Incidental Mutation 'R0108:Zfand3'
ID 17829
Institutional Source Beutler Lab
Gene Symbol Zfand3
Ensembl Gene ENSMUSG00000044477
Gene Name zinc finger, AN1-type domain 3
Synonyms TEG-27, Tex27
MMRRC Submission 038394-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.317) question?
Stock # R0108 (G1)
Quality Score
Status Validated
Chromosome 17
Chromosomal Location 30224013-30429797 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 30354372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 63 (E63G)
Ref Sequence ENSEMBL: ENSMUSP00000154782 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057897] [ENSMUST00000226208]
AlphaFold Q497H0
Predicted Effect probably damaging
Transcript: ENSMUST00000057897
AA Change: E63G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000063158
Gene: ENSMUSG00000044477
AA Change: E63G

DomainStartEndE-ValueType
Pfam:zf-A20 17 36 8.7e-9 PFAM
low complexity region 43 58 N/A INTRINSIC
low complexity region 61 77 N/A INTRINSIC
Pfam:zf-AN1 135 175 8.6e-11 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226208
AA Change: E63G

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226308
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226421
Meta Mutation Damage Score 0.4240 question?
Coding Region Coverage
  • 1x: 87.1%
  • 3x: 81.7%
  • 10x: 58.7%
  • 20x: 25.7%
Validation Efficiency 90% (92/102)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,224,692 (GRCm39) N910K probably benign Het
Ackr4 T A 9: 103,976,387 (GRCm39) I187F probably benign Het
Adamts12 T C 15: 11,311,184 (GRCm39) V1147A probably benign Het
Adcy2 A T 13: 68,800,054 (GRCm39) V858E probably damaging Het
Adgrv1 A G 13: 81,726,523 (GRCm39) probably benign Het
Atg4c C T 4: 99,109,677 (GRCm39) H215Y possibly damaging Het
Ccdc88a T A 11: 29,453,463 (GRCm39) S337T probably damaging Het
Evpl T C 11: 116,111,702 (GRCm39) E1996G probably damaging Het
Fbxw10 A G 11: 62,767,887 (GRCm39) T903A probably benign Het
Frem2 G T 3: 53,555,382 (GRCm39) D1718E probably benign Het
Gatad2b T A 3: 90,265,250 (GRCm39) Y576N probably damaging Het
Gm136 G T 4: 34,746,593 (GRCm39) H139Q possibly damaging Het
Helq C A 5: 100,916,234 (GRCm39) E913* probably null Het
Itgb7 C T 15: 102,131,917 (GRCm39) R222H probably damaging Het
Lmtk2 C T 5: 144,111,103 (GRCm39) R608C possibly damaging Het
Lonp2 G A 8: 87,442,983 (GRCm39) V815I probably benign Het
Mpdz C T 4: 81,300,042 (GRCm39) V319I probably damaging Het
Ntng1 T C 3: 109,759,071 (GRCm39) probably benign Het
Nup210l A G 3: 90,096,882 (GRCm39) T1364A probably damaging Het
Or10q1b A T 19: 13,683,042 (GRCm39) T284S probably damaging Het
Pcdha1 T A 18: 37,131,809 (GRCm39) W293R probably benign Het
Plcl1 A G 1: 55,737,098 (GRCm39) Y813C possibly damaging Het
Plekho2 A T 9: 65,466,705 (GRCm39) D128E probably damaging Het
Pstpip1 A G 9: 56,035,050 (GRCm39) E341G probably benign Het
Rps6ka2 G A 17: 7,563,442 (GRCm39) D617N probably benign Het
Scin A G 12: 40,177,986 (GRCm39) V83A possibly damaging Het
Sec11a A G 7: 80,584,787 (GRCm39) V50A probably damaging Het
Sel1l3 C T 5: 53,295,244 (GRCm39) A786T possibly damaging Het
Shroom1 T C 11: 53,357,764 (GRCm39) S772P possibly damaging Het
Slc30a5 G T 13: 100,939,908 (GRCm39) A669E probably damaging Het
Tm6sf1 G A 7: 81,515,093 (GRCm39) probably null Het
Ttll4 G T 1: 74,718,928 (GRCm39) V260L probably benign Het
Other mutations in Zfand3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01148:Zfand3 APN 17 30,354,374 (GRCm39) missense probably benign 0.01
IGL01676:Zfand3 APN 17 30,354,337 (GRCm39) missense possibly damaging 0.90
IGL02931:Zfand3 APN 17 30,411,611 (GRCm39) missense probably benign 0.00
IGL03052:Zfand3 UTSW 17 30,279,798 (GRCm39) missense probably benign 0.03
R0083:Zfand3 UTSW 17 30,354,372 (GRCm39) missense probably damaging 1.00
R0661:Zfand3 UTSW 17 30,354,372 (GRCm39) missense probably damaging 1.00
R3732:Zfand3 UTSW 17 30,411,630 (GRCm39) missense probably benign 0.06
R3732:Zfand3 UTSW 17 30,411,630 (GRCm39) missense probably benign 0.06
R3733:Zfand3 UTSW 17 30,411,630 (GRCm39) missense probably benign 0.06
R4694:Zfand3 UTSW 17 30,354,362 (GRCm39) missense possibly damaging 0.66
R8029:Zfand3 UTSW 17 30,354,407 (GRCm39) missense probably benign 0.01
R9383:Zfand3 UTSW 17 30,354,479 (GRCm39) missense probably benign 0.01
R9546:Zfand3 UTSW 17 30,372,302 (GRCm39) missense probably benign 0.00
Posted On 2013-03-25