Incidental Mutation 'R1587:Zfp59'
ID 177567
Institutional Source Beutler Lab
Gene Symbol Zfp59
Ensembl Gene ENSMUSG00000078779
Gene Name zinc finger protein 59
Synonyms Mfg2, Mfg-2
MMRRC Submission 039624-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R1587 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 27538032-27555863 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27553559 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 337 (E337G)
Ref Sequence ENSEMBL: ENSMUSP00000145671 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108331] [ENSMUST00000205701] [ENSMUST00000205715]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000108331
AA Change: E337G

PolyPhen 2 Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000103968
Gene: ENSMUSG00000078779
AA Change: E337G

DomainStartEndE-ValueType
KRAB 14 75 1.2e-35 SMART
ZnF_C2H2 172 194 2.91e-2 SMART
ZnF_C2H2 200 222 1.95e-3 SMART
ZnF_C2H2 256 278 2.02e-1 SMART
ZnF_C2H2 284 306 3.21e-4 SMART
ZnF_C2H2 312 334 1.92e-2 SMART
ZnF_C2H2 340 362 1.22e-4 SMART
ZnF_C2H2 368 390 2.53e-2 SMART
ZnF_C2H2 396 418 6.78e-3 SMART
ZnF_C2H2 424 446 3.44e-4 SMART
ZnF_C2H2 452 474 1.38e-3 SMART
ZnF_C2H2 480 502 3.34e-2 SMART
ZnF_C2H2 508 530 2.2e-2 SMART
ZnF_C2H2 536 558 2.71e-2 SMART
ZnF_C2H2 564 586 2.4e-3 SMART
ZnF_C2H2 592 614 1.92e-2 SMART
ZnF_C2H2 620 642 2.57e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000205701
AA Change: E337G

