Incidental Mutation 'R1615:Lmcd1'
ID177042
Institutional Source Beutler Lab
Gene Symbol Lmcd1
Ensembl Gene ENSMUSG00000057604
Gene NameLIM and cysteine-rich domains 1
Synonymsdyxin
MMRRC Submission 039652-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.284) question?
Stock #R1615 (G1)
Quality Score183
Status Validated
Chromosome6
Chromosomal Location112273758-112330425 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 112273950 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 7 (D7G)
Ref Sequence ENSEMBL: ENSMUSP00000032376 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032376]
Predicted Effect probably benign
Transcript: ENSMUST00000032376
AA Change: D7G

PolyPhen 2 Score 0.400 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000032376
Gene: ENSMUSG00000057604
AA Change: D7G

DomainStartEndE-ValueType
Pfam:PET 107 201 4.9e-39 PFAM
LIM 242 299 7.29e-8 SMART
LIM 307 359 1.97e-13 SMART
Meta Mutation Damage Score 0.258 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 88.8%
Validation Efficiency 98% (64/65)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the LIM-domain family of zinc finger proteins. The encoded protein contains an N-terminal cysteine-rich domain and two C-terminal LIM domains. The presence of LIM domains suggests involvement in protein-protein interactions. The protein may act as a co-regulator of transcription along with other transcription factors. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030419C18Rik C T 9: 58,499,068 A87V probably damaging Het
Adcy8 A T 15: 64,871,776 C328S probably benign Het
Adgrv1 G T 13: 81,424,288 T4918K probably benign Het
Aen T C 7: 78,905,912 Y108H probably damaging Het
Amer3 T C 1: 34,588,171 M497T probably damaging Het
Arid2 C T 15: 96,371,654 T1216M possibly damaging Het
Birc6 A G 17: 74,609,409 probably null Het
Bzw2 A G 12: 36,119,127 probably benign Het
Ccr1 T C 9: 123,963,536 H319R probably benign Het
Dnah11 A G 12: 118,050,722 I2010T probably damaging Het
Dnhd1 A G 7: 105,703,206 Y2522C probably benign Het
Dnhd1 T A 7: 105,713,706 I3825K possibly damaging Het
Dst A T 1: 34,199,371 D3718V probably damaging Het
Esp36 A G 17: 38,419,439 probably benign Het
Fbxw21 T C 9: 109,143,726 Y380C probably damaging Het
Fhad1 G A 4: 141,922,323 T836M probably damaging Het
Fhod1 C T 8: 105,347,831 probably benign Het
Flt1 A G 5: 147,639,288 C637R probably damaging Het
Fmnl2 A G 2: 53,118,424 K809E probably damaging Het
Grm1 G T 10: 10,741,508 Y510* probably null Het
Hey1 A T 3: 8,664,838 H186Q possibly damaging Het
Itga2b C T 11: 102,460,137 probably null Het
Kcnv1 G A 15: 45,114,444 T66M probably damaging Het
Lrrc1 T C 9: 77,435,118 D358G possibly damaging Het
Lyn A G 4: 3,748,765 K248E probably benign Het
Map4k4 A G 1: 40,006,830 probably benign Het
Map4k5 A T 12: 69,844,413 L160H probably damaging Het
Myo6 C T 9: 80,307,725 R1247C probably damaging Het
Myo9a A G 9: 59,788,456 E347G possibly damaging Het
Ndfip1 C T 18: 38,460,619 P213S probably benign Het
Neurl3 T C 1: 36,269,389 E114G possibly damaging Het
Nlrp14 A T 7: 107,196,163 I877F probably benign Het
Obscn A G 11: 59,099,825 S1733P probably benign Het
Oxgr1 A T 14: 120,022,773 S7R probably benign Het
Plcb1 A T 2: 135,362,444 probably benign Het
Prkag2 G T 5: 24,875,178 N120K possibly damaging Het
Rnf43 C T 11: 87,731,659 R529* probably null Het
Saraf A G 8: 34,165,288 K174E possibly damaging Het
Scrib T C 15: 76,066,205 Q264R probably benign Het
Sh3rf3 T A 10: 59,131,077 M747K probably benign Het
Shf T C 2: 122,349,432 H421R probably damaging Het
Slc35g3 A G 11: 69,760,542 S228P probably damaging Het
Slit1 A G 19: 41,650,671 probably benign Het
Soga1 T G 2: 157,020,743 H1422P probably damaging Het
Srrm4 A G 5: 116,447,300 probably benign Het
Stfa1 T G 16: 36,280,467 V23G probably damaging Het
Swap70 A G 7: 110,273,291 D371G probably benign Het
Tada2a T C 11: 84,103,100 D186G probably damaging Het
Tdpoz3 C A 3: 93,826,311 Q98K probably benign Het
Tgfbrap1 A G 1: 43,051,985 V660A probably benign Het
Tnn A G 1: 160,118,408 Y947H possibly damaging Het
Trim60 A T 8: 65,000,510 C362* probably null Het
Vmn1r81 T A 7: 12,260,514 N56Y probably damaging Het
Vsig8 A G 1: 172,559,713 D52G probably damaging Het
Wdfy4 G A 14: 33,042,512 R2140C probably damaging Het
Other mutations in Lmcd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Lmcd1 APN 6 112329808 missense probably benign 0.29
IGL00963:Lmcd1 APN 6 112329934 missense probably damaging 1.00
IGL01339:Lmcd1 APN 6 112310625 missense probably benign
IGL01373:Lmcd1 APN 6 112310625 missense probably benign
IGL03088:Lmcd1 APN 6 112310688 missense probably damaging 1.00
IGL03090:Lmcd1 APN 6 112310499 missense probably benign 0.32
R0940:Lmcd1 UTSW 6 112328697 missense probably benign 0.01
R1144:Lmcd1 UTSW 6 112310751 splice site probably benign
R1245:Lmcd1 UTSW 6 112315712 missense probably benign 0.01
R1338:Lmcd1 UTSW 6 112305128 missense probably damaging 1.00
R1567:Lmcd1 UTSW 6 112310565 missense probably damaging 1.00
R1748:Lmcd1 UTSW 6 112329914 missense probably benign 0.01
R1793:Lmcd1 UTSW 6 112328751 missense probably benign 0.00
R2014:Lmcd1 UTSW 6 112328741 missense probably damaging 1.00
R2042:Lmcd1 UTSW 6 112315890 missense probably benign 0.00
R4322:Lmcd1 UTSW 6 112315763 missense possibly damaging 0.54
R4344:Lmcd1 UTSW 6 112288007 intron probably benign
R4771:Lmcd1 UTSW 6 112315873 missense probably damaging 1.00
R4863:Lmcd1 UTSW 6 112287871 intron probably benign
R5256:Lmcd1 UTSW 6 112288126 intron probably benign
R5296:Lmcd1 UTSW 6 112315588 missense probably damaging 1.00
R6453:Lmcd1 UTSW 6 112315828 missense probably benign
Predicted Primers PCR Primer
(F):5'- GGGAGTCCCGCTCTCCAATTAAAG -3'
(R):5'- TGGCTGCTATTGCCAACTGCAC -3'

Sequencing Primer
(F):5'- TCTCCAATTAAAGCGGGCAG -3'
(R):5'- TACGGCACAGTGCAAATACTTTC -3'
Posted On2014-04-24