|Institutional Source||Beutler Lab|
|Gene Name||cyclin B2|
|Is this an essential gene?||Probably essential (E-score: 0.758)|
|Stock #||R1585 (G1)|
|Chromosomal Location||70407692-70421547 bp(-) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||A to T at 70410277 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000034742 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034742]|
|Predicted Effect||probably null
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.644|
|Coding Region Coverage||
|Validation Efficiency||95% (81/85)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced body weight and reduced litter size. Homozygous pups are underrepresented in litters from a heterozygous intercross. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ccnb2||
(F):5'- TGGAACCTGCCTCACAGACAGATG -3'
(R):5'- ACTGTGCTCAGTCTTAGCCCAAAC -3'
(F):5'- agctcagtaaagtacgagcc -3'
(R):5'- ggagtcaaacaagtgttgcatatag -3'