Mutagenetix > Incidental Mutation

Incidental Mutation 'R1564:Scn3a'

175076

Institutional Source

Beutler Lab

Gene Symbol

Scn3a

Ensembl Gene

ENSMUSG00000057182

Gene Name

sodium channel, voltage-gated, type III, alpha

Synonyms

Nav1.3, LOC381367

MMRRC Submission

039603-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1564 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

65287462-65397935 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 65344979 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Methionine at position 503 (R503M)

Ref Sequence

ENSEMBL: ENSMUSP00000097647 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066432] [ENSMUST00000100069]

AlphaFold

A2ASI5

Predicted Effect

probably damaging
Transcript: ENSMUST00000066432
AA Change: R503M

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000065023
Gene: ENSMUSG00000057182
AA Change: R503M

Domain	Start	End	E-Value	Type
low complexity region	23	40	N/A	INTRINSIC
Pfam:Ion_trans	127	435	5.2e-83	PFAM
low complexity region	473	498	N/A	INTRINSIC
Pfam:Na_trans_cytopl	504	626	2e-42	PFAM
Pfam:Ion_trans	710	945	1.4e-58	PFAM
Pfam:Na_trans_assoc	949	1153	2.7e-58	PFAM
Pfam:Ion_trans	1157	1430	3e-67	PFAM
Pfam:Ion_trans	1477	1734	6.3e-55	PFAM
Pfam:PKD_channel	1573	1728	8e-7	PFAM
IQ	1851	1873	5.75e-2	SMART
low complexity region	1913	1921	N/A	INTRINSIC
low complexity region	1927	1943	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000100069
AA Change: R503M

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000097647
Gene: ENSMUSG00000057182
AA Change: R503M

Domain	Start	End	E-Value	Type
low complexity region	23	40	N/A	INTRINSIC
Pfam:Ion_trans	127	435	5.2e-83	PFAM
low complexity region	473	498	N/A	INTRINSIC
Pfam:Na_trans_cytopl	504	626	2e-42	PFAM
Pfam:Ion_trans	710	945	1.4e-58	PFAM
Pfam:Na_trans_assoc	949	1153	2.7e-58	PFAM
Pfam:Ion_trans	1157	1430	3e-67	PFAM
Pfam:Ion_trans	1477	1734	6.3e-55	PFAM
Pfam:PKD_channel	1573	1728	8e-7	PFAM
IQ	1851	1873	5.75e-2	SMART
low complexity region	1913	1921	N/A	INTRINSIC
low complexity region	1927	1943	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145994

