Incidental Mutation 'R1611:Naa35'
ID 176820
Institutional Source Beutler Lab
Gene Symbol Naa35
Ensembl Gene ENSMUSG00000021555
Gene Name N(alpha)-acetyltransferase 35, NatC auxiliary subunit
Synonyms Mak10, A330027C19Rik, C030004C14Rik, A330021G12Rik
MMRRC Submission 039648-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.962) question?
Stock # R1611 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 59733147-59782612 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 59776747 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 574 (R574L)
Ref Sequence ENSEMBL: ENSMUSP00000022038 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022038] [ENSMUST00000165253] [ENSMUST00000172419]
AlphaFold Q6PHQ8
Predicted Effect probably benign
Transcript: ENSMUST00000022038
AA Change: R574L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000022038
Gene: ENSMUSG00000021555
AA Change: R574L

DomainStartEndE-ValueType
Pfam:Mak10 45 145 2.2e-29 PFAM
Pfam:Mak10 141 194 3.7e-10 PFAM
low complexity region 561 568 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163395
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165129
Predicted Effect probably benign
Transcript: ENSMUST00000165253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165841
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168242
Predicted Effect noncoding transcript
Transcript: ENSMUST00000172118
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168633
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171391
Predicted Effect probably benign
Transcript: ENSMUST00000172419
SMART Domains Protein: ENSMUSP00000126079
Gene: ENSMUSG00000021555

