Incidental Mutation 'IGL01843:Mapk12'
ID 178119
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mapk12
Ensembl Gene ENSMUSG00000022610
Gene Name mitogen-activated protein kinase 12
Synonyms Sapk3, P38gamma, Prkm12, Erk6
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01843
Quality Score
Status
Chromosome 15
Chromosomal Location 89014787-89024906 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 89021669 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000086207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088827]
AlphaFold O08911
Predicted Effect probably benign
Transcript: ENSMUST00000088827
SMART Domains Protein: ENSMUSP00000086207
Gene: ENSMUSG00000022610

DomainStartEndE-ValueType
S_TKc 27 311 1.63e-96 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229193
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230266
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230352
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230509
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231014
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231056
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are viable and fertile with no obvious abnormalities. Mice homozygous for a conditional allele activated in muscle cell exhibit decreased endurance exercise-induced mitochondrial biogenesis and angiogenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,530,301 (GRCm39) probably benign Het
Ap1b1 T C 11: 4,989,169 (GRCm39) L782P probably damaging Het
Arid1a T C 4: 133,408,765 (GRCm39) D1914G unknown Het
C8a G A 4: 104,719,808 (GRCm39) Q57* probably null Het
Cachd1 T C 4: 100,850,069 (GRCm39) S1144P probably damaging Het
Cdh23 A T 10: 60,255,598 (GRCm39) probably null Het
Cenpe A G 3: 134,924,268 (GRCm39) Q198R possibly damaging Het
Cpne8 T C 15: 90,453,700 (GRCm39) I228V probably benign Het
Cr2 A T 1: 194,833,222 (GRCm39) probably benign Het
Csmd3 T C 15: 47,522,395 (GRCm39) probably benign Het
Cyp2c23 A G 19: 43,994,046 (GRCm39) V440A probably benign Het
Dag1 T C 9: 108,085,281 (GRCm39) D620G possibly damaging Het
Dmxl1 T A 18: 50,011,449 (GRCm39) L1202* probably null Het
Dnah3 T G 7: 119,542,798 (GRCm39) H3538P probably benign Het
Dock8 A T 19: 25,067,292 (GRCm39) Q312L probably benign Het
E2f7 T G 10: 110,610,596 (GRCm39) V407G probably benign Het
F13b T C 1: 139,444,165 (GRCm39) S500P probably damaging Het
F5 A G 1: 164,039,395 (GRCm39) I2002V probably benign Het
Flywch1 T A 17: 23,979,319 (GRCm39) M439L possibly damaging Het
Gcn1 C A 5: 115,757,759 (GRCm39) A2488E probably damaging Het
Gria1 T C 11: 57,208,600 (GRCm39) S832P probably damaging Het
Hnrnpr T C 4: 136,066,724 (GRCm39) probably benign Het
Hps3 A G 3: 20,083,165 (GRCm39) I177T probably benign Het
Irgm2 G A 11: 58,111,167 (GRCm39) G298D probably benign Het
Kcnk7 G A 19: 5,756,230 (GRCm39) G152D probably damaging Het
Man2a2 T C 7: 80,012,654 (GRCm39) T620A probably benign Het
Mapk6 T C 9: 75,297,572 (GRCm39) Y315C probably damaging Het
Mdga2 T A 12: 66,769,905 (GRCm39) probably null Het
Met T A 6: 17,491,700 (GRCm39) I154N probably damaging Het
Mtrex T C 13: 113,055,095 (GRCm39) probably benign Het
Nap1l1 A G 10: 111,328,772 (GRCm39) R234G possibly damaging Het
Olfm5 C A 7: 103,809,951 (GRCm39) V137F possibly damaging Het
Or4d11 G T 19: 12,014,041 (GRCm39) H22N probably benign Het
Pcdha11 C T 18: 37,145,886 (GRCm39) T659I probably benign Het
Pfkm T C 15: 98,027,187 (GRCm39) V620A possibly damaging Het
Rbak A G 5: 143,162,355 (GRCm39) probably benign Het
Rbl2 A G 8: 91,816,844 (GRCm39) I401M probably benign Het
Rragc T C 4: 123,814,852 (GRCm39) S183P probably damaging Het
Septin3 A G 15: 82,163,814 (GRCm39) probably benign Het
Slc22a6 A T 19: 8,603,578 (GRCm39) probably benign Het
Spag4 A T 2: 155,910,417 (GRCm39) T348S probably benign Het
Sptbn1 T C 11: 30,054,623 (GRCm39) R2157G probably benign Het
Tmem168 G A 6: 13,582,940 (GRCm39) T263M probably damaging Het
Tnik T A 3: 28,625,007 (GRCm39) probably null Het
Tnpo2 T A 8: 85,777,137 (GRCm39) V549E probably damaging Het
Ttll7 A C 3: 146,645,776 (GRCm39) K545Q possibly damaging Het
Tubgcp5 T G 7: 55,449,221 (GRCm39) D139E probably benign Het
Vmn1r233 T A 17: 21,214,861 (GRCm39) N30Y probably damaging Het
Vmn2r25 T G 6: 123,829,962 (GRCm39) D63A possibly damaging Het
Vmn2r79 T A 7: 86,686,485 (GRCm39) L622Q probably damaging Het
Vmn2r84 T C 10: 130,222,148 (GRCm39) M691V probably benign Het
Zc3hc1 A T 6: 30,372,729 (GRCm39) probably benign Het
Other mutations in Mapk12
AlleleSourceChrCoordTypePredicted EffectPPH Score
revenge UTSW 15 89,017,350 (GRCm39) missense probably damaging 1.00
R0106:Mapk12 UTSW 15 89,017,187 (GRCm39) unclassified probably benign
R0106:Mapk12 UTSW 15 89,017,187 (GRCm39) unclassified probably benign
R0523:Mapk12 UTSW 15 89,019,848 (GRCm39) missense probably benign 0.12
R1148:Mapk12 UTSW 15 89,018,826 (GRCm39) missense probably damaging 1.00
R1148:Mapk12 UTSW 15 89,018,826 (GRCm39) missense probably damaging 1.00
R1667:Mapk12 UTSW 15 89,024,344 (GRCm39) missense probably damaging 1.00
R3887:Mapk12 UTSW 15 89,019,840 (GRCm39) missense possibly damaging 0.93
R4901:Mapk12 UTSW 15 89,018,841 (GRCm39) nonsense probably null
R7011:Mapk12 UTSW 15 89,019,803 (GRCm39) missense probably damaging 1.00
R7080:Mapk12 UTSW 15 89,017,350 (GRCm39) missense probably damaging 1.00
R7105:Mapk12 UTSW 15 89,015,361 (GRCm39) missense probably benign
R9076:Mapk12 UTSW 15 89,024,611 (GRCm39) missense probably benign 0.02
X0022:Mapk12 UTSW 15 89,021,630 (GRCm39) missense probably damaging 0.99
Posted On 2014-05-07