Incidental Mutation 'IGL01861:Olfr890'
ID178315
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr890
Ensembl Gene ENSMUSG00000096409
Gene Nameolfactory receptor 890
SynonymsMOR162-3, MOR162-15_p, GA_x6K02T2PVTD-31822365-31823309
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL01861
Quality Score
Status
Chromosome9
Chromosomal Location38142517-38148375 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 38143750 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 205 (I205T)
Ref Sequence ENSEMBL: ENSMUSP00000078733 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079804] [ENSMUST00000213087] [ENSMUST00000213458]
Predicted Effect probably damaging
Transcript: ENSMUST00000079804
AA Change: I205T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000078733
Gene: ENSMUSG00000096409
AA Change: I205T

DomainStartEndE-ValueType
Pfam:7tm_4 36 311 2.3e-48 PFAM
Pfam:7tm_1 46 293 9.6e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213087
AA Change: I200T
Predicted Effect probably damaging
Transcript: ENSMUST00000213458
AA Change: I200T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arrdc5 T C 17: 56,300,144 T34A possibly damaging Het
Atm C A 9: 53,494,612 R1252L probably null Het
Cd34 T C 1: 194,958,580 probably benign Het
Cmya5 A G 13: 93,089,748 V2944A probably damaging Het
Cntnap3 C T 13: 64,799,108 G169D probably damaging Het
Dnah7a T A 1: 53,640,349 T326S probably benign Het
Dnah7a C T 1: 53,584,449 probably benign Het
Fam133b A G 5: 3,564,242 probably benign Het
Fhod1 A G 8: 105,331,176 S906P probably damaging Het
Gli3 A G 13: 15,725,325 Y1099C probably damaging Het
Gpr63 C T 4: 25,008,545 T423M probably damaging Het
Hpx A T 7: 105,592,186 Y339* probably null Het
Lingo2 A T 4: 35,709,526 D151E probably benign Het
Mill2 A T 7: 18,856,640 Q215L probably damaging Het
Naf1 T C 8: 66,864,533 probably benign Het
Ndufv1 A G 19: 4,008,803 V235A probably benign Het
Pafah1b1 A T 11: 74,690,577 N22K possibly damaging Het
Prune1 G T 3: 95,265,557 R66S probably damaging Het
Ptcd1 A T 5: 145,158,777 I291N possibly damaging Het
Ptprk A G 10: 28,383,445 I294V possibly damaging Het
Rfx6 G A 10: 51,721,579 V471M probably damaging Het
Rnase6 C A 14: 51,130,291 Q47K probably benign Het
Skint5 T C 4: 113,559,824 probably benign Het
Srcap T A 7: 127,525,285 probably benign Het
Stap1 A G 5: 86,096,524 I217V possibly damaging Het
Taf1d T C 9: 15,308,739 probably null Het
Tecta T C 9: 42,373,362 H809R probably benign Het
Tex15 A G 8: 33,570,689 N49S probably damaging Het
Tubb4b-ps1 A G 5: 7,179,374 probably benign Het
Uhrf2 A G 19: 30,086,404 Y589C probably damaging Het
Zfp616 A T 11: 74,082,916 T4S possibly damaging Het
Zfp687 A T 3: 95,011,860 F200L probably damaging Het
Other mutations in Olfr890
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01505:Olfr890 APN 9 38143871 nonsense probably null
IGL02174:Olfr890 APN 9 38143785 missense possibly damaging 0.90
IGL02723:Olfr890 APN 9 38143411 missense probably benign 0.02
IGL03085:Olfr890 APN 9 38143183 missense probably damaging 0.98
FR4449:Olfr890 UTSW 9 38143188 missense probably benign 0.00
FR4737:Olfr890 UTSW 9 38143188 missense probably benign 0.00
R0637:Olfr890 UTSW 9 38143882 missense probably benign 0.00
R1353:Olfr890 UTSW 9 38143728 missense probably benign 0.03
R1813:Olfr890 UTSW 9 38143729 missense possibly damaging 0.78
R5997:Olfr890 UTSW 9 38143801 missense probably damaging 1.00
R6004:Olfr890 UTSW 9 38143960 missense probably damaging 1.00
R6417:Olfr890 UTSW 9 38143315 missense probably damaging 1.00
R6420:Olfr890 UTSW 9 38143315 missense probably damaging 1.00
R6720:Olfr890 UTSW 9 38143153 start codon destroyed probably null 1.00
Posted On2014-05-07