PolyPhen 2 Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000205715
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.2%
  • 20x: 88.9%
Validation Efficiency
MGI Phenotype FUNCTION: The Krueppel-associated box (KRAB) is a domain of around 75 amino acids found in the N-terminal portion of about one third of eukaryotic Krueppel-type C2H2 zinc finger proteins (ZFPs). The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. Although the function of KRAB-ZFPs is largely unknown, they appear to play important roles during cell differentiation and development. This gene encodes a protein belonging to the Krueppel family of C2H2-type zinc finger proteins and has been shown to accumulate in the nuclei of mature sperm in association with the nuclear matrix. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A T 17: 48,473,585 (GRCm39) S111T probably benign Het
Abhd2 A T 7: 79,003,758 (GRCm39) H279L probably benign Het
Ablim1 C T 19: 57,071,979 (GRCm39) M1I probably null Het
Agrn T C 4: 156,263,897 (GRCm39) Q122R probably damaging Het
Arfgef1 A T 1: 10,230,184 (GRCm39) F1218I probably damaging Het
Bud13 C T 9: 46,201,513 (GRCm39) P395S probably damaging Het
Ccdc110 G A 8: 46,394,783 (GRCm39) V225M probably benign Het
Ccdc30 A T 4: 119,210,373 (GRCm39) S248T probably damaging Het
Cdh20 C A 1: 110,027,757 (GRCm39) Q501K probably damaging Het
Cwc27 T C 13: 104,929,145 (GRCm39) D266G probably benign Het
Cyp2d40 T A 15: 82,645,334 (GRCm39) probably null Het
Cyp4a32 T G 4: 115,467,731 (GRCm39) N238K probably benign Het
Ddx11 T C 17: 66,456,251 (GRCm39) L770P probably damaging Het
Dgcr8 C T 16: 18,098,155 (GRCm39) G412E probably damaging Het
Disp2 C A 2: 118,622,064 (GRCm39) A932D probably damaging Het
Dlg4 T A 11: 69,922,572 (GRCm39) N291K possibly damaging Het
Dnajc7 A G 11: 100,492,556 (GRCm39) I39T probably damaging Het
Elp1 G A 4: 56,786,666 (GRCm39) Q426* probably null Het
Eno3 T C 11: 70,552,296 (GRCm39) V316A probably damaging Het
Ep400 G A 5: 110,874,768 (GRCm39) T944I probably benign Het
Ezh2 T G 6: 47,529,424 (GRCm39) probably null Het
F7 A T 8: 13,084,783 (GRCm39) I270F possibly damaging Het
Fancc A G 13: 63,488,246 (GRCm39) F245L probably benign Het
Fzd7 G A 1: 59,522,165 (GRCm39) C16Y possibly damaging Het
Gm29394 A G 15: 57,892,008 (GRCm39) *200Q probably null Het
Ints8 A G 4: 11,245,722 (GRCm39) probably null Het
Krt36 A T 11: 99,993,128 (GRCm39) I449N probably damaging Het
Ldlr A T 9: 21,649,209 (GRCm39) H328L probably damaging Het
Limk2 T C 11: 3,303,455 (GRCm39) N101S possibly damaging Het
Lrp4 A G 2: 91,306,650 (GRCm39) N321S probably benign Het
Mafk T C 5: 139,785,900 (GRCm39) S33P probably damaging Het
Mbtps1 T C 8: 120,244,958 (GRCm39) Y831C probably damaging Het
Mfge8 T A 7: 78,784,513 (GRCm39) I344F probably damaging Het
Myo5b T C 18: 74,867,061 (GRCm39) V1430A probably benign Het
Nbas G A 12: 13,608,686 (GRCm39) R2154H probably benign Het
Nlrp6 G A 7: 140,502,959 (GRCm39) R355H probably damaging Het
Noc4l T C 5: 110,800,889 (GRCm39) T76A probably benign Het
Nrp1 T A 8: 129,202,763 (GRCm39) C583S probably damaging Het
Or2w4 C T 13: 21,796,083 (GRCm39) D19N probably benign Het
Or5d35 T A 2: 87,855,477 (GRCm39) M137K probably damaging Het
Pgm5 T A 19: 24,793,113 (GRCm39) I318F probably damaging Het
Phf1 T A 17: 27,156,466 (GRCm39) V536D probably damaging Het
Prpf4b C A 13: 35,076,133 (GRCm39) A641D probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rbm47 A G 5: 66,182,334 (GRCm39) I433T probably benign Het
Resf1 G T 6: 149,228,018 (GRCm39) V355F probably damaging Het
S100a3 G A 3: 90,509,618 (GRCm39) E88K probably benign Het
Sesn1 A G 10: 41,687,108 (GRCm39) I31V probably benign Het
Son T A 16: 91,456,606 (GRCm39) S1784R probably damaging Het
Srbd1 G T 17: 86,292,865 (GRCm39) D901E probably damaging Het
St8sia6 C T 2: 13,677,416 (GRCm39) D134N possibly damaging Het
Synpo2 T A 3: 122,908,047 (GRCm39) D423V probably damaging Het
Vmn2r108 A G 17: 20,692,383 (GRCm39) S158P probably damaging Het
Vmn2r109 A T 17: 20,761,002 (GRCm39) V785E probably damaging Het
Zfp143 A G 7: 109,673,275 (GRCm39) D124G probably benign Het
Zfp251 A G 15: 76,754,484 (GRCm39) L54P probably damaging Het
Zfp324 G T 7: 12,704,570 (GRCm39) S253I possibly damaging Het
Zfp663 G T 2: 165,195,437 (GRCm39) Q261K probably benign Het
Zhx3 T C 2: 160,623,613 (GRCm39) probably null Het
Other mutations in Zfp59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02976:Zfp59 APN 7 27,552,821 (GRCm39) missense probably benign 0.00
R0689:Zfp59 UTSW 7 27,553,142 (GRCm39) missense probably benign 0.19
R0726:Zfp59 UTSW 7 27,553,513 (GRCm39) missense probably damaging 0.98
R1570:Zfp59 UTSW 7 27,553,016 (GRCm39) missense probably benign 0.03
R2067:Zfp59 UTSW 7 27,552,935 (GRCm39) missense probably benign 0.01
R4880:Zfp59 UTSW 7 27,543,742 (GRCm39) missense probably damaging 0.99
R5677:Zfp59 UTSW 7 27,553,594 (GRCm39) missense probably benign 0.15
R6969:Zfp59 UTSW 7 27,552,922 (GRCm39) missense probably damaging 0.98
R7574:Zfp59 UTSW 7 27,552,863 (GRCm39) missense probably benign 0.04
R7837:Zfp59 UTSW 7 27,554,342 (GRCm39) frame shift probably null
R8332:Zfp59 UTSW 7 27,552,971 (GRCm39) missense probably benign 0.00
R8891:Zfp59 UTSW 7 27,554,313 (GRCm39) missense probably benign 0.00
R9314:Zfp59 UTSW 7 27,554,029 (GRCm39) missense possibly damaging 0.86
R9583:Zfp59 UTSW 7 27,554,483 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CCGTGTCTCCAGCCTTGTTGAAC -3'
(R):5'- GAAGGACTTCCCACATACCTTGCATT -3'

Sequencing Primer
(F):5'- GCTTattcatgctgatgtgaaacc -3'
(R):5'- acctgaagccgaaaagcc -3'
Posted On 2014-04-24