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.7%
20x: 91.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in lethality of most mutants by weaning. Heterozygous mice exhibit improved glucose tolerance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	C	T	11: 9,384,316 (GRCm39)	Q3923*	probably null	Het
Abcc12	T	A	8: 87,244,115 (GRCm39)	T1013S	probably benign	Het
Acad9	T	C	3: 36,143,578 (GRCm39)	I558T	possibly damaging	Het
Agbl4	C	A	4: 110,812,761 (GRCm39)		probably null	Het
Akr1b1	C	T	6: 34,283,470 (GRCm39)		probably null	Het
Aktip	A	G	8: 91,857,709 (GRCm39)	M1T	probably null	Het
Apc	G	T	18: 34,448,202 (GRCm39)	Q1665H	probably benign	Het
Arfgef3	T	C	10: 18,467,452 (GRCm39)	D1916G	probably damaging	Het
Arhgef11	T	C	3: 87,609,817 (GRCm39)	V365A	probably benign	Het
Bank1	C	A	3: 135,919,602 (GRCm39)	E265*	probably null	Het
Bbs7	A	T	3: 36,629,944 (GRCm39)	D578E	probably damaging	Het
Bin3	T	C	14: 70,372,218 (GRCm39)	F172L	probably damaging	Het
Bves	A	G	10: 45,245,377 (GRCm39)	D350G	probably benign	Het
Cacna1h	A	T	17: 25,596,835 (GRCm39)	C80*	probably null	Het
Cacna2d4	T	C	6: 119,218,156 (GRCm39)	F164L	possibly damaging	Het
Cenpj	T	C	14: 56,789,523 (GRCm39)	D842G	probably benign	Het
Col12a1	C	A	9: 79,521,122 (GRCm39)	R2781L	probably damaging	Het
Cyp2c68	A	T	19: 39,724,024 (GRCm39)	C213*	probably null	Het
Defb33	T	A	8: 21,387,597 (GRCm39)	C45S	possibly damaging	Het
Dolk	A	T	2: 30,175,633 (GRCm39)	N137K	probably damaging	Het
Fam171b	G	A	2: 83,710,628 (GRCm39)	E767K	probably damaging	Het
Fbxl20	A	T	11: 97,989,312 (GRCm39)	D189E	probably damaging	Het
Gm10643	A	T	8: 84,791,111 (GRCm39)	M1K	probably null	Het
Gm572	T	G	4: 148,735,643 (GRCm39)	I24S	possibly damaging	Het
Gnpda1	A	G	18: 38,471,142 (GRCm39)		probably null	Het
Gpr141b	T	C	13: 19,913,470 (GRCm39)		noncoding transcript	Het
Helz2	G	T	2: 180,875,021 (GRCm39)	N1824K	probably benign	Het
Insl3	G	T	8: 72,142,935 (GRCm39)	A99S	possibly damaging	Het
Lpin2	G	A	17: 71,532,055 (GRCm39)	V137I	probably benign	Het
Lrrc9	A	G	12: 72,533,827 (GRCm39)	E1032G	probably damaging	Het
Macf1	T	C	4: 123,353,150 (GRCm39)	T1510A	probably benign	Het
Mnd1	T	C	3: 84,023,738 (GRCm39)	E116G	probably benign	Het
Mycbp2	A	G	14: 103,407,287 (GRCm39)		probably null	Het
Myoz3	G	A	18: 60,713,914 (GRCm39)	S23L	probably benign	Het
Napsa	G	T	7: 44,236,073 (GRCm39)	V371F	probably damaging	Het
Nefh	T	C	11: 4,889,878 (GRCm39)	T914A	unknown	Het
Neurod2	A	T	11: 98,218,250 (GRCm39)	C305S	probably damaging	Het
Nmnat3	T	C	9: 98,236,219 (GRCm39)		probably null	Het
Nuf2	A	G	1: 169,326,362 (GRCm39)	V463A	unknown	Het
