Incidental Mutation 'IGL01843:Tmem168'
ID 178086
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem168
Ensembl Gene ENSMUSG00000029569
Gene Name transmembrane protein 168
Synonyms 8430437G11Rik, 5730526F17Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # IGL01843
Quality Score
Status
Chromosome 6
Chromosomal Location 13580688-13608097 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 13582940 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 263 (T263M)
Ref Sequence ENSEMBL: ENSMUSP00000145372 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031554] [ENSMUST00000149123]
AlphaFold Q91VX9
Predicted Effect probably damaging
Transcript: ENSMUST00000031554
AA Change: T647M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000031554
Gene: ENSMUSG00000029569
AA Change: T647M

DomainStartEndE-ValueType
transmembrane domain 35 57 N/A INTRINSIC
transmembrane domain 63 85 N/A INTRINSIC
transmembrane domain 92 109 N/A INTRINSIC
low complexity region 152 163 N/A INTRINSIC
transmembrane domain 170 192 N/A INTRINSIC
transmembrane domain 199 216 N/A INTRINSIC
transmembrane domain 226 248 N/A INTRINSIC
transmembrane domain 261 283 N/A INTRINSIC
transmembrane domain 298 320 N/A INTRINSIC
transmembrane domain 359 378 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000149123
AA Change: T263M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145372
Gene: ENSMUSG00000029569
AA Change: T263M

DomainStartEndE-ValueType
SCOP:d1jxqa_ 29 167 8e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,530,301 (GRCm39) probably benign Het
Ap1b1 T C 11: 4,989,169 (GRCm39) L782P probably damaging Het
Arid1a T C 4: 133,408,765 (GRCm39) D1914G unknown Het
C8a G A 4: 104,719,808 (GRCm39) Q57* probably null Het
Cachd1 T C 4: 100,850,069 (GRCm39) S1144P probably damaging Het
Cdh23 A T 10: 60,255,598 (GRCm39) probably null Het
Cenpe A G 3: 134,924,268 (GRCm39) Q198R possibly damaging Het
Cpne8 T C 15: 90,453,700 (GRCm39) I228V probably benign Het
Cr2 A T 1: 194,833,222 (GRCm39) probably benign Het
Csmd3 T C 15: 47,522,395 (GRCm39) probably benign Het
Cyp2c23 A G 19: 43,994,046 (GRCm39) V440A probably benign Het
Dag1 T C 9: 108,085,281 (GRCm39) D620G possibly damaging Het
Dmxl1 T A 18: 50,011,449 (GRCm39) L1202* probably null Het
Dnah3 T G 7: 119,542,798 (GRCm39) H3538P probably benign Het
Dock8 A T 19: 25,067,292 (GRCm39) Q312L probably benign Het
E2f7 T G 10: 110,610,596 (GRCm39) V407G probably benign Het
F13b T C 1: 139,444,165 (GRCm39) S500P probably damaging Het
F5 A G 1: 164,039,395 (GRCm39) I2002V probably benign Het
Flywch1 T A 17: 23,979,319 (GRCm39) M439L possibly damaging Het
Gcn1 C A 5: 115,757,759 (GRCm39) A2488E probably damaging Het
Gria1 T C 11: 57,208,600 (GRCm39) S832P probably damaging Het
Hnrnpr T C 4: 136,066,724 (GRCm39) probably benign Het
Hps3 A G 3: 20,083,165 (GRCm39) I177T probably benign Het
Irgm2 G A 11: 58,111,167 (GRCm39) G298D probably benign Het
Kcnk7 G A 19: 5,756,230 (GRCm39) G152D probably damaging Het
Man2a2 T C 7: 80,012,654 (GRCm39) T620A probably benign Het
Mapk12 A G 15: 89,021,669 (GRCm39) probably benign Het
Mapk6 T C 9: 75,297,572 (GRCm39) Y315C probably damaging Het
Mdga2 T A 12: 66,769,905 (GRCm39) probably null Het
Met T A 6: 17,491,700 (GRCm39) I154N probably damaging Het
Mtrex T C 13: 113,055,095 (GRCm39) probably benign Het
