Incidental Mutation 'R1566:Klra7'
ID 175263
Institutional Source Beutler Lab
Gene Symbol Klra7
Ensembl Gene ENSMUSG00000067599
Gene Name killer cell lectin-like receptor, subfamily A, member 7
Synonyms Ly-49G.3, Ly49g, LGL-1, Ly49g1, Ly49g2, Ly-49G.1, Ly-49G.2
MMRRC Submission 039605-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1566 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 130195568-130210285 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130208564 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 6 (V6A)
Ref Sequence ENSEMBL: ENSMUSP00000107644 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032286] [ENSMUST00000049304] [ENSMUST00000088011] [ENSMUST00000112013]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000032286
AA Change: V6A

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000032286
Gene: ENSMUSG00000067599
AA Change: V6A

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
Blast:CLECT 73 123 9e-22 BLAST
CLECT 157 272 3.09e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000049304
AA Change: V6A

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000037917
Gene: ENSMUSG00000067599
AA Change: V6A

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
Blast:CLECT 73 123 7e-22 BLAST
CLECT 144 259 3.09e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000088011
AA Change: V6A

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000085326
Gene: ENSMUSG00000067599
AA Change: V6A

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
Blast:CLECT 73 123 7e-22 BLAST
CLECT 144 259 3.09e-16 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000112013
AA Change: V6A

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000107644
Gene: ENSMUSG00000067599
AA Change: V6A

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
Blast:CLECT 73 123 9e-22 BLAST
CLECT 157 272 3.09e-16 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B07Rik T A 11: 109,679,632 (GRCm39) I247F probably benign Het
Afap1l1 T C 18: 61,888,714 (GRCm39) N119S probably benign Het
Ap2a1 T C 7: 44,552,904 (GRCm39) D721G probably benign Het
Ap3m2 C T 8: 23,293,967 (GRCm39) V28M probably damaging Het
Arhgef7 A G 8: 11,832,620 (GRCm39) T32A possibly damaging Het
Avl9 C T 6: 56,713,467 (GRCm39) R242* probably null Het
Bsn G A 9: 108,003,184 (GRCm39) T407I probably benign Het
Capn3 A T 2: 120,333,474 (GRCm39) R627S possibly damaging Het
Car13 G A 3: 14,715,758 (GRCm39) R92Q probably benign Het
Clcn1 T C 6: 42,268,374 (GRCm39) I149T possibly damaging Het
Col1a2 G T 6: 4,523,613 (GRCm39) G514V probably damaging Het
Ctsw C A 19: 5,515,445 (GRCm39) C347F probably damaging Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Eif1ad8 A T 12: 87,564,001 (GRCm39) H112L probably benign Het
Eml1 T A 12: 108,438,151 (GRCm39) V97D probably damaging Het
Epb41l1 A G 2: 156,363,879 (GRCm39) E796G probably benign Het
Gdnf A G 15: 7,863,895 (GRCm39) K102R probably benign Het
Gm1110 T C 9: 26,792,166 (GRCm39) E618G probably damaging Het
Gmnc T C 16: 26,782,689 (GRCm39) D22G probably damaging Het
Greb1 T C 12: 16,761,829 (GRCm39) D517G possibly damaging Het
Gsta1 A T 9: 78,149,741 (GRCm39) K185* probably null Het
Ift88 A G 14: 57,678,468 (GRCm39) D160G probably benign Het
Intu T A 3: 40,647,008 (GRCm39) I627N probably damaging Het
Itgav T A 2: 83,566,974 (GRCm39) F101L probably damaging Het
Kars1 C T 8: 112,724,290 (GRCm39) V475I probably benign Het
Klra3 G C 6: 130,310,107 (GRCm39) R138G probably benign Het
Krtap6-2 A G 16: 89,216,626 (GRCm39) S114P unknown Het
Ldlrad4 T C 18: 68,383,669 (GRCm39) S122P probably benign Het
Lig4 C A 8: 10,023,650 (GRCm39) L43F probably benign Het
Mfsd4a T C 1: 131,986,917 (GRCm39) D137G probably damaging Het
Mmel1 C T 4: 154,968,110 (GRCm39) R149C probably damaging Het
Morc2b T A 17: 33,355,948 (GRCm39) H608L probably benign Het
Mrgpra6 G A 7: 46,838,652 (GRCm39) T182I probably benign Het
Nat8l C A 5: 34,158,200 (GRCm39) N203K probably benign Het
Nin A T 12: 70,101,253 (GRCm39) V448E probably damaging Het
Or10a4 T G 7: 106,696,759 (GRCm39) F29C probably damaging Het
Or2m12 T A 16: 19,105,077 (GRCm39) M139L possibly damaging Het
Or5k15 T A 16: 58,709,903 (GRCm39) I227F probably damaging Het
Or8k21 G A 2: 86,145,129 (GRCm39) T167I probably benign Het
Pank4 T C 4: 155,064,978 (GRCm39) L759P probably damaging Het
Pcm1 T A 8: 41,743,810 (GRCm39) N1152K probably damaging Het
Pitpnm3 A T 11: 71,949,785 (GRCm39) probably null Het
Plekhg3 T C 12: 76,618,839 (GRCm39) M497T possibly damaging Het
Ppfia3 T C 7: 44,990,112 (GRCm39) D1138G probably damaging Het
Prl6a1 T A 13: 27,499,410 (GRCm39) S59R possibly damaging Het
Pth2r A G 1: 65,427,697 (GRCm39) S457G possibly damaging Het
Rbm25 T A 12: 83,721,828 (GRCm39) N671K probably damaging Het
Rbm26 T A 14: 105,397,980 (GRCm39) K47N unknown Het
Ryr1 T A 7: 28,791,600 (GRCm39) I1435F possibly damaging Het
Scin T A 12: 40,131,673 (GRCm39) H287L probably benign Het
Serpinb9e T C 13: 33,437,477 (GRCm39) L120P probably damaging Het
Slc34a1 A C 13: 55,559,844 (GRCm39) probably null Het
Slc39a10 A G 1: 46,875,245 (GRCm39) F19S possibly damaging Het
Sos1 A G 17: 80,761,345 (GRCm39) V117A probably damaging Het
Spta1 C A 1: 174,012,272 (GRCm39) N359K probably benign Het
Sspo G A 6: 48,443,804 (GRCm39) probably null Het
Stx5a T A 19: 8,719,675 (GRCm39) D13E probably damaging Het
Supt16 G A 14: 52,414,112 (GRCm39) A489V probably damaging Het
Tap1 T A 17: 34,408,520 (GRCm39) L253Q probably benign Het
Tmc6 A G 11: 117,660,262 (GRCm39) S659P probably damaging Het
Tnfsf14 T C 17: 57,500,876 (GRCm39) D65G probably benign Het
Ttc28 G A 5: 111,373,543 (GRCm39) S962N probably damaging Het
Ugt8a T C 3: 125,669,207 (GRCm39) Y299C probably damaging Het
Upk1a A G 7: 30,309,145 (GRCm39) V59A possibly damaging Het
Usp38 T C 8: 81,711,432 (GRCm39) T868A probably benign Het
Wdsub1 G A 2: 59,707,059 (GRCm39) H58Y probably damaging Het
Zc3h7b T C 15: 81,653,035 (GRCm39) S19P possibly damaging Het
Zfp385b A C 2: 77,246,257 (GRCm39) F257V probably benign Het
Zmym4 A C 4: 126,804,940 (GRCm39) I188S possibly damaging Het
Other mutations in Klra7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01369:Klra7 APN 6 130,203,498 (GRCm39) nonsense probably null
IGL02708:Klra7 APN 6 130,203,463 (GRCm39) missense probably damaging 1.00
R0890:Klra7 UTSW 6 130,195,916 (GRCm39) missense probably benign 0.00
R1815:Klra7 UTSW 6 130,201,070 (GRCm39) missense probably benign 0.23
R1843:Klra7 UTSW 6 130,206,957 (GRCm39) missense possibly damaging 0.79
R2216:Klra7 UTSW 6 130,205,549 (GRCm39) missense probably benign 0.18
R2313:Klra7 UTSW 6 130,205,505 (GRCm39) missense probably benign 0.04
R4067:Klra7 UTSW 6 130,208,612 (GRCm39) splice site probably null
R5855:Klra7 UTSW 6 130,195,921 (GRCm39) missense possibly damaging 0.75
R6651:Klra7 UTSW 6 130,206,908 (GRCm39) missense probably benign 0.40
R7508:Klra7 UTSW 6 130,207,054 (GRCm39) splice site probably null
R8445:Klra7 UTSW 6 130,204,078 (GRCm39) missense possibly damaging 0.86
R8458:Klra7 UTSW 6 130,201,109 (GRCm39) missense probably damaging 1.00
R9801:Klra7 UTSW 6 130,205,477 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GTGCATAACCAAGCCCCAATGAGAT -3'
(R):5'- AATTTGGTCAGTCCATGTCAGGGTG -3'

Sequencing Primer
(F):5'- CACTTACCTCTGTAGCAAGCT -3'
(R):5'- CATGTCAGGGTGTTTATAGCATTAAG -3'
Posted On 2014-04-24