Mutagenetix > Incidental Mutation

Incidental Mutation 'R1603:Dchs1'

176256

Institutional Source

Beutler Lab

Gene Symbol

Dchs1

Ensembl Gene

ENSMUSG00000036862

Gene Name

dachsous cadherin related 1

Synonyms

C130033F22Rik, 3110041P15Rik

MMRRC Submission

039640-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1603 (G1)

Quality Score

100

Status

Validated

Chromosome

Chromosomal Location

105402197-105436861 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 105411977 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 1380 (R1380S)

Ref Sequence

ENSEMBL: ENSMUSP00000077574 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078482]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000078482
AA Change: R1380S

PolyPhen 2 Score 0.241 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000077574
Gene: ENSMUSG00000036862
AA Change: R1380S

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
CA	58	135	5.2e-11	SMART
CA	159	247	6.1e-17	SMART
CA	271	354	2.6e-30	SMART
CA	382	464	7.8e-26	SMART
CA	489	570	1.2e-34	SMART
CA	594	677	1.9e-27	SMART
CA	701	782	5.3e-11	SMART
CA	806	886	1e-12	SMART
CA	910	990	3.3e-14	SMART
CA	1016	1097	3.6e-18	SMART
CA	1121	1203	3.1e-34	SMART
CA	1233	1307	8.8e-16	SMART
low complexity region	1323	1335	N/A	INTRINSIC
CA	1344	1427	9.9e-9	SMART
CA	1451	1537	1.5e-23	SMART
CA	1560	1640	7.2e-32	SMART
CA	1664	1742	1.8e-31	SMART
CA	1765	1846	7.8e-30	SMART
CA	1870	1951	3.7e-26	SMART
low complexity region	1957	1965	N/A	INTRINSIC
CA	1979	2059	1.1e-6	SMART
CA	2083	2162	2.7e-18	SMART
CA	2186	2268	2.2e-26	SMART
CA	2291	2367	1e-18	SMART
CA	2391	2473	1.8e-23	SMART
CA	2497	2593	3.5e-21	SMART
CA	2617	2697	1.2e-25	SMART
CA	2721	2804	1.9e-18	SMART
CA	2828	2919	3e-3	SMART
transmembrane domain	2932	2954	N/A	INTRINSIC
low complexity region	3001	3017	N/A	INTRINSIC
low complexity region	3046	3055	N/A	INTRINSIC
low complexity region	3088	3097	N/A	INTRINSIC
low complexity region	3185	3196	N/A	INTRINSIC
low complexity region	3237	3259	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131504

Predicted Effect

probably benign
Transcript: ENSMUST00000140959

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154659

Meta Mutation Damage Score

0.0983

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.4%
20x: 89.3%

Validation Efficiency

96% (65/68)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110032F04Rik	G	A	3: 68,777,546 (GRCm39)	S169N	probably benign	Het
Ace	T	A	11: 105,862,925 (GRCm39)	S315R	probably benign	Het
Adamtsl1	A	G	4: 86,333,767 (GRCm39)	I1491V	probably benign	Het
Adrb2	A	T	18: 62,312,579 (GRCm39)	M82K	probably damaging	Het
Aebp2	A	G	6: 140,587,979 (GRCm39)	N350D	probably damaging	Het
Ankrd42	T	C	7: 92,268,899 (GRCm39)		probably benign	Het
Asap1	A	T	15: 64,001,106 (GRCm39)	C492S	probably damaging	Het
Atp8b3	C	A	10: 80,361,619 (GRCm39)	A768S	probably benign	Het
Chga	T	A	12: 102,530,866 (GRCm39)		probably null	Het
Clca4b	A	G	3: 144,627,780 (GRCm39)	V397A	probably benign	Het
Cntnap5a	A	C	1: 116,339,831 (GRCm39)	T697P	possibly damaging	Het
Col12a1	T	C	9: 79,520,244 (GRCm39)	Q2810R	probably damaging	Het
Dgkg	T	A	16: 22,388,909 (GRCm39)		probably benign	Het
Dlgap3	G	A	4: 127,089,021 (GRCm39)	G206R	probably damaging	Het
Dnah5	A	G	15: 28,295,131 (GRCm39)		probably benign	Het
Dnah5	A	T	15: 28,449,326 (GRCm39)	I4243L	probably benign	Het
Eif1ad16	C	A	12: 87,985,134 (GRCm39)	E136D	probably benign	Het
Fbxw22	G	T	9: 109,207,915 (GRCm39)	P452H	probably benign	Het
Fgl1	T	A	8: 41,650,055 (GRCm39)	D242V	probably damaging	Het
Gba2	C	T	4: 43,567,823 (GRCm39)	G794R	probably damaging	Het
Gimap7	A	T	6: 48,700,864 (GRCm39)	D150V	probably damaging	Het
Gm5334	T	C	7: 68,268,620 (GRCm39)	V13A	probably benign	Het
Grk5	T	C	19: 61,057,800 (GRCm39)	F167L	probably benign	Het
Ice1	A	G	13: 70,751,472 (GRCm39)	L1538P	probably benign	Het
Idh2	T	G	7: 79,748,906 (GRCm39)	E125A	probably damaging	Het
Kmt2a	A	T	9: 44,752,858 (GRCm39)		probably null	Het
Kras	A	T	6: 145,170,871 (GRCm39)	L168*	probably null	Het
Lrrc66	G	A	5: 73,764,769 (GRCm39)	S758L	possibly damaging	Het
Mak	T	C	13: 41,195,582 (GRCm39)	D377G	possibly damaging	Het
Matn2	T	C	15: 34,388,914 (GRCm39)	C335R	probably damaging	Het
Mcoln2	C	T	3: 145,885,977 (GRCm39)	S276F	probably damaging	Het
Morc3	C	A	16: 93,663,391 (GRCm39)	N531K	probably benign	Het
Obp2a	G	A	2: 25,592,757 (GRCm39)	S175N	probably benign	Het
Or2ak6	T	C	11: 58,593,286 (GRCm39)	V253A	probably benign	Het
Or4n4b	T	G	14: 50,536,491 (GRCm39)	I92L	possibly damaging	Het
Or5an1b	A	T	19: 12,299,348 (GRCm39)	V281E	probably damaging	Het
Osbpl3	C	A	6: 50,300,073 (GRCm39)	K510N	probably damaging	Het
Pcnx2	G	A	8: 126,566,365 (GRCm39)	S1026F	probably damaging	Het
Pom121l2	A	T	13: 22,167,514 (GRCm39)	D595V	probably damaging	Het
Poteg	T	A	8: 27,938,033 (GRCm39)	M1K	probably null	Het
Rbl1	G	A	2: 157,017,579 (GRCm39)	L547F	possibly damaging	Het
Rpap3	T	C	15: 97,599,002 (GRCm39)	T82A	possibly damaging	Het
Sema7a	G	A	9: 57,867,959 (GRCm39)	D512N	probably benign	Het
Sgpl1	C	T	10: 60,941,230 (GRCm39)	V294M	possibly damaging	Het
Slc22a28	A	G	19: 8,040,674 (GRCm39)	S526P	probably damaging	Het
Spata31e2	T	A	1: 26,724,650 (GRCm39)	R177W	probably damaging	Het
Tent2	G	A	13: 93,312,073 (GRCm39)	A209V	probably benign	Het
Trim30b	T	G	7: 104,015,019 (GRCm39)	Q123P	possibly damaging	Het
Trpm5	A	G	7: 142,638,946 (GRCm39)	L275P	probably benign	Het
Ttc33	A	G	15: 5,219,275 (GRCm39)	E71G	probably damaging	Het
Unc13d	T	C	11: 115,964,481 (GRCm39)	T288A	possibly damaging	Het
Unc93a	T	A	17: 13,328,521 (GRCm39)	E444V	probably benign	Het
Usf3	T	A	16: 44,038,535 (GRCm39)	M1005K	probably benign	Het
Vmn2r91	T	C	17: 18,326,405 (GRCm39)	I230T	probably benign	Het
Wdr49	G	A	3: 75,304,177 (GRCm39)	Q448*	probably null	Het
Zfp939	T	A	7: 39,122,695 (GRCm39)		noncoding transcript	Het