Nap1l1 A G 10: 111,328,772 (GRCm39) R234G possibly damaging Het
Olfm5 C A 7: 103,809,951 (GRCm39) V137F possibly damaging Het
Or4d11 G T 19: 12,014,041 (GRCm39) H22N probably benign Het
Pcdha11 C T 18: 37,145,886 (GRCm39) T659I probably benign Het
Pfkm T C 15: 98,027,187 (GRCm39) V620A possibly damaging Het
Rbak A G 5: 143,162,355 (GRCm39) probably benign Het
Rbl2 A G 8: 91,816,844 (GRCm39) I401M probably benign Het
Rragc T C 4: 123,814,852 (GRCm39) S183P probably damaging Het
Septin3 A G 15: 82,163,814 (GRCm39) probably benign Het
Slc22a6 A T 19: 8,603,578 (GRCm39) probably benign Het
Spag4 A T 2: 155,910,417 (GRCm39) T348S probably benign Het
Sptbn1 T C 11: 30,054,623 (GRCm39) R2157G probably benign Het
Tnik T A 3: 28,625,007 (GRCm39) probably null Het
Tnpo2 T A 8: 85,777,137 (GRCm39) V549E probably damaging Het
Ttll7 A C 3: 146,645,776 (GRCm39) K545Q possibly damaging Het
Tubgcp5 T G 7: 55,449,221 (GRCm39) D139E probably benign Het
Vmn1r233 T A 17: 21,214,861 (GRCm39) N30Y probably damaging Het
Vmn2r25 T G 6: 123,829,962 (GRCm39) D63A possibly damaging Het
Vmn2r79 T A 7: 86,686,485 (GRCm39) L622Q probably damaging Het
Vmn2r84 T C 10: 130,222,148 (GRCm39) M691V probably benign Het
Zc3hc1 A T 6: 30,372,729 (GRCm39) probably benign Het
Other mutations in Tmem168
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00786:Tmem168 APN 6 13,602,674 (GRCm39) missense probably benign 0.06
IGL01305:Tmem168 APN 6 13,583,045 (GRCm39) missense probably damaging 1.00
IGL02742:Tmem168 APN 6 13,603,261 (GRCm39) missense probably benign 0.04
IGL02863:Tmem168 APN 6 13,582,917 (GRCm39) missense probably damaging 0.98
ANU22:Tmem168 UTSW 6 13,583,045 (GRCm39) missense probably damaging 1.00
R0193:Tmem168 UTSW 6 13,583,312 (GRCm39) missense possibly damaging 0.81
R0537:Tmem168 UTSW 6 13,603,360 (GRCm39) missense probably damaging 1.00
R0630:Tmem168 UTSW 6 13,583,064 (GRCm39) missense probably benign
R0890:Tmem168 UTSW 6 13,603,271 (GRCm39) missense probably damaging 1.00
R1416:Tmem168 UTSW 6 13,591,400 (GRCm39) missense probably damaging 0.96
R1900:Tmem168 UTSW 6 13,583,070 (GRCm39) missense probably benign 0.02
R3947:Tmem168 UTSW 6 13,583,051 (GRCm39) missense probably damaging 1.00
R4362:Tmem168 UTSW 6 13,595,072 (GRCm39) missense probably benign 0.31
R4620:Tmem168 UTSW 6 13,594,952 (GRCm39) missense probably benign 0.03
R5693:Tmem168 UTSW 6 13,602,320 (GRCm39) missense probably benign 0.01
R6142:Tmem168 UTSW 6 13,591,368 (GRCm39) missense probably benign
R6328:Tmem168 UTSW 6 13,602,710 (GRCm39) missense probably benign
R6438:Tmem168 UTSW 6 13,602,673 (GRCm39) missense probably benign 0.06
R6711:Tmem168 UTSW 6 13,603,120 (GRCm39) missense probably damaging 1.00
R6827:Tmem168 UTSW 6 13,582,837 (GRCm39) missense probably damaging 0.99
R6987:Tmem168 UTSW 6 13,591,476 (GRCm39) missense possibly damaging 0.82
R7696:Tmem168 UTSW 6 13,602,937 (GRCm39) missense probably benign 0.01
R8295:Tmem168 UTSW 6 13,602,850 (GRCm39) missense probably damaging 0.99
R8344:Tmem168 UTSW 6 13,583,324 (GRCm39) missense probably benign
R8432:Tmem168 UTSW 6 13,602,535 (GRCm39) missense probably benign 0.30
R8992:Tmem168 UTSW 6 13,602,849 (GRCm39) missense possibly damaging 0.72
R9003:Tmem168 UTSW 6 13,591,446 (GRCm39) missense probably benign 0.06
R9325:Tmem168 UTSW 6 13,583,253 (GRCm39) missense probably benign
Posted On 2014-05-07