|Institutional Source||Beutler Lab|
|Gene Name||WD repeat domain 3|
|Is this an essential gene?||Probably essential (E-score: 0.937)|
|Stock #||R1612 (G1)|
|Chromosomal Location||100138180-100162407 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 100151199 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000060613 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000052120]|
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
|Validation Efficiency||97% (69/71)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Wdr3||
(F):5'- TCCGAGCTGAAGGACAAAGTGC -3'
(R):5'- ATCTTGTCACAGTCACAGCCCGTG -3'
(F):5'- GGACGCATTGAGCGAATACA -3'
(R):5'- ggacccacattgtagaaggaaag -3'