DomainStartEndE-ValueType
Pfam:Mak10 40 193 1.2e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172166
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224194
Meta Mutation Damage Score 0.0634 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.2%
  • 20x: 88.9%
Validation Efficiency 97% (75/77)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 A T 11: 54,216,390 (GRCm39) I186F possibly damaging Het
Actr6 T A 10: 89,568,064 (GRCm39) K14* probably null Het
Adgrv1 A T 13: 81,707,236 (GRCm39) V1390E probably damaging Het
Akap1 C T 11: 88,736,104 (GRCm39) R186K probably benign Het
Alg10b T A 15: 90,109,984 (GRCm39) V99D probably damaging Het
Atp2c1 C T 9: 105,320,051 (GRCm39) G407S probably damaging Het
Atp9a T C 2: 168,515,489 (GRCm39) M401V probably damaging Het
Auh G A 13: 52,989,532 (GRCm39) P308L probably benign Het
Bclaf1 T C 10: 20,198,998 (GRCm39) probably benign Het
Bcr T A 10: 74,961,034 (GRCm39) probably null Het
Bivm T C 1: 44,165,907 (GRCm39) I119T possibly damaging Het
Cacna1h A G 17: 25,600,445 (GRCm39) I1632T probably damaging Het
Capn9 G A 8: 125,338,251 (GRCm39) V537M possibly damaging Het
Cdk11b G A 4: 155,726,032 (GRCm39) probably benign Het
Cdk18 T A 1: 132,050,113 (GRCm39) I21F probably damaging Het
Cep85l T C 10: 53,224,777 (GRCm39) T271A probably benign Het
Chrm5 T C 2: 112,309,532 (GRCm39) N528S possibly damaging Het
Cpsf6 T A 10: 117,197,733 (GRCm39) probably benign Het
Cpt1c T C 7: 44,609,536 (GRCm39) T689A probably benign Het
D030068K23Rik T C 8: 109,975,935 (GRCm39) Y64C unknown Het
Ddb1 T A 19: 10,604,128 (GRCm39) probably null Het
Ddb1 T A 19: 10,590,252 (GRCm39) C260S probably damaging Het
Depdc5 C A 5: 33,148,297 (GRCm39) Q1478K probably damaging Het
Diaph1 A C 18: 38,033,755 (GRCm39) M247R unknown Het
Dnai3 T C 3: 145,801,113 (GRCm39) Y115C probably damaging Het
Dusp8 T C 7: 141,636,694 (GRCm39) S299G probably benign Het
Erbb4 C A 1: 68,079,547 (GRCm39) G1178C probably damaging Het
Exoc7 A T 11: 116,186,091 (GRCm39) I370N possibly damaging Het
Fam120a G T 13: 49,039,219 (GRCm39) A979E possibly damaging Het
Gm12353 T A 4: 19,631,843 (GRCm39) Y27* probably null Het
Gnl1 C T 17: 36,298,441 (GRCm39) T395I probably damaging Het
Hpse2 G A 19: 42,777,504 (GRCm39) T554I probably damaging Het
Hsd17b11 T C 5: 104,157,765 (GRCm39) I116V probably benign Het
Inava G A 1: 136,143,855 (GRCm39) P527L probably damaging Het
Kif24 A T 4: 41,423,552 (GRCm39) V233E probably benign Het
Klhl5 A G 5: 65,321,992 (GRCm39) T673A probably benign Het
Kmt2c C A 5: 25,564,309 (GRCm39) probably null Het
Lipg T C 18: 75,081,130 (GRCm39) N317S possibly damaging Het
Lpin1 A T 12: 16,627,219 (GRCm39) L109Q probably null Het
Lyst A G 13: 13,809,482 (GRCm39) E384G probably damaging Het
Mical2 T A 7: 111,980,671 (GRCm39) I105N probably damaging Het
Muc4 C T 16: 32,569,804 (GRCm39) T288I possibly damaging Het
Ncor2 T C 5: 125,187,084 (GRCm39) probably benign Het
Nedd9 T A 13: 41,470,406 (GRCm39) D249V probably benign Het
Nsg1 T A 5: 38,296,060 (GRCm39) K38* probably null Het
Nup155 T A 15: 8,159,644 (GRCm39) D518E probably damaging Het
Or5i1 T A 2: 87,612,968 (GRCm39) I28N probably benign Het
Ovol1 T A 19: 5,601,098 (GRCm39) H231L probably damaging Het
Parg A G 14: 31,960,527 (GRCm39) I586V probably damaging Het
Pde7b T C 10: 20,310,236 (GRCm39) N242S probably benign Het
Pias3 T A 3: 96,607,013 (GRCm39) probably null Het
Pramel13 A T 4: 144,119,382 (GRCm39) V395E probably benign Het
Ptprf A G 4: 118,093,430 (GRCm39) V404A probably benign Het
Rigi T C 4: 40,223,862 (GRCm39) Y339C probably damaging Het
Rnf145 T C 11: 44,442,625 (GRCm39) L259P probably damaging Het
Rps6ka5 C G 12: 100,537,111 (GRCm39) V540L possibly damaging Het
Ryr3 C T 2: 112,483,850 (GRCm39) D3966N possibly damaging Het
Samd9l A T 6: 3,373,771 (GRCm39) S1163R probably benign Het
Serpinb9g T C 13: 33,676,857 (GRCm39) I213T possibly damaging Het
Sil1 A T 18: 35,402,141 (GRCm39) V331E possibly damaging Het
Ski A G 4: 155,244,395 (GRCm39) F410S probably damaging Het
Slc25a25 C T 2: 32,310,391 (GRCm39) E123K probably damaging Het
Slfnl1 A G 4: 120,390,574 (GRCm39) E75G probably benign Het
Sp1 T A 15: 102,339,370 (GRCm39) I436N probably damaging Het
Taf4b A T 18: 14,977,526 (GRCm39) E766V probably null Het
Tgfbr1 A G 4: 47,396,526 (GRCm39) Y180C probably damaging Het
Ube4a T C 9: 44,868,035 (GRCm39) probably benign Het
Vmn2r1 T A 3: 64,011,958 (GRCm39) C606* probably null Het
Zfp341 C A 2: 154,487,623 (GRCm39) H702Q probably damaging Het
Other mutations in Naa35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Naa35 APN 13 59,777,869 (GRCm39) missense probably damaging 1.00
IGL00743:Naa35 APN 13 59,778,485 (GRCm39) missense probably benign 0.33
IGL01335:Naa35 APN 13 59,764,610 (GRCm39) missense probably damaging 1.00
IGL01385:Naa35 APN 13 59,748,880 (GRCm39) missense probably damaging 1.00
IGL01541:Naa35 APN 13 59,748,777 (GRCm39) missense probably damaging 1.00
IGL02129:Naa35 APN 13 59,757,339 (GRCm39) missense probably damaging 0.99
IGL02867:Naa35 APN 13 59,756,668 (GRCm39) intron probably benign
IGL02966:Naa35 APN 13 59,734,085 (GRCm39) missense probably benign
IGL03260:Naa35 APN 13 59,775,699 (GRCm39) missense probably benign 0.05
R0312:Naa35 UTSW 13 59,757,395 (GRCm39) missense probably benign 0.01
R0557:Naa35 UTSW 13 59,775,778 (GRCm39) missense probably damaging 0.99
R1553:Naa35 UTSW 13 59,766,093 (GRCm39) critical splice donor site probably null
R1676:Naa35 UTSW 13 59,760,490 (GRCm39) missense probably damaging 1.00
R3709:Naa35 UTSW 13 59,765,846 (GRCm39) splice site probably benign
R3896:Naa35 UTSW 13 59,755,109 (GRCm39) missense probably damaging 1.00
R5001:Naa35 UTSW 13 59,773,345 (GRCm39) missense possibly damaging 0.75
R5647:Naa35 UTSW 13 59,770,680 (GRCm39) unclassified probably benign
R5649:Naa35 UTSW 13 59,770,680 (GRCm39) unclassified probably benign
R5650:Naa35 UTSW 13 59,770,680 (GRCm39) unclassified probably benign
R5656:Naa35 UTSW 13 59,770,680 (GRCm39) unclassified probably benign
R6734:Naa35 UTSW 13 59,756,005 (GRCm39) missense possibly damaging 0.83
R6735:Naa35 UTSW 13 59,773,378 (GRCm39) missense probably damaging 1.00
R6985:Naa35 UTSW 13 59,775,757 (GRCm39) missense probably benign 0.03
R7165:Naa35 UTSW 13 59,733,997 (GRCm39) missense probably benign 0.05
R7531:Naa35 UTSW 13 59,765,755 (GRCm39) nonsense probably null
R7713:Naa35 UTSW 13 59,745,919 (GRCm39) missense probably benign 0.01
R7739:Naa35 UTSW 13 59,747,598 (GRCm39) missense probably damaging 1.00
R8685:Naa35 UTSW 13 59,734,036 (GRCm39) missense probably benign 0.43
R8818:Naa35 UTSW 13 59,748,761 (GRCm39) missense probably damaging 1.00
R8838:Naa35 UTSW 13 59,775,775 (GRCm39) missense probably benign
R9006:Naa35 UTSW 13 59,748,842 (GRCm39) missense possibly damaging 0.68
R9132:Naa35 UTSW 13 59,772,341 (GRCm39) missense possibly damaging 0.84
R9403:Naa35 UTSW 13 59,748,817 (GRCm39) missense possibly damaging 0.74
Predicted Primers PCR Primer
(F):5'- AGCCAAAACCTTCTCTCATCTATGCCTA -3'
(R):5'- TGCTCAGGCCAGCCACACTA -3'

Sequencing Primer
(F):5'- TCTCATCTATGCCTACAGCAC -3'
(R):5'- caccagaagagggcatcag -3'
Posted On 2014-04-24