Incidental Mutation 'R1625:Kif21a'
| ID |
175003 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif21a
|
| Ensembl Gene |
ENSMUSG00000022629 |
| Gene Name |
kinesin family member 21A |
| Synonyms |
N-5 kinesin |
| MMRRC Submission |
039662-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R1625 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
90817479-90934151 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 90826378 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1360
(S1360P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000066911
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000067205]
[ENSMUST00000088614]
[ENSMUST00000100304]
[ENSMUST00000109287]
[ENSMUST00000109288]
[ENSMUST00000229801]
|
| AlphaFold |
Q9QXL2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000067205
AA Change: S1360P
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000066911
Gene: ENSMUSG00000022629
AA Change: S1360P
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1234 |
N/A |
INTRINSIC |
|
low complexity region
|
1251 |
1271 |
N/A |
INTRINSIC |
|
WD40
|
1290 |
1327 |
1.21e-7 |
SMART |
|
WD40
|
1330 |
1368 |
7.28e-2 |
SMART |
|
WD40
|
1394 |
1432 |
3.33e-1 |
SMART |
|
WD40
|
1435 |
1477 |
7e-4 |
SMART |
|
WD40
|
1485 |
1523 |
2.4e-1 |
SMART |
|
WD40
|
1527 |
1566 |
1.48e-2 |
SMART |
|
WD40
|
1569 |
1606 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000088614
AA Change: S1404P
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000085985
Gene: ENSMUSG00000022629
AA Change: S1404P
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1114 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100304
AA Change: S1404P
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000097877
Gene: ENSMUSG00000022629
AA Change: S1404P
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
1e-8 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
564 |
N/A |
INTRINSIC |
|
low complexity region
|
584 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
602 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
713 |
726 |
N/A |
INTRINSIC |
|
coiled coil region
|
937 |
1021 |
N/A |
INTRINSIC |
|
coiled coil region
|
1056 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1271 |
1283 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1316 |
N/A |
INTRINSIC |
|
WD40
|
1334 |
1371 |
1.21e-7 |
SMART |
|
WD40
|
1374 |
1412 |
7.28e-2 |
SMART |
|
WD40
|
1438 |
1476 |
3.33e-1 |
SMART |
|
WD40
|
1479 |
1521 |
7e-4 |
SMART |
|
WD40
|
1529 |
1567 |
2.4e-1 |
SMART |
|
WD40
|
1571 |
1610 |
1.48e-2 |
SMART |
|
WD40
|
1613 |
1650 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109287
AA Change: S1299P
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104910
Gene: ENSMUSG00000022629
AA Change: S1299P
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1101 |
1112 |
N/A |
INTRINSIC |
|
WD40
|
1229 |
1266 |
1.21e-7 |
SMART |
|
WD40
|
1269 |
1307 |
7.28e-2 |
SMART |
|
WD40
|
1333 |
1371 |
3.33e-1 |
SMART |
|
WD40
|
1374 |
1416 |
7e-4 |
SMART |
|
WD40
|
1424 |
1462 |
2.4e-1 |
SMART |
|
WD40
|
1466 |
1505 |
1.48e-2 |
SMART |
|
WD40
|
1508 |
1545 |
2.07e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109288
AA Change: S1305P
PolyPhen 2
Score 0.827 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000104911
Gene: ENSMUSG00000022629
AA Change: S1305P
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
7 |
379 |
8.97e-163 |
SMART |
|
Blast:KISc
|
469 |
513 |
9e-9 |
BLAST |
|
low complexity region
|
514 |
525 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
557 |