Olfml1	A	T	7: 107,170,346 (GRCm39)	T78S	possibly damaging	Het
Opcml	G	A	9: 28,814,612 (GRCm39)	C288Y	probably damaging	Het
Oprl1	T	C	2: 181,360,733 (GRCm39)	I222T	possibly damaging	Het
Or13a28	G	A	7: 140,217,967 (GRCm39)	V118I	probably benign	Het
Or4c104	A	T	2: 88,587,000 (GRCm39)	N6K	possibly damaging	Het
Or4c122	G	T	2: 89,080,016 (GRCm39)	N7K	probably benign	Het
Or6c210	T	C	10: 129,495,884 (GRCm39)	F70L	probably benign	Het
Pcsk5	A	G	19: 17,632,120 (GRCm39)	Y349H	probably damaging	Het
Pla2g4d	C	A	2: 120,099,384 (GRCm39)	R706L	possibly damaging	Het
Pmm1	A	G	15: 81,840,401 (GRCm39)	Y55H	probably damaging	Het
Polb	A	G	8: 23,120,357 (GRCm39)		probably null	Het
Pom121l2	T	C	13: 22,167,523 (GRCm39)	I598T	possibly damaging	Het
Pxmp2	C	T	5: 110,429,062 (GRCm39)		probably null	Het
Rbm39	G	T	2: 155,996,177 (GRCm39)	L403I	probably benign	Het
Rec8	T	C	14: 55,859,732 (GRCm39)		probably null	Het
Reck	T	C	4: 43,912,061 (GRCm39)	I190T	probably benign	Het
Rer1	A	T	4: 155,160,050 (GRCm39)	I166N	probably damaging	Het
Rgs17	T	A	10: 5,792,567 (GRCm39)	K60*	probably null	Het
Ripor2	C	T	13: 24,859,768 (GRCm39)	T152M	probably damaging	Het
Scgb1b2	A	T	7: 30,991,200 (GRCm39)		probably benign	Het
Scn4a	C	A	11: 106,236,367 (GRCm39)	D298Y	probably benign	Het
Scn9a	A	G	2: 66,314,648 (GRCm39)	F1679S	probably damaging	Het
Scyl3	G	T	1: 163,767,553 (GRCm39)		probably null	Het
Sec23ip	A	G	7: 128,368,005 (GRCm39)		probably null	Het
She	C	T	3: 89,756,921 (GRCm39)	A325V	possibly damaging	Het
Skint2	T	G	4: 112,483,195 (GRCm39)	M200R	probably damaging	Het
Slc17a5	A	T	9: 78,485,981 (GRCm39)	C35S	probably damaging	Het
Slc25a24	T	A	3: 109,070,819 (GRCm39)	S393T	probably damaging	Het
Slc6a19	C	T	13: 73,834,243 (GRCm39)	V320M	probably damaging	Het
Snap91	T	C	9: 86,674,249 (GRCm39)	D579G	possibly damaging	Het
Spats2l	C	T	1: 57,985,383 (GRCm39)	R479C	probably damaging	Het
Syngr3	G	C	17: 24,905,642 (GRCm39)		probably null	Het
Tas2r107	A	C	6: 131,636,785 (GRCm39)	I88R	probably damaging	Het
Them7	A	T	2: 105,128,259 (GRCm39)	N80I	probably damaging	Het
Tmprss7	C	T	16: 45,482,516 (GRCm39)		probably null	Het
Tnrc6b	A	G	15: 80,764,369 (GRCm39)	N624D	possibly damaging	Het
Trpm2	T	G	10: 77,778,833 (GRCm39)	I378L	probably benign	Het
Ttn	C	A	2: 76,554,876 (GRCm39)	W30676L	probably damaging	Het
Ttn	A	G	2: 76,774,384 (GRCm39)	V2220A	unknown	Het
Uba6	T	C	5: 86,302,266 (GRCm39)	T134A	probably benign	Het
Vmn2r55	A	G	7: 12,418,678 (GRCm39)	S81P	probably damaging	Het
Zfp616	T	A	11: 73,975,548 (GRCm39)	S606T	probably damaging	Het
Zfp653	C	A	9: 21,967,155 (GRCm39)	A577S	probably damaging	Het

Other mutations in Scn3a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00953:Scn3a	APN	2	65,327,736 (GRCm39)	missense	probably benign	0.05
IGL01086:Scn3a	APN	2	65,300,503 (GRCm39)	missense	probably benign	0.27
IGL01141:Scn3a	APN	2	65,325,457 (GRCm39)	missense	possibly damaging	0.73
IGL01150:Scn3a	APN	2	65,327,709 (GRCm39)	splice site	probably null
IGL01564:Scn3a	APN	2	65,291,790 (GRCm39)	missense	probably damaging	1.00
IGL01594:Scn3a	APN	2	65,291,775 (GRCm39)	missense	probably damaging	1.00
IGL01751:Scn3a	APN	2	65,291,596 (GRCm39)	missense	possibly damaging	0.87
IGL01803:Scn3a	APN	2	65,352,127 (GRCm39)	unclassified	probably benign
IGL01822:Scn3a	APN	2	65,325,608 (GRCm39)	missense	probably damaging	1.00
IGL02063:Scn3a	APN	2	65,291,854 (GRCm39)	missense	probably damaging	1.00
IGL02142:Scn3a	APN	2	65,356,965 (GRCm39)	missense	possibly damaging	0.95
IGL02198:Scn3a	APN	2	65,338,833 (GRCm39)	missense	probably benign	0.12
IGL02501:Scn3a	APN	2	65,356,899 (GRCm39)	missense	possibly damaging	0.82
IGL02608:Scn3a	APN	2	65,354,510 (GRCm39)	nonsense	probably null
IGL02645:Scn3a	APN	2	65,344,871 (GRCm39)	missense	probably benign	0.12
IGL02653:Scn3a	APN	2	65,291,531 (GRCm39)	missense	probably damaging	1.00
IGL03077:Scn3a	APN	2	65,367,016 (GRCm39)	missense	probably damaging	0.99
IGL03099:Scn3a	APN	2	65,367,016 (GRCm39)	missense	probably damaging	0.99
IGL03299:Scn3a	APN	2	65,327,860 (GRCm39)	missense	probably benign	0.01
IGL03327:Scn3a	APN	2	65,367,016 (GRCm39)	missense	probably damaging	0.99
IGL03346:Scn3a	APN	2	65,367,016 (GRCm39)	missense	probably damaging	0.99
IGL03355:Scn3a	APN	2	65,290,912 (GRCm39)	missense	possibly damaging	0.91
curtsey	UTSW	2	65,295,180 (GRCm39)	missense	probably damaging	1.00
dip	UTSW	2	65,354,523 (GRCm39)	missense	probably benign	0.01
Regime	UTSW	2	65,355,194 (GRCm39)	missense	possibly damaging	0.93
Willpower	UTSW	2	65,356,098 (GRCm39)	missense	possibly damaging	0.92
R0019:Scn3a	UTSW	2	65,292,045 (GRCm39)	missense	probably damaging	1.00
R0316:Scn3a	UTSW	2	65,291,173 (GRCm39)	missense	probably damaging	1.00
R0374:Scn3a	UTSW	2	65,338,918 (GRCm39)	missense	probably damaging	0.97
R0414:Scn3a	UTSW	2	65,356,326 (GRCm39)	splice site	probably benign
R0609:Scn3a	UTSW	2	65,366,854 (GRCm39)	missense	probably damaging	0.96
R0613:Scn3a	UTSW	2	65,302,628 (GRCm39)	missense	possibly damaging	0.92
R0645:Scn3a	UTSW	2	65,355,194 (GRCm39)	missense	possibly damaging	0.93
R0665:Scn3a	UTSW	2	65,314,755 (GRCm39)	missense	probably null	0.00
R0667:Scn3a	UTSW	2	65,314,755 (GRCm39)	missense	probably null	0.00
R0710:Scn3a	UTSW	2	65,299,390 (GRCm39)	missense	probably damaging	0.99
R1202:Scn3a	UTSW	2	65,336,491 (GRCm39)	missense	probably benign	0.07
R1440:Scn3a	UTSW	2	65,359,785 (GRCm39)	missense	possibly damaging	0.95
R1447:Scn3a	UTSW	2	65,300,324 (GRCm39)	missense	probably damaging	1.00
R1595:Scn3a	UTSW	2	65,329,323 (GRCm39)	missense	probably damaging	0.99
R1775:Scn3a	UTSW	2	65,302,686 (GRCm39)	missense	probably damaging	1.00
R1781:Scn3a	UTSW	2	65,302,729 (GRCm39)	missense	probably damaging	1.00
R1822:Scn3a	UTSW	2	65,314,716 (GRCm39)	missense	probably damaging	1.00
R1924:Scn3a	UTSW	2	65,291,878 (GRCm39)	missense	probably damaging	1.00
R2061:Scn3a	UTSW	2	65,291,652 (GRCm39)	missense	probably damaging	1.00
R2070:Scn3a	UTSW	2	65,351,210 (GRCm39)	missense	possibly damaging	0.72
R2174:Scn3a	UTSW	2	65,337,550 (GRCm39)	missense	probably damaging	0.99
R2656:Scn3a	UTSW	2	65,356,862 (GRCm39)	missense	probably damaging	0.99
R2680:Scn3a	UTSW	2	65,366,880 (GRCm39)	missense	probably benign	0.04
R3882:Scn3a	UTSW	2	65,312,623 (GRCm39)	missense	probably benign	0.03
R4019:Scn3a	UTSW	2	65,356,295 (GRCm39)	intron	probably benign
R4106:Scn3a	UTSW	2	65,325,379 (GRCm39)	missense	probably benign	0.07
R4108:Scn3a	UTSW	2	65,325,379 (GRCm39)	missense	probably benign	0.07
R4109:Scn3a	UTSW	2	65,325,379 (GRCm39)	missense	probably benign	0.07
R4225:Scn3a	UTSW	2	65,366,771 (GRCm39)	missense	probably damaging	0.99
R4419:Scn3a	UTSW	2	65,297,304 (GRCm39)	missense	probably damaging	1.00
R4552:Scn3a	UTSW	2	65,354,523 (GRCm39)	missense	probably benign	0.01
R4687:Scn3a	UTSW	2	65,295,074 (GRCm39)	missense	possibly damaging	0.65
R4780:Scn3a	UTSW	2	65,336,537 (GRCm39)	missense	probably damaging	1.00
R4820:Scn3a	UTSW	2	65,291,622 (GRCm39)	missense	probably damaging	1.00
R4856:Scn3a	UTSW	2	65,291,376 (GRCm39)	missense	probably damaging	1.00
R4886:Scn3a	UTSW	2	65,291,376 (GRCm39)	missense	probably damaging	1.00
R4914:Scn3a	UTSW	2	65,291,799 (GRCm39)	missense	probably damaging	1.00
R4915:Scn3a	UTSW	2	65,291,799 (GRCm39)	missense	probably damaging	1.00
R4918:Scn3a	UTSW	2	65,291,799 (GRCm39)	missense	probably damaging	1.00
R5088:Scn3a	UTSW	2	65,302,643 (GRCm39)	missense	probably damaging	1.00
R5101:Scn3a	UTSW	2	65,291,850 (GRCm39)	missense	probably damaging	1.00
R5128:Scn3a	UTSW	2	65,338,862 (GRCm39)	missense	probably benign	0.08
R5132:Scn3a	UTSW	2	65,298,548 (GRCm39)	missense	probably benign	0.09
R5297:Scn3a	UTSW	2	65,299,378 (GRCm39)	missense	possibly damaging	0.83
R5595:Scn3a	UTSW	2	65,291,057 (GRCm39)	missense	probably benign
R5699:Scn3a	UTSW	2	65,337,608 (GRCm39)	missense	possibly damaging	0.54
R5730:Scn3a	UTSW	2	65,325,604 (GRCm39)	missense	probably benign	0.00
R5735:Scn3a	UTSW	2	65,314,803 (GRCm39)	missense	probably benign	0.09
R5735:Scn3a	UTSW	2	65,312,622 (GRCm39)	missense	probably damaging	0.98
R5855:Scn3a	UTSW	2	65,295,074 (GRCm39)	missense	possibly damaging	0.65
R5888:Scn3a	UTSW	2	65,327,742 (GRCm39)	missense	probably benign	0.06
R5898:Scn3a	UTSW	2	65,345,039 (GRCm39)	missense	probably damaging	0.96
R5935:Scn3a	UTSW	2	65,295,180 (GRCm39)	missense	probably damaging	1.00
R5970:Scn3a	UTSW	2	65,325,125 (GRCm39)	intron	probably benign
R6214:Scn3a	UTSW	2	65,325,380 (GRCm39)	missense	probably benign	0.29
R6215:Scn3a	UTSW	2	65,325,380 (GRCm39)	missense	probably benign	0.29
R6235:Scn3a	UTSW	2	65,291,679 (GRCm39)	missense	probably damaging	0.97
R6307:Scn3a	UTSW	2	65,302,685 (GRCm39)	missense	probably damaging	1.00
