Incidental Mutation 'R1584:Corin'
| ID |
177326 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin, serine peptidase |
| Synonyms |
Lrp4 |
| MMRRC Submission |
039621-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.267)
|
| Stock # |
R1584 (G1)
|
| Quality Score |
165 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
72457368-72661816 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (1 bp from exon) |
| DNA Base Change (assembly) |
C to T
at 72460133 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000094710]
[ENSMUST00000126664]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000005352
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094710
|
| SMART Domains |
Protein: ENSMUSP00000142749
Gene: ENSMUSG00000046808
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1eula_
|
5 |
180 |
9e-15 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126664
|
| SMART Domains |
Protein: ENSMUSP00000143594
Gene: ENSMUSG00000046808
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:PhoLip_ATPase_N
|
111 |
176 |
1.2e-21 |
PFAM |
|
Pfam:E1-E2_ATPase
|
181 |
450 |
3e-10 |
PFAM |
|
low complexity region
|
523 |
534 |
N/A |
INTRINSIC |
|
low complexity region
|
684 |
696 |
N/A |
INTRINSIC |
|
Pfam:Cation_ATPase
|
739 |
859 |
3.4e-7 |
PFAM |
|
Pfam:HAD
|
754 |
1114 |
1.3e-12 |
PFAM |
|
Pfam:PhoLip_ATPase_C
|
1131 |
1376 |
4.3e-77 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136350
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146393
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158570
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000167460
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175766
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176974
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177290
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Meta Mutation Damage Score |
0.9470 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.6%
- 20x: 90.2%
|
| Validation Efficiency |
99% (106/107) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abhd15 |
C |
T |
11: 77,406,236 (GRCm39) |
A71V |
probably damaging |
Het |
| Ager |
A |
G |
17: 34,819,692 (GRCm39) |
E357G |
probably damaging |
Het |
| Akap13 |
T |
C |
7: 75,378,797 (GRCm39) |
S2095P |
possibly damaging |
Het |
| Ampd2 |
T |
C |
3: 107,987,653 (GRCm39) |
|
probably null |
Het |
| Arrdc1 |
T |
C |
2: 24,815,807 (GRCm39) |
I398V |
probably benign |
Het |
| Ash1l |
T |
C |
3: 88,959,372 (GRCm39) |
Y2250H |
probably damaging |
Het |
| Brca2 |
G |
A |
5: 150,475,723 (GRCm39) |
A2478T |
probably damaging |
Het |
| Btrc |
T |
A |
19: 45,501,821 (GRCm39) |
|
probably benign |
Het |
| C8g |
C |
T |
2: 25,390,228 (GRCm39) |
A6T |
probably benign |
Het |
| Ccdc121rt3 |
C |
T |
5: 112,502,630 (GRCm39) |
G358D |
probably benign |
Het |
| Cdc123 |
T |
A |
2: 5,808,788 (GRCm39) |
|
probably null |
Het |
| Cilp |
G |
A |
9: 65,186,997 (GRCm39) |
G1031S |
probably damaging |
Het |
| Cldn5 |
G |
A |
16: 18,596,227 (GRCm39) |
G161D |
probably damaging |
Het |
| Cndp2 |
G |
A |
18: 84,695,440 (GRCm39) |
|
probably benign |
Het |
| Cntnap1 |
C |
A |
11: 101,071,186 (GRCm39) |
F366L |
probably damaging |
Het |
| Ctdspl2 |
G |
A |
2: 121,834,410 (GRCm39) |
R332K |
probably benign |
Het |
| Dido1 |
G |
A |
2: 180,304,121 (GRCm39) |
P1261L |
probably damaging |
Het |
| Dop1a |
A |
T |
9: 86,430,225 (GRCm39) |
R2200* |
probably null |
Het |
| Dtx3l |
G |
A |
16: 35,753,098 (GRCm39) |
L503F |
probably damaging |
Het |
| Dysf |
A |
G |
6: 84,044,029 (GRCm39) |
K259R |
probably benign |
Het |
| Enpep |
T |
A |
3: 129,113,097 (GRCm39) |
T203S |
probably damaging |
Het |
| Epha2 |
T |
A |
4: 141,049,358 (GRCm39) |
|
probably null |
Het |
| Fam20b |
T |
C |
1: 156,513,758 (GRCm39) |
|
probably benign |
Het |
| Fbln7 |
A |
G |
2: 128,719,349 (GRCm39) |
T49A |
probably benign |
Het |
| Fgf14 |
T |
A |
14: 124,913,951 (GRCm39) |
K60M |
probably benign |
Het |
| Fhad1 |
T |
C |
4: 141,712,822 (GRCm39) |
I206V |
probably benign |
Het |
| Figla |
A |
G |
6: 85,997,764 (GRCm39) |
E164G |
probably benign |
Het |
| Gimap4 |
C |
A |
6: 48,668,216 (GRCm39) |
Q196K |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,537,964 (GRCm39) |
T6I |
probably damaging |
Het |
| Grk4 |
T |
C |
5: 34,852,094 (GRCm39) |
S113P |
probably benign |
Het |
| Hectd3 |
G |
A |
4: 116,853,763 (GRCm39) |
E220K |
probably damaging |
Het |
| Hecw1 |
A |
G |
13: 14,515,328 (GRCm39) |
|
probably null |
Het |
| Helz2 |
G |
A |