N/A |
INTRINSIC |
|
low complexity region
|
571 |
585 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
628 |
N/A |
INTRINSIC |
|
low complexity region
|
700 |
713 |
N/A |
INTRINSIC |
|
coiled coil region
|
924 |
1008 |
N/A |
INTRINSIC |
|
coiled coil region
|
1043 |
1066 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1216 |
N/A |
INTRINSIC |
|
WD40
|
1235 |
1272 |
1.21e-7 |
SMART |
|
WD40
|
1275 |
1313 |
7.28e-2 |
SMART |
|
WD40
|
1339 |
1377 |
3.33e-1 |
SMART |
|
WD40
|
1380 |
1422 |
7e-4 |
SMART |
|
WD40
|
1430 |
1468 |
2.4e-1 |
SMART |
|
WD40
|
1472 |
1511 |
1.48e-2 |
SMART |
|
WD40
|
1514 |
1551 |
2.07e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000229801
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000230487
AA Change: S106P
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.3%
- 20x: 89.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
T |
A |
11: 109,857,947 (GRCm39) |
M605L |
probably benign |
Het |
| Abcc5 |
A |
T |
16: 20,184,567 (GRCm39) |
S1031T |
probably damaging |
Het |
| Acot7 |
T |
A |
4: 152,270,748 (GRCm39) |
C31S |
probably benign |
Het |
| Acss3 |
A |
T |
10: 106,773,263 (GRCm39) |
|
probably null |
Het |
| Adipor1 |
T |
C |
1: 134,351,802 (GRCm39) |
F83S |
possibly damaging |
Het |
| Agrn |
G |
A |
4: 156,257,317 (GRCm39) |
S1171L |
probably damaging |
Het |
| Aoc1l1 |
T |
A |
6: 48,952,105 (GRCm39) |
L10Q |
probably damaging |
Het |
| Arhgap5 |
T |
A |
12: 52,564,159 (GRCm39) |
C377S |
probably benign |
Het |
| Arid4b |
T |
A |
13: 14,361,699 (GRCm39) |
V721D |
probably damaging |
Het |
| Aspm |
G |
A |
1: 139,408,777 (GRCm39) |
A2555T |
probably benign |
Het |
| Atp6v0a1 |
T |
A |
11: 100,946,380 (GRCm39) |
L791Q |
probably damaging |
Het |
| Car11 |
A |
G |
7: 45,350,731 (GRCm39) |
K76E |
probably benign |
Het |
| Casp8ap2 |
T |
A |
4: 32,648,068 (GRCm39) |
M1925K |
probably benign |
Het |
| Cc2d1a |
A |
T |
8: 84,866,001 (GRCm39) |
L418Q |
probably damaging |
Het |
| Ccl9 |
G |
A |
11: 83,466,736 (GRCm39) |
R64W |
probably damaging |
Het |
| Cfap20dc |
A |
G |
14: 8,431,668 (GRCm38) |
Y655H |
probably damaging |
Het |
| Cfap43 |
T |
A |
19: 47,739,527 (GRCm39) |
K1325N |
probably damaging |
Het |
| Dars2 |
G |
A |
1: 160,881,614 (GRCm39) |
P305L |
possibly damaging |
Het |
| Ddx11 |
C |
T |
17: 66,457,692 (GRCm39) |
T859I |
probably benign |
Het |
| Dock7 |
C |
T |
4: 98,850,433 (GRCm39) |
|
probably null |
Het |
| Efcab6 |
A |
G |
15: 83,831,839 (GRCm39) |
V570A |
probably benign |
Het |
| Fermt1 |
T |
A |
2: 132,764,751 (GRCm39) |
I369F |
probably damaging |
Het |
| Fras1 |
A |
G |
5: 96,861,849 (GRCm39) |
Y2161C |
probably damaging |
Het |
| Fras1 |
C |
A |
5: 96,857,837 (GRCm39) |
P2044T |
possibly damaging |
Het |
| Gucy1a1 |
T |
C |
3: 82,009,362 (GRCm39) |
I549V |
probably benign |
Het |
| Hspg2 |
G |
A |
4: 137,246,282 (GRCm39) |
S1020N |
probably benign |
Het |
| Lrp3 |
T |
C |
7: 34,903,350 (GRCm39) |
Y332C |
probably damaging |
Het |
| Ltc4s |
C |
A |
11: 50,128,215 (GRCm39) |
A32S |
possibly damaging |
Het |
| Mgrn1 |
T |
C |
16: 4,728,627 (GRCm39) |
L84P |
probably damaging |
Het |
| Muc2 |
C |
G |
7: 141,283,405 (GRCm39) |
C672W |
probably damaging |
Het |
| Mvp |
A |
T |
7: 126,600,845 (GRCm39) |
V52E |
probably damaging |
Het |
| Ndrg2 |
T |
C |
14: 52,144,420 (GRCm39) |
T269A |
probably damaging |
Het |
| Notch2 |
T |
A |
3: 98,018,891 (GRCm39) |
D684E |
probably damaging |
Het |
| Nup205 |
A |
G |
6: 35,168,878 (GRCm39) |
D316G |
probably benign |
Het |
| Or12e7 |
T |
A |
2: 87,288,016 (GRCm39) |
I169K |
probably damaging |
Het |
| Or2v2 |
T |
C |
11: 49,004,071 (GRCm39) |
M161V |
probably benign |
Het |
| Or7d11 |
A |
G |
9: 19,966,678 (GRCm39) |
L27P |
probably damaging |
Het |
| Pcsk1 |
A |
T |
13: 75,274,971 (GRCm39) |
D520V |
probably benign |
Het |
| Pik3cg |
A |
T |
12: 32,244,741 (GRCm39) |
D904E |
probably damaging |
Het |
| Pitpnm2 |
T |
A |
5: 124,271,496 (GRCm39) |
D359V |
probably benign |
Het |
| Ppih |
T |
C |
4: 119,175,779 (GRCm39) |
I69V |
probably damaging |
Het |
| Rab11fip3 |
T |
C |
17: 26,287,865 (GRCm39) |
E96G |
possibly damaging |
Het |
| Retreg3 |
C |
A |
11: 100,992,875 (GRCm39) |
M1I |
probably null |
Het |
| Rfpl4 |
C |
T |
7: 5,118,409 (GRCm39) |
V54I |
possibly damaging |
Het |
| Rif1 |
T |
C |
2: 51,993,652 (GRCm39) |
I855T |
probably benign |
Het |
| Rrm1 |
T |
A |
7: 102,117,554 (GRCm39) |
I748N |
probably damaging |
Het |
| Sap130 |
T |
A |
18: 31,807,517 (GRCm39) |
N441K |
probably damaging |
Het |
| Sf3b1 |
T |
A |
1: 55,058,536 (GRCm39) |
I18F |
probably damaging |
Het |
| Skor2 |
A |
G |
18: 76,946,499 (GRCm39) |
N74D |
unknown |
Het |
| Slc17a6 |
C |
A |
7: 51,311,208 (GRCm39) |
F307L |
probably benign |
Het |
| Slc25a13 |
G |
A |
6: 6,096,675 (GRCm39) |
L410F |
probably damaging |
Het |
| Slc47a1 |
A |
T |
11: 61,262,625 (GRCm39) |
V38E |
probably damaging |
Het |
| Slc8a1 |
T |
A |
17: 81,956,670 (GRCm39) |
T123S |
probably damaging |
Het |
| Slc9a5 |
C |
A |
8: 106,094,755 (GRCm39) |
T782K |
possibly damaging |
Het |
| Spmip7 |
C |
A |
11: 11,438,644 (GRCm39) |
|
probably benign |
Het |
| Sppl2c |
C |
A |
11: 104,077,995 (GRCm39) |
T265K |
probably damaging |
Het |
| Srfbp1 |
A |
G |
18: 52,621,788 (GRCm39) |
K283R |
probably benign |
Het |
| Ssr1 |
C |
T |
13: 38,173,479 (GRCm39) |
|
probably null |
Het |
| Stard3nl |
T |
C |
13: 19,556,754 (GRCm39) |
|
probably null |
Het |
| Timeless |
G |
T |
10: 128,076,493 (GRCm39) |
S134I |
probably damaging |
Het |
| Tll1 |
A |
G |
8: 64,494,476 (GRCm39) |
F760L |
probably damaging |
Het |
| Tspear |
A |
G |
10: 77,706,333 (GRCm39) |
I368V |
probably benign |
Het |
| Txnrd2 |
G |
T |
16: 18,257,116 (GRCm39) |
W144L |
probably damaging |
Het |
| Unc5d |
T |
C |
8: 29,173,234 (GRCm39) |
E668G |
probably damaging |
Het |
| Urb1 |
C |
T |
16: 90,570,936 (GRCm39) |
|
probably null |
Het |
| Uts2r |
A |
G |
11: 121,052,033 (GRCm39) |
Y299C |
probably damaging |
Het |
| Vmn1r66 |
G |
T |
7: 10,008,316 (GRCm39) |
T239K |
probably benign |
Het |
| Vps39 |
C |
T |
2: 120,154,106 (GRCm39) |
V630M |
probably damaging |
Het |
| Wrn |
T |
C |
8: 33,819,158 (GRCm39) |
T22A |
probably benign |
Het |
| Zfp7 |
T |
A |
15: 76,765,374 (GRCm39) |
D22E |
probably damaging |
Het |
|
| Other mutations in Kif21a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00539:Kif21a
|
APN |
15 |
90,821,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01476:Kif21a
|
APN |
15 |
90,828,067 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL01617:Kif21a
|
APN |
15 |
90,879,840 (GRCm39) |
splice site |
probably benign |
|
|
IGL01736:Kif21a
|
APN |
15 |
90,843,948 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL01923:Kif21a
|
APN |
15 |
90,840,633 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01985:Kif21a
|
APN |
15 |
90,875,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02304:Kif21a
|
APN |
15 |
90,849,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02589:Kif21a
|
APN |
15 |
90,869,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kif21a
|
APN |
15 |
