| Wdr95 |
T |
A |
5: 149,497,581 (GRCm39) |
L253Q |
probably damaging |
Het |
| Zfp113 |
T |
C |
5: 138,143,930 (GRCm39) |
M107V |
probably benign |
Het |
| Zfp142 |
T |
C |
1: 74,610,934 (GRCm39) |
T851A |
possibly damaging |
Het |
|
| Other mutations in Vmn2r60 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01622:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01623:Vmn2r60
|
APN |
7 |
41,785,910 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02363:Vmn2r60
|
APN |
7 |
41,844,578 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02485:Vmn2r60
|
APN |
7 |
41,844,890 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
IGL02651:Vmn2r60
|
APN |
7 |
41,845,010 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02660:Vmn2r60
|
APN |
7 |
41,791,720 (GRCm39) |
nonsense |
probably null |
|
|
IGL03135:Vmn2r60
|
APN |
7 |
41,786,018 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03307:Vmn2r60
|
APN |
7 |
41,765,971 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0310:Vmn2r60
|
UTSW |
7 |
41,844,564 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R0314:Vmn2r60
|
UTSW |
7 |
41,784,985 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r60
|
UTSW |
7 |
41,791,744 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Vmn2r60
|
UTSW |
7 |
41,785,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0755:Vmn2r60
|
UTSW |
7 |
41,844,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1119:Vmn2r60
|
UTSW |
7 |
41,844,365 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1162:Vmn2r60
|
UTSW |
7 |
41,845,195 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1241:Vmn2r60
|
UTSW |
7 |
41,786,476 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1404:Vmn2r60
|
UTSW |
7 |
41,786,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1488:Vmn2r60
|
UTSW |
7 |
41,786,137 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1628:Vmn2r60
|
UTSW |
7 |
41,785,830 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1884:Vmn2r60
|
UTSW |
7 |
41,786,094 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2182:Vmn2r60
|
UTSW |
7 |
41,844,931 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2275:Vmn2r60
|
UTSW |
7 |
41,786,251 (GRCm39) |
nonsense |
probably null |
|
|
R2847:Vmn2r60
|
UTSW |
7 |
41,785,857 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2885:Vmn2r60
|
UTSW |
7 |
41,790,403 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2894:Vmn2r60
|
UTSW |
7 |
41,785,220 (GRCm39) |
missense |
probably benign |
|
|
R2921:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2922:Vmn2r60
|
UTSW |
7 |
41,790,459 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3772:Vmn2r60
|
UTSW |
7 |
41,765,980 (GRCm39) |
missense |
probably benign |
0.35 |
|
R3820:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3822:Vmn2r60
|
UTSW |
7 |
41,785,125 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3872:Vmn2r60
|
UTSW |
7 |
41,785,878 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4222:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4223:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4224:Vmn2r60
|
UTSW |
7 |
41,765,952 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4526:Vmn2r60
|
UTSW |
7 |
41,844,667 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4547:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R4840:Vmn2r60
|
UTSW |
7 |
41,785,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5173:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5231:Vmn2r60
|
UTSW |
7 |
41,786,448 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5480:Vmn2r60
|
UTSW |
7 |
41,785,154 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5521:Vmn2r60
|
UTSW |
7 |
41,845,049 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5834:Vmn2r60
|
UTSW |
7 |
41,765,932 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6038:Vmn2r60
|
UTSW |
7 |
41,844,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6112:Vmn2r60
|
UTSW |
7 |
41,844,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6149:Vmn2r60
|
UTSW |
7 |
41,786,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6170:Vmn2r60
|
UTSW |
7 |
41,785,045 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6383:Vmn2r60
|
UTSW |
7 |
41,765,895 (GRCm39) |
start codon destroyed |
probably null |
0.04 |
|
R6811:Vmn2r60
|
UTSW |
7 |
41,844,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6876:Vmn2r60
|
UTSW |
7 |
41,785,087 (GRCm39) |
missense |
probably null |
0.54 |
|
R6997:Vmn2r60
|
UTSW |
7 |
41,791,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7040:Vmn2r60
|
UTSW |
7 |
41,791,666 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7116:Vmn2r60
|
UTSW |
7 |
41,786,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Vmn2r60
|
UTSW |
7 |
41,844,536 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7232:Vmn2r60
|
UTSW |
7 |
41,786,166 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7296:Vmn2r60
|
UTSW |
7 |
41,785,826 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7376:Vmn2r60
|
UTSW |
7 |
41,844,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7526:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7527:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7528:Vmn2r60
|
UTSW |
7 |
41,845,158 (GRCm39) |
frame shift |
probably null |
|
|
R7764:Vmn2r60
|
UTSW |
7 |
41,844,535 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7843:Vmn2r60
|
UTSW |
7 |
41,844,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8080:Vmn2r60
|
UTSW |
7 |
41,790,521 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8290:Vmn2r60
|
UTSW |
7 |
41,791,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8342:Vmn2r60
|
UTSW |
7 |
41,790,494 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8362:Vmn2r60
|
UTSW |
7 |
41,844,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8418:Vmn2r60
|
UTSW |
7 |
41,844,850 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8848:Vmn2r60
|
UTSW |
7 |
41,786,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8860:Vmn2r60
|
UTSW |
7 |
41,791,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8882:Vmn2r60
|
UTSW |
7 |
41,790,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8913:Vmn2r60
|
UTSW |
7 |
41,785,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9190:Vmn2r60
|
UTSW |
7 |
41,844,935 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9229:Vmn2r60
|
UTSW |
7 |
41,791,723 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9295:Vmn2r60
|
UTSW |
7 |
41,785,955 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9335:Vmn2r60
|
UTSW |
7 |
41,844,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9796:Vmn2r60
|
UTSW |
7 |
41,785,172 (GRCm39) |
missense |
probably benign |
|
|
RF024:Vmn2r60
|
UTSW |
7 |
41,790,363 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Vmn2r60
|
UTSW |
7 |
41,790,538 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGGAACCCTGATCTTCTACCCAAT -3'
(R):5'- AGACTATGGCAAATGGCAGAGATGTG -3'
Sequencing Primer
(F):5'- ACCCTGATCTTCTACCCAATATAAC -3'
(R):5'- TGGCATCAGACAAAATCCTAGTG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation