Mutagenetix > Incidental Mutation

Incidental Mutation 'R1565:Myo9b'

175201

Institutional Source

Beutler Lab

Gene Symbol

Myo9b

Ensembl Gene

ENSMUSG00000004677

Gene Name

myosin IXb

Synonyms

MMRRC Submission

039604-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.826) question?

Stock #

R1565 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

71725358-71813357 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 71767836 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 303 (N303S)

Ref Sequence

ENSEMBL: ENSMUSP00000131635 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071935] [ENSMUST00000168839] [ENSMUST00000170242] [ENSMUST00000212935]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000071935
AA Change: N303S

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000071827
Gene: ENSMUSG00000004677
AA Change: N303S

Domain	Start	End	E-Value	Type
RA	15	114	3.7e-30	SMART
MYSc	140	954	N/A	SMART
IQ	955	977	1.2e-3	SMART
IQ	978	1000	1.6e-5	SMART
IQ	1001	1022	4.3e-5	SMART
IQ	1023	1045	8.4e-5	SMART
low complexity region	1050	1064	N/A	INTRINSIC
low complexity region	1127	1145	N/A	INTRINSIC
low complexity region	1211	1222	N/A	INTRINSIC
low complexity region	1232	1246	N/A	INTRINSIC
Blast:MYSc	1247	1323	3e-19	BLAST
low complexity region	1348	1359	N/A	INTRINSIC
coiled coil region	1563	1590	N/A	INTRINSIC
C1	1591	1639	1.7e-14	SMART
RhoGAP	1668	1843	4.7e-71	SMART
coiled coil region	1901	1925	N/A	INTRINSIC
low complexity region	1940	1952	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168839
AA Change: N303S

PolyPhen 2 Score 0.457 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000131635
Gene: ENSMUSG00000004677
AA Change: N303S

Domain	Start	End	E-Value	Type
RA	15	114	5.79e-28	SMART
MYSc	140	954	N/A	SMART
IQ	955	977	2.46e-1	SMART
IQ	978	1000	3.35e-3	SMART
IQ	1001	1022	8.84e-3	SMART
IQ	1023	1045	1.77e-2	SMART
low complexity region	1050	1064	N/A	INTRINSIC
low complexity region	1127	1145	N/A	INTRINSIC
low complexity region	1211	1222	N/A	INTRINSIC
low complexity region	1234	1257	N/A	INTRINSIC
Blast:MYSc	1258	1334	3e-19	BLAST
low complexity region	1361	1372	N/A	INTRINSIC
low complexity region	1581	1601	N/A	INTRINSIC
C1	1605	1653	3.58e-12	SMART
RhoGAP	1682	1857	7.78e-69	SMART
coiled coil region	1915	1939	N/A	INTRINSIC
low complexity region	1954	1966	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000170242
AA Change: N303S

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000129220
Gene: ENSMUSG00000004677
AA Change: N303S

Domain	Start	End	E-Value	Type
RA	15	114	5.79e-28	SMART
MYSc	140	954	N/A	SMART
IQ	955	977	2.46e-1	SMART
IQ	978	1000	3.35e-3	SMART
IQ	1001	1022	8.84e-3	SMART
IQ	1023	1045	1.77e-2	SMART
low complexity region	1050	1064	N/A	INTRINSIC
low complexity region	1127	1145	N/A	INTRINSIC
low complexity region	1211	1222	N/A	INTRINSIC
low complexity region	1234	1257	N/A	INTRINSIC
Blast:MYSc	1258	1334	3e-19	BLAST
low complexity region	1361	1372	N/A	INTRINSIC
low complexity region	1581	1601	N/A	INTRINSIC
C1	1605	1653	3.58e-12	SMART
RhoGAP	1682	1857	7.78e-69	SMART
coiled coil region	1931	1955	N/A	INTRINSIC
low complexity region	1970	1982	N/A	INTRINSIC
low complexity region	1992	2003	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000212935
AA Change: N303S

PolyPhen 2 Score 0.425 (Sensitivity: 0.89; Specificity: 0.90)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.5%
20x: 90.0%

Validation Efficiency

96% (82/85)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutants breed normal, but shows defect in macrophage motility and chemotaxis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810021J22Rik	G	A	11: 58,771,327 (GRCm39)	G270S	probably benign	Het
Abtb1	T	C	6: 88,813,536 (GRCm39)	T401A	probably benign	Het
Adamts14	A	T	10: 61,106,676 (GRCm39)	M148K	probably damaging	Het
Adcy5	A	G	16: 35,089,327 (GRCm39)	E508G	probably damaging	Het
Ankfy1	T	A	11: 72,648,144 (GRCm39)	L875H	probably damaging	Het
Cacng3	A	T	7: 122,367,624 (GRCm39)	D168V	probably damaging	Het
Clpb	G	A	7: 101,434,668 (GRCm39)	R488Q	probably benign	Het
Cltrn	A	G	X: 162,901,230 (GRCm39)	D184G	possibly damaging	Het
Cpxm2	A	T	7: 131,663,874 (GRCm39)	Y350N	probably damaging	Het
D130040H23Rik	T	A	8: 69,755,812 (GRCm39)	*406R	probably null	Het
Dnah10	T	A	5: 124,906,678 (GRCm39)	D4236E	probably damaging	Het
Dpf3	T	A	12: 83,417,391 (GRCm39)	Y27F	probably damaging	Het
Esp4	T	C	17: 40,913,486 (GRCm39)	*118Q	probably null	Het
Fam222b	T	C	11: 78,045,488 (GRCm39)	S222P	possibly damaging	Het
Flnc	T	C	6: 29,455,170 (GRCm39)	V1933A	probably damaging	Het
Gem	T	C	4: 11,713,709 (GRCm39)	F282L	possibly damaging	Het
Gli2	T	C	1: 118,769,660 (GRCm39)	T631A	possibly damaging	Het
Gpld1	T	A	13: 25,140,051 (GRCm39)	V116E	probably damaging	Het
Gpr176	A	G	2: 118,110,695 (GRCm39)	M188T	probably benign	Het
Grk5	T	C	19: 61,078,410 (GRCm39)	V489A	probably damaging	Het
Hpdl	T	C	4: 116,678,080 (GRCm39)	N127S	probably damaging	Het
Hsd17b8	C	T	17: 34,246,469 (GRCm39)	V105I	possibly damaging	Het
Id4	G	T	13: 48,415,770 (GRCm39)	V151L	possibly damaging	Het
Kcnh8	G	T	17: 53,263,909 (GRCm39)	G802V	probably benign	Het
Lamc1	C	A	1: 153,118,489 (GRCm39)	S894I	probably benign	Het
Larp1b	A	G	3: 40,926,819 (GRCm39)	N184S	probably damaging	Het
Lhx1	A	T	11: 84,410,647 (GRCm39)	S226T	probably benign	Het
Lmo7	A	T	14: 102,124,957 (GRCm39)	Q472L	probably damaging	Het
Mog	G	C	17: 37,328,474 (GRCm39)	N152K	possibly damaging	Het
Mttp	A	G	3: 137,822,166 (GRCm39)		probably null	Het
Mycbp2	A	G	14: 103,489,945 (GRCm39)	V953A	possibly damaging	Het
Myo3a	A	T	2: 22,345,091 (GRCm39)	Y509F	probably damaging	Het
Nek3	T	C	8: 22,622,217 (GRCm39)		probably null	Het
Nlrc4	A	T	17: 74,748,926 (GRCm39)	D771E	probably benign	Het
Nup160	A	T	2: 90,552,405 (GRCm39)	N1127I	possibly damaging	Het
Oas1h	A	T	5: 121,000,663 (GRCm39)	N91I	probably damaging	Het
Or13p4	T	A	4: 118,547,389 (GRCm39)	N87Y	probably damaging	Het
Or4c120	A	T	2: 89,000,971 (GRCm39)	V195D	probably benign	Het
Or4c121	G	T	2: 89,024,227 (GRCm39)	S50R	probably damaging	Het
Parp4	T	C	14: 56,827,329 (GRCm39)		probably benign	Het
Pi4ka	G	A	16: 17,099,764 (GRCm39)	C96Y	probably null	Het
Pira2	A	T	7: 3,847,548 (GRCm39)	F47Y	probably damaging	Het
Pkhd1	C	A	1: 20,417,681 (GRCm39)	G2490V	probably damaging	Het
Plekhg1	C	T	10: 3,890,526 (GRCm39)	T394I	probably damaging	Het
Pramel22	G	A	4: 143,382,187 (GRCm39)	Q170*	probably null	Het
Psmd1	T	C	1: 86,019,719 (GRCm39)		probably benign	Het
Rab3ip	A	T	10: 116,775,128 (GRCm39)	C77S	probably benign	Het
Reln	A	T	5: 22,130,211 (GRCm39)	M2700K	probably benign	Het
Rfx1	A	G	8: 84,800,575 (GRCm39)	T59A	probably benign	Het
Ric8b	G	T	10: 84,815,963 (GRCm39)	V405L	probably benign	Het
Rufy3	G	T	5: 88,788,491 (GRCm39)	A479S	probably damaging	Het
Sardh	A	T	2: 27,132,731 (GRCm39)	Y166N	probably damaging	Het
Slamf6	T	G	1: 171,761,975 (GRCm39)	V132G	possibly damaging	Het
Slc12a3	T	G	8: 95,072,505 (GRCm39)	H674Q	possibly damaging	Het
Sned1	G	A	1: 93,209,376 (GRCm39)	V830M	possibly damaging	Het
Srsf9	A	G	5: 115,465,429 (GRCm39)	N21S	possibly damaging	Het
Stkld1	A	T	2: 26,840,102 (GRCm39)	T391S	probably benign	Het
Sumf2	C	A	5: 129,888,755 (GRCm39)	N230K	probably damaging	Het
Tbc1d22a	T	C	15: 86,119,770 (GRCm39)	V22A	possibly damaging	Het
Thsd7b	T	A	1: 129,523,778 (GRCm39)	S194T	possibly damaging	Het
Tnn	T	A	1: 159,924,835 (GRCm39)	Y1173F	probably damaging	Het
Top2a	A	G	11: 98,891,880 (GRCm39)	F1122L	probably damaging	Het
Trappc9	G	A	15: 72,897,816 (GRCm39)	R377W	probably damaging	Het
Trim39	G	A	17: 36,579,746 (GRCm39)	R70W	probably damaging	Het
Ttn	G	A	2: 76,624,605 (GRCm39)	T15289I	probably damaging	Het
Ugt2b38	A	T	5: 87,559,773 (GRCm39)	V373E	probably damaging	Het
Usp54	A	G	14: 20,657,227 (GRCm39)	S24P	probably damaging	Het
Vmn2r27	C	T	6: 124,208,593 (GRCm39)	G51S	probably benign	Het
Xylt2	C	T	11: 94,558,420 (GRCm39)	A579T	probably benign	Het
Zbtb21	A	G	16: 97,753,627 (GRCm39)	S247P	probably benign	Het
Zc3h7b	C	T	15: 81,661,289 (GRCm39)	P376L	probably benign	Het
Zfp251	T	A	15: 76,737,238 (GRCm39)	R613S	probably damaging	Het
Zfp251	C	T	15: 76,737,239 (GRCm39)	R613K	possibly damaging	Het
Zfp91	T	C	19: 12,756,439 (GRCm39)	D135G	probably benign	Het

Other mutations in Myo9b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Myo9b	APN	8	71,801,379 (GRCm39)	missense	probably benign
IGL01020:Myo9b	APN	8	71,804,644 (GRCm39)	missense	probably benign
IGL01479:Myo9b	APN	8	71,811,986 (GRCm39)	missense	probably damaging	1.00
IGL01704:Myo9b	APN	8	71,812,286 (GRCm39)	missense	probably damaging	0.98
IGL01761:Myo9b	APN	8	71,801,796 (GRCm39)	missense	probably damaging	0.96
IGL01766:Myo9b	APN	8	71,743,161 (GRCm39)	missense	probably damaging	1.00
IGL01834:Myo9b	APN	8	71,807,901 (GRCm39)	missense	possibly damaging	0.93
IGL01834:Myo9b	APN	8	71,808,962 (GRCm39)	missense	probably damaging	1.00
IGL01838:Myo9b	APN	8	71,787,034 (GRCm39)	missense	probably damaging	0.99
IGL02318:Myo9b	APN	8	71,806,768 (GRCm39)	missense	probably damaging	0.98
IGL02333:Myo9b	APN	8	71,811,637 (GRCm39)	missense	possibly damaging	0.65
IGL02340:Myo9b	APN	8	71,743,689 (GRCm39)	missense	probably damaging	1.00
IGL02514:Myo9b	APN	8	71,743,650 (GRCm39)	missense	probably damaging	1.00
IGL02593:Myo9b	APN	8	71,743,417 (GRCm39)	missense	probably damaging	1.00
IGL03075:Myo9b	APN	8	71,807,171 (GRCm39)	missense	probably damaging	1.00
IGL03332:Myo9b	APN	8	71,801,418 (GRCm39)	missense	possibly damaging	0.78
avantgarde	UTSW	8	71,796,806 (GRCm39)	missense	probably damaging	1.00
Freaky	UTSW	8	71,743,463 (GRCm39)	missense	probably damaging	1.00
iconoclastic	UTSW	8	71,743,119 (GRCm39)	missense	probably benign	0.37
unconventional	UTSW	8	71,801,241 (GRCm39)	missense	probably benign	0.00
PIT4418001:Myo9b	UTSW	8	71,775,591 (GRCm39)	missense	probably damaging	1.00
PIT4651001:Myo9b	UTSW	8	71,795,456 (GRCm39)	missense	possibly damaging	0.83
R0023:Myo9b	UTSW	8	71,786,412 (GRCm39)	missense	probably damaging	1.00
R0103:Myo9b	UTSW	8	71,776,493 (GRCm39)	splice site	probably benign
R0103:Myo9b	UTSW	8	71,776,493 (GRCm39)	splice site	probably benign
R0144:Myo9b	UTSW	8	71,798,687 (GRCm39)	missense	probably damaging	1.00
R0207:Myo9b	UTSW	8	71,807,869 (GRCm39)	splice site	probably benign
R0226:Myo9b	UTSW	8	71,806,476 (GRCm39)	missense	probably damaging	1.00
R0227:Myo9b	UTSW	8	71,796,806 (GRCm39)	missense	probably damaging	1.00
R0244:Myo9b	UTSW	8	71,774,457 (GRCm39)	missense	probably damaging	1.00
R0277:Myo9b	UTSW	8	71,808,596 (GRCm39)	splice site	probably benign
R0362:Myo9b	UTSW	8	71,800,414 (GRCm39)	missense	probably damaging	1.00
R0689:Myo9b	UTSW	8	71,783,400 (GRCm39)	missense	probably damaging	1.00
R0844:Myo9b	UTSW	8	71,743,119 (GRCm39)	missense	probably benign	0.37
R1051:Myo9b	UTSW	8	71,808,466 (GRCm39)	missense	probably damaging	1.00
R1469:Myo9b	UTSW	8	71,743,680 (GRCm39)	missense	probably damaging	1.00
R1469:Myo9b	UTSW	8	71,743,680 (GRCm39)	missense	probably damaging	1.00
R1526:Myo9b	UTSW	8	71,808,408 (GRCm39)	missense	probably damaging	1.00
R1544:Myo9b	UTSW	8	71,743,620 (GRCm39)	missense	probably damaging	1.00
R1645:Myo9b	UTSW	8	71,775,622 (GRCm39)	missense	probably damaging	1.00
R1745:Myo9b	UTSW	8	71,806,691 (GRCm39)	missense	probably damaging	1.00
R1820:Myo9b	UTSW	8	71,786,002 (GRCm39)	missense	probably damaging	1.00
R2037:Myo9b	UTSW	8	71,743,510 (GRCm39)	missense	probably damaging	1.00
R2050:Myo9b	UTSW	8	71,743,194 (GRCm39)	missense	probably damaging	1.00
R2056:Myo9b	UTSW	8	71,812,334 (GRCm39)	missense	possibly damaging	0.78
R2129:Myo9b	UTSW	8	71,786,343 (GRCm39)	missense	probably damaging	1.00
R2423:Myo9b	UTSW	8	71,780,584 (GRCm39)	missense	probably damaging	1.00
R2869:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2869:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2871:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2871:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2872:Myo9b	UTSW	8	71,743,610 (GRCm39)	missense	probably benign	0.01
R2872:Myo9b	UTSW	8	71,743,610 (GRCm39)	missense	probably benign	0.01
R2873:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2874:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2920:Myo9b	UTSW	8	71,778,501 (GRCm39)	missense	probably damaging	0.98
R2926:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2939:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R2940:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R3033:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R3040:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R3689:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R3691:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R3735:Myo9b	UTSW	8	71,801,241 (GRCm39)	missense	probably benign	0.00
R4194:Myo9b	UTSW	8	71,812,268 (GRCm39)	missense	possibly damaging	0.71
R4258:Myo9b	UTSW	8	71,808,409 (GRCm39)	missense	probably damaging	1.00
R4457:Myo9b	UTSW	8	71,743,643 (GRCm39)	missense	probably damaging	1.00
R4478:Myo9b	UTSW	8	71,743,725 (GRCm39)	missense	probably damaging	1.00
R4496:Myo9b	UTSW	8	71,786,981 (GRCm39)	missense	probably benign	0.01
R4544:Myo9b	UTSW	8	71,780,585 (GRCm39)	missense	probably damaging	1.00
R4580:Myo9b	UTSW	8	71,767,779 (GRCm39)	missense	probably damaging	1.00
R4736:Myo9b	UTSW	8	71,809,236 (GRCm39)	missense	probably damaging	1.00
R5068:Myo9b	UTSW	8	71,801,699 (GRCm39)	missense	probably damaging	1.00
R5124:Myo9b	UTSW	8	71,808,483 (GRCm39)	missense	probably damaging	1.00
R5194:Myo9b	UTSW	8	71,801,733 (GRCm39)	missense	probably benign	0.01
R5296:Myo9b	UTSW	8	71,786,032 (GRCm39)	missense	possibly damaging	0.69
R5528:Myo9b	UTSW	8	71,775,918 (GRCm39)	missense	probably benign	0.06
R5664:Myo9b	UTSW	8	71,812,526 (GRCm39)	missense	probably benign	0.13
R5677:Myo9b	UTSW	8	71,796,330 (GRCm39)	missense	probably damaging	1.00
R5680:Myo9b	UTSW	8	71,743,016 (GRCm39)	missense	probably benign	0.00
R5982:Myo9b	UTSW	8	71,801,040 (GRCm39)	missense	probably benign	0.05
R6344:Myo9b	UTSW	8	71,780,558 (GRCm39)	missense	probably damaging	1.00
R6352:Myo9b	UTSW	8	71,801,055 (GRCm39)	missense	probably benign
R6352:Myo9b	UTSW	8	71,801,054 (GRCm39)	missense	probably benign	0.16
R6411:Myo9b	UTSW	8	71,775,599 (GRCm39)	nonsense	probably null
R6425:Myo9b	UTSW	8	71,786,272 (GRCm39)	missense	probably damaging	1.00
R6505:Myo9b	UTSW	8	71,808,501 (GRCm39)	missense	possibly damaging	0.88
R6743:Myo9b	UTSW	8	71,804,803 (GRCm39)	splice site	probably null
R6811:Myo9b	UTSW	8	71,809,222 (GRCm39)	missense	probably damaging	1.00
R6813:Myo9b	UTSW	8	71,775,949 (GRCm39)	missense	probably damaging	1.00
R6954:Myo9b	UTSW	8	71,743,463 (GRCm39)	missense	probably damaging	1.00
R7124:Myo9b	UTSW	8	71,786,345 (GRCm39)	nonsense	probably null
R7255:Myo9b	UTSW	8	71,743,535 (GRCm39)	missense	probably damaging	1.00
R7293:Myo9b	UTSW	8	71,778,549 (GRCm39)	missense	probably benign	0.00
R7342:Myo9b	UTSW	8	71,808,418 (GRCm39)	missense	probably damaging	1.00
R7451:Myo9b	UTSW	8	71,804,832 (GRCm39)	missense	probably benign	0.28
R7482:Myo9b	UTSW	8	71,795,442 (GRCm39)	missense	probably benign	0.00
R7508:Myo9b	UTSW	8	71,807,445 (GRCm39)	missense	probably benign	0.00
R7957:Myo9b	UTSW	8	71,807,405 (GRCm39)	missense	probably benign	0.12
R8062:Myo9b	UTSW	8	71,774,457 (GRCm39)	missense	probably damaging	0.99
R8108:Myo9b	UTSW	8	71,800,986 (GRCm39)	missense	probably damaging	0.99
R8197:Myo9b	UTSW	8	71,743,607 (GRCm39)	missense	probably damaging	1.00
R8274:Myo9b	UTSW	8	71,812,480 (GRCm39)	missense	probably benign	0.00
R8686:Myo9b	UTSW	8	71,786,966 (GRCm39)	missense	probably benign	0.01
R8731:Myo9b	UTSW	8	71,806,486 (GRCm39)	critical splice donor site	probably null
R8924:Myo9b	UTSW	8	71,801,675 (GRCm39)	missense	probably benign
R9056:Myo9b	UTSW	8	71,804,906 (GRCm39)	missense	probably benign	0.17
R9117:Myo9b	UTSW	8	71,800,451 (GRCm39)	missense	probably benign	0.03
R9151:Myo9b	UTSW	8	71,807,871 (GRCm39)	splice site	probably benign
R9315:Myo9b	UTSW	8	71,801,811 (GRCm39)	missense	possibly damaging	0.54
R9332:Myo9b	UTSW	8	71,812,246 (GRCm39)	missense	probably benign	0.07
R9364:Myo9b	UTSW	8	71,808,483 (GRCm39)	missense	probably damaging	1.00
R9569:Myo9b	UTSW	8	71,811,629 (GRCm39)	missense	probably benign
R9581:Myo9b	UTSW	8	71,812,543 (GRCm39)	missense	probably benign	0.19
R9600:Myo9b	UTSW	8	71,743,075 (GRCm39)	missense	possibly damaging	0.80
X0066:Myo9b	UTSW	8	71,776,542 (GRCm39)	missense	probably damaging	1.00
Z1177:Myo9b	UTSW	8	71,743,353 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACCCAAGCCTCTGAGTAAGTAAGTAGC -3'
(R):5'- TTCTGCCTGTGACACCCAACAC -3'

Sequencing Primer
(F):5'- CTGAGTAAGTAAGTAGCTCAGGG -3'
(R):5'- TTCTGAGTCAAGGCTGCCAC -3'

Posted On

2014-04-24