90,869,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03211:Kif21a
|
APN |
15 |
90,882,166 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03372:Kif21a
|
APN |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
reflex
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0052:Kif21a
|
UTSW |
15 |
90,855,060 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0304:Kif21a
|
UTSW |
15 |
90,860,724 (GRCm39) |
splice site |
probably null |
|
|
R0378:Kif21a
|
UTSW |
15 |
90,853,977 (GRCm39) |
splice site |
probably null |
|
|
R0420:Kif21a
|
UTSW |
15 |
90,852,257 (GRCm39) |
unclassified |
probably benign |
|
|
R0536:Kif21a
|
UTSW |
15 |
90,843,886 (GRCm39) |
splice site |
probably benign |
|
|
R0826:Kif21a
|
UTSW |
15 |
90,881,744 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0971:Kif21a
|
UTSW |
15 |
90,824,784 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1052:Kif21a
|
UTSW |
15 |
90,819,853 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1168:Kif21a
|
UTSW |
15 |
90,877,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1324:Kif21a
|
UTSW |
15 |
90,832,525 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1471:Kif21a
|
UTSW |
15 |
90,840,622 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1636:Kif21a
|
UTSW |
15 |
90,869,008 (GRCm39) |
splice site |
probably benign |
|
|
R1647:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Kif21a
|
UTSW |
15 |
90,878,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1699:Kif21a
|
UTSW |
15 |
90,843,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1703:Kif21a
|
UTSW |
15 |
90,833,250 (GRCm39) |
splice site |
probably null |
|
|
R1795:Kif21a
|
UTSW |
15 |
90,856,930 (GRCm39) |
splice site |
probably null |
|
|
R1812:Kif21a
|
UTSW |
15 |
90,855,969 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1959:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1960:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1961:Kif21a
|
UTSW |
15 |
90,855,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Kif21a
|
UTSW |
15 |
90,878,574 (GRCm39) |
nonsense |
probably null |
|
|
R2230:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2231:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2232:Kif21a
|
UTSW |
15 |
90,869,565 (GRCm39) |
nonsense |
probably null |
|
|
R2424:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2429:Kif21a
|
UTSW |
15 |
90,882,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Kif21a
|
UTSW |
15 |
90,878,594 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2846:Kif21a
|
UTSW |
15 |
90,818,667 (GRCm39) |
missense |
probably benign |
|
|
R3027:Kif21a
|
UTSW |
15 |
90,856,845 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Kif21a
|
UTSW |
15 |
90,849,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3820:Kif21a
|
UTSW |
15 |
90,852,277 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3923:Kif21a
|
UTSW |
15 |
90,821,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3962:Kif21a
|
UTSW |
15 |
90,869,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Kif21a
|
UTSW |
15 |
90,855,036 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4516:Kif21a
|
UTSW |
15 |
90,855,345 (GRCm39) |
missense |
probably benign |
0.38 |
|
R4530:Kif21a
|
UTSW |
15 |
90,852,292 (GRCm39) |
splice site |
probably null |
|
|
R4612:Kif21a
|
UTSW |
15 |
90,852,426 (GRCm39) |
splice site |
probably null |
|
|
R4674:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4675:Kif21a
|
UTSW |
15 |
90,824,748 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4698:Kif21a
|
UTSW |
15 |
