Incidental Mutation 'R1598:Or5w8'
ID 175925
Institutional Source Beutler Lab
Gene Symbol Or5w8
Ensembl Gene ENSMUSG00000047039
Gene Name olfactory receptor family 5 subfamily W member 8
Synonyms MOR177-9, Olfr1151, GA_x6K02T2Q125-49358694-49359620
MMRRC Submission 039635-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R1598 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87687521-87688447 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87688095 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 192 (I192K)
Ref Sequence ENSEMBL: ENSMUSP00000151107 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061081] [ENSMUST00000217376]
AlphaFold Q8VFQ8
Predicted Effect probably benign
Transcript: ENSMUST00000061081
AA Change: I192K

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000055394
Gene: ENSMUSG00000047039
AA Change: I192K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.6e-45 PFAM
Pfam:7tm_1 41 290 1.7e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217376
AA Change: I192K

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.7%
  • 20x: 90.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730455P16Rik G A 11: 80,254,838 (GRCm39) Q328* probably null Het
Aadacl4fm4 T A 4: 144,396,994 (GRCm39) K246I possibly damaging Het
Adamts1 G A 16: 85,595,399 (GRCm39) Q260* probably null Het
Add2 A T 6: 86,075,628 (GRCm39) Y259F probably benign Het
Bora T C 14: 99,305,840 (GRCm39) V403A probably benign Het
Ccnl1 G A 3: 65,854,191 (GRCm39) R477W probably damaging Het
Cdc25a CG CGG 9: 109,708,961 (GRCm39) probably null Het
Cdr2l T C 11: 115,284,203 (GRCm39) S180P probably damaging Het
Cep290 T A 10: 100,385,191 (GRCm39) L1889Q probably damaging Het
Ces4a T C 8: 105,869,453 (GRCm39) V208A probably damaging Het
Col2a1 T C 15: 97,877,131 (GRCm39) D1049G probably damaging Het
Coro1a A T 7: 126,300,864 (GRCm39) N154K possibly damaging Het
Cubn T A 2: 13,474,600 (GRCm39) R401S probably benign Het
Cul7 A T 17: 46,974,017 (GRCm39) Q1434L probably benign Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dars1 G T 1: 128,301,709 (GRCm39) D308E probably benign Het
Dna2 T A 10: 62,797,436 (GRCm39) F604I probably damaging Het
Dnah1 T G 14: 31,023,219 (GRCm39) I1033L probably benign Het
Erlin1 T C 19: 44,036,112 (GRCm39) E206G probably damaging Het
Esrp2 T A 8: 106,859,905 (GRCm39) E345D probably damaging Het
Foxa1 T C 12: 57,589,473 (GRCm39) D249G possibly damaging Het
Ghsr C A 3: 27,426,426 (GRCm39) L161M probably benign Het
Gm57858 C T 3: 36,073,146 (GRCm39) A379T probably damaging Het
Gpr155 C A 2: 73,200,434 (GRCm39) V358F probably damaging Het
H2-Eb2 A T 17: 34,553,348 (GRCm39) N178I probably damaging Het
Hydin T A 8: 111,137,306 (GRCm39) I703N possibly damaging Het
Kctd15 A G 7: 34,341,417 (GRCm39) V170A probably damaging Het
Klhl31 A T 9: 77,558,298 (GRCm39) Y338F possibly damaging Het
Krt5 C T 15: 101,620,876 (GRCm39) A124T probably benign Het
Krt72 T A 15: 101,688,688 (GRCm39) I331F probably benign Het
Lrp1b T A 2: 41,401,490 (GRCm39) D388V probably damaging Het
Ly9 A G 1: 171,424,075 (GRCm39) V382A probably benign Het
Mon2 T C 10: 122,852,301 (GRCm39) Y1024C probably damaging Het
Myh14 A G 7: 44,287,818 (GRCm39) F572L probably damaging Het
Myh3 A T 11: 66,983,997 (GRCm39) D987V probably damaging Het
Ndn C T 7: 61,998,256 (GRCm39) P34L probably benign Het
Nphp4 A G 4: 152,646,547 (GRCm39) T1360A probably benign Het
Oog4 A G 4: 143,164,571 (GRCm39) L320P probably damaging Het
Or4k49 G T 2: 111,495,099 (GRCm39) S176I probably damaging Het
Or5m9 C T 2: 85,877,657 (GRCm39) T277I probably damaging Het
Pcnx2 T C 8: 126,498,825 (GRCm39) N1558S probably benign Het
Pde10a A G 17: 9,147,976 (GRCm39) E147G probably damaging Het
Pgbd5 T A 8: 125,101,026 (GRCm39) H410L probably benign Het
Plce1 A C 19: 38,709,440 (GRCm39) D1098A probably damaging Het
Psg25 G A 7: 18,265,928 (GRCm39) Q16* probably null Het
Psmd9 T A 5: 123,379,980 (GRCm39) V133E probably damaging Het
Rabgap1 C T 2: 37,451,911 (GRCm39) S937F probably damaging Het
Rbck1 A G 2: 152,165,090 (GRCm39) probably null Het
Rprd2 C G 3: 95,726,051 (GRCm39) probably benign Het
Rrs1 A G 1: 9,616,137 (GRCm39) N130S probably benign Het
Scmh1 A T 4: 120,372,327 (GRCm39) I377F possibly damaging Het
Skor1 G T 9: 63,053,286 (GRCm39) R228S probably damaging Het
Slc2a4 A G 11: 69,835,844 (GRCm39) V335A probably benign Het
Slc4a9 G A 18: 36,661,424 (GRCm39) W62* probably null Het
Styxl2 G A 1: 165,937,828 (GRCm39) T77I probably benign Het
Taar9 G T 10: 23,985,305 (GRCm39) A43D possibly damaging Het
Tns4 T C 11: 98,961,243 (GRCm39) Y645C probably damaging Het
Tpcn2 G T 7: 144,830,957 (GRCm39) Y129* probably null Het
Trpm3 T C 19: 22,710,388 (GRCm39) S278P possibly damaging Het
Ttc3 T C 16: 94,223,156 (GRCm39) W615R probably damaging Het
Ttll5 T C 12: 85,910,372 (GRCm39) V207A probably damaging Het
Ubr7 G T 12: 102,736,153 (GRCm39) M358I probably damaging Het
Urb1 C A 16: 90,574,328 (GRCm39) V918F possibly damaging Het
Vmn2r51 G A 7: 9,839,432 (GRCm39) T52I probably benign Het
Vmn2r95 A T 17: 18,672,575 (GRCm39) I771F probably benign Het
Wfdc16 T C 2: 164,477,350 (GRCm39) S107G probably benign Het
Zmym2 A G 14: 57,140,226 (GRCm39) T22A possibly damaging Het
Zmym2 G A 14: 57,151,524 (GRCm39) G470R probably damaging Het
Other mutations in Or5w8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01755:Or5w8 APN 2 87,687,854 (GRCm39) missense possibly damaging 0.60
IGL02314:Or5w8 APN 2 87,688,400 (GRCm39) missense probably damaging 1.00
R0127:Or5w8 UTSW 2 87,687,827 (GRCm39) missense probably benign
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0398:Or5w8 UTSW 2 87,688,401 (GRCm39) missense probably damaging 1.00
R1079:Or5w8 UTSW 2 87,687,699 (GRCm39) missense probably damaging 1.00
R1965:Or5w8 UTSW 2 87,687,759 (GRCm39) missense probably benign 0.44
R3409:Or5w8 UTSW 2 87,688,005 (GRCm39) nonsense probably null
R4824:Or5w8 UTSW 2 87,687,621 (GRCm39) missense probably benign 0.24
R4962:Or5w8 UTSW 2 87,687,632 (GRCm39) missense probably benign 0.02
R4986:Or5w8 UTSW 2 87,687,858 (GRCm39) missense probably damaging 0.97
R5324:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
R5934:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R6335:Or5w8 UTSW 2 87,687,811 (GRCm39) nonsense probably null
R6389:Or5w8 UTSW 2 87,688,367 (GRCm39) missense probably damaging 1.00
R6958:Or5w8 UTSW 2 87,688,295 (GRCm39) missense probably damaging 1.00
R7329:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R8228:Or5w8 UTSW 2 87,688,284 (GRCm39) missense probably benign 0.12
R8506:Or5w8 UTSW 2 87,688,181 (GRCm39) missense probably damaging 1.00
R8726:Or5w8 UTSW 2 87,688,161 (GRCm39) missense probably benign 0.14
R8845:Or5w8 UTSW 2 87,687,545 (GRCm39) missense probably benign 0.00
R9548:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
Z1177:Or5w8 UTSW 2 87,687,768 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- AATGCTGGTGGATCTCTTAGCTGC -3'
(R):5'- AGTTCCCTGGAAAATGGCAACTGTG -3'

Sequencing Primer
(F):5'- TGATAGATACCAGGCCATTAGC -3'
(R):5'- ATGGCAACTGTGGTGAGATG -3'
Posted On 2014-04-24