Other mutations in Dchs1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00235:Dchs1	APN	7	105,407,950 (GRCm39)	missense	probably damaging	1.00
IGL00422:Dchs1	APN	7	105,407,236 (GRCm39)	missense	possibly damaging	0.88
IGL00427:Dchs1	APN	7	105,407,631 (GRCm39)	missense	probably damaging	0.98
IGL00469:Dchs1	APN	7	105,404,468 (GRCm39)	missense	probably damaging	1.00
IGL00470:Dchs1	APN	7	105,407,414 (GRCm39)	missense	probably damaging	1.00
IGL00534:Dchs1	APN	7	105,407,150 (GRCm39)	missense	probably benign
IGL01292:Dchs1	APN	7	105,410,098 (GRCm39)	missense	probably damaging	0.98
IGL01380:Dchs1	APN	7	105,411,418 (GRCm39)	missense	probably damaging	1.00
IGL01396:Dchs1	APN	7	105,421,490 (GRCm39)	missense	probably damaging	1.00
IGL01448:Dchs1	APN	7	105,421,134 (GRCm39)	missense	probably damaging	0.98
IGL01759:Dchs1	APN	7	105,404,509 (GRCm39)	missense	probably benign	0.00
IGL01829:Dchs1	APN	7	105,404,604 (GRCm39)	missense	probably damaging	0.99
IGL01946:Dchs1	APN	7	105,408,312 (GRCm39)	missense	probably damaging	1.00
IGL01955:Dchs1	APN	7	105,406,798 (GRCm39)	missense	probably benign	0.00
IGL02012:Dchs1	APN	7	105,413,504 (GRCm39)	missense	probably damaging	0.98
IGL02222:Dchs1	APN	7	105,414,094 (GRCm39)	missense	probably damaging	1.00
IGL02261:Dchs1	APN	7	105,421,776 (GRCm39)	missense	probably damaging	1.00
IGL02365:Dchs1	APN	7	105,404,395 (GRCm39)	missense	probably benign	0.22
IGL02430:Dchs1	APN	7	105,421,178 (GRCm39)	missense	probably benign	0.34
IGL02500:Dchs1	APN	7	105,405,013 (GRCm39)	missense	probably benign
IGL02741:Dchs1	APN	7	105,406,530 (GRCm39)	missense	probably damaging	1.00
IGL02890:Dchs1	APN	7	105,405,698 (GRCm39)	missense	probably damaging	1.00
IGL03213:Dchs1	APN	7	105,404,279 (GRCm39)	missense	probably damaging	1.00
G1patch:Dchs1	UTSW	7	105,408,000 (GRCm39)	missense	probably damaging	0.99
P0026:Dchs1	UTSW	7	105,407,612 (GRCm39)	missense	probably damaging	0.99
PIT4377001:Dchs1	UTSW	7	105,406,795 (GRCm39)	missense	probably damaging	1.00
PIT4791001:Dchs1	UTSW	7	105,408,178 (GRCm39)	missense	probably damaging	1.00
R0013:Dchs1	UTSW	7	105,405,043 (GRCm39)	missense	possibly damaging	0.90
R0090:Dchs1	UTSW	7	105,405,139 (GRCm39)	missense	probably benign	0.18
R0091:Dchs1	UTSW	7	105,415,301 (GRCm39)	splice site	probably benign
R0193:Dchs1	UTSW	7	105,414,190 (GRCm39)	missense	probably benign	0.40
R0395:Dchs1	UTSW	7	105,407,745 (GRCm39)	missense	probably damaging	1.00
R0448:Dchs1	UTSW	7	105,415,134 (GRCm39)	missense	probably benign	0.00
R0480:Dchs1	UTSW	7	105,420,696 (GRCm39)	missense	probably benign	0.14
R0485:Dchs1	UTSW	7	105,421,934 (GRCm39)	missense	probably benign	0.00
R0566:Dchs1	UTSW	7	105,408,402 (GRCm39)	missense	probably benign	0.00
R0571:Dchs1	UTSW	7	105,421,203 (GRCm39)	missense	probably damaging	1.00
R0573:Dchs1	UTSW	7	105,407,985 (GRCm39)	missense	probably damaging	0.98
R0577:Dchs1	UTSW	7	105,413,462 (GRCm39)	missense	possibly damaging	0.78
R0622:Dchs1	UTSW	7	105,412,656 (GRCm39)	missense	probably damaging	1.00
R0654:Dchs1	UTSW	7	105,421,556 (GRCm39)	missense	probably damaging	1.00
R0677:Dchs1	UTSW	7	105,414,191 (GRCm39)	missense	probably damaging	1.00
