Incidental Mutation 'R1566:Zmym4'
ID 175253
Institutional Source Beutler Lab
Gene Symbol Zmym4
Ensembl Gene ENSMUSG00000042446
Gene Name zinc finger, MYM-type 4
Synonyms Zfp262, 6330503C17Rik
MMRRC Submission 039605-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.586) question?
Stock # R1566 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 126755732-126861928 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 126804940 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 188 (I188S)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106108]
AlphaFold A2A791
Predicted Effect probably benign
Transcript: ENSMUST00000106108
AA Change: I440S

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: I440S

DomainStartEndE-ValueType
TRASH 341 377 6.53e-4 SMART
TRASH 389 429 7.22e-6 SMART
TRASH 441 479 1.77e0 SMART
TRASH 486 525 4.95e-4 SMART
TRASH 531 569 1.05e-2 SMART
TRASH 579 615 2.82e1 SMART
low complexity region 640 649 N/A INTRINSIC
TRASH 687 723 8.49e-3 SMART
TRASH 729 764 1.14e-3 SMART
TRASH 772 810 4.48e-2 SMART
TRASH 816 851 2.06e-1 SMART
low complexity region 974 993 N/A INTRINSIC
low complexity region 1002 1021 N/A INTRINSIC
Pfam:DUF3504 1357 1527 1.7e-68 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000135003
AA Change: I188S

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446
AA Change: I188S

DomainStartEndE-ValueType
TRASH 90 126 6.53e-4 SMART
TRASH 138 178 7.22e-6 SMART
TRASH 190 228 1.77e0 SMART
TRASH 235 274 3.05e-4 SMART
low complexity region 300 309 N/A INTRINSIC
TRASH 347 383 8.49e-3 SMART
TRASH 389 424 1.14e-3 SMART
TRASH 432 470 4.48e-2 SMART
TRASH 476 511 2.06e-1 SMART
low complexity region 634 653 N/A INTRINSIC
low complexity region 662 681 N/A INTRINSIC
Pfam:DUF3504 1017 1187 1.5e-68 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151026
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152489
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152952
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik T A 11: 109,679,632 (GRCm39) I247F probably benign Het
Afap1l1 T C 18: 61,888,714 (GRCm39) N119S probably benign Het
Ap2a1 T C 7: 44,552,904 (GRCm39) D721G probably benign Het
Ap3m2 C T 8: 23,293,967 (GRCm39) V28M probably damaging Het
Arhgef7 A G 8: 11,832,620 (GRCm39) T32A possibly damaging Het
Avl9 C T 6: 56,713,467 (GRCm39) R242* probably null Het
Bsn G A 9: 108,003,184 (GRCm39) T407I probably benign Het
Capn3 A T 2: 120,333,474 (GRCm39) R627S possibly damaging Het
Car13 G A 3: 14,715,758 (GRCm39) R92Q probably benign Het
Clcn1 T C 6: 42,268,374 (GRCm39) I149T possibly damaging Het
Col1a2 G T 6: 4,523,613 (GRCm39) G514V probably damaging Het
Ctsw C A 19: 5,515,445 (GRCm39) C347F probably damaging Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Eif1ad8 A T 12: 87,564,001 (GRCm39) H112L probably benign Het
Eml1 T A 12: 108,438,151 (GRCm39) V97D probably damaging Het
Epb41l1 A G 2: 156,363,879 (GRCm39) E796G probably benign Het
Gdnf A G 15: 7,863,895 (GRCm39) K102R probably benign Het
Gm1110 T C 9: 26,792,166 (GRCm39) E618G probably damaging Het
Gmnc T C 16: 26,782,689 (GRCm39) D22G probably damaging Het
Greb1 T C 12: 16,761,829 (GRCm39) D517G possibly damaging Het
Gsta1 A T 9: 78,149,741 (GRCm39) K185* probably null Het
Ift88 A G 14: 57,678,468 (GRCm39) D160G probably benign Het
Intu T A 3: 40,647,008 (GRCm39) I627N probably damaging Het
Itgav T A 2: 83,566,974 (GRCm39) F101L probably damaging Het
Kars1 C T 8: 112,724,290 (GRCm39) V475I probably benign Het
Klra3 G C 6: 130,310,107 (GRCm39) R138G probably benign Het
Klra7 A G 6: 130,208,564 (GRCm39) V6A probably damaging Het
Krtap6-2 A G 16: 89,216,626 (GRCm39) S114P unknown Het
Ldlrad4 T C 18: 68,383,669 (GRCm39) S122P probably benign Het
Lig4 C A 8: 10,023,650 (GRCm39) L43F probably benign Het
Mfsd4a T C 1: 131,986,917 (GRCm39) D137G probably damaging Het
Mmel1 C T 4: 154,968,110 (GRCm39) R149C probably damaging Het
Morc2b T A 17: 33,355,948 (GRCm39) H608L probably benign Het
Mrgpra6 G A 7: 46,838,652 (GRCm39) T182I probably benign Het
Nat8l C A 5: 34,158,200 (GRCm39) N203K probably benign Het
Nin A T 12: 70,101,253 (GRCm39) V448E probably damaging Het
Or10a4 T G 7: 106,696,759 (GRCm39) F29C probably damaging Het
Or2m12 T A 16: 19,105,077 (GRCm39) M139L possibly damaging Het
Or5k15 T A 16: 58,709,903 (GRCm39) I227F probably damaging Het
Or8k21 G A 2: 86,145,129 (GRCm39) T167I probably benign Het
Pank4 T C 4: 155,064,978 (GRCm39) L759P probably damaging Het
Pcm1 T A 8: 41,743,810 (GRCm39) N1152K probably damaging Het
Pitpnm3 A T 11: 71,949,785 (GRCm39) probably null Het
Plekhg3 T C 12: 76,618,839 (GRCm39) M497T possibly damaging Het
Ppfia3 T C 7: 44,990,112 (GRCm39) D1138G probably damaging Het
Prl6a1 T A 13: 27,499,410 (GRCm39) S59R possibly damaging Het
Pth2r A G 1: 65,427,697 (GRCm39) S457G possibly damaging Het
Rbm25 T A 12: 83,721,828 (GRCm39) N671K probably damaging Het
Rbm26 T A 14: 105,397,980 (GRCm39) K47N unknown Het
Ryr1 T A 7: 28,791,600 (GRCm39) I1435F possibly damaging Het
Scin T A 12: 40,131,673 (GRCm39) H287L probably benign Het
Serpinb9e T C 13: 33,437,477 (GRCm39) L120P probably damaging Het
Slc34a1 A C 13: 55,559,844 (GRCm39) probably null Het
Slc39a10 A G 1: 46,875,245 (GRCm39) F19S possibly damaging Het
Sos1 A G 17: 80,761,345 (GRCm39) V117A probably damaging Het
Spta1 C A 1: 174,012,272 (GRCm39) N359K probably benign Het
Sspo G A 6: 48,443,804 (GRCm39) probably null Het
Stx5a T A 19: 8,719,675 (GRCm39) D13E probably damaging Het
Supt16 G A 14: 52,414,112 (GRCm39) A489V probably damaging Het
Tap1 T A 17: 34,408,520 (GRCm39) L253Q probably benign Het
Tmc6 A G 11: 117,660,262 (GRCm39) S659P probably damaging Het
Tnfsf14 T C 17: 57,500,876 (GRCm39) D65G probably benign Het
Ttc28 G A 5: 111,373,543 (GRCm39) S962N probably damaging Het
Ugt8a T C 3: 125,669,207 (GRCm39) Y299C probably damaging Het
Upk1a A G 7: 30,309,145 (GRCm39) V59A possibly damaging Het
Usp38 T C 8: 81,711,432 (GRCm39) T868A probably benign Het
Wdsub1 G A 2: 59,707,059 (GRCm39) H58Y probably damaging Het
Zc3h7b T C 15: 81,653,035 (GRCm39) S19P possibly damaging Het
Zfp385b A C 2: 77,246,257 (GRCm39) F257V probably benign Het
Other mutations in Zmym4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00537:Zmym4 APN 4 126,783,851 (GRCm39) missense probably benign
IGL00845:Zmym4 APN 4 126,794,406 (GRCm39) missense probably benign 0.28
IGL01122:Zmym4 APN 4 126,758,045 (GRCm39) missense probably damaging 1.00
IGL01374:Zmym4 APN 4 126,762,750 (GRCm39) missense probably damaging 1.00
IGL01564:Zmym4 APN 4 126,805,073 (GRCm39) missense possibly damaging 0.84
IGL02014:Zmym4 APN 4 126,794,462 (GRCm39) missense possibly damaging 0.67
IGL02187:Zmym4 APN 4 126,764,066 (GRCm39) missense probably damaging 0.97
IGL02887:Zmym4 APN 4 126,842,268 (GRCm39) missense probably damaging 0.96
IGL03371:Zmym4 APN 4 126,808,881 (GRCm39) missense possibly damaging 0.90
IGL03400:Zmym4 APN 4 126,816,920 (GRCm39) missense probably benign 0.12
arriba UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
foreclosed UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
Foreshortened UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
levantese UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
terminated UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
BB004:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
BB014:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R0149:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0361:Zmym4 UTSW 4 126,804,938 (GRCm39) missense probably benign 0.00
R0423:Zmym4 UTSW 4 126,776,112 (GRCm39) splice site probably benign
R0532:Zmym4 UTSW 4 126,792,194 (GRCm39) nonsense probably null
R0745:Zmym4 UTSW 4 126,796,496 (GRCm39) splice site probably benign
R1183:Zmym4 UTSW 4 126,819,632 (GRCm39) missense probably damaging 0.99
R1401:Zmym4 UTSW 4 126,804,962 (GRCm39) missense probably benign 0.00
R1446:Zmym4 UTSW 4 126,776,275 (GRCm39) missense probably damaging 1.00
R1491:Zmym4 UTSW 4 126,776,105 (GRCm39) critical splice acceptor site probably null
R1962:Zmym4 UTSW 4 126,796,463 (GRCm39) missense possibly damaging 0.47
R2398:Zmym4 UTSW 4 126,816,929 (GRCm39) missense probably damaging 1.00
R2930:Zmym4 UTSW 4 126,819,316 (GRCm39) missense probably benign 0.00
R3891:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R3892:Zmym4 UTSW 4 126,798,269 (GRCm39) missense probably benign 0.04
R4659:Zmym4 UTSW 4 126,842,221 (GRCm39) splice site probably null
R4702:Zmym4 UTSW 4 126,816,958 (GRCm39) missense probably benign 0.01
R5160:Zmym4 UTSW 4 126,763,977 (GRCm39) missense probably damaging 0.97
R5614:Zmym4 UTSW 4 126,804,729 (GRCm39) missense possibly damaging 0.75
R5773:Zmym4 UTSW 4 126,799,163 (GRCm39) missense possibly damaging 0.52
R6450:Zmym4 UTSW 4 126,789,099 (GRCm39) missense probably damaging 1.00
R6741:Zmym4 UTSW 4 126,808,878 (GRCm39) missense possibly damaging 0.80
R7023:Zmym4 UTSW 4 126,762,593 (GRCm39) missense probably damaging 1.00
R7315:Zmym4 UTSW 4 126,776,385 (GRCm39) missense probably benign 0.09
R7468:Zmym4 UTSW 4 126,776,029 (GRCm39) missense probably benign 0.40
R7546:Zmym4 UTSW 4 126,757,961 (GRCm39) missense probably damaging 0.99
R7609:Zmym4 UTSW 4 126,819,588 (GRCm39) missense probably benign 0.02
R7764:Zmym4 UTSW 4 126,819,409 (GRCm39) missense probably benign 0.06
R7897:Zmym4 UTSW 4 126,783,332 (GRCm39) missense possibly damaging 0.76
R7918:Zmym4 UTSW 4 126,804,797 (GRCm39) critical splice acceptor site probably null
R7927:Zmym4 UTSW 4 126,799,170 (GRCm39) missense probably benign 0.42
R8129:Zmym4 UTSW 4 126,808,956 (GRCm39) missense possibly damaging 0.87
R8240:Zmym4 UTSW 4 126,798,188 (GRCm39) critical splice donor site probably null
R8248:Zmym4 UTSW 4 126,799,162 (GRCm39) missense possibly damaging 0.56
R8261:Zmym4 UTSW 4 126,798,360 (GRCm39) missense probably damaging 1.00
R8313:Zmym4 UTSW 4 126,804,762 (GRCm39) missense probably benign 0.19
R8353:Zmym4 UTSW 4 126,800,905 (GRCm39) missense possibly damaging 0.46
R8747:Zmym4 UTSW 4 126,787,198 (GRCm39) missense probably damaging 1.00
R8787:Zmym4 UTSW 4 126,816,953 (GRCm39) missense probably benign 0.41
R8795:Zmym4 UTSW 4 126,799,819 (GRCm39) missense probably benign 0.35
R8948:Zmym4 UTSW 4 126,758,060 (GRCm39) missense probably damaging 1.00
R9218:Zmym4 UTSW 4 126,809,415 (GRCm39) missense probably damaging 0.97
R9233:Zmym4 UTSW 4 126,776,310 (GRCm39) missense probably damaging 0.99
R9286:Zmym4 UTSW 4 126,783,812 (GRCm39) missense probably damaging 1.00
R9468:Zmym4 UTSW 4 126,800,993 (GRCm39) missense probably benign 0.01
R9542:Zmym4 UTSW 4 126,799,164 (GRCm39) missense probably benign 0.00
R9756:Zmym4 UTSW 4 126,771,502 (GRCm39) missense probably damaging 1.00
R9776:Zmym4 UTSW 4 126,804,942 (GRCm39) missense possibly damaging 0.51
U24488:Zmym4 UTSW 4 126,819,453 (GRCm39) missense possibly damaging 0.69
Z1177:Zmym4 UTSW 4 126,801,005 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACTGCCCCTCAATTTGCAGCAC -3'
(R):5'- tctcaccagccccCAAAATTACAAATG -3'

Sequencing Primer
(F):5'- ATTTGCAGCACATGGCACTG -3'
(R):5'- GTTCCTTTAATATACCAAGAGGGTGG -3'
Posted On 2014-04-24