|Institutional Source||Beutler Lab|
|Gene Name||LIM and cysteine-rich domains 1|
|Is this an essential gene?||Possibly non essential (E-score: 0.284)|
|Stock #||R1615 (G1)|
|Chromosomal Location||112273758-112330425 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 112273950 bp|
|Amino Acid Change||Aspartic acid to Glycine at position 7 (D7G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000032376 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000032376]|
|Predicted Effect||probably benign
AA Change: D7G
PolyPhen 2 Score 0.400 (Sensitivity: 0.89; Specificity: 0.89)
AA Change: D7G
|Meta Mutation Damage Score||0.258|
|Coding Region Coverage||
|Validation Efficiency||98% (64/65)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Lmcd1||
(F):5'- GGGAGTCCCGCTCTCCAATTAAAG -3'
(R):5'- TGGCTGCTATTGCCAACTGCAC -3'
(F):5'- TCTCCAATTAAAGCGGGCAG -3'
(R):5'- TACGGCACAGTGCAAATACTTTC -3'