R1171:Dchs1	UTSW	7	105,406,921 (GRCm39)	missense	probably benign
R1241:Dchs1	UTSW	7	105,407,385 (GRCm39)	missense	probably damaging	1.00
R1389:Dchs1	UTSW	7	105,404,778 (GRCm39)	missense	probably benign	0.40
R1427:Dchs1	UTSW	7	105,415,398 (GRCm39)	missense	probably benign	0.06
R1458:Dchs1	UTSW	7	105,404,451 (GRCm39)	missense	probably damaging	1.00
R1513:Dchs1	UTSW	7	105,421,278 (GRCm39)	nonsense	probably null
R1524:Dchs1	UTSW	7	105,413,732 (GRCm39)	missense	probably damaging	1.00
R1525:Dchs1	UTSW	7	105,408,138 (GRCm39)	missense	probably damaging	1.00
R1534:Dchs1	UTSW	7	105,421,247 (GRCm39)	missense	probably damaging	0.98
R1567:Dchs1	UTSW	7	105,421,068 (GRCm39)	missense	probably benign	0.01
R1577:Dchs1	UTSW	7	105,415,162 (GRCm39)	missense	probably damaging	1.00
R1676:Dchs1	UTSW	7	105,404,128 (GRCm39)	missense	probably benign	0.40
R1794:Dchs1	UTSW	7	105,420,927 (GRCm39)	missense	probably benign	0.02
R1826:Dchs1	UTSW	7	105,406,834 (GRCm39)	missense	probably damaging	1.00
R1892:Dchs1	UTSW	7	105,413,363 (GRCm39)	missense	probably benign	0.00
R1924:Dchs1	UTSW	7	105,421,487 (GRCm39)	missense	possibly damaging	0.81
R1932:Dchs1	UTSW	7	105,415,109 (GRCm39)	missense	probably damaging	1.00
R1962:Dchs1	UTSW	7	105,413,408 (GRCm39)	missense	probably damaging	1.00
R1985:Dchs1	UTSW	7	105,421,605 (GRCm39)	missense	possibly damaging	0.72
R1993:Dchs1	UTSW	7	105,411,755 (GRCm39)	missense	probably benign	0.00
R2007:Dchs1	UTSW	7	105,404,532 (GRCm39)	missense	probably damaging	1.00
R2316:Dchs1	UTSW	7	105,413,411 (GRCm39)	missense	possibly damaging	0.71
R2351:Dchs1	UTSW	7	105,403,301 (GRCm39)	missense	probably benign
R2474:Dchs1	UTSW	7	105,422,045 (GRCm39)	missense	probably damaging	1.00
R2474:Dchs1	UTSW	7	105,404,281 (GRCm39)	missense	probably benign	0.37
R3429:Dchs1	UTSW	7	105,405,711 (GRCm39)	missense	possibly damaging	0.85
R3430:Dchs1	UTSW	7	105,405,711 (GRCm39)	missense	possibly damaging	0.85
R3737:Dchs1	UTSW	7	105,411,523 (GRCm39)	missense	possibly damaging	0.88
R3767:Dchs1	UTSW	7	105,406,292 (GRCm39)	missense	possibly damaging	0.67
R3874:Dchs1	UTSW	7	105,410,842 (GRCm39)	missense	probably damaging	1.00
R3883:Dchs1	UTSW	7	105,411,770 (GRCm39)	missense	probably damaging	1.00
R4105:Dchs1	UTSW	7	105,414,347 (GRCm39)	missense	probably damaging	1.00
R4209:Dchs1	UTSW	7	105,415,397 (GRCm39)	missense	probably damaging	0.99
R4329:Dchs1	UTSW	7	105,402,966 (GRCm39)	missense	probably damaging	1.00
R4516:Dchs1	UTSW	7	105,404,059 (GRCm39)	missense	probably damaging	1.00
R4579:Dchs1	UTSW	7	105,408,180 (GRCm39)	missense	probably benign
R4579:Dchs1	UTSW	7	105,403,972 (GRCm39)	missense	probably damaging	1.00
R4588:Dchs1	UTSW	7	105,405,248 (GRCm39)	missense	probably benign
R4613:Dchs1	UTSW	7	105,421,931 (GRCm39)	missense	probably damaging	1.00
R4632:Dchs1	UTSW	7	105,403,562 (GRCm39)	missense	probably benign	0.02
R4696:Dchs1	UTSW	7	105,413,834 (GRCm39)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,414,759 (GRCm39)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,404,460 (GRCm39)	missense	probably damaging	0.98
R4738:Dchs1	UTSW	7	105,407,880 (GRCm39)	missense	probably damaging	0.96
R4768:Dchs1	UTSW	7	105,420,827 (GRCm39)	missense	possibly damaging	0.96
R4784:Dchs1	UTSW	7	105,415,133 (GRCm39)	missense	probably damaging	1.00
R4864:Dchs1	UTSW	7	105,404,460 (GRCm39)	missense	probably damaging	0.98
R4880:Dchs1	UTSW	7	105,404,937 (GRCm39)	missense	probably benign	0.00
R4909:Dchs1	UTSW	7	105,415,462 (GRCm39)	missense	probably damaging	1.00
R5102:Dchs1	UTSW	7	105,421,384 (GRCm39)	missense	probably benign	0.09
R5109:Dchs1	UTSW	7	105,414,221 (GRCm39)	missense	probably benign
R5126:Dchs1	UTSW	7	105,402,724 (GRCm39)	missense	probably damaging	1.00
R5149:Dchs1	UTSW	7	105,404,865 (GRCm39)	missense	probably damaging	0.98
R5330:Dchs1	UTSW	7	105,403,809 (GRCm39)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,421,262 (GRCm39)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,407,236 (GRCm39)	missense	probably damaging	1.00
R5386:Dchs1	UTSW	7	105,407,236 (GRCm39)	missense	probably damaging	1.00
R5622:Dchs1	UTSW	7	105,404,500 (GRCm39)	missense	probably benign	0.11
R5623:Dchs1	UTSW	7	105,421,976 (GRCm39)	missense	probably damaging	1.00
R5708:Dchs1	UTSW	7	105,422,016 (GRCm39)	missense	probably damaging	1.00
R5718:Dchs1	UTSW	7	105,404,955 (GRCm39)	missense	probably benign	0.01
R5743:Dchs1	UTSW	7	105,420,803 (GRCm39)	missense	probably benign
R5759:Dchs1	UTSW	7	105,413,383 (GRCm39)	missense	probably damaging	0.99
R5772:Dchs1	UTSW	7	105,422,247 (GRCm39)	missense	probably damaging	1.00
R5860:Dchs1	UTSW	7	105,421,242 (GRCm39)	missense	probably damaging	1.00
R5916:Dchs1	UTSW	7	105,408,373 (GRCm39)	missense	probably damaging	1.00
R5965:Dchs1	UTSW	7	105,405,132 (GRCm39)	missense	probably damaging	1.00
R5997:Dchs1	UTSW	7	105,403,302 (GRCm39)	missense	probably benign	0.08
R6065:Dchs1	UTSW	7	105,404,628 (GRCm39)	missense	probably damaging	1.00
R6136:Dchs1	UTSW	7	105,410,132 (GRCm39)	missense	probably benign
R6137:Dchs1	UTSW	7	105,414,313 (GRCm39)	missense	probably damaging	0.99
R6324:Dchs1	UTSW	7	105,414,145 (GRCm39)	missense	probably benign	0.05
R6363:Dchs1	UTSW	7	105,407,679 (GRCm39)	missense	probably benign	0.12
R6466:Dchs1	UTSW	7	105,413,748 (GRCm39)	missense	probably benign	0.09
R6544:Dchs1	UTSW	7	105,407,385 (GRCm39)	missense	probably damaging	1.00
R6572:Dchs1	UTSW	7	105,408,013 (GRCm39)	missense	possibly damaging	0.94
R6579:Dchs1	UTSW	7	105,412,120 (GRCm39)	missense	probably benign	0.17
R6632:Dchs1	UTSW	7	105,411,085 (GRCm39)	missense	probably damaging	1.00
R6725:Dchs1	UTSW	7	105,408,000 (GRCm39)	missense	probably damaging	0.99
R6789:Dchs1	UTSW	7	105,406,210 (GRCm39)	missense	possibly damaging	0.61
R6868:Dchs1	UTSW	7	105,412,710 (GRCm39)	missense	possibly damaging	0.91
R7058:Dchs1	UTSW	7	105,406,228 (GRCm39)	missense	probably benign
R7064:Dchs1	UTSW	7	105,412,392 (GRCm39)	missense	probably damaging	0.99
R7076:Dchs1	UTSW	7	105,411,078 (GRCm39)	missense	probably benign	0.04
R7191:Dchs1	UTSW	7	105,414,646 (GRCm39)	missense	possibly damaging	0.89
R7298:Dchs1	UTSW	7	105,404,338 (GRCm39)	nonsense	probably null
R7380:Dchs1	UTSW	7	105,407,835 (GRCm39)	missense	probably benign	0.35
R7438:Dchs1	UTSW	7	105,404,155 (GRCm39)	missense	probably benign	0.30
R7496:Dchs1	UTSW	7	105,411,066 (GRCm39)	missense	probably damaging	1.00
R7534:Dchs1	UTSW	7	105,421,580 (GRCm39)	missense	probably benign	0.00
R7604:Dchs1	UTSW	7	105,415,189 (GRCm39)	missense	probably damaging	1.00
R7631:Dchs1	UTSW	7	105,408,445 (GRCm39)	missense	probably benign
R7821:Dchs1	UTSW	7	105,414,352 (GRCm39)	missense	probably benign	0.00
R7834:Dchs1	UTSW	7	105,414,774 (GRCm39)	missense	probably benign	0.39
R7841:Dchs1	UTSW	7	105,412,180 (GRCm39)	missense	probably benign
R7913:Dchs1	UTSW	7	105,408,435 (GRCm39)	missense	possibly damaging	0.61
R8041:Dchs1	UTSW	7	105,404,395 (GRCm39)	missense	probably benign	0.45
R8076:Dchs1	UTSW	7	105,411,189 (GRCm39)	missense	probably damaging	1.00
R8076:Dchs1	UTSW	7	105,405,128 (GRCm39)	missense	possibly damaging	0.52
R8087:Dchs1	UTSW	7	105,402,706 (GRCm39)	missense	probably benign	0.41
R8125:Dchs1	UTSW	7	105,414,089 (GRCm39)	missense	possibly damaging	0.91
R8223:Dchs1	UTSW	7	105,411,824 (GRCm39)	missense	possibly damaging	0.81
R8239:Dchs1	UTSW	7	105,414,718 (GRCm39)	missense	probably benign	0.22
R8476:Dchs1	UTSW	7	105,408,015 (GRCm39)	missense	probably benign	0.05
R8497:Dchs1	UTSW	7	105,408,168 (GRCm39)	missense	probably damaging	1.00
R8770:Dchs1	UTSW	7	105,420,945 (GRCm39)	missense	probably damaging	1.00
R8856:Dchs1	UTSW	7	105,410,064 (GRCm39)	missense	probably damaging	1.00
R8866:Dchs1	UTSW	7	105,404,597 (GRCm39)	missense	probably benign	0.00
R8948:Dchs1	UTSW	7	105,408,212 (GRCm39)	missense	probably benign	0.30
R8950:Dchs1	UTSW	7	105,408,212 (GRCm39)	missense	probably benign	0.30
R9029:Dchs1	UTSW	7	105,402,919 (GRCm39)	missense	probably benign	0.13
R9039:Dchs1	UTSW	7	105,405,215 (GRCm39)	missense	probably benign	0.11
R9081:Dchs1	UTSW	7	105,403,636 (GRCm39)	missense	probably benign	0.00
R9134:Dchs1	UTSW	7	105,404,910 (GRCm39)	missense	probably damaging	0.96
R9159:Dchs1	UTSW	7	105,415,126 (GRCm39)	missense	probably benign
R9162:Dchs1	UTSW	7	105,414,732 (GRCm39)	missense	probably damaging	1.00
R9169:Dchs1	UTSW	7	105,422,114 (GRCm39)	missense	probably damaging	1.00
R9262:Dchs1	UTSW	7	105,404,833 (GRCm39)	missense	probably damaging	1.00
R9292:Dchs1	UTSW	7	105,403,120 (GRCm39)	missense	probably damaging	1.00
R9325:Dchs1	UTSW	7	105,415,402 (GRCm39)	missense	possibly damaging	0.51
R9376:Dchs1	UTSW	7	105,414,981 (GRCm39)	critical splice donor site	probably null
R9392:Dchs1	UTSW	7	105,421,869 (GRCm39)	missense	probably benign	0.09
R9619:Dchs1	UTSW	7	105,413,662 (GRCm39)	missense	probably benign	0.07
R9680:Dchs1	UTSW	7	105,411,625 (GRCm39)	missense	probably damaging	1.00
R9687:Dchs1	UTSW	7	105,407,191 (GRCm39)	missense	probably damaging	0.99
R9747:Dchs1	UTSW	7	105,412,682 (GRCm39)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,406,900 (GRCm39)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,407,758 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CGTCTGATGCGCGGAAAGTGTATAG -3'
(R):5'- TAGAAGCTGACTCAGCGGCAAC -3'

Sequencing Primer
(F):5'- AGTGTATAGCGTGGCACC -3'
(R):5'- GCAACAGTGCCTGTAGTACTTAC -3'

Posted On

2014-04-24