2: 180,878,090 (GRCm39) |
P903S |
probably damaging |
Het |
| Hydin |
T |
C |
8: 111,307,447 (GRCm39) |
V3942A |
probably benign |
Het |
| Irs1 |
G |
T |
1: 82,267,165 (GRCm39) |
H350Q |
probably benign |
Het |
| Kdm1b |
G |
A |
13: 47,217,530 (GRCm39) |
E46K |
probably damaging |
Het |
| Klf11 |
A |
G |
12: 24,705,304 (GRCm39) |
N253D |
probably damaging |
Het |
| Klhl23 |
T |
C |
2: 69,664,232 (GRCm39) |
I527T |
probably damaging |
Het |
| Lars1 |
G |
A |
18: 42,343,115 (GRCm39) |
R1101C |
probably damaging |
Het |
| Lcn4 |
G |
A |
2: 26,558,588 (GRCm39) |
P166L |
probably damaging |
Het |
| Letmd1 |
T |
A |
15: 100,370,423 (GRCm39) |
|
probably null |
Het |
| Lilra6 |
T |
A |
7: 3,915,661 (GRCm39) |
D358V |
probably damaging |
Het |
| Mmrn2 |
A |
G |
14: 34,097,642 (GRCm39) |
D24G |
probably benign |
Het |
| Mroh2b |
G |
T |
15: 4,955,166 (GRCm39) |
D720Y |
probably damaging |
Het |
| Mrps35 |
C |
T |
6: 146,957,482 (GRCm39) |
T169M |
probably damaging |
Het |
| Muc4 |
G |
A |
16: 32,574,886 (GRCm39) |
G1157D |
probably benign |
Het |
| Naga |
T |
A |
15: 82,218,989 (GRCm39) |
M237L |
probably null |
Het |
| Nfu1 |
G |
A |
6: 86,997,791 (GRCm39) |
E225K |
probably damaging |
Het |
| Nin |
A |
T |
12: 70,089,443 (GRCm39) |
L1324Q |
probably benign |
Het |
| Oc90 |
T |
A |
15: 65,769,569 (GRCm39) |
Y96F |
probably damaging |
Het |
| Or4a80 |
C |
T |
2: 89,582,611 (GRCm39) |
C187Y |
probably damaging |
Het |
| Or5b116 |
T |
C |
19: 13,423,023 (GRCm39) |
Y216H |
probably damaging |
Het |
| Or5m11b |
T |
A |
2: 85,806,339 (GRCm39) |
F251I |
probably damaging |
Het |
| Or6ae1 |
A |
G |
7: 139,742,116 (GRCm39) |
V249A |
probably damaging |
Het |
| Or8c9 |
G |
A |
9: 38,241,427 (GRCm39) |
M181I |
possibly damaging |
Het |
| Orc4 |
A |
T |
2: 48,799,506 (GRCm39) |
C324S |
possibly damaging |
Het |
| Pals1 |
A |
G |
12: 78,876,501 (GRCm39) |
I482V |
probably benign |
Het |
| Pdzrn4 |
T |
C |
15: 92,668,418 (GRCm39) |
S857P |
probably benign |
Het |
| Plec |
C |
T |
15: 76,070,108 (GRCm39) |
E1000K |
possibly damaging |
Het |
| Plvap |
A |
T |
8: 71,961,125 (GRCm39) |
V149D |
probably benign |
Het |
| Pm20d2 |
A |
T |
4: 33,174,772 (GRCm39) |
N371K |
probably damaging |
Het |
| Ppp2r5d |
A |
G |
17: 46,995,610 (GRCm39) |
Y480H |
probably benign |
Het |
| Prkd1 |
A |
T |
12: 50,472,298 (GRCm39) |
V205E |
probably damaging |
Het |
| R3hdm2 |
A |
G |
10: 127,312,559 (GRCm39) |
I434V |
probably benign |
Het |
| Rel |
T |
A |
11: 23,695,546 (GRCm39) |
T246S |
probably damaging |
Het |
| Rnf215 |
T |
A |
11: 4,086,719 (GRCm39) |
V172E |
probably damaging |
Het |
| Scara3 |
T |
C |
14: 66,158,553 (GRCm39) |
D485G |
probably damaging |
Het |
| Sec16a |
A |
T |
2: 26,321,169 (GRCm39) |
Y1308N |
probably damaging |
Het |
| Sis |
A |
T |
3: 72,839,393 (GRCm39) |
D824E |
possibly damaging |
Het |
| Slc27a4 |
T |
A |
2: 29,701,202 (GRCm39) |
V331E |
probably damaging |
Het |
| Srebf1 |
C |
T |
11: 60,091,528 (GRCm39) |
R999H |
probably benign |
Het |
| St3gal3 |
A |
C |
4: 117,964,859 (GRCm39) |
M1R |
probably null |
Het |
| Tapbp |
C |
T |
17: 34,138,914 (GRCm39) |
|
probably null |
Het |
| Tep1 |
A |
T |
14: 51,103,494 (GRCm39) |
N265K |
probably damaging |
Het |
| Thoc2l |
T |
A |
5: 104,666,123 (GRCm39) |
I215N |
probably damaging |
Het |
| Tln2 |
T |
A |
9: 67,203,696 (GRCm39) |
N470I |
probably damaging |
Het |
| Trim43a |
G |
T |
9: 88,470,211 (GRCm39) |
W339L |
probably damaging |
Het |
| Ttc22 |
T |
C |
4: 106,479,977 (GRCm39) |
F77S |
probably damaging |
Het |
| Ttc8 |
A |
G |
12: 98,887,023 (GRCm39) |
E32G |
probably benign |
Het |
| Uhmk1 |
A |
T |
1: 170,036,222 (GRCm39) |
|
probably null |
Het |
| Usp17lc |
A |
G |
7: 103,068,148 (GRCm39) |
H481R |
possibly damaging |
Het |
| Vamp8 |
G |
A |
6: 72,362,617 (GRCm39) |
T35M |
probably damaging |
Het |
| Vill |
A |
G |
9: 118,894,654 (GRCm39) |
Y53C |
probably damaging |
Het |
| Vmn1r222 |
A |
T |
13: 23,416,932 (GRCm39) |
S94T |
probably damaging |
Het |
| Vmn2r93 |
A |
G |
17: 18,525,413 (GRCm39) |
Y357C |
possibly damaging |
Het |
| Vps13c |
T |
A |
9: 67,800,394 (GRCm39) |
V536D |
possibly damaging |
Het |
| Vrtn |
G |
A |
12: 84,696,855 (GRCm39) |
C535Y |
probably damaging |
Het |
| Vwa3a |
A |
G |
7: 120,367,388 (GRCm39) |
Y181C |
probably damaging |
Het |
| Wfikkn2 |
G |
A |
11: 94,129,721 (GRCm39) |
T140I |
probably damaging |
Het |
| Ykt6 |
T |
A |
11: 5,912,349 (GRCm39) |
F101I |
probably damaging |
Het |
| Zfp277 |
C |
T |
