Incidental Mutation 'R1601:Or2b2'
ID 176170
Institutional Source Beutler Lab
Gene Symbol Or2b2
Ensembl Gene ENSMUSG00000108674
Gene Name olfactory receptor family 2 subfamily B member 2
Synonyms MOR256-60, MOR256-35, Olfr1359, GA_x6K02T2QHY8-11534186-11533245
MMRRC Submission 039638-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # R1601 (G1)
Quality Score 130
Status Not validated
Chromosome 13
Chromosomal Location 21887144-21888135 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 21887396 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 75 (T75K)
Ref Sequence ENSEMBL: ENSMUSP00000150106 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077843] [ENSMUST00000079135] [ENSMUST00000205788] [ENSMUST00000214435]
AlphaFold Q7TQU5
Predicted Effect probably damaging
Transcript: ENSMUST00000077843
AA Change: T75K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000077010
Gene: ENSMUSG00000108674
AA Change: T75K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2e-55 PFAM
Pfam:7tm_1 41 290 1.7e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000079135
AA Change: T75K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074361
Gene: ENSMUSG00000108534
AA Change: T75K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-55 PFAM
Pfam:7tm_1 41 290 1.1e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205788
AA Change: T75K
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214006
Predicted Effect probably damaging
Transcript: ENSMUST00000214435
AA Change: T75K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik G A 3: 68,777,546 (GRCm39) S169N probably benign Het
Adgra2 T C 8: 27,600,046 (GRCm39) probably null Het
Adgrb2 T C 4: 129,886,630 (GRCm39) S257P probably benign Het
Adgre1 A G 17: 57,748,353 (GRCm39) K518E probably benign Het
Anxa7 A T 14: 20,514,683 (GRCm39) Y64* probably null Het
Arhgef7 A G 8: 11,832,638 (GRCm39) probably null Het
Cdc42bpa T A 1: 179,892,566 (GRCm39) Y243* probably null Het
Cdk14 C T 5: 5,185,378 (GRCm39) V176M probably damaging Het
Cnbd2 A G 2: 156,175,551 (GRCm39) E54G probably damaging Het
Crx T C 7: 15,601,736 (GRCm39) probably null Het
Cyp24a1 A G 2: 170,327,611 (GRCm39) F511L possibly damaging Het
Ddx11 A G 17: 66,457,380 (GRCm39) M810V probably damaging Het
Dock10 T C 1: 80,527,519 (GRCm39) T1077A probably benign Het
Dop1a G A 9: 86,418,303 (GRCm39) D2011N probably damaging Het
Ehhadh T A 16: 21,585,158 (GRCm39) H241L probably benign Het
Elp1 T A 4: 56,774,756 (GRCm39) K740* probably null Het
Enah A T 1: 181,747,185 (GRCm39) L523* probably null Het
Fabp3 T C 4: 130,202,641 (GRCm39) L24P probably benign Het
Fat2 A G 11: 55,172,836 (GRCm39) S2626P probably benign Het
Fbxo4 A G 15: 3,998,447 (GRCm39) M337T possibly damaging Het
Gas6 G T 8: 13,515,786 (GRCm39) T662N probably damaging Het
Gm10608 CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA 9: 118,989,784 (GRCm39) probably null Het
Hrh4 G A 18: 13,148,955 (GRCm39) V106I possibly damaging Het
Ido2 G T 8: 25,066,205 (GRCm39) H20Q possibly damaging Het
Itga10 G T 3: 96,560,974 (GRCm39) R613L possibly damaging Het
Itsn2 T C 12: 4,708,452 (GRCm39) S836P probably benign Het
Kcng3 A T 17: 83,895,768 (GRCm39) C233S probably damaging Het
