|Institutional Source||Beutler Lab|
|Gene Name||sulfotransferase family, cytosolic, 1C, member 2|
|Is this an essential gene?||Probably non essential (E-score: 0.058)|
|Stock #||R1570 (G1)|
|Chromosomal Location||53829637-53846339 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 53836963 bp|
|Amino Acid Change||Isoleucine to Valine at position 105 (I105V)|
|Ref Sequence||ENSEMBL: ENSMUSP00000023886 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000023886]|
|Predicted Effect||probably benign
AA Change: I105V
PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
AA Change: I105V
|Meta Mutation Damage Score||0.066|
|Coding Region Coverage||
|Validation Efficiency||93% (77/83)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sult1c2||
(F):5'- CCCGGTGTTTGACTTTACTGCCAAG -3'
(R):5'- CCCAGCACTTCAGCTATGTAAGCC -3'
(F):5'- TGCCAAGTATTAGGTCTCAGCAG -3'
(R):5'- GGCAAACACAAAAGCAATACTTCTC -3'