Incidental Mutation 'R1624:Cdh11'
ID 174892
Institutional Source Beutler Lab
Gene Symbol Cdh11
Ensembl Gene ENSMUSG00000031673
Gene Name cadherin 11
Synonyms Cad11, osteoblast-cadherin, OB-cadherin
MMRRC Submission 039661-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1624 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 103358727-103512125 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 103391233 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000074681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075190]
AlphaFold P55288
PDB Structure Crystal structure of mouse cadherin-11 EC1 [X-RAY DIFFRACTION]
Crystal structure of mouse cadherin-11 EC1-2 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000075190
SMART Domains Protein: ENSMUSP00000074681
Gene: ENSMUSG00000031673

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
CA 76 157 1.99e-19 SMART
CA 181 266 3.33e-30 SMART
CA 290 382 3.37e-17 SMART
CA 405 486 1.14e-23 SMART
CA 513 600 4.77e-8 SMART
transmembrane domain 618 640 N/A INTRINSIC
Pfam:Cadherin_C 643 788 1.1e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210425
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 95.9%
  • 20x: 91.4%
Validation Efficiency 99% (90/91)
MGI Phenotype FUNCTION: This gene encodes a type II classical cadherin and preproprotein that is proteolytically processed to generate a mature protein product. This protein product is an integral membrane protein that mediates calcium-dependent cell-cell adhesion, specifically in the context of bone development. Homozygous knockout mice for this gene exhibit impaired synovium development and reduced bone density. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]
PHENOTYPE: Homozygous mutant animals appear healthy and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510009E07Rik T C 16: 21,472,496 (GRCm39) Y68C probably damaging Het
6820408C15Rik A T 2: 152,276,031 (GRCm39) H81L probably damaging Het
Acbd4 A G 11: 102,994,785 (GRCm39) T48A probably damaging Het
Acp3 T A 9: 104,197,200 (GRCm39) E146D probably benign Het
Acsm1 T A 7: 119,251,796 (GRCm39) I307N probably damaging Het
Adcy4 T C 14: 56,019,384 (GRCm39) T89A possibly damaging Het
Agl T C 3: 116,580,895 (GRCm39) T356A probably benign Het
Ago1 A G 4: 126,357,534 (GRCm39) I47T probably damaging Het
Akr1c6 T A 13: 4,496,363 (GRCm39) Y75N probably benign Het
Anxa2 T A 9: 69,386,990 (GRCm39) S92T probably benign Het
Arid4b T C 13: 14,358,979 (GRCm39) S585P probably damaging Het
Arl4d T C 11: 101,557,842 (GRCm39) S123P possibly damaging Het
Atad2 A T 15: 57,963,415 (GRCm39) D1067E probably damaging Het
Brap C A 5: 121,820,922 (GRCm39) T403K possibly damaging Het
Brwd1 A T 16: 95,809,344 (GRCm39) N1895K possibly damaging Het
Ccdc187 T C 2: 26,171,087 (GRCm39) T464A probably benign Het
Ccn6 G A 10: 39,029,239 (GRCm39) R230W probably damaging Het
Chd9 A T 8: 91,725,163 (GRCm39) Y691F probably benign Het
Clhc1 A T 11: 29,519,287 (GRCm39) I365F possibly damaging Het
Col11a1 A G 3: 113,951,804 (GRCm39) Q1078R probably damaging Het
Creb3 G A 4: 43,566,375 (GRCm39) V294I possibly damaging Het
Cspg4 T C 9: 56,795,754 (GRCm39) I1163T probably damaging Het
Cyp3a57 A C 5: 145,327,225 (GRCm39) probably null Het
Dnah3 A T 7: 119,618,918 (GRCm39) I1661N probably damaging Het
Dpysl4 A C 7: 138,669,469 (GRCm39) D49A probably damaging Het
