Incidental Mutation 'R1615:Neurl3'
ID 177024
Institutional Source Beutler Lab
Gene Symbol Neurl3
Ensembl Gene ENSMUSG00000047180
Gene Name neuralized E3 ubiquitin protein ligase 3
Synonyms Lincr, 2010300P06Rik
MMRRC Submission 039652-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R1615 (G1)
Quality Score 191
Status Validated
Chromosome 1
Chromosomal Location 36303683-36313755 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36308470 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 114 (E114G)
Ref Sequence ENSEMBL: ENSMUSP00000139665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056946] [ENSMUST00000188666]
AlphaFold Q8CJC5
Predicted Effect probably benign
Transcript: ENSMUST00000056946
AA Change: E114G

PolyPhen 2 Score 0.155 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000055437
Gene: ENSMUSG00000047180
AA Change: E114G

DomainStartEndE-ValueType
Pfam:Neuralized 19 85 8.3e-25 PFAM
RING 197 235 7.16e-6 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000188666
AA Change: E114G

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000139665
Gene: ENSMUSG00000047180
AA Change: E114G

DomainStartEndE-ValueType
NEUZ 15 138 6.4e-30 SMART
Meta Mutation Damage Score 0.0826 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 88.8%
Validation Efficiency 98% (64/65)
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 A T 15: 64,743,625 (GRCm39) C328S probably benign Het
Adgrv1 G T 13: 81,572,407 (GRCm39) T4918K probably benign Het
Aen T C 7: 78,555,660 (GRCm39) Y108H probably damaging Het
Amer3 T C 1: 34,627,252 (GRCm39) M497T probably damaging Het
Arid2 C T 15: 96,269,535 (GRCm39) T1216M possibly damaging Het
Birc6 A G 17: 74,916,404 (GRCm39) probably null Het
Bzw2 A G 12: 36,169,126 (GRCm39) probably benign Het
Ccr1 T C 9: 123,763,573 (GRCm39) H319R probably benign Het
Dnah11 A G 12: 118,014,457 (GRCm39) I2010T probably damaging Het
Dnhd1 A G 7: 105,352,413 (GRCm39) Y2522C probably benign Het
Dnhd1 T A 7: 105,362,913 (GRCm39) I3825K possibly damaging Het
Dst A T 1: 34,238,452 (GRCm39) D3718V probably damaging Het
Esp36 A G 17: 38,730,330 (GRCm39) probably benign Het
Fbxw21 T C 9: 108,972,794 (GRCm39) Y380C probably damaging Het
Fhad1 G A 4: 141,649,634 (GRCm39) T836M probably damaging Het
Fhod1 C T 8: 106,074,463 (GRCm39) probably benign Het
Flt1 A G 5: 147,576,098 (GRCm39) C637R probably damaging Het
Fmnl2 A G 2: 53,008,436 (GRCm39) K809E probably damaging Het
Grm1 G T 10: 10,617,252 (GRCm39) Y510* probably null Het
Hey1 A T 3: 8,729,898 (GRCm39) H186Q possibly damaging Het
Insyn1 C T 9: 58,406,351 (GRCm39) A87V probably damaging Het
Itga2b C T 11: 102,350,963 (GRCm39) probably null Het
Kcnv1 G A 15: 44,977,840 (GRCm39) T66M probably damaging Het
Lmcd1 A G 6: 112,250,911 (GRCm39) D7G probably benign Het
Lrrc1 T C 9: 77,342,400 (GRCm39) D358G possibly damaging Het
Lyn A G 4: 3,748,765 (GRCm39) K248E probably benign Het
Map4k4 A G 1: 40,045,990 (GRCm39) probably benign Het
Map4k5 A T 12: 69,891,187 (GRCm39) L160H probably damaging Het
Mtcl2 T G 2: 156,862,663 (GRCm39) H1422P probably damaging Het
Myo6 C T 9: 80,215,007 (GRCm39) R1247C probably damaging Het
Myo9a A G 9: 59,695,739 (GRCm39) E347G possibly damaging Het
Ndfip1 C T 18: 38,593,672 (GRCm39) P213S probably benign Het
Nlrp14 A T 7: 106,795,370 (GRCm39) I877F probably benign Het
Obscn A G 11: 58,990,651 (GRCm39) S1733P probably benign Het
Oxgr1 A T 14: 120,260,185 (GRCm39) S7R probably benign Het
Plcb1 A T 2: 135,204,364 (GRCm39) probably benign Het
Prkag2 G T 5: 25,080,176 (GRCm39) N120K possibly damaging Het
Rnf43 C T 11: 87,622,485 (GRCm39) R529* probably null Het
Saraf A G 8: 34,632,442 (GRCm39) K174E possibly damaging Het
Scrib T C 15: 75,938,054 (GRCm39) Q264R probably benign Het
Sh3rf3 T A 10: 58,966,899 (GRCm39) M747K probably benign Het
Shf T C 2: 122,179,913 (GRCm39) H421R probably damaging Het
Slc35g3 A G 11: 69,651,368 (GRCm39) S228P probably damaging Het
Slit1 A G 19: 41,639,110 (GRCm39) probably benign Het
Srrm4 A G 5: 116,585,359 (GRCm39) probably benign Het
Stfa1 T G 16: 36,100,829 (GRCm39) V23G probably damaging Het
Swap70 A G 7: 109,872,498 (GRCm39) D371G probably benign Het
Tada2a T C 11: 83,993,926 (GRCm39) D186G probably damaging Het
Tdpoz3 C A 3: 93,733,618 (GRCm39) Q98K probably benign Het
Tgfbrap1 A G 1: 43,091,145 (GRCm39) V660A probably benign Het
Tnn A G 1: 159,945,978 (GRCm39) Y947H possibly damaging Het
Trim60 A T 8: 65,453,162 (GRCm39) C362* probably null Het
Vmn1r81 T A 7: 11,994,441 (GRCm39) N56Y probably damaging Het
Vsig8 A G 1: 172,387,280 (GRCm39) D52G probably damaging Het
Wdfy4 G A 14: 32,764,469 (GRCm39) R2140C probably damaging Het
Other mutations in Neurl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1555:Neurl3 UTSW 1 36,305,613 (GRCm39) missense probably benign 0.00
R5055:Neurl3 UTSW 1 36,312,463 (GRCm39) start gained probably benign
R5242:Neurl3 UTSW 1 36,308,501 (GRCm39) nonsense probably null
R5444:Neurl3 UTSW 1 36,308,571 (GRCm39) missense probably damaging 1.00
R5698:Neurl3 UTSW 1 36,305,587 (GRCm39) missense possibly damaging 0.67
R6823:Neurl3 UTSW 1 36,307,785 (GRCm39) nonsense probably null
R7088:Neurl3 UTSW 1 36,308,302 (GRCm39) missense possibly damaging 0.67
R8184:Neurl3 UTSW 1 36,308,662 (GRCm39) missense probably damaging 0.99
R9686:Neurl3 UTSW 1 36,305,539 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACCCAGAAGCTCAATGGCTTTCG -3'
(R):5'- AATGGACCCTCACTGACTGCTCAC -3'

Sequencing Primer
(F):5'- AATGGCTTTCGTGGTCCC -3'
(R):5'- TTAGTTTCCACGGGAACGC -3'
Posted On 2014-04-24