90,840,508 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4712:Kif21a
|
UTSW |
15 |
90,868,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4955:Kif21a
|
UTSW |
15 |
90,821,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4974:Kif21a
|
UTSW |
15 |
90,833,213 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5034:Kif21a
|
UTSW |
15 |
90,852,561 (GRCm39) |
missense |
probably null |
1.00 |
|
R5165:Kif21a
|
UTSW |
15 |
90,840,579 (GRCm39) |
missense |
probably benign |
0.38 |
|
R5464:Kif21a
|
UTSW |
15 |
90,878,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5541:Kif21a
|
UTSW |
15 |
90,852,316 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5757:Kif21a
|
UTSW |
15 |
90,835,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5936:Kif21a
|
UTSW |
15 |
90,819,850 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5976:Kif21a
|
UTSW |
15 |
90,820,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6074:Kif21a
|
UTSW |
15 |
90,865,095 (GRCm39) |
missense |
probably benign |
|
|
R6638:Kif21a
|
UTSW |
15 |
90,850,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Kif21a
|
UTSW |
15 |
90,824,649 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6785:Kif21a
|
UTSW |
15 |
90,819,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Kif21a
|
UTSW |
15 |
90,865,040 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Kif21a
|
UTSW |
15 |
90,833,106 (GRCm39) |
splice site |
probably null |
|
|
R7147:Kif21a
|
UTSW |
15 |
90,865,086 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7290:Kif21a
|
UTSW |
15 |
90,851,432 (GRCm39) |
nonsense |
probably null |
|
|
R7438:Kif21a
|
UTSW |
15 |
90,877,999 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7593:Kif21a
|
UTSW |
15 |
90,828,064 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7661:Kif21a
|
UTSW |
15 |
90,865,122 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7891:Kif21a
|
UTSW |
15 |
90,840,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8137:Kif21a
|
UTSW |
15 |
90,852,645 (GRCm39) |
missense |
probably benign |
|
|
R8182:Kif21a
|
UTSW |
15 |
90,819,964 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8303:Kif21a
|
UTSW |
15 |
90,855,399 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8388:Kif21a
|
UTSW |
15 |
90,843,327 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8867:Kif21a
|
UTSW |
15 |
90,852,382 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8921:Kif21a
|
UTSW |
15 |
90,855,930 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8984:Kif21a
|
UTSW |
15 |
90,840,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Kif21a
|
UTSW |
15 |
90,821,399 (GRCm39) |
nonsense |
probably null |
|
|
R9254:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9366:Kif21a
|
UTSW |
15 |
90,843,951 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9379:Kif21a
|
UTSW |
15 |
90,854,030 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9393:Kif21a
|
UTSW |
15 |
90,853,981 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kif21a
|
UTSW |
15 |
90,840,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9712:Kif21a
|
UTSW |
15 |
90,879,715 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9712:Kif21a
|
UTSW |
15 |
90,869,528 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9721:Kif21a
|
UTSW |
15 |
90,855,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGGCAGTGTGTCCATCCTAAAAC -3'
(R):5'- GGTCATGCCCAGTTCAGGAAAATCG -3'
Sequencing Primer
(F):5'- GTGTCCATCCTAAAACATGCTTGG -3'
(R):5'- ATCGGGAAGTACCATCATCCTTTG -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation