Incidental Mutation 'R1601:Paqr3'
ID 176141
Institutional Source Beutler Lab
Gene Symbol Paqr3
Ensembl Gene ENSMUSG00000055725
Gene Name progestin and adipoQ receptor family member III
Synonyms 6330415A20Rik, RKTG
MMRRC Submission 039638-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # R1601 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 97230188-97259455 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 97259248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 19 (Y19H)
Ref Sequence ENSEMBL: ENSMUSP00000108592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069453] [ENSMUST00000112968] [ENSMUST00000112969] [ENSMUST00000196078]
AlphaFold Q6TCG8
Predicted Effect probably benign
Transcript: ENSMUST00000069453
AA Change: Y19H

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000069324
Gene: ENSMUSG00000055725
AA Change: Y19H

DomainStartEndE-ValueType
Pfam:HlyIII 64 289 3.4e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112968
AA Change: Y19H

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000108592
Gene: ENSMUSG00000055725
AA Change: Y19H

DomainStartEndE-ValueType
Pfam:HlyIII 64 171 1.5e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112969
AA Change: Y19H

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000108593
Gene: ENSMUSG00000055725
AA Change: Y19H

DomainStartEndE-ValueType
Pfam:HlyIII 64 289 1.4e-51 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132127
Predicted Effect probably benign
Transcript: ENSMUST00000196078
AA Change: Y19H

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000142871
Gene: ENSMUSG00000055725
AA Change: Y19H

DomainStartEndE-ValueType
Pfam:HlyIII 64 179 7e-24 PFAM
transmembrane domain 181 203 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Targeted deletion of this gene causes faster chemical carcinogen-induced skin cell proliferation, higher epidermal thickness, increased number and size of skin papillomas, shorter tumor latency and delayed tumor regression. Heterozygotes develop tumors earlier and more frequently than control mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik G A 3: 68,777,546 (GRCm39) S169N probably benign Het
Adgra2 T C 8: 27,600,046 (GRCm39) probably null Het
Adgrb2 T C 4: 129,886,630 (GRCm39) S257P probably benign Het
Adgre1 A G 17: 57,748,353 (GRCm39) K518E probably benign Het
Anxa7 A T 14: 20,514,683 (GRCm39) Y64* probably null Het
Arhgef7 A G 8: 11,832,638 (GRCm39) probably null Het
Cdc42bpa T A 1: 179,892,566 (GRCm39) Y243* probably null Het
Cdk14 C T 5: 5,185,378 (GRCm39) V176M probably damaging Het
Cnbd2 A G 2: 156,175,551 (GRCm39) E54G probably damaging Het
Crx T C 7: 15,601,736 (GRCm39) probably null Het
Cyp24a1 A G 2: 170,327,611 (GRCm39) F511L possibly damaging Het
Ddx11 A G 17: 66,457,380 (GRCm39) M810V probably damaging Het
Dock10 T C 1: 80,527,519 (GRCm39) T1077A probably benign Het
Dop1a G A 9: 86,418,303 (GRCm39) D2011N probably damaging Het
Ehhadh T A 16: 21,585,158 (GRCm39) H241L probably benign Het
Elp1 T A 4: 56,774,756 (GRCm39) K740* probably null Het
Enah A T 1: 181,747,185 (GRCm39) L523* probably null Het
Fabp3 T C 4: 130,202,641 (GRCm39) L24P probably benign Het
Fat2 A G 11: 55,172,836 (GRCm39) S2626P probably benign Het
Fbxo4 A G 15: 3,998,447 (GRCm39) M337T possibly damaging Het
Gas6 G T 8: 13,515,786 (GRCm39) T662N probably damaging Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably null Het
Hrh4 G A 18: 13,148,955 (GRCm39) V106I possibly damaging Het
Ido2 G T 8: 25,066,205 (GRCm39) H20Q possibly damaging Het
Itga10 G T 3: 96,560,974 (GRCm39) R613L possibly damaging Het
Itsn2 T C 12: 4,708,452 (GRCm39) S836P probably benign Het
Kcng3 A T 17: 83,895,768 (GRCm39) C233S probably damaging Het
Kdm3b A G 18: 34,941,784 (GRCm39) Q625R probably damaging Het
Kidins220 A G 12: 25,055,087 (GRCm39) S553G probably benign Het
Krt82 A T 15: 101,453,588 (GRCm39) I266N probably damaging Het
Lama5 A T 2: 179,839,538 (GRCm39) L736Q probably damaging Het
Lnx2 A G 5: 146,970,329 (GRCm39) C138R probably damaging Het
Mcm5 T C 8: 75,845,982 (GRCm39) C397R possibly damaging Het
Me1 A C 9: 86,560,065 (GRCm39) Y52D probably damaging Het
Muc4 C A 16: 32,575,875 (GRCm39) probably benign Het
Myo18b G T 5: 113,019,364 (GRCm39) Q638K possibly damaging Het
Ncapd2 A G 6: 125,162,735 (GRCm39) L170P probably damaging Het
Neb A T 2: 52,177,264 (GRCm39) L1359* probably null Het
Nomo1 C A 7: 45,696,379 (GRCm39) S299Y probably damaging Het
Onecut1 A T 9: 74,769,973 (GRCm39) H132L probably benign Het
Or2b2 C A 13: 21,887,396 (GRCm39) T75K probably damaging Het
Or2w3 A T 11: 58,556,903 (GRCm39) R173W probably damaging Het
Or4e2 A C 14: 52,687,899 (GRCm39) T10P probably benign Het
Or7a41 A T 10: 78,871,338 (GRCm39) Y236F possibly damaging Het
Prdx5 T C 19: 6,884,926 (GRCm39) H140R possibly damaging Het
Prox1 T C 1: 189,893,203 (GRCm39) D414G probably damaging Het
Ptprh T G 7: 4,555,637 (GRCm39) E774A probably damaging Het
Rnpepl1 A T 1: 92,844,944 (GRCm39) D412V possibly damaging Het
Sars2 C T 7: 28,448,396 (GRCm39) T259M probably benign Het
Sbf2 T C 7: 109,939,283 (GRCm39) probably null Het
Sbno2 C T 10: 79,896,326 (GRCm39) R898H probably damaging Het
Smox C A 2: 131,362,094 (GRCm39) T172N probably damaging Het
Taf7l2 T C 10: 115,949,521 (GRCm39) S2G probably damaging Het
Tdrd9 C T 12: 111,989,687 (GRCm39) R341* probably null Het
Thrap3 C G 4: 126,073,894 (GRCm39) G284A probably damaging Het
Tmtc4 A G 14: 123,182,238 (GRCm39) V271A probably benign Het
Trank1 A G 9: 111,202,545 (GRCm39) T1637A probably damaging Het
Tspan5 T A 3: 138,602,596 (GRCm39) I166N probably damaging Het
Vps13b T C 15: 35,642,582 (GRCm39) V1398A probably benign Het
Xbp1 C T 11: 5,471,975 (GRCm39) R34W probably damaging Het
Other mutations in Paqr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Paqr3 APN 5 97,243,796 (GRCm39) missense probably benign
IGL01966:Paqr3 APN 5 97,247,502 (GRCm39) missense probably benign 0.21
IGL02133:Paqr3 APN 5 97,243,790 (GRCm39) missense probably benign
PIT4618001:Paqr3 UTSW 5 97,251,330 (GRCm39) missense possibly damaging 0.82
R2864:Paqr3 UTSW 5 97,247,595 (GRCm39) missense possibly damaging 0.65
R3419:Paqr3 UTSW 5 97,247,559 (GRCm39) missense probably damaging 1.00
R3799:Paqr3 UTSW 5 97,259,175 (GRCm39) missense probably damaging 1.00
R4352:Paqr3 UTSW 5 97,247,455 (GRCm39) missense probably benign 0.05
R4368:Paqr3 UTSW 5 97,256,150 (GRCm39) missense probably damaging 1.00
R4515:Paqr3 UTSW 5 97,251,220 (GRCm39) missense possibly damaging 0.72
R4583:Paqr3 UTSW 5 97,256,069 (GRCm39) nonsense probably null
R4647:Paqr3 UTSW 5 97,256,069 (GRCm39) nonsense probably null
R4648:Paqr3 UTSW 5 97,256,069 (GRCm39) nonsense probably null
R4811:Paqr3 UTSW 5 97,243,842 (GRCm39) missense probably benign 0.00
R4855:Paqr3 UTSW 5 97,256,053 (GRCm39) missense possibly damaging 0.83
R5910:Paqr3 UTSW 5 97,243,887 (GRCm39) splice site probably null
R6053:Paqr3 UTSW 5 97,259,137 (GRCm39) missense probably benign 0.12
R6156:Paqr3 UTSW 5 97,256,128 (GRCm39) missense probably damaging 1.00
R6957:Paqr3 UTSW 5 97,256,110 (GRCm39) missense possibly damaging 0.48
R6974:Paqr3 UTSW 5 97,256,146 (GRCm39) missense probably damaging 1.00
R9201:Paqr3 UTSW 5 97,245,365 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- GGGAGCAGCCACTGTACCTTTTGAT -3'
(R):5'- TCCTGCTGGTAAAGCCCGAAGGAA -3'

Sequencing Primer
(F):5'- GTACCTTTTGATACACAGTCTGG -3'
(R):5'- GTCCAGAGCTGAAGCGG -3'
Posted On 2014-04-24