Efhb T A 17: 53,733,306 (GRCm39) I522F probably damaging Het
Epha4 T C 1: 77,376,329 (GRCm39) T517A probably damaging Het
Fasn A G 11: 120,703,937 (GRCm39) S1466P probably damaging Het
Fgd6 A T 10: 93,973,298 (GRCm39) D1253V probably benign Het
Fjx1 G A 2: 102,281,509 (GRCm39) A142V probably benign Het
Foxb1 T C 9: 69,666,598 (GRCm39) T311A probably benign Het
Fpgs A G 2: 32,581,200 (GRCm39) probably null Het
Gm10024 A G 10: 77,547,606 (GRCm39) probably null Het
Gnat3 A T 5: 18,208,841 (GRCm39) T182S possibly damaging Het
Igsf3 T A 3: 101,362,543 (GRCm39) F875I probably benign Het
Kif13b A G 14: 64,976,068 (GRCm39) E461G probably damaging Het
Kif23 A T 9: 61,832,982 (GRCm39) probably null Het
Kntc1 G A 5: 123,896,540 (GRCm39) R134Q possibly damaging Het
Krt33a A T 11: 99,905,072 (GRCm39) Y145N probably damaging Het
Lama5 A G 2: 179,848,551 (GRCm39) V313A probably benign Het
Lamb1 T C 12: 31,328,651 (GRCm39) probably null Het
Megf6 G T 4: 154,261,578 (GRCm39) V68L probably benign Het
Mtor C T 4: 148,632,133 (GRCm39) L2336F probably damaging Het
Naglu T C 11: 100,967,351 (GRCm39) S434P probably damaging Het
Ncoa7 T A 10: 30,580,655 (GRCm39) H101L possibly damaging Het
Nlrc4 G A 17: 74,752,184 (GRCm39) T733I possibly damaging Het
Nr3c2 A G 8: 77,636,573 (GRCm39) E558G probably damaging Het
Nsun4 A T 4: 115,891,397 (GRCm39) N327K probably benign Het
Or11g27 A G 14: 50,771,100 (GRCm39) Y77C probably damaging Het
Or1x2 T C 11: 50,917,952 (GRCm39) V41A probably damaging Het
Or2m13 T A 16: 19,226,454 (GRCm39) Y104F probably benign Het
Or4f6 T A 2: 111,838,877 (GRCm39) Y218F probably damaging Het
Or6b13 T C 7: 139,781,864 (GRCm39) N273S probably damaging Het
Pdia2 T A 17: 26,415,495 (GRCm39) I441F probably damaging Het
Phyh T C 2: 4,930,494 (GRCm39) S74P probably benign Het
Pigo A G 4: 43,024,661 (GRCm39) L146P probably damaging Het
Plce1 A G 19: 38,713,219 (GRCm39) D1191G probably damaging Het
Plrg1 T C 3: 82,975,301 (GRCm39) probably benign Het
Plrg1 G A 3: 82,977,051 (GRCm39) R364Q probably damaging Het
Polr3b T C 10: 84,515,669 (GRCm39) L614S probably damaging Het
Pramel16 A T 4: 143,676,400 (GRCm39) C235S possibly damaging Het
Prrg4 A G 2: 104,663,027 (GRCm39) V193A probably damaging Het
Prss16 T A 13: 22,187,483 (GRCm39) E47V probably benign Het
Ptpru G A 4: 131,499,861 (GRCm39) T1261I probably damaging Het
Pycard A G 7: 127,591,970 (GRCm39) S124P possibly damaging Het
Riok1 C A 13: 38,221,487 (GRCm39) D17E probably damaging Het
Scin T A 12: 40,177,929 (GRCm39) Y102F probably benign Het
Scmh1 A G 4: 120,386,425 (GRCm39) H655R probably damaging Het
Scyl2 A T 10: 89,476,598 (GRCm39) N842K probably benign Het
Sec23b T A 2: 144,409,049 (GRCm39) M211K probably benign Het
Serpina3i A C 12: 104,234,897 (GRCm39) *409C probably null Het
Sgk2 G A 2: 162,839,779 (GRCm39) R129H probably benign Het
Slc39a13 A G 2: 90,898,871 (GRCm39) I80T probably damaging Het
Smarcad1 A G 6: 65,029,631 (GRCm39) D73G probably benign Het
Spata18 A C 5: 73,826,888 (GRCm39) T276P probably damaging Het
Srgap1 T G 10: 121,691,278 (GRCm39) M319L probably benign Het
Stx7 T A 10: 24,060,903 (GRCm39) V210E probably damaging Het
Tjp2 T A 19: 24,108,776 (GRCm39) H112L probably benign Het
Tuba8 A T 6: 121,197,385 (GRCm39) I16F probably damaging Het
Ube3c G A 5: 29,851,617 (GRCm39) A815T probably benign Het