Kdm3b A G 18: 34,941,784 (GRCm39) Q625R probably damaging Het
Kidins220 A G 12: 25,055,087 (GRCm39) S553G probably benign Het
Krt82 A T 15: 101,453,588 (GRCm39) I266N probably damaging Het
Lama5 A T 2: 179,839,538 (GRCm39) L736Q probably damaging Het
Lnx2 A G 5: 146,970,329 (GRCm39) C138R probably damaging Het
Mcm5 T C 8: 75,845,982 (GRCm39) C397R possibly damaging Het
Me1 A C 9: 86,560,065 (GRCm39) Y52D probably damaging Het
Muc4 C A 16: 32,575,875 (GRCm39) probably benign Het
Myo18b G T 5: 113,019,364 (GRCm39) Q638K possibly damaging Het
Ncapd2 A G 6: 125,162,735 (GRCm39) L170P probably damaging Het
Neb A T 2: 52,177,264 (GRCm39) L1359* probably null Het
Nomo1 C A 7: 45,696,379 (GRCm39) S299Y probably damaging Het
Onecut1 A T 9: 74,769,973 (GRCm39) H132L probably benign Het
Or2w3 A T 11: 58,556,903 (GRCm39) R173W probably damaging Het
Or4e2 A C 14: 52,687,899 (GRCm39) T10P probably benign Het
Or7a41 A T 10: 78,871,338 (GRCm39) Y236F possibly damaging Het
Paqr3 A G 5: 97,259,248 (GRCm39) Y19H probably benign Het
Prdx5 T C 19: 6,884,926 (GRCm39) H140R possibly damaging Het
Prox1 T C 1: 189,893,203 (GRCm39) D414G probably damaging Het
Ptprh T G 7: 4,555,637 (GRCm39) E774A probably damaging Het
Rnpepl1 A T 1: 92,844,944 (GRCm39) D412V possibly damaging Het
Sars2 C T 7: 28,448,396 (GRCm39) T259M probably benign Het
Sbf2 T C 7: 109,939,283 (GRCm39) probably null Het
Sbno2 C T 10: 79,896,326 (GRCm39) R898H probably damaging Het
Smox C A 2: 131,362,094 (GRCm39) T172N probably damaging Het
Taf7l2 T C 10: 115,949,521 (GRCm39) S2G probably damaging Het
Tdrd9 C T 12: 111,989,687 (GRCm39) R341* probably null Het
Thrap3 C G 4: 126,073,894 (GRCm39) G284A probably damaging Het
Tmtc4 A G 14: 123,182,238 (GRCm39) V271A probably benign Het
Trank1 A G 9: 111,202,545 (GRCm39) T1637A probably damaging Het
Tspan5 T A 3: 138,602,596 (GRCm39) I166N probably damaging Het
Vps13b T C 15: 35,642,582 (GRCm39) V1398A probably benign Het
Xbp1 C T 11: 5,471,975 (GRCm39) R34W probably damaging Het
Other mutations in Or2b2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01563:Or2b2 APN 13 21,887,243 (GRCm39) missense probably benign 0.21
R1743:Or2b2 UTSW 13 21,887,620 (GRCm39) missense probably benign 0.00
R1944:Or2b2 UTSW 13 21,887,287 (GRCm39) missense possibly damaging 0.95
R4084:Or2b2 UTSW 13 21,887,239 (GRCm39) missense probably damaging 1.00
R4084:Or2b2 UTSW 13 21,887,238 (GRCm39) nonsense probably null
R5677:Or2b2 UTSW 13 21,887,393 (GRCm39) missense probably benign 0.03
R6485:Or2b2 UTSW 13 21,887,600 (GRCm39) missense probably benign 0.00
R6981:Or2b2 UTSW 13 21,887,243 (GRCm39) missense probably benign 0.21
R7028:Or2b2 UTSW 13 21,887,440 (GRCm39) missense possibly damaging 0.95
R7221:Or2b2 UTSW 13 21,887,272 (GRCm39) missense probably damaging 1.00
R7799:Or2b2 UTSW 13 21,887,369 (GRCm39) missense probably damaging 1.00
R8400:Or2b2 UTSW 13 21,888,085 (GRCm39) missense probably benign 0.00
R9050:Or2b2 UTSW 13 21,887,150 (GRCm39) utr 5 prime probably benign
Predicted Primers PCR Primer
(F):5'- GAGAGCATCTCACGGGAGTTCATTC -3'
(R):5'- TGAGTTGCTGAAGCCACTGATCC -3'

Sequencing Primer
(F):5'- TCACGGGAGTTCATTCTCTTAG -3'
(R):5'- GCCTCTGGTGCATGATGAC -3'
Posted On 2014-04-24