Incidental Mutation 'R1587:Or2w4'
ID 177589
Institutional Source Beutler Lab
Gene Symbol Or2w4
Ensembl Gene ENSMUSG00000051258
Gene Name olfactory receptor family 2 subfamily W member 4
Synonyms Olfr1363-ps1, Olfr1362, GA_x6K02T2QHY8-11617756-11618682, GA_x6K02T2QHY8-11628399-11628868, MOR256-8
MMRRC Submission 039624-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.138) question?
Stock # R1587 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 21795190-21796174 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 21796083 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 19 (D19N)
Ref Sequence ENSEMBL: ENSMUSP00000061660 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051874]
AlphaFold Q5SZZ8
Predicted Effect probably benign
Transcript: ENSMUST00000051874
AA Change: D19N

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000061660
Gene: ENSMUSG00000051258
AA Change: D19N

DomainStartEndE-ValueType
Pfam:7tm_4 32 307 3.5e-51 PFAM
Pfam:7tm_1 41 290 9e-24 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.2%
  • 20x: 88.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530064D06Rik A T 17: 48,473,585 (GRCm39) S111T probably benign Het
Abhd2 A T 7: 79,003,758 (GRCm39) H279L probably benign Het
Ablim1 C T 19: 57,071,979 (GRCm39) M1I probably null Het
Agrn T C 4: 156,263,897 (GRCm39) Q122R probably damaging Het
Arfgef1 A T 1: 10,230,184 (GRCm39) F1218I probably damaging Het
Bud13 C T 9: 46,201,513 (GRCm39) P395S probably damaging Het
Ccdc110 G A 8: 46,394,783 (GRCm39) V225M probably benign Het
Ccdc30 A T 4: 119,210,373 (GRCm39) S248T probably damaging Het
Cdh20 C A 1: 110,027,757 (GRCm39) Q501K probably damaging Het
Cwc27 T C 13: 104,929,145 (GRCm39) D266G probably benign Het
Cyp2d40 T A 15: 82,645,334 (GRCm39) probably null Het
Cyp4a32 T G 4: 115,467,731 (GRCm39) N238K probably benign Het
Ddx11 T C 17: 66,456,251 (GRCm39) L770P probably damaging Het
Dgcr8 C T 16: 18,098,155 (GRCm39) G412E probably damaging Het
Disp2 C A 2: 118,622,064 (GRCm39) A932D probably damaging Het
Dlg4 T A 11: 69,922,572 (GRCm39) N291K possibly damaging Het
Dnajc7 A G 11: 100,492,556 (GRCm39) I39T probably damaging Het
Elp1 G A 4: 56,786,666 (GRCm39) Q426* probably null Het
Eno3 T C 11: 70,552,296 (GRCm39) V316A probably damaging Het
Ep400 G A 5: 110,874,768 (GRCm39) T944I probably benign Het
Ezh2 T G 6: 47,529,424 (GRCm39) probably null Het
F7 A T 8: 13,084,783 (GRCm39) I270F possibly damaging Het
Fancc A G 13: 63,488,246 (GRCm39) F245L probably benign Het
Fzd7 G A 1: 59,522,165 (GRCm39) C16Y possibly damaging Het
Gm29394 A G 15: 57,892,008 (GRCm39) *200Q probably null Het
Ints8 A G 4: 11,245,722 (GRCm39) probably null Het
Krt36 A T 11: 99,993,128 (GRCm39) I449N probably damaging Het
Ldlr A T 9: 21,649,209 (GRCm39) H328L probably damaging Het
Limk2 T C 11: 3,303,455 (GRCm39) N101S possibly damaging Het
Lrp4 A G 2: 91,306,650 (GRCm39) N321S probably benign Het
Mafk T C 5: 139,785,900 (GRCm39) S33P probably damaging Het
Mbtps1 T C 8: 120,244,958 (GRCm39) Y831C probably damaging Het
Mfge8 T A 7: 78,784,513 (GRCm39) I344F probably damaging Het
Myo5b T C 18: 74,867,061 (GRCm39) V1430A probably benign Het
Nbas G A 12: 13,608,686 (GRCm39) R2154H probably benign Het
Nlrp6 G A 7: 140,502,959 (GRCm39) R355H probably damaging Het
Noc4l T C 5: 110,800,889 (GRCm39) T76A probably benign Het
Nrp1 T A 8: 129,202,763 (GRCm39) C583S probably damaging Het
Or5d35 T A 2: 87,855,477 (GRCm39) M137K probably damaging Het
Pgm5 T A 19: 24,793,113 (GRCm39) I318F probably damaging Het
Phf1 T A 17: 27,156,466 (GRCm39) V536D probably damaging Het
Prpf4b C A 13: 35,076,133 (GRCm39) A641D probably benign Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rbm47 A G 5: 66,182,334 (GRCm39) I433T probably benign Het
Resf1 G T 6: 149,228,018 (GRCm39) V355F probably damaging Het
S100a3 G A 3: 90,509,618 (GRCm39) E88K probably benign Het
Sesn1 A G 10: 41,687,108 (GRCm39) I31V probably benign Het
Son T A 16: 91,456,606 (GRCm39) S1784R probably damaging Het
Srbd1 G T 17: 86,292,865 (GRCm39) D901E probably damaging Het
St8sia6 C T 2: 13,677,416 (GRCm39) D134N possibly damaging Het
Synpo2 T A 3: 122,908,047 (GRCm39) D423V probably damaging Het
Vmn2r108 A G 17: 20,692,383 (GRCm39) S158P probably damaging Het
Vmn2r109 A T 17: 20,761,002 (GRCm39) V785E probably damaging Het
Zfp143 A G 7: 109,673,275 (GRCm39) D124G probably benign Het
Zfp251 A G 15: 76,754,484 (GRCm39) L54P probably damaging Het
Zfp324 G T 7: 12,704,570 (GRCm39) S253I possibly damaging Het
Zfp59 A G 7: 27,553,559 (GRCm39) E337G possibly damaging Het
Zfp663 G T 2: 165,195,437 (GRCm39) Q261K probably benign Het
Zhx3 T C 2: 160,623,613 (GRCm39) probably null Het
Other mutations in Or2w4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00949:Or2w4 APN 13 21,795,521 (GRCm39) missense probably damaging 0.99
R0070:Or2w4 UTSW 13 21,795,431 (GRCm39) missense possibly damaging 0.60
R0070:Or2w4 UTSW 13 21,795,431 (GRCm39) missense possibly damaging 0.60
R1458:Or2w4 UTSW 13 21,795,992 (GRCm39) missense probably benign 0.37
R1588:Or2w4 UTSW 13 21,796,083 (GRCm39) missense probably benign 0.01
R1607:Or2w4 UTSW 13 21,795,934 (GRCm39) missense probably benign 0.04
R1708:Or2w4 UTSW 13 21,795,240 (GRCm39) missense probably damaging 0.98
R4633:Or2w4 UTSW 13 21,795,398 (GRCm39) missense probably damaging 0.99
R6223:Or2w4 UTSW 13 21,795,536 (GRCm39) missense probably benign
R6229:Or2w4 UTSW 13 21,795,819 (GRCm39) missense probably benign
R7140:Or2w4 UTSW 13 21,795,297 (GRCm39) missense possibly damaging 0.87
R8385:Or2w4 UTSW 13 21,795,522 (GRCm39) missense probably benign 0.12
R9433:Or2w4 UTSW 13 21,795,224 (GRCm39) missense probably benign 0.04
R9654:Or2w4 UTSW 13 21,795,915 (GRCm39) missense possibly damaging 0.93
R9744:Or2w4 UTSW 13 21,795,827 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- CCCAGAGGTTTACCAGCATCTGTG -3'
(R):5'- TGGATGGGAATGTTAAACTCAGTGGC -3'

Sequencing Primer
(F):5'- AGCATCTGTGGGATGCAGC -3'
(R):5'- TGTTAAACTCAGTGGCTGAATG -3'
Posted On 2014-04-24