Vmn2r5 A T 3: 64,417,116 (GRCm39) V14E probably benign Het
Vmn2r79 A T 7: 86,653,247 (GRCm39) probably null Het
Zdbf2 A G 1: 63,343,018 (GRCm39) T466A possibly damaging Het
Other mutations in Cdh11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00598:Cdh11 APN 8 103,377,281 (GRCm39) missense probably damaging 1.00
IGL01019:Cdh11 APN 8 103,406,377 (GRCm39) missense probably benign
IGL01286:Cdh11 APN 8 103,391,261 (GRCm39) missense probably damaging 0.98
IGL01556:Cdh11 APN 8 103,406,276 (GRCm39) missense probably damaging 1.00
IGL01964:Cdh11 APN 8 103,391,375 (GRCm39) missense probably benign 0.03
IGL02322:Cdh11 APN 8 103,374,151 (GRCm39) missense probably benign 0.01
IGL03094:Cdh11 APN 8 103,385,035 (GRCm39) missense probably benign
IGL03110:Cdh11 APN 8 103,400,502 (GRCm39) missense probably damaging 1.00
IGL03391:Cdh11 APN 8 103,400,655 (GRCm39) missense possibly damaging 0.89
R0401:Cdh11 UTSW 8 103,400,638 (GRCm39) missense probably damaging 1.00
R0466:Cdh11 UTSW 8 103,396,690 (GRCm39) missense possibly damaging 0.89
R0731:Cdh11 UTSW 8 103,394,651 (GRCm39) missense probably damaging 1.00
R0925:Cdh11 UTSW 8 103,361,356 (GRCm39) missense probably damaging 1.00
R1597:Cdh11 UTSW 8 103,377,343 (GRCm39) missense probably benign 0.06
R1829:Cdh11 UTSW 8 103,361,273 (GRCm39) missense possibly damaging 0.92
R2029:Cdh11 UTSW 8 103,406,404 (GRCm39) missense probably benign 0.00
R4191:Cdh11 UTSW 8 103,377,380 (GRCm39) missense probably damaging 0.98
R4270:Cdh11 UTSW 8 103,391,258 (GRCm39) missense possibly damaging 0.69
R4271:Cdh11 UTSW 8 103,391,258 (GRCm39) missense possibly damaging 0.69
R4455:Cdh11 UTSW 8 103,374,455 (GRCm39) missense probably benign
R4516:Cdh11 UTSW 8 103,400,594 (GRCm39) missense possibly damaging 0.59
R4900:Cdh11 UTSW 8 103,374,090 (GRCm39) splice site probably null
R5441:Cdh11 UTSW 8 103,374,178 (GRCm39) missense probably benign 0.11
R5699:Cdh11 UTSW 8 103,361,175 (GRCm39) missense probably damaging 0.96
R6170:Cdh11 UTSW 8 103,361,442 (GRCm39) missense probably benign 0.00
R6846:Cdh11 UTSW 8 103,391,276 (GRCm39) missense probably damaging 0.97
R7018:Cdh11 UTSW 8 103,360,953 (GRCm39) missense possibly damaging 0.82
R7095:Cdh11 UTSW 8 103,384,899 (GRCm39) missense probably damaging 1.00
R7497:Cdh11 UTSW 8 103,400,456 (GRCm39) missense probably benign 0.00
R7632:Cdh11 UTSW 8 103,400,515 (GRCm39) missense probably damaging 0.99
R7715:Cdh11 UTSW 8 103,391,346 (GRCm39) missense possibly damaging 0.66
R8321:Cdh11 UTSW 8 103,361,416 (GRCm39) missense probably damaging 0.99
R8529:Cdh11 UTSW 8 103,391,387 (GRCm39) missense probably benign 0.01
R8530:Cdh11 UTSW 8 103,391,387 (GRCm39) missense probably benign 0.01
R8682:Cdh11 UTSW 8 103,377,348 (GRCm39) missense probably benign 0.24
R9105:Cdh11 UTSW 8 103,360,968 (GRCm39) missense probably damaging 0.99
R9404:Cdh11 UTSW 8 103,406,254 (GRCm39) missense probably damaging 1.00
R9660:Cdh11 UTSW 8 103,384,879 (GRCm39) missense possibly damaging 0.70
R9684:Cdh11 UTSW 8 103,391,327 (GRCm39) missense probably benign 0.04
R9721:Cdh11 UTSW 8 103,406,257 (GRCm39) missense probably damaging 1.00
R9802:Cdh11 UTSW 8 103,391,276 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TCCTCAGAGTTCAAGCCTTAGCCAC -3'
(R):5'- TGACCTCATCATCTTACCAGGACCC -3'

Sequencing Primer
(F):5'- GTTCAAGCCTTAGCCACAAATTG -3'
(R):5'- GTAAGGAACACATTCTTCCTGC -3'
Posted On 2014-04-24