R6355:Scn3a	UTSW	2	65,291,643 (GRCm39)	missense	probably damaging	0.99
R6376:Scn3a	UTSW	2	65,291,843 (GRCm39)	missense	possibly damaging	0.88
R6517:Scn3a	UTSW	2	65,327,907 (GRCm39)	missense	possibly damaging	0.73
R6775:Scn3a	UTSW	2	65,352,159 (GRCm39)	missense	possibly damaging	0.82
R6893:Scn3a	UTSW	2	65,356,098 (GRCm39)	missense	possibly damaging	0.92
R6986:Scn3a	UTSW	2	65,338,962 (GRCm39)	missense	probably damaging	0.97
R7065:Scn3a	UTSW	2	65,295,199 (GRCm39)	missense	probably benign
R7078:Scn3a	UTSW	2	65,327,944 (GRCm39)	missense	probably damaging	1.00
R7146:Scn3a	UTSW	2	65,313,486 (GRCm39)	missense	probably damaging	1.00
R7240:Scn3a	UTSW	2	65,299,386 (GRCm39)	missense	possibly damaging	0.77
R7294:Scn3a	UTSW	2	65,302,685 (GRCm39)	missense	probably damaging	1.00
R7352:Scn3a	UTSW	2	65,356,045 (GRCm39)	missense	possibly damaging	0.51
R7636:Scn3a	UTSW	2	65,328,033 (GRCm39)	missense	probably damaging	1.00
R7708:Scn3a	UTSW	2	65,313,512 (GRCm39)	missense	possibly damaging	0.47
R7733:Scn3a	UTSW	2	65,338,994 (GRCm39)	missense	probably benign	0.08
R7761:Scn3a	UTSW	2	65,359,798 (GRCm39)	missense	possibly damaging	0.95
R7792:Scn3a	UTSW	2	65,297,334 (GRCm39)	nonsense	probably null
R7828:Scn3a	UTSW	2	65,338,918 (GRCm39)	missense	probably damaging	0.97
R7875:Scn3a	UTSW	2	65,327,826 (GRCm39)	missense	probably damaging	1.00
R7884:Scn3a	UTSW	2	65,366,859 (GRCm39)	missense	probably damaging	0.96
R7958:Scn3a	UTSW	2	65,336,537 (GRCm39)	missense	probably damaging	1.00
R7965:Scn3a	UTSW	2	65,336,555 (GRCm39)	missense	probably damaging	1.00
R8171:Scn3a	UTSW	2	65,361,154 (GRCm39)	missense	possibly damaging	0.85
R8345:Scn3a	UTSW	2	65,329,335 (GRCm39)	missense	possibly damaging	0.86
R8356:Scn3a	UTSW	2	65,291,017 (GRCm39)	missense	probably benign	0.08
R8456:Scn3a	UTSW	2	65,291,017 (GRCm39)	missense	probably benign	0.08
R8527:Scn3a	UTSW	2	65,327,863 (GRCm39)	missense	probably damaging	0.99
R8688:Scn3a	UTSW	2	65,356,047 (GRCm39)	missense	possibly damaging	0.92
R8731:Scn3a	UTSW	2	65,298,507 (GRCm39)	nonsense	probably null
R8901:Scn3a	UTSW	2	65,352,252 (GRCm39)	missense	probably benign	0.00
R8910:Scn3a	UTSW	2	65,338,883 (GRCm39)	missense	probably damaging	1.00
R9011:Scn3a	UTSW	2	65,352,170 (GRCm39)	missense	possibly damaging	0.71
R9364:Scn3a	UTSW	2	65,291,596 (GRCm39)	missense	possibly damaging	0.87
R9460:Scn3a	UTSW	2	65,300,535 (GRCm39)	missense	probably damaging	1.00
R9496:Scn3a	UTSW	2	65,312,493 (GRCm39)	critical splice donor site	probably null
R9542:Scn3a	UTSW	2	65,366,860 (GRCm39)	missense	probably damaging	0.99
R9563:Scn3a	UTSW	2	65,291,595 (GRCm39)	missense	probably damaging	1.00
X0062:Scn3a	UTSW	2	65,355,191 (GRCm39)	nonsense	probably null
X0062:Scn3a	UTSW	2	65,297,345 (GRCm39)	missense	probably damaging	0.98
Z1177:Scn3a	UTSW	2	65,329,236 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CAGATCATCAGACCGCGATACCTG -3'
(R):5'- CTGGGCTGTTCTTGCTTTAATGCAC -3'

Sequencing Primer
(F):5'- ACCGCGATACCTGATGGG -3'
(R):5'- TGATCATAGGTGGCAGCACTC -3'

Posted On

2014-04-24