12: 40,428,825 (GRCm39) |
G174D |
probably benign |
Het |
| Zfp638 |
A |
G |
6: 83,955,047 (GRCm39) |
|
probably null |
Het |
| Zzef1 |
C |
T |
11: 72,815,505 (GRCm39) |
P2942S |
probably damaging |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,462,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,462,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,496,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,611,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,511,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,529,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,490,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,511,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,518,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,460,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,458,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,490,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,500,304 (GRCm39) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,611,816 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,490,138 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,458,993 (GRCm39) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,462,276 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,488,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1617:Corin
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,515,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,473,394 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,661,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,490,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,496,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,592,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,579,508 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,529,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,497,222 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,515,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,661,226 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,500,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,496,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,460,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,529,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,511,194 (GRCm39) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,496,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,500,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,473,441 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,514,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,592,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,462,376 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,515,827 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,473,449 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,462,357 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,579,497 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,592,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,473,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,518,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,529,439 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,496,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,458,870 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,462,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,592,590 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,458,967 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,458,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,579,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,473,446 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,515,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,462,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,514,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,462,274 (GRCm39) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,592,750 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,592,695 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,486,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,497,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,592,597 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,611,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTTATACATGGCAATGCCCTCTG -3'
(R):5'- CTTTGAACGCAGTGCCCTTTAAGC -3'
Sequencing Primer
(F):5'- CTGCTTAAGACAGTGGATTTGAAG -3'
(R):5'- GATCTGTGCTGGCTATGAGT -3'
|
| Posted On |
2014-04-